INCREDB ID : 257
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Devendra Parmar, Ph.D.
Scientist F 
 
Indian Institute of Toxicology Research
Developmental Toxicology
Post Box No. 80, Mahatma Gandhi Marg
Lucknow - 226 001   
Uttar Pradesh   
 
E-mail: parmar_devendra@hotmail.com
Phone: +91-522-2627586, +91-522-2613786 Extn. 261
Fax: +91-522-2628227, +91-522-2611547
 
URL: http://www.iitrindia.org/Staff/DParmar.htm
 
Positions Held:
Position Affiliation Time Period
Scientist F Indian Institute of Toxicology Research, Lucknow, India Present
 
Area of Specialization:
Molecular Toxicology
Research Summary:
Expression of cytochrome P450s in brain and their role in neurobehavioral toxicity of pesticides
Blood cytochrome P450 (CYPs) expression profiles as biomarker of chemical exposure and effect
Predictive toxicology and single nucleotide polymorphism (SNPs)
 
Publications:
1. Singh, A. P., Pant, M. C., Ruwali, M., Shah, P. P., Prasad, R., Mathur, N. and Parmar, D.  Polymorphism in cytochrome P450 1A2 and their interaction with risk factors in determining risk of squamous cell lung carcinoma in men. Cancer Biomarkers : Section A of Disease Markers. 2010-2011.  8, 351-359. [PubMed]
2. Paul, S., Pant, M. C., Parmar, D. and Verma, J.  Association and treatment response to capecitabine-based chemoradiotherapy with CYP2C9 polymorphism in head and neck cancer. Indian Journal of Cancer. 2011.  48, 223-229. [PubMed]
3. Ruwali, M., Singh, M., Pant, M. C. and Parmar, D.  Polymorphism in glutathione S-transferases: susceptibility and treatment outcome for head and neck cancer. Xenobiotica; the Fate of Foreign Compounds in Biological Systems. 2011.  41, 1122-1130. [PubMed]
4. Yadav, S., Pandey, A., Shukla, A., Talwelkar, S. S., Kumar, A., Pant, A. B. and Parmar, D.  miR-497 and miR-302b regulate ethanol-induced neuronal cell death through BCL2 protein and cyclin D2. The Journal of Biological Chemistry. 2011.  286, 37347-37357. [PubMed]
5. Sharma, A., Saurabh, K., Yadav, S., Jain, S. K. and Parmar, D.  Ethanol induced induction of cytochrome P450 2E1 and activation of mitogen activated protein kinases in peripheral blood lymphocytes. Xenobiotica; the Fate of Foreign Compounds in Biological Systems. 2012.  42, 317-326. [PubMed]
6. Srivastava, A., Yadav, S., Sharma, A., Dwivedi, U. N., Flora, S. J. and Parmar, D.  Similarities in diesel exhaust particles induced alterations in expression of cytochrome P-450 and glutathione S-transferases in rat lymphocytes and lungs. Xenobiotica; the Fate of Foreign Compounds in Biological Systems. 2012.  42, 624-632. [PubMed]
7. Sankhwar, M. L., Yadav, R. S., Shukla, R. K., Pant, A. B., Singh, D., Parmar, D. and Khanna, V. K.  Impaired cholinergic mechanisms following exposure to monocrotophos in young rats. Human & Experimental Toxicology. 2012.  31, 606-616. [PubMed]
8. Shukla, P., Gupta, D., Pant, M. C. and Parmar, D.  CYP 2D6 polymorphism: a predictor of susceptibility and response to chemoradiotherapy in head and neck cancer. Journal of Cancer Research and Therapeutics. 2012.  8, 40-45. [PubMed]
9. Sharma, A., Dinesh, K., Yadav, S., Jain, S. K., Pant, M. C. and Parmar, D.  Cytochrome P450 2A isoenzymes in freshly prepared blood lymphocytes isolated from rats and validation as a biomarker for clinical studies in humans. Xenobiotica; the Fate of Foreign Compounds in Biological Systems. 2013.  43, 311-319. [PubMed]
10. Sharma, A., Saurabh, K., Yadav, S., Jain, S. K. and Parmar, D.  Expression profiling of selected genes of toxication and detoxication pathways in peripheral blood lymphocytes as a biomarker for predicting toxicity of environmental chemicals. International Journal of Hygiene and Environmental Health. 2013.  216, 645-651. [PubMed]
11. Shukla, A., Mohapatra, T. M., Agrawal, A. K., Parmar, D. and Seth, K.  Salsolinol induced apoptotic changes in neural stem cells: amelioration by neurotrophin support. Neurotoxicology. 2013.  35, 50-61. [PubMed]
12. Singh, A., Yadav, S., Srivastava, V., Kumar, R., Singh, D., Sethumadhavan, R. and Parmar, D.  Imprinting of cerebral and hepatic cytochrome p450s in rat offsprings exposed prenatally to low doses of cypermethrin. Molecular Neurobiology. 2013.  48, 128-140. [PubMed]
13. Kazmi, H. R., Chandra, A., Nigam, J., Noushif, M., Parmar, D. and Gupta, V.  Prognostic significance of K-ras codon 12 mutation in patients with resected gallbladder cancer. Digestive Surgery. 2013.  30, 233-239. [PubMed]
14. Khan, A. J., Sharma, A., Dinesh, K. and Parmar, D.  Similarities in lindane induced alteration in cytochrome P450s and associated signaling events in peripheral blood lymphocytes and brain. Food and Chemical Toxicology : An International Journal Published For the British Industrial Biological Research Association. 2013.  60, 318-327. [PubMed]
15. Ruwali, M. and Parmar, D.  Association of functionally important polymorphisms in cytochrome P450s with squamous cell carcinoma of head and neck. Indian Journal of Experimental Biology. 2010.  48, 651-665. [PubMed]
16. Khan, A. J., Sharma, A., Choudhuri, G. and Parmar, D.  Induction of blood lymphocyte cytochrome P450 2E1 in early stage alcoholic liver cirrhosis. Alcohol. 2011.  45, 81-87. [PubMed]
17. Singh, M., Khanna, V. K., Shukla, R. and Parmar, D.  Association of polymorphism in cytochrome P450 2D6 and N-acetyltransferase-2 with Parkinson's disease. Disease Markers. 2010.  28, 87-93. [PubMed]
18. Singh, K., Singh, S., Singhal, N. K., Sharma, A., Parmar, D. and Singh, M. P.  Nicotine- and caffeine-mediated changes in gene expression patterns of MPTP-lesioned mouse striatum: Implications in neuroprotection mechanism. Chemico-biological Interactions. 2010.  185, 81-93. [PubMed]
19. Khan, A. J., Husain, Q., Choudhuri, G. and Parmar, D.  Association of polymorphism in alcohol dehydrogenase and interaction with other genetic risk factors with alcoholic liver cirrhosis. Drug and Alcohol Dependence. 2010.  109, 190-197. [PubMed]
20. Yadav, S. S., Ruwali, M., Pant, M. C., Shukla, P., Singh, R. L. and Parmar, D.  Interaction of drug metabolizing cytochrome P450 2D6 poor metabolizers with cytochrome P450 2C9 and 2C19 genotypes modify the susceptibility to head and neck cancer and treatment response. Mutation Research. 2010.  684, 49-55. [PubMed]
21. Saurabh, K., Sharma, A., Yadav, S. and Parmar, D.  Polycyclic aromatic hydrocarbon metabolizing cytochrome P450s in freshly prepared uncultured rat blood lymphocytes. Biochemical Pharmacology. 2010.  79, 1182-1188. [PubMed]
22. Singh, A. P., Shah, P. P., Ruwali, M., Mathur, N., Pant, M. C. and Parmar, D.  Polymorphism in cytochrome P4501A1 is significantly associated with head and neck cancer risk. Cancer Investigation. 2009.  27, 869-876. [PubMed]
23. Shah, P. P., Saurabh, K., Pant, M. C., Mathur, N. and Parmar, D.  Evidence for increased cytochrome P450 1A1 expression in blood lymphocytes of lung cancer patients. Mutation Research. 2009.  670, 74-78. [PubMed]
24. Khan, A. J., Ruwali, M., Choudhuri, G., Mathur, N., Husain, Q. and Parmar, D.  Polymorphism in cytochrome P450 2E1 and interaction with other genetic risk factors and susceptibility to alcoholic liver cirrhosis. Mutation Research. 2009.  664, 55-63. [PubMed]
25. Ruwali, M., Pant, M. C., Shah, P. P., Mishra, B. N. and Parmar, D.  Polymorphism in cytochrome P450 2A6 and glutathione S-transferase P1 modifies head and neck cancer risk and treatment outcome. Mutation Research. 2009.  669, 36-41. [PubMed]
26. Sharma, V., Shukla, R. K., Saxena, N., Parmar, D., Das, M. and Dhawan, A.  DNA damaging potential of zinc oxide nanoparticles in human epidermal cells. Toxicology Letters. 2009.  185, 211-218. [PubMed]
27. Ruwali, M., Khan, A. J., Shah, P. P., Singh, A. P., Pant, M. C. and Parmar, D.  Cytochrome P450 2E1 and head and neck cancer: interaction with genetic and environmental risk factors. Environmental and Molecular Mutagenesis. 2009.  50, 473-482. [PubMed]
28. Khan, A. J., Choudhuri, G., Husain, Q. and Parmar, D.  Polymorphism in glutathione-S-transferases: a risk factor in alcoholic liver cirrhosis. Drug and Alcohol Dependence. 2009.  101, 183-190. [PubMed]
29. Pandey, A. K., Gurbani, D., Bajpayee, M., Parmar, D., Ajmani, S. and Dhawan, A.  In silico studies with human DNA topoisomerase-II alpha to unravel the mechanism of in vitro genotoxicity of benzene and its metabolites. Mutation Research. 2009.  661, 57-70. [PubMed]
30. Pandey, A. K., Bajpayee, M., Parmar, D., Kumar, R., Rastogi, S. K., Mathur, N., Thorning, P., de, M., Shao, Q., Anderson, D. and Dhawan, A.  Multipronged evaluation of genotoxicity in Indian petrol-pump workers. Environmental and Molecular Mutagenesis. 2008.  49, 695-707. [PubMed]
31. Singh, V., Parmar, D. and Singh, M. P.  Do single nucleotide polymorphisms in xenobiotic metabolizing genes determine breast cancer susceptibility and treatment outcomes? Cancer Investigation. 2008.  26, 769-783. [PubMed]
32. Yadav, S. S., Ruwali, M., Shah, P. P., Mathur, N., Singh, R. L., Pant, M. C. and Parmar, D.  Association of poor metabolizers of cytochrome P450 2C19 with head and neck cancer and poor treatment response. Mutation Research. 2008.  644, 31-37. [PubMed]
33. Shah, P. P., Singh, A. P., Singh, M., Mathur, N., Mishra, B. N., Pant, M. C. and Parmar, D.  Association of functionally important polymorphisms in cytochrome P4501B1 with lung cancer. Mutation Research. 2008.  643, 4-10. [PubMed]
34. Johri, A., Yadav, S., Dhawan, A. and Parmar, D.  Responsiveness of cerebral and hepatic cytochrome P450s in rat offspring prenatally exposed to lindane. Toxicology and Applied Pharmacology. 2008.  231, 10-16. [PubMed]
35. Dhawan, A., Bajpayee, M. and Parmar, D.  Comet assay: a reliable tool for the assessment of DNA damage in different models. Cell Biology and Toxicology. 2009.  25, 5-32. [PubMed]
36. Singh, M., Khan, A. J., Shah, P. P., Shukla, R., Khanna, V. K. and Parmar, D.  Polymorphism in environment responsive genes and association with Parkinson disease. Molecular and Cellular Biochemistry. 2008.  312, 131-138. [PubMed]
37. Shah, P. P., Singh, A. P., Singh, M., Mathur, N., Pant, M. C., Mishra, B. N. and Parmar, D.  Interaction of cytochrome P4501A1 genotypes with other risk factors and susceptibility to lung cancer. Mutation Research. 2008.  639, 1-10. [PubMed]
38. Singh, A. P., Shah, P. P., Mathur, N., Buters, J. T., Pant, M. C. and Parmar, D.  Genetic polymorphisms in cytochrome P4501B1 and susceptibility to head and neck cancer. Mutation Research. 2008.  639, 11-19. [PubMed]
39. Singh, M., Shah, P. P., Singh, A. P., Ruwali, M., Mathur, N., Pant, M. C. and Parmar, D.  Association of genetic polymorphisms in glutathione S-transferases and susceptibility to head and neck cancer. Mutation Research. 2008.  638, 184-194. [PubMed]
40. Johri, A., Dhawan, A., Singh, R. L. and Parmar, D.  Persistence in alterations in the ontogeny of cerebral and hepatic cytochrome P450s following prenatal exposure to low doses of lindane. Toxicological Sciences : An Official Journal of the Society of Toxicology. 2008.  101, 331-340. [PubMed]
41. Johri, A., Yadav, S., Dhawan, A. and Parmar, D.  Overexpression of cerebral and hepatic cytochrome P450s alters behavioral activity of rat offspring following prenatal exposure to lindane. Toxicology and Applied Pharmacology. 2007.  225, 278-292. [PubMed]
42. Kapoor, N., Pant, A. B., Dhawan, A., Dwievedi, U. N., Seth, P. K. and Parmar, D.  Differences in the expression and inducibility of cytochrome P450 2B isoenzymes in cultured rat brain neuronal and glial cells. Molecular and Cellular Biochemistry. 2007.  305, 199-207. [PubMed]
43. Patel, S., Bajpayee, M., Pandey, A. K., Parmar, D. and Dhawan, A.  In vitro induction of cytotoxicity and DNA strand breaks in CHO cells exposed to cypermethrin, pendimethalin and dichlorvos. Toxicology in Vitro . 2007.  21, 1409-1418. [PubMed]
44. Sinha, A., Singh, C., Parmar, D. and Singh, M. P.  Proteomics in clinical interventions: achievements and limitations in biomarker development. Life Sciences. 2007.  80, 1345-1354. [PubMed]
45. Yadav, S., Johri, A., Dhawan, A., Seth, P. K. and Parmar, D.  Regional specificity in deltamethrin induced cytochrome P450 expression in rat brain. Toxicology and Applied Pharmacology. 2006.  217, 15-24. [PubMed]
46. Kapoor, N., Pant, A. B., Dhawan, A., Dwievedi, U. N., Seth, P. K. and Parmar, D.  Cytochrome P450 1A isoenzymes in brain cells: Expression and inducibility in cultured rat brain neuronal and glial cells. Life Sciences. 2006.  79, 2387-2394. [PubMed]
47. Bajpayee, M., Pandey, A. K., Zaidi, S., Musarrat, J., Parmar, D., Mathur, N., Seth, P. K. and Dhawan, A.  DNA damage and mutagenicity induced by endosulfan and its metabolites. Environmental and Molecular Mutagenesis. 2006.  47, 682-692. [PubMed]
48. Johri, A., Yadav, S., Singh, R. L., Dhawan, A., Ali, M. and Parmar, D.  Long lasting effects of prenatal exposure to deltamethrin on cerebral and hepatic cytochrome P450s and behavioral activity in rat offspring. European Journal of Pharmacology. 2006.  544, 58-68. [PubMed]
49. Dey, A., Yadav, S., Dhawan, A., Seth, P. K. and Parmar, D.  Evidence for cytochrome P450 3A expression and catalytic activity in rat blood lymphocytes. Life Sciences. 2006.  79, 1729-1735. [PubMed]
50. Patel, S., Pandey, A. K., Bajpayee, M., Parmar, D. and Dhawan, A.  Cypermethrin-induced DNA damage in organs and tissues of the mouse: evidence from the comet assay. Mutation Research. 2006.  607, 176-183. [PubMed]
51. Kapoor, N., Pant, A. B., Dhawan, A., Dwievedi, U. N., Gupta, Y. K., Seth, P. K. and Parmar, D.  Differences in sensitivity of cultured rat brain neuronal and glial cytochrome P450 2E1 to ethanol. Life Sciences. 2006.  79, 1514-1522. [PubMed]
52. Yadav, S., Dhawan, A., Seth, P. K., Singh, R. L. and Parmar, D.  Cytochrome P4503A: evidence for mRNA expression and catalytic activity in rat brain. Molecular and Cellular Biochemistry. 2006.  287, 91-99. [PubMed]
53. Yadav, S., Dhawan, A., Singh, R. L., Seth, P. K. and Parmar, D.  Expression of constitutive and inducible cytochrome P450 2E1 in rat brain. Molecular and Cellular Biochemistry. 2006.  286, 171-180. [PubMed]
54. Johri, A., Dhawan, A., Lakhan, S. and Parmar, D.  Effect of prenatal exposure of deltamethrin on the ontogeny of xenobiotic metabolizing cytochrome P450s in the brain and liver of offsprings. Toxicology and Applied Pharmacology. 2006.  214, 279-289. [PubMed]
55. Pandey, M. K., Yadav, S., Parmar, D. and Das, M.  Induction of hepatic cytochrome P450 isozymes, benzo(a)pyrene metabolism and DNA binding following exposure to polycyclic aromatic hydrocarbon residues generated during repeated fish fried oil in rats. Toxicology and Applied Pharmacology. 2006.  213, 126-134. [PubMed]
56. Pandey, A. K., Bajpayee, M., Parmar, D., Rastogi, S. K., Mathur, N., Seth, P. K. and Dhawan, A.  DNA damage in lymphocytes of Indian rickshaw pullers as measured by the alkaline Comet assay. Environmental and Molecular Mutagenesis. 2006.  47, 25-30. [PubMed]
57. Dey, A., Dhawan, A., Kishore, S. and Parmar, D.  Evidence for cytochrome P450 2E1 catalytic activity and expression in rat blood lymphocytes. Life Sciences. 2005.  77, 1082-1093. [PubMed]
58. Pandey, A. K., Bajpayee, M., Parmar, D., Rastogi, S. K., Mathur, N., Seth, P. K. and Dhawan, A.  DNA damage in lymphocytes of rural Indian women exposed to biomass fuel smoke as assessed by the Comet assay. Environmental and Molecular Mutagenesis. 2005.  45, 435-441. [PubMed]
59. Bajpayee, M., Pandey, A. K., Parmar, D., Mathur, N., Seth, P. K. and Dhawan, A.  Comet assay responses in human lymphocytes are not influenced by the menstrual cycle: a study in healthy Indian females. Mutation Research. 2005.  565, 163-172. [PubMed]
60. Bajpayee, M., Pandey, A. K., Parmar, D. and Dhawan, A.  Current Status of Short-Term Tests for Evaluation of Genotoxicity, Mutagenicity, and Carcinogenicity of Environmental Chemicals and NCEs. Toxicology Mechanisms and Methods. 2005.  15, 155-180. [PubMed]
61. Bajpayee, M., Dhawan, A., Parmar, D., Pandey, A. K., Mathur, N. and Seth, P. K.  Gender-related differences in basal DNA damage in lymphocytes of a healthy Indian population using the alkaline Comet assay. Mutation Research. 2002.  520, 83-91. [PubMed]
 

 
My CV:   Download
 
Education 
::
Ph.D.
Honors and Awards
::
2010, Lecture Award in the field of Toxicology, Memorial Lectures, The National Academy of Sciences, India
  Last modified on : Dec 14, 2015
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