INCREDB ID : 230
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Surajit Ganguly, Ph.D.
Principal Investigator 
 
Institute of Molecular Medicine
254 Okhla Industrial Estate, Phase III
New Delhi - 110 020   
 
E-mail: surajitg@immindia.org
Phone: +91-11-41028710
Fax: +91-11-41028709
 
URL: http://immindia.org/surajit.htm
 
Positions Held:
Position Affiliation Time Period
Team Lead Institute of Molecular Medicine, New Delhi, India. 2007-Present
Research Scientist National Institutes of Health, Bethesda, Maryland, USA. 2007
Research Scientist Johns Hopkins School of Medicine, Baltimore, MD, USA. 2005-2007
Adjunct Scientist National Institutes of Health, Bethesda, Maryland, USA. 2005-2007
Staff Fellow National Institutes of Health, Bethesda, Maryland, USA. 2003-2005
Visiting Fellow National Institutes of Health, Bethesda, Maryland, USA. 1998-2003
Research Associate Loyola University Medical center, Maywood, Illinois, USA 1998
 
Area of Specialization:
Molecular Biology
Research Summary:
To obtain novel molecular profile of breast cancer in the context of Indian population and to apply this knowledge to the early detection, diagnosis and therapy of breast cancer
 
Publications:
1. Chatterjee, M., Ganguly, S., Srivastava, M. and Palit, G.  Effect of 'chronic' versus 'acute' ketamine administration and its 'withdrawal' effect on behavioural alterations in mice: implications for experimental psychosis. Behavioural Brain Research. 2011.  216, 247-254. [PubMed]
2. Klein, D. C., Bailey, M. J., Carter, D. A., Kim, J. S., Shi, Q., Ho, A. K., Chik, C. L., Gaildrat, P., Morin, F., Ganguly, S., Rath, M. F., Moller, M., Sugden, D., Rangel, Z. G., Munson, P. J., Weller, J. L. and Coon, S. L.  Pineal function: impact of microarray analysis. Molecular and Cellular Endocrinology. 2010.  314, 170-183. [PubMed]
3. Bailey, M. J., Coon, S. L., Carter, D. A., Humphries, A., Kim, J. S., Shi, Q., Gaildrat, P., Morin, F., Ganguly, S., Hogenesch, J. B., Weller, J. L., Rath, M. F., Moller, M., Baler, R., Sugden, D., Rangel, Z. G., Munson, P. J. and Klein, D. C.  Night/day changes in pineal expression of >600 genes: central role of adrenergic/cAMP signaling. The Journal of Biological Chemistry. 2009.  284, 7606-7622. [PubMed]
4. Pavlicek, J., Coon, S. L., Ganguly, S., Weller, J. L., Hassan, S. A., Sackett, D. L. and Klein, D. C.  Evidence that proline focuses movement of the floppy loop of arylalkylamine N-acetyltransferase (EC 2.3.1.87). The Journal of Biological Chemistry. 2008.  283, 14552-14558. [PubMed]
5. Szewczuk, L. M., Saldanha, S. A., Ganguly, S., Bowers, E. M., Javoroncov, M., Karanam, B., Culhane, J. C., Holbert, M. A., Klein, D. C., Abagyan, R. and Cole, P. A.  De novo discovery of serotonin N-acetyltransferase inhibitors. Journal of Medicinal Chemistry. 2007.  50, 5330-5338. [PubMed]
6. Ganguly, S., Grodzki, C., Sugden, D., Moller, M., Odom, S., Gaildrat, P., Gery, I., Siraganian, R. P., Rivera, J. and Klein, D. C.  Neural adrenergic/cyclic AMP regulation of the immunoglobulin E receptor alpha-subunit expression in the mammalian pinealocyte: a neuroendocrine/immune response link? The Journal of Biological Chemistry. 2007.  282, 32758-32764. [PubMed]
7. Rath, M. F., Munoz, E., Ganguly, S., Morin, F., Shi, Q., Klein, D. C. and Moller, M.  Expression of the Otx2 homeobox gene in the developing mammalian brain: embryonic and adult expression in the pineal gland. Journal of Neurochemistry. 2006.  97, 556-566. [PubMed]
8. Ganguly, S., Weller, J. L., Ho, A., Chemineau, P., Malpaux, B. and Klein, D. C.  Melatonin synthesis: 14-3-3-dependent activation and inhibition of arylalkylamine N-acetyltransferase mediated by phosphoserine-205. Proceedings of the National Academy of Sciences of the United States of America. 2005.  102, 1222-1227. [PubMed]
9. Zheng, W., Zhang, Z., Ganguly, S., Weller, J. L., Klein, D. C. and Cole, P. A.  Cellular stabilization of the melatonin rhythm enzyme induced by nonhydrolyzable phosphonate incorporation. Nature Structural Biology. 2003.  10, 1054-1057. [PubMed]
10. Ganguly, S., Coon, S. L. and Klein, D. C.  Control of melatonin synthesis in the mammalian pineal gland: the critical role of serotonin acetylation. Cell and Tissue Research. 2002.  309, 127-137. [PubMed]
11. Ganguly, S., Mummaneni, P., Steinbach, P. J., Klein, D. C. and Coon, S. L.  Characterization of the Saccharomyces cerevisiae homolog of the melatonin rhythm enzyme arylalkylamine N-acetyltransferase (EC 2.3.1.87). The Journal of Biological Chemistry. 2001.  276, 47239-47247. [PubMed]
12. Ganguly, S., Gastel, J. A., Weller, J. L., Schwartz, C., Jaffe, H., Namboodiri, M. A., Coon, S. L., Hickman, A. B., Rollag, M., Obsil, T., Beauverger, P., Ferry, G., Boutin, J. A. and Klein, D. C.  Role of a pineal cAMP-operated arylalkylamine N-acetyltransferase/14-3-3-binding switch in melatonin synthesis. Proceedings of the National Academy of Sciences of the United States of America. 2001.  98, 8083-8088. [PubMed]
13. Obsil, T., Ghirlando, R., Klein, D. C., Ganguly, S. and Dyda, F.  Crystal structure of the 14-3-3zeta:serotonin N-acetyltransferase complex. a role for scaffolding in enzyme regulation. Cell. 2001.  105, 257-267. [PubMed]
14. Chakrabarti, S. R., Sood, R., Ganguly, S., Bohlander, S., Shen, Z. and Nucifora, G.  Modulation of TEL transcription activity by interaction with the ubiquitin-conjugating enzyme UBC9. Proceedings of the National Academy of Sciences of the United States of America. 1999.  96, 7467-7472. [PubMed]
 

 
 
Education 
::
M.Sc. Calcutta University, India
::
Ph.D. Indian Institute of Chemical Biology, Calcutta, India
Honors and Awards
::
2002, Award of Merit for Productivity and Cutting-edge Research, National Institutes of Health, Maryland, USA.
Type of Neoplasms
Breast
Female
  Last modified on : Mar 4, 2011
India Cancer Research Database has been developed by the Institute of Bioinformatics with funding from the Department of Biotechnology, Government of India.