INCREDB ID : 287
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Amere Subbarao Sreedhar, Ph.D.
Scientist 
 
Centre for Cellular and Molecular Biology
Uppal Road
Hyderabad - 500 007   
Andhra Pradesh   
 
E-mail: assr@ccmb.res.in
Phone: +91-40-27192698
Fax: +91-40-27160311, +91-40-27160591
 
URL: http://www.ccmb.res.in/scientistdetails.php?grpid=23
 
Positions Held:
Position Affiliation Time Period
Scientist Center for Cellular and Molecular Biology, Hyderabad, India Present
 
Area of Specialization:
Molecular Biology
Research Summary:
Heat Shock Proteins in Biology and Medicine
 
Publications:
1. Rao, P. K., Kumar, J. K., Chaturvedi, V. and Sreedhar, A. S. Combinatorial effect of 17aag and doxorubicin on stress induced cellular senescence of human neuroblastoma cells. Journal of the Indian Academy of Geriatrics. 2010. 6, 133.
2. Chaturvedi, V. and Sreedhar, A. S. Hsp90 inhibition induces destabilization of actin cytoskeleton in tumor cells: functional significance of Hsp90 interaction with F–actin. Asian Pacific Journal of Tropical Medicine. 2010. 3, 715-722.
3. Taiyab, A., Srinivas, U. K.  And Sreedhar, A. S. 17-(Allylamino)-17-demethoxygeldanamycin combination with diferuloylmethane selectively targets mitogen kinase pathway in a human neuroblastoma cell line. Journal of Cancer Therapy. 2010. 1, 197-204.
4. Sreedhar, A. S. p53 pseudogene: potential role in heat shock induced apoptosis in a rat histiocytoma. Health. 2010. 2, 1065-1071.
5. Sreedhar, A. S. Hsp70 confines tumor progression of rat histiocytoma and impedes the cytotoxicity induced by natural killer cells and peritoneal macrophages. Asian Pacific Journal of Tropical Medicine. 2010. 3, 302-309.
6. Sreedhar, A. S., Vanathi, P. and Rao, P. K. Stress proteins in biology and medicine: evolution, adaptation and clinical evaluation. International Journal of Pharma and Bio Sciences. 2010. 1, 1-35.
7. Jyothi, D., Vanathi, P., Mangala, G., Rama, S., Rao, M. and Sreedhar, A. S.  Diferuloylmethane augments the cytotoxic effects of piplartine isolated from Piper chaba. Toxicology in Vitro. 2009.  23, 1085-1091. [PubMed]
8. Taiyab, A., Sreedhar, A. S. and Rao, M.  Hsp90 inhibitors, GA and 17AAG, lead to ER stress-induced apoptosis in rat histiocytoma. Biochemical Pharmacology. 2009.  78, 142-152. [PubMed]
9. Sreedhar, A. S. Stress response and emerging roles of heat shock proteins: Bench to Bedside. ICFAI Journal of Biotechnology. 2008. 2, 31-50.
10. Prasad, K. V., Taiyab, A., Jyothi, D., Srinivas, U. K. and Sreedhar, A. S.  Heat shock transcription factors regulate heat induced cell death in a rat histiocytoma. Journal of Biosciences. 2007.  32, 585-593. [PubMed]
11. Sreedhar, A. S. Hyperthermia and pharmacological interventions of heat shock proteins in anticancer treatments. Japanese Journal of Hyperthermic Oncology. 2006. 22, 201-227.
12. Sreedhar, A. S. Hidden dimensions of stress response. Everyman's Science. 2005. XL: 179-185.
13. Sreedhar, A. S. and Kuppa, U. S. Effect of Hsp90 inhibitors, geldanamycin, 17-allylamino-17-demethoxygeldanamycin and curcumin on human neuroblastoma cells, IMR-32. FEBS Journal. 2005. 272, G1-008P.
14. Sreedhar, A. S., Nardai, G. and Csermely, P. Enhancement of complement-induced cell lysis. A novel mechanism for the anticancer effects of Hsp90 inhibitors. Immunology Letters. 2004. 92, 157-161.
15. Gupta, S. C., Vegh, K. R., Takacs, T. and Sreedhar, A. S. Effect of potassium application on growth attributes and stem histology of chickpea grown in vertisol. National Journal of Life Sciences. 2004. 1, 187-191.
16. Sreedhar, A. S., Nardai, G. and Csermely, P.  Enhancement of complement-induced cell lysis: a novel mechanism for the anticancer effects of Hsp90 inhibitors. Immunology Letters. 2004.  92, 157-161. [PubMed]
17. Sreedhar, A. S., Kalmar, E., Csermely, P. and Shen, Y. F.  Hsp90 isoforms: functions, expression and clinical importance. FEBS Letters. 2004.  562, 11-15. [PubMed]
18. Sreedhar, A. S. and Csermely, P.  Heat shock proteins in the regulation of apoptosis: new strategies in tumor therapy: a comprehensive review. Pharmacology & Therapeutics. 2004.  101, 227-257. [PubMed]
19. Sreedhar, A. S., Soti, C. and Csermely, P.  Inhibition of Hsp90: a new strategy for inhibiting protein kinases. Biochimica et Biophysica Acta. 2004.  1697, 233-242. [PubMed]
20. Sreedhar, A. S. and Csermely, P. Novel Roles of Hsp90 inhibitors and Hsp90 in: redox regulation and cytoarchitecture. Recent Research Developments in Life Sciences. 2003. 1, 153-171.
21. Csermely, P., Soti, C., Kalmar, E., Papp, E., Pato, B., Vermes, A. and Sreedhar, A. S. Molecular chaperones, evolution and in medicine. Journal of Molecular Structure (Theochem). 2003. 666-667, 373-380.
22. Ishiwatari-Hayasaka, H., Maruya, M., Sreedhar, A. S., Nemoto, T. K., Csermely, P. and Yahara, I.  Interaction of neuropeptide Y and Hsp90 through a novel peptide binding region. Biochemistry. 2003.  42, 12972-12980. [PubMed]
23. Soti, C., Sreedhar, A. S. and Csermely, P.  Apoptosis, necrosis and cellular senescence: chaperone occupancy as a potential switch. Aging Cell. 2003.  2, 39-45. [PubMed]
24. Sreedhar, A. S., Mihaly, K., Pato, B., Schnaider, T., Stetak, A., Kis-Petik, K., Fidy, J., Simonics, T., Maraz, A. and Csermely, P.  Hsp90 inhibition accelerates cell lysis. Anti-Hsp90 ribozyme reveals a complex mechanism of Hsp90 inhibitors involving both superoxide- and Hsp90-dependent events. The Journal of Biological Chemistry. 2003.  278, 35231-35240. [PubMed]
25. Sreedhar, A. S. and Srinivas, U. K.  Activation of stress response by ionomycin in rat hepatoma cells. Journal of Cellular Biochemistry. 2002.  86, 154-161. [PubMed]
26. Sreedhar, A. S., Pardhasaradhi, B. V., Khar, A. and Srinivas, U. K.  Effect of C-terminal deletion of P53 on heat induced CD95 expression and apoptosis in a rat histiocytoma. Oncogene. 2002.  21, 4042-4049. [PubMed]
27. Sreedhar, A. S., Pardhasaradhi, B. V., Khar, A. and Srinivas, U. K.  A cross talk between cellular signalling and cellular redox state during heat-induced apoptosis in a rat histiocytoma. Free Radical Biology & Medicine. 2002.  32, 221-227. [PubMed]
28. Csermely, P., Sreedhar, A. S., Kalmare, E., Mihaly, K., Pato, B. and Soti, C. Emerging role for Hsp90 in protein folding, evolution, cell organization, and aging. European Journal of Biochemistry. 2002. 269, 3-5.
29. Khar, A., Srinivas, U. K., Pardhasaradhi, B. V. V., Sreedhar, A. S., Varalakshmi, Ch. and Ali, A. M. Role of stress response proteins in the regulation of cell death process. Cell Stress and Chaperones. 2001. 5, 338.
30. Sreedhar, A. S., Pardhasaradhi, B. V., Khar, A. and Srinivas, U. K.  Heat induced expression of CD95 and its correlation with the activation of apoptosis upon heat shock in rat histiocytic tumor cells. FEBS Letters. 2000.  472, 271-275. [PubMed]
31. Sreedhar, A. S., Pardhasaradhi, B. V., Begum, Z., Khar, A. and Srinivas, U. K.  Lack of heat shock response triggers programmed cell death in a rat histiocytic cell line. FEBS Letters. 1999.  456, 339-342. [PubMed]

 
Book Chapters:
Sreedhar, A. S., Oommen, D., Asthana, A. and Srinivas, U. K. Heat shock transcription factors: A comprehensive review. In: Stress Response: A Molecular Biology Approach. Sreedhar, A. S. and Srinivas, U. K., Eds. Research Signpost, Kerala, India. 2006. pp 25-42.
Sreedhar, A. S., Taiyab, A. and Asthana, A. Heat shock proteins in the clinical and pharmacological perspective. In: Stress Response: A Molecular Biology Approach. Sreedhar, A. S. and Srinivas, U. K., Eds. Research Signpost, Kerala, India. 2006. pp 265.
Stress Response: A Molecular Biology Approach. Sreedhar, A. S. and Srinivas, U. K., Eds. Research Signpost, Kerala, India. 2006.
Papp, E., Nardai, G., Sreedhar, A. S., Korcsmaros, T. and Csermely, P. Effect of unfolded protein accumulation on the redox state of the endoplasmic reticulum. In: Redox regulation. Pompella, A., Banhegyi, G. and Wellman-Rousseau, M., Eds. NATO Science Series. 2005. 363. pp 111-119.
 
 
Education 
::
Ph.D. in , , Semmelweis University, Budapest, Hungary
  Last modified on : Mar 4, 2011
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