INCREDB ID : 246
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Rathindranath Baral, Ph.D.
Senior Scientific Officer Gr-1 
 
Chittaranjan National Cancer Institute
Immunoregulation and Immunodiagnostics
37, S. P. Mukherjee Road
Kolkata - 700 026   
West Bengal   
 
E-mail: rathindranath.baral@cnci.org.in
Phone: +91-33-24765101, Extn.334
Fax: +91-33-4757606
 
URL: http://www.cnci.org.in/research/research_main.html#
 
Positions Held:
Position Affiliation Time Period
Senior Scientific Officer Gr-1 Chittaranjan National Cancer Institute, Kolkata, India Present
 
Area of Specialization:
Immunology
Research Summary:
Effect of neem leaf glycoprotein on tumor growth
 
Publications:
1. Roy, S., Goswami, S., Bose, A., Chakraborty, K., Pal, S., Haldar, A., Basu, P., Biswas, J. and Baral, R.  Neem leaf glycoprotein partially rectifies suppressed dendritic cell functions and associated T cell efficacy in stage IIIB cervical cancer patients. Clinical and Vaccine Immunology. 2011.  [PubMed]
2. Chakraborty, K., Bose, A., Chakraborty, T., Sarkar, K., Goswami, S., Pal, S. and Baral, R.  Restoration of dysregulated CC chemokine signaling for monocyte/macrophage chemotaxis in head and neck squamous cell carcinoma patients by neem leaf glycoprotein maximizes tumor cell cytotoxicity. Cellular & Molecular Immunology. 2010.  7, 396-408. [PubMed]
3. Sarkar, K., Goswami, S., Roy, S., Mallick, A., Chakraborty, K., Bose, A. and Baral, R.  Neem leaf glycoprotein enhances carcinoembryonic antigen presentation of dendritic cells to T and B cells for induction of anti-tumor immunity by allowing generation of immune effector/memory response. International Immunopharmacology. 2010.  10, 865-874. [PubMed]
4. Goswami, S., Bose, A., Sarkar, K., Roy, S., Chakraborty, T., Sanyal, U. and Baral, R.  Neem leaf glycoprotein matures myeloid derived dendritic cells and optimizes anti-tumor T cell functions. Vaccine. 2010.  28, 1241-1252. [PubMed]
5. Ghosh, D., Bose, A., Haque, E. and Baral, R.  Neem (Azadirachta indica) leaf preparation prevents leukocyte apoptosis mediated by cisplatin plus 5-fluorouracil treatment in Swiss mice. Chemotherapy. 2009.  55, 137-144. [PubMed]
6. Baral, R., Bose, A., Ray, C., Paul, S., Pal, S., Haque, E., Mishra, B., Pal, D., Nagpal, J. K., Panda, C. K. and Das, B. R.  Association of early phase of colorectal carcinogenesis with STAT3 activation and its relevance in apoptosis regulation. Experimental and Molecular Pathology. 2009.  87, 36-41. [PubMed]
7. Bose, A., Chakraborty, K., Sarkar, K., Goswami, S., Chakraborty, T., Pal, S. and Baral, R.  Neem leaf glycoprotein induces perforin-mediated tumor cell killing by T and NK cells through differential regulation of IFNgamma signaling. Journal of Immunotherapy. 2009.  32, 42-53. [PubMed]
8. Sarkar, K., Bose, A., Haque, E., Chakraborty, K., Chakraborty, T., Goswami, S., Ghosh, D. and Baral, R.  Induction of type 1 cytokines during neem leaf glycoprotein assisted carcinoembryonic antigen vaccination is associated with nitric oxide production. International Immunopharmacology. 2009.  9, 753-760. [PubMed]
9. Bose, A., Chakraborty, K., Sarkar, K., Goswami, S., Haque, E., Chakraborty, T., Ghosh, D., Roy, S., Laskar, S. and Baral, R.  Neem leaf glycoprotein directs T-bet-associated type 1 immune commitment. Human Immunology. 2009.  70, 6-15. [PubMed]
10. Chakraborty, K., Bose, A., Pal, S., Chattopadhyay, U. and Baral, R.  Interferon-alpha2b restores the impaired chemotactic activity of peripheral blood mononuclear cells from head and neck squamous cell carcinoma patients by modulating CXC receptor ligand interaction. Journal of Interferon & Cytokine Research. 2008.  28, 487-499. [PubMed]
11. Sarkar, K., Bose, A., Chakraborty, K., Haque, E., Ghosh, D., Goswami, S., Chakraborty, T., Laskar, S. and Baral, R.  Neem leaf glycoprotein helps to generate carcinoembryonic antigen specific anti-tumor immune responses utilizing macrophage-mediated antigen presentation. Vaccine. 2008.  26, 4352-4362. [PubMed]
12. Bose, A., Chakraborty, T., Chakraborty, K., Pal, S. and Baral, R.  Dysregulation in immune functions is reflected in tumor cell cytotoxicity by peripheral blood mononuclear cells from head and neck squamous cell carcinoma patients. Cancer Immunity. 2008.  8, 10. [PubMed]
13. Chakroborty, D., Chowdhury, U. R., Sarkar, C., Baral, R., Dasgupta, P. S. and Basu, S.  Dopamine regulates endothelial progenitor cell mobilization from mouse bone marrow in tumor vascularization. The Journal of Clinical Investigation. 2008.  118, 1380-1389. [PubMed]
14. Chakraborty, K., Bose, A., Pal, S., Sarkar, K., Goswami, S., Ghosh, D., Laskar, S., Chattopadhyay, U. and Baral, R.  Neem leaf glycoprotein restores the impaired chemotactic activity of peripheral blood mononuclear cells from head and neck squamous cell carcinoma patients by maintaining CXCR3/CXCL10 balance. International Immunopharmacology. 2008.  8, 330-340. [PubMed]
15. Bose, A. and Baral, R.  Natural killer cell mediated cytotoxicity of tumor cells initiated by neem leaf preparation is associated with CD40-CD40L-mediated endogenous production of interleukin-12. Human Immunology. 2007.  68, 823-831. [PubMed]
16. Bose, A., Haque, E. and Baral, R.  Neem leaf preparation induces apoptosis of tumor cells by releasing cytotoxic cytokines from human peripheral blood mononuclear cells. Phytotherapy Research. 2007.  21, 914-920. [PubMed]
17. Mandal-Ghosh, I., Chattopadhyay, U. and Baral, R.  Neem leaf preparation enhances Th1 type immune response and anti-tumor immunity against breast tumor associated antigen. Cancer Immunity. 2007.  7, 8. [PubMed]
18. Sarkar, K., Bose, A., Laskar, S., Choudhuri, S. K., Dey, S., Roychowdhury, P. K. and Baral, R.  Antibody response against neem leaf preparation recognizes carcinoembryonic antigen. International Immunopharmacology. 2007.  7, 306-312. [PubMed]
19. Bose, A. and Baral, R.  IFNalpha2b stimulated release of IFNgamma differentially regulates T cell and NK cell mediated tumor cell cytotoxicity. Immunology Letters. 2007.  108, 68-77. [PubMed]
20. Haque, E. and Baral, R.  Neem (Azadirachta indica) leaf preparation induces prophylactic growth inhibition of murine Ehrlich carcinoma in Swiss and C57BL/6 mice by activation of NK cells and NK-T cells. Immunobiology. 2006.  211, 721-731. [PubMed]
21. Ghosh, D., Bose, A., Haque, E. and Baral, R.  Pretreatment with neem (Azadirachta indica) leaf preparation in Swiss mice diminishes leukopenia and enhances the antitumor activity of cyclophosphamide. Phytotherapy Research : PTR. 2006.  20, 814-818. [PubMed]
22. Haque, E., Mandal, I., Pal, S. and Baral, R.  Prophylactic dose of neem (Azadirachta indica) leaf preparation restricting murine tumor growth is nontoxic, hematostimulatory and immunostimulatory. Immunopharmacology and Immunotoxicology. 2006.  28, 33-50. [PubMed]
23. Bose, A., Ghosh, D., Pal, S., Mukherjee, K. K., Biswas, J. and Baral, R.  Interferon alpha2b augments suppressed immune functions in tobacco-related head and neck squamous cell carcinoma patients by modulating cytokine signaling. Oral Oncology. 2006.  42, 161-171. [PubMed]
24. Baral, R., Mandal, I. and Chattopadhyay, U.  Immunostimulatory neem leaf preparation acts as an adjuvant to enhance the efficacy of poorly immunogenic B16 melanoma surface antigen vaccine. International Immunopharmacology. 2005.  5, 1343-1352. [PubMed]
25. Baral R.  Tumor vaccine: current trends in antigen specific immunotherapy. Indian Journal of Experimental Biology. 2005.  43, 389-406. [PubMed]
26. Baral, R. and Chattopadhyay, U.  Neem (Azadirachta indica) leaf mediated immune activation causes prophylactic growth inhibition of murine Ehrlich carcinoma and B16 melanoma. International Immunopharmacology. 2004.  4, 355-366. [PubMed]
27. Baral, R., Sautya, D. K. and Maity, P.  A comparative study on expression of mucin related antigens in preneoplastic and neoplastic rat colorectal mucosa. Cancer Letters. 1996.  105, 15-22. [PubMed]
28. Baral, R., Chakraborty, A. and Maity, P.  Alterations in large gut associated lymphatic tissues (LGALT) during experimental colorectal carcinogenesis. Indian Journal of Experimental Biology. 1993.  31, 793-796. [PubMed]
 

 
 
Education 
::
M.Sc.
::
Ph.D.
  Last modified on : Mar 4, 2011
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