INCREDB ID : 253
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Sudin Bhattacharya, Ph.D.
Senior Scientific Officer (Assistant Director Grade) 
 
Chittaranjan National Cancer Institute
Department of Cancer Chemoprevention
37, S. P. Mukherjee Road
Kolkata - 700 026   
West Bengal   
 
E-mail: sudin.bhattacharaya@cnci.org.in, sudinb1957@gmail.com
Phone: +91-33-24765101, Extn.316
Mobile: 09830446739
Fax: +91-33-4757606
 
URL: http://www.cnci.org.in/research/research_main.html
 
Positions Held:
Position Affiliation Time Period
Senior Scientific Officer (Assistant Director Grade) and Head Department of Cancer Chemoprevention, Chittaranjan National Cancer Institute, Kolkata, India Present
 
Area of Specialization:
Pharmacology
Oncology
Medicinal Chemistry
Cancer Chemoprevention
Research Summary:
Synthesis and evaluation of antioxidative as well as cancer chemopreventive properties of novel synthetic compounds such as organoselenium compounds, thiazolidinedione derivatives etc and naturally occurring tea polyphenols against carbon tetrachloride, cadmium, lead and arsenic etc. induced acute toxicity model in mice and on a number of animal carcinogenesis models viz. skin, colon and lung
To reduce the toxic manifestation imparted by different cancer chemotherapeutic drugs by novel organoselenium compounds, nanoselenium and complementary alternative medicines
 
Publications:
1. Das J.K., Sarkar S., Hossain U. S. K., Chakraborty P., Das R. K. and Bhattacharya S. Diphenylmethyl selenocyanate attenuates malachite green induced oxidative injury through antioxidation and inhibition of DNA damage in mice. Indian Journal of Medical Research 2012 (in press).
2. Dhar S., Rana D. K. ,Roy S. S., Roy S. , Bhattacharya S., Bhattacharya S. C. Effect of solvent environment on the Photophysics of a newly synthesized bioactive 7-oxy(5-selenocyanato-pentyl)-2H-1-benzopyran-2-one. Journal of Luminescence, 2012, Volume 132, Issue 4, Pages 957-964.
3. Roy S. S., Chakraborty P., Ghosh P., Bhattacharya S.. Micronutrient for Prevention of Cancer Chemotherapeutic Drugs Induced DNA Damage and Cellular Toxicities, With Special Reference to Selenium. Perspectives in Cytology and Genetics,  2011, Vol.-XV, 123-138
4. Ghosh, P., Roy, S. S., Chakraborty, P., Ghosh, S. and Bhattacharya, S.  Effects of organoselenium compound 2-(5-selenocyanato-pentyl)-benzo[de]isoquinoline 1,3-dione on cisplatin induced nephrotoxicity and genotoxicity: an investigation of the influence of the compound on oxidative stress and antioxidant enzyme system. Biometals. 2012.  [PubMed]
5. Roy, S. S., Chakraborty, P., Ghosh, P., Ghosh, S., Biswas, J. and Bhattacharya, S.  Influence of novel naphthalimide-based organoselenium on genotoxicity induced by an alkylating agent: the role of reactive oxygen species and selenoenzymes. Redox Report : Communications in Free Radical Research. 2012.  17, 157-166. [PubMed]
6. Das, I., Acharya, A., Berry, D. L., Sen, S., Williams, E., Permaul, E., Sengupta, A., Bhattacharya, S. and Saha, T.  Antioxidative effects of the spice cardamom against non-melanoma skin cancer by modulating nuclear factor erythroid-2-related factor 2 and NF-kappaB signalling pathways. The British Journal of Nutrition. 2012.  108, 984-997. [PubMed]
7. Dhar, S., Roy, S. S.,  Rana, D., Bhattacharya, S., Bhattacharya, S., Bhattacharya, S. Tunable Solvatochromic Response of Newly Synthesized Antioxidative Naphthalimide Derivatives: Intramolecular Charge Transfer Associated with Hydrogen Bonding Effect. The Journal of Physical Chemistry A. 2011
8. Chatterjee, A., Biswas, J., Chatterjee, A., Bhattacharya, S., Mukhopadhyay, B. and Mandal, S.  Psorinum therapy in treating stomach, gall bladder, pancreatic, and liver cancers: a prospective clinical study. Evidence-based Complementary and Alternative Medicine . 2011.  2011, 724743. [PubMed]
9. Chakraborty, P., Roy, S. S., Sk, U. H. and Bhattacharya, S.  Amelioration of cisplatin-induced nephrotoxicity in mice by oral administration of diphenylmethyl selenocyanate. Free Radical Research. 2011.  45, 177-187. [PubMed]
10. Ugir Hossain S. K., Arun K. Sharma, Sulekha Ghosh, Bhattacharya, S.. Synthesis and biological evaluation of novel spiro 6-methoxytetralin-1,30-pyrrolidine based organoselenocyanates against cadmium-induced oxidative and hepatic damage in mice. European Journal of Medicinal Chemistry 2010, 45, 3265-3273.
11. A. Chatterjee, Biswas, J.,  A. K.Chatterjee,  Bhattacharya, S. et al. A Phase II, single-arm clinical trial involving an alternative cancer treatment psorinum therapy in patients with advanced non-small cell lung cancer. American Society of Clinical Oncology.  2010, 28: 15s
12. Roy, S. S., Ghosh, P., Sk, U. H., Chakraborty, P., Biswas, J., Mandal, S., Bhattacharjee, A. and Bhattacharya, S.  Naphthalimide based novel organoselenocyanates: finding less toxic forms of selenium that would retain protective efficacy. Bioorganic & Medicinal Chemistry Letters. 2010.  20, 6951-6955. [PubMed]
13. Sarkar, A., Banerjee, P., Hossain, S. U., Bhattacharya, S. and Bhattacharya, S. C.  Role of hydrogen bonding on the spectroscopic properties of thiazolidinedione derivatives in homogeneous solvents. Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy. 2009.  72, 1097-1102. [PubMed]
14. A.Chatterjee , Bhattacharya, S., A. K. Chatterjee , J. Biswas , B. P. Mukhopadhyay . A prospective observational clinical study involving an alternative cancer treatment, psorinum therapy, in treating stomach, gall bladder, pancreas and liver cancers. American Society of Clinical Oncology.  2009; 27: 15s
15. Pramita Chakraborty, Ugir Hossain S. K., Nabendu Murmu, Jayanta K. Das, Smarajit Pal & Bhattacharya, S. Modulation of Cyclophosphamide Induced Cellular Toxicity by Diphenylmethyl Selenocyanate In Vivo, an Enzymatic Study. Journal of Cancer Molecules 2009, 4(6), 183-189.
16. Chakraborty, P., Sk, U. H. and Bhattacharya, S.  Chemoprotection and enhancement of cancer chemotherapeutic efficacy of cyclophosphamide in mice bearing Ehrlich ascites carcinoma by diphenylmethyl selenocyanate. Cancer Chemotherapy and Pharmacology. 2009.  64, 971-980. [PubMed]
17. Banerjee, P., Chatterjee, S., Pramanik, S., Hossain, S. U., Bhattacharya, S. and Bhattacharya, S. C.  Spectroscopic studies of 2-(2-bromo-ethyl)-6-nitro-benzo[de]isoquinolene-1,3-dione in water/alkanol mixed solvents and nonionic micelle of Igepal CO series. Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy. 2007.  66, 1110-1114. [PubMed]
18. Ugir Hossain S. K. and Bhattacharya, S. Synthesis of some 2,4-thiazolidinedione compounds and Evaluation of their Free Radical Scavenging Activity as well as Effect on some phase II Antioxidant. Bioorganic and Medicinal Chemistry Letter, 2007, 17, 1149-1154
19. Sujan Chatterjee, Smritimoy Pramanik, S. K. Ugir Hossain, Bhattacharya, S. and Subhash Chandra Bhattacharya. Synthesis and Photoinduced intramolecular charge transfer of N-substituted1,8-Naphthalimide derivatives in homogeneous solvents and in presence of reduced glutathione. Journal of Photochemistry and Photobiology A: Chemistry  2007, 187 (1), 64-71
20. Das, R. K. and Bhattacharya, S.  Anti-tumour promoting activity of diphenylmethyl selenocyanate against two-stage mouse skin carcinogenesis. Asian Pacific Journal of Cancer Prevention.  6, 181-188. [PubMed]
21. Das, R. K., Hossain, S. U. and Bhattacharya, S.  Protective effect of diphenylmethyl selenocyanate against CCl4-induced hepatic injury. Journal of Applied Toxicology . 2007.  27, 527-537. [PubMed]
22. Hossain, S. U. and Bhattacharya, S.  Synthesis of O-prenylated and O-geranylated derivatives of 5-benzylidene2,4-thiazolidinediones and evaluation of their free radical scavenging activity as well as effect on some phase II antioxidant/detoxifying enzymes. Bioorganic & Medicinal Chemistry Letters. 2007.  17, 1149-1154. [PubMed]
23. Das, R. K., Banerjee, S. and Bhattacharya, S.  Amelioration of benzo (a) pyrene-induced lung carcinogenesis in strain A mice by diphenylmethyl selenocyanate. Experimental and Toxicologic Pathology . 2007.  58, 351-360. [PubMed]
24. Sengupta, A., Ghosh, S., Das, R. K., Bhattacharjee, S. and Bhattacharya, S.  Chemopreventive potential of diallylsulfide, lycopene and theaflavin during chemically induced colon carcinogenesis in rat colon through modulation of cyclooxygenase-2 and inducible nitric oxide synthase pathways. European Journal of Cancer Prevention. 2006.  15, 301-305. [PubMed]
25. Ugir Hossain S. K. and Bhattacharya, S.   Prevention of cadmium induced lipid peroxidation, depletion of some antioxidative enzymes and glutathione by a series of novel organoselenocyanates.  Environmental Toxicology and Pharmacology.  2006, 22 (3), 298-308.
26. Das, R. K., Hossain, S. K. and Bhattacharya, S.  Diphenylmethyl selenocyanate inhibits DMBA-croton oil induced two-stage mouse skin carcinogenesis by inducing apoptosis and inhibiting cutaneous cell proliferation. Cancer Letters. 2005.  230, 90-101. [PubMed]
27. Hossain, S. U., Sengupta, S. and Bhattacharya, S.  Synthesis and evaluation of antioxidative properties of a series of organoselenium compounds. Bioorganic & Medicinal Chemistry. 2005.  13, 5750-5758. [PubMed]
28. Ghosh, S., Das, R. K., Sengupta, A. and Bhattacharya, S.  Inhibition of azoxymethane-induced aberrant crypt foci in rat by diphenylmethyl selenocyanate through downregulation of COX-2 and modulation of glutathione-S-transferase and lipid peroxidation. Biological Trace Element Research. 2005.  105, 171-185. [PubMed]
29. Ghosh, S.K., Hossain, U., Bhattacharya, S. and Bhattacharya, S.,C. 2-(2-Selenocyanic acid ethyl ester) –1H-benz[de] isoquonoline –1,3-(2H)- dione, synthesis photophysics and interaction with bovine serum albumin: A spectroscopic approach. Journal of Photochemistry and Photobiology. 2005. 81, 121-128.
30. Das, R. K., Das, S. and Bhattacharya, S.  Protective effect of diphenylmethyl selenocyanate against carbon tetrachloride-induced hepatotoxicity in vivo. Journal of Environmental Pathology, Toxicology and Oncology . 2004.  23, 287-296. [PubMed]
31. Das, R. K., Ghosh, S., Sengupta, A., Das, S. and Bhattacharya, S.  Inhibition of DMBA/croton oil-induced two-stage mouse skin carcinogenesis by diphenylmethyl selenocyanate. European Journal of Cancer Prevention . 2004.  13, 411-417. [PubMed]
32. Murmu, N., Ghosh, P., Gomes, A., Mitra, S., Das, M., Besra, S. E., Majumdar, J., Bhattacharya, S., Sur, P. and Vedasiromoni, J. R.  Antineoplastic effect of new boron compounds against leukemic cell lines and cells from leukemic patients. Journal of Experimental & Clinical Cancer Research. 2002.  21, 351-356. [PubMed]
33. Murmu, N., Mitra, S., Das, M., Gomes, A., Vedasiromoni, J. R., Ghosh, M., Bhattacharya, M., Ghosh, P., Biswas, J., Bhattacharya, S. and Sur, P.  Boron compounds against human leukemic cells. Journal of Experimental & Clinical Cancer Research : CR. 2001.  20, 511-515. [PubMed]
34. Ghosh, M., Sadhu, U., Bhattacharya, S., Dutta, S., Bhattacharya, B. and Sanyal, U.  Evaluation of toxicity of beta-tethymustine, a new anticancer compound, in mice. Cancer Letters. 1999.  138, 107-114. [PubMed]
35. Ghosh, M., Bhattacharya, S., Sadhu, U., Dutta, S. and Sanyal, U.  Evaluation of beta-tethymustine, a new anticancer compound, in murine tumour models. Cancer Letters. 1997.  119, 7-12. [PubMed]
36. Bhattacharya, S., Ghosh, M., Sadhu, U., Dutta, S. and Sanyal, U.  Evaluation of phthalmustine, a new anticancer compound. II. Tumor inhibitory effect in murine Ehrlich ascites carcinoma and sarcoma-180. Neoplasma. 1996.  43, 209-213. [PubMed]
37. Sadhu, U., Ghosh, M., Bhattacharya, S., Dutta, S., Das, H. and Sanyal, U.  Evaluation of toxicity of cypenhymustine, a new anticancer compound, in mice. Cancer Letters. 1994.  85, 65-72. [PubMed]
38. Bhattacharya, S., Ganguly, C., Sanyal, U. and Das, S.  Evaluation of phthalmustine, a new anticancer compound. I. Effect on Dalton's ascitic lymphoma in mice. Neoplasma. 1994.  41, 35-38. [PubMed]
39. Sanyal, U., Bhattacharya, S., Sadhu, U., Dutta, S., Das, H. and Ghosh, M.  Evaluation of 'cypenhymustine', a new anticancer compound, in murine tumour models. Cancer Letters. 1993.  70, 1-6. [PubMed]

 
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Education 
::
M.Sc.
::
Ph.D.
Type of Neoplasms
Pulmonary system
Lung
Gastrointestinal tract
Colon
Skin
Epidermis, Dermis, Appendages
  Last modified on : Nov 28, 2012
India Cancer Research Database has been developed by the Institute of Bioinformatics with funding from the Department of Biotechnology, Government of India.