Rajat Kumar Das, Ph.D.
Senior Scientific Officer, Gr-II
Chittaranjan National Cancer Institute
37, S. P. Mukherjee Road
Kolkata - 700 026
West Bengal
E-mail: rajatkumar.das@cnci.org.in
Phone: +91-33-24765101, Extn.327
Fax: +91-33-4757606
URL: http://www.cnci.org.in/research/research_main.html#
Positions Held:
Position
Affiliation
Time Period
Senior Scientific Officer, Gr-II
Chittaranjan National Cancer Institute, Kolkata, India
Present
Area of Specialization:
Pharmacology
Oncology
Research Summary:
To identify the changes in cell signaling that occur as tumors spread by metastasis and develop resistance to chemotherapy
To identify the transcription factors that regulate gene transcription of Nucleotide Excision Repair associated genes
Publications:
1.
Das, R. K. , Hossain, S. U. and Bhattacharya, S. Protective effect of diphenylmethyl selenocyanate against CCl4-induced hepatic injury. Journal of Applied Toxicology : JAT. 2007. 27, 527-537. [PubMed]
2.
Das, R. K., Banerjee, S. and Bhattacharya, S. Amelioration of benzo (a) pyrene-induced lung carcinogenesis in strain A mice by diphenylmethyl selenocyanate. Experimental and Toxicologic Pathology. 2007. 58, 351-360. [PubMed]
3.
Sengupta, A., Ghosh, S., Das, R. K. , Bhattacharjee, S. and Bhattacharya, S. Chemopreventive potential of diallylsulfide, lycopene and theaflavin during chemically induced colon carcinogenesis in rat colon through modulation of cyclooxygenase-2 and inducible nitric oxide synthase pathways. European Journal of Cancer Prevention. 2006. 15, 301-305. [PubMed]
4.
Das, R. K. , Hossain, S. K. and Bhattacharya, S. Diphenylmethyl selenocyanate inhibits DMBA-croton oil induced two-stage mouse skin carcinogenesis by inducing apoptosis and inhibiting cutaneous cell proliferation. Cancer Letters. 2005. 230, 90-101. [PubMed]
5.
Das, R. K. , Das, S. and Bhattacharya, S. Protective effect of diphenylmethyl selenocyanate against carbon tetrachloride-induced hepatotoxicity in vivo. Journal of Environmental Pathology, Toxicology and Oncology. 2004. 23, 287-296. [PubMed]
6.
Das, R. K. , Ghosh, S., Sengupta, A., Das, S. and Bhattacharya, S. Inhibition of DMBA/croton oil-induced two-stage mouse skin carcinogenesis by diphenylmethyl selenocyanate. European Journal of Cancer Prevention. 2004. 13, 411-417. [PubMed]
7.
Ghosh, S., Das, R. K. , Sengupta, A. & Bhattacharya, S. (2005). Induction of apoptosis and inhibition of cell proliferation by Diphenylmethyl selenocyanate during azoxymethane induced rat colon carcinogenesis. 2005. International Journal of Cancer Prevention .2, 63-70.
8.
Ghosh, S., Das, R. K. , Sengupta, A. & Bhattacharya, S. Inhibition of azoxymethane-induced aberrant crypt foci in rat by Diphenylmethyl selenocyanate through downregulation of COX-2 and modulation of glutathione-S-transferase and lipid peroxidation. Biological Trace Element Research. 2005. 105, 171-186.
Education
::
M.Sc.
::
Ph.D.
Type of Neoplasms
Pulmonary system
Lung