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Sutapa Mukherjee, Ph.D.
Senior Scientific Officer, Gr-II 
 
Chittaranjan National Cancer Institute
Environmental Carcinogenesis and Toxicology
37, S. P. Mukherjee Road
Kolkata - 700 026   
West Bengal   
 
E-mail: sutapa mukherjee@cnci.org.in
Phone: +91-33-24765101, Extn.317
Fax: +91-33-4757606
 
URL: http://www.cnci.org.in/research/research_main.html
 
Positions Held:
Position Affiliation Time Period
Senior Scientific Officer, Gr-II Chittaranjan National Cancer Institute, Kolkata, India Present
 
Area of Specialization:
Pharmacology
Oncology
Research Summary:
Cancer chemoprevention by natural compounds like phenolic, polyphenolic compounds, indoles and isothiocyanates in Chinese hamster lung fibroblast (V79) cells as well as in lymphocytes from healthy human donors
Potential of these compounds in induction of various antioxidant enzymes
Role of curcumin in modulating DNA damage in lymphocytes isolated from human population chronically exposed to arsenic in different districts of West Bengal
Role of curcumin in inducing enhanced repair activity in lymphocytes isolated from human population exposed to arsenic
Modulatory role of several plant products on tumor markers like telomerase (using TRAP assay), different isoforms of protein kinase C (PKC), NFkB, histone deacetylase, signal transducers and activators of transcription (STAT) in tumor cell lines followed by induction of apoptosis in tumor cell lines
Sensitization and potentiation efficacy of natural compounds towards tumor cells apoptosis induced by conventional chemotherapeutic drugs
 
Publications:
1. Roy, M., Sinha, D., Mukherjee, S. and Biswas, J.  Curcumin prevents DNA damage and enhances the repair potential in a chronically arsenic-exposed human population in West Bengal, India. European Journal of Cancer Prevention. 2011.  20, 123-131. [PubMed]
2. Biswas, J., Roy, S., Mukherjee, S., Sinha, D. and Roy, M.  Indian spice curcumin may be an effective strategy to combat the genotoxicity of arsenic in Swiss albino mice. Asian Pacific Journal of Cancer Prevention : APJCP. 2010.  11, 239-247. [PubMed]
3. Mukherjee, S., Bhattacharya, R. K. and Roy, M.  Targeting protein kinase C (PKC) and telomerase by phenethyl isothiocyanate (PEITC) sensitizes PC-3 cells towards chemotherapeutic drug-induced apoptosis. Journal of Environmental Pathology, Toxicology and Oncology. 2009.  28, 269-282. [PubMed]
4. Mukherjee, S., Dey, S., Bhattacharya, R. K. and Roy, M.  Isothiocyanates sensitize the effect of chemotherapeutic drugs via modulation of protein kinase C and telomerase in cervical cancer cells. Molecular and Cellular Biochemistry. 2009.  330, 9-22. [PubMed]
5. Roy, M., Sinha, D., Mukherjee, S., Paul, S. and Bhattacharya, R. K.  Protective effect of dietary phytochemicals against arsenite induced genotoxicity in mammalian V79 cells. Indian Journal of Experimental Biology. 2008.  46, 690-697. [PubMed]
6. Mukherjee, S., Roy, M., Dey, S. and Bhattacharya, R. K.  A Mechanistic Approach for Modulation of Arsenic Toxicity in Human Lymphocytes by Curcumin, an Active Constituent of Medicinal Herb Curcuma longa Linn. Journal of Clinical Biochemistry and Nutrition. 2007.  41, 32-42. [PubMed]
7. Mukherjee, S.,Ghosh, U.,  Bhattacharya, N. P., Bhattacharya, R. K., Dey, S., Roy, M.  Curcumin Induced Apoptosis in Human Leukemia Cell HL-60 is Associated with Inhibition of Telomerase Activity. Molecular and Cellular Biochemistry. 2007. 297. 31-39.
8. Chakraborty, S., Ghosh, U., Bhattacharyya, N. P., Bhattacharya, R. K. and Roy, M.  Inhibition of telomerase activity and induction of apoptosis by curcumin in K-562 cells. Mutation Research. 2006. 596, 81-90. [PubMed]
9. Chakraborty, S., Kundu, T., Dey, S., Bhattacharya, R. K., Siddiqi, M. and Roy, M.  Tea-induced apoptosis in human leukemia K562 cells as assessed by comet formation. Asian Pacific Journal of Cancer Prevention : APJCP. 2006. 7, 201-207. [PubMed]
10. Halder, M., Mukherjee, S., Roy, M., Ray, J. G. Evaluation of DNA damage in whole blood of patients with oral precancers and oral squamous carcinoma by comet assay. The J Indian Dental Association. 2005. Vol 21, No. 3. 32-40.

 

 
Book Chapters:
Chakraborty, S., Roy, M., Bhattacharya, R. K. Tumor cell apoptosis by phytochemicals and herbal extracts, : Herbal Drugs, A twenty First Century Perspective Eds. R H Sharma and Rajesh Arora. JAYPEE Brothers. 2006. Article 35. 342-351.
 
Grant Support:
Project Title Role Funding Agency Sanction Number Sanction Date
Role of histome deacetylase inhibitors of natural origin towards sensitization of tumor celes via modulation of p53,p21waf1/cip1 and c-myc Department of Science & Technology, Government of India

 
 
 
Education 
::
M.Sc.
::
Ph.D.
Type of Neoplasms
Hemato-lymphoid system
Blood
  Last modified on : Mar 4, 2011
India Cancer Research Database has been developed by the Institute of Bioinformatics with funding from the Department of Biotechnology, Government of India.