INCREDB ID : 259
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Mrinal Kanti Ghosh, Ph.D.
Scientist E-I 
 
Indian Institute of Chemical Biology
Cell Biology and Physiology Division (CSIR)
4, Raja S. C. Mullick Road, Jadavpur
Kolkata - 700 032   
West Bengal   
 
E-mail: mrinalghosh@iicb.res.in, mrinal.res@gmail.com
 
URL: http://www.iicb.res.in/divisionwiselistofscientists/cbp/mkghosh.html
 
Positions Held:
Position Affiliation Time Period
Scientist E-I Indian Institute of Chemical Biology, Kolkata, India 2007-Present
Senior Lecturer Division of Biotechnology, HITK, Kolkata, India 2005-2007
Staff Cleveland Clinic Foundation, Ohio, USA 2003-2005
Post Doctoral Fellow Cleveland Clinic Foundation, Ohio, USA 1997-2003
 
Area of Specialization:
Cancer Biology
Stem Cells
Research Summary:
Cross-regulation of Wnt/beta-catenin and EGFR signalling in cancer
Role of DEAD Box RNA helicases in cancer
Role of Ubiquitinases and Deubiquitinases in cancer
Anti-cancer drug discovery from natural products and using target based synthetic peptides
 
Publications:
1. Sha, J.*, Ghosh, M. K.*, Zhang, K. and Harter, M. L.  E1A interacts with two opposing transcriptional pathways to induce quiescent cells into S phase. Journal of Virology. 2010.  84, 4050-4059 (*Contributed equally). [PubMed]
2. Ghosh, M. K., Sharma, P., Harbor, P. C., Rahaman, S. O. and Haque, S. J.  PI3K-AKT pathway negatively controls EGFR-dependent DNA-binding activity of Stat3 in glioblastoma multiforme cells. Oncogene. 2005.  24, 7290-7300. [PubMed]
3. Ghosh, M. K. and Harter, M. L.  A viral mechanism for remodeling chromatin structure in G0 cells. Molecular Cell. 2003.  12, 255-260. [PubMed]
4. Chattopadhyay, D., Ghosh, M. K., Mal, A. and Harter, M. L.  Inactivation of p21 by E1A leads to the induction of apoptosis in DNA-damaged cells. Journal of Virology. 2001.  75, 9844-9856. [PubMed]
5. Mal, A., Sturniolo, M., Schiltz, R. L., Ghosh, M. K. and Harter, M. L.  A role for histone deacetylase HDAC1 in modulating the transcriptional activity of MyoD: inhibition of the myogenic program. The EMBO Journal. 2001.  20, 1739-1753. [PubMed]
6. Mal, A., Chattopadhyay, D., Ghosh, M. K., Poon, R. Y., Hunter, T. and Harter, M. L.  p21 and retinoblastoma protein control the absence of DNA replication in terminally differentiated muscle cells. The Journal of Cell Biology. 2000.  149, 281-292. [PubMed]
7. Panda, K., Chattopadhyay, R., Ghosh, M. K., Chattopadhyay, D. J. and Chatterjee, I. B.  Vitamin C prevents cigarette smoke induced oxidative damage of proteins and increased proteolysis. Free Radical Biology  and Medicine. 1999.  27, 1064-1079. [PubMed]
8. Ghosh, M. K., Mukhopadhyay, M. and Chatterjee, I. B.  NADPH-initiated cytochrome P450-dependent free iron-independent microsomal lipid peroxidation: specific prevention by ascorbic acid. Molecular and Cellular Biochemistry. 1997.  166, 35-44. [PubMed]
9. Ghosh, M. K., Chattopadhyay, D. J. and Chatterjee, I. B.  Vitamin C prevents oxidative damage. Free Radical Research. 1996.  25, 173-179. [PubMed]
10. Ghosh, M.K., Arun, R., Chattopadhyay, D.J. and Chatterjee, I.B. Cytochrome P450-mediated oxidative damage of nuclear membrane proteins and its prevention by vitamin C. Indian Journal of Biochemistry and Boiphysics. 2003. 40, 309-314.
 

 
 
Education 
::
Ph.D. University of Calcutta, Kolkata, India
  Last modified on : Mar 4, 2011
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