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Neelam V. Shirsat, Ph.D.
Scientific Officer F 
Advanced Centre for Treatment Research and Education in Cancer
Shirsat Lab
Tata Memorial Centre, Kharghar
Navi Mumbai - 410 208   
Phone: +91-22-27405016
Fax: +91-22-27412894
Positions Held:
Position Affiliation Time Period
Scientific Officer F Advanced Centre for Treatment, Research and Education in Cancer, Navi Mumbai, India Present
Principal Investigator Advanced Centre for Treatment, Research and Education in Cancer, Navi Mumbai, India
Area of Specialization:
Research Summary:
Role of Fra-1, a component of AP-1 transcription factor in glioma cell proliferation, differentiation and apoptosis
Molecular mechanism of tamoxifen-induced apoptosis of glioma cells
Studies on the pathogenesis of medulloblastoma, a common childhood brain tumour
1. Ranade, K. J., Nerurkar, A. V., Phulpagar, M. D. and Shirsat, N. V.  Expression of survivin and p53 proteins and their correlation with hormone receptor status in Indian breast cancer patients. Indian Journal of Medical Sciences. 2009.  63, 481-490. [PubMed]
2. Jane, C., Nerurkar, A. V., Shirsat, N. V., Deshpande, R. B., Amrapurkar, A. D. and Karjodkar, F. R.  Increased survivin expression in high-grade oral squamous cell carcinoma: a study in Indian tobacco chewers. Journal of Oral Pathology & Medicine. 2006.  35, 595-601. [PubMed]
3. Harmalkar, M. N. and Shirsat, N. V.  Staurosporine-induced growth inhibition of glioma cells is accompanied by altered expression of cyclins, CDKs and CDK inhibitors. Neurochemical Research. 2006.  31, 685-692. [PubMed]
4. Moodbidri, M. S. and Shirsat, N. V.  Induction of BAALC and down regulation of RAMP3 in astrocytes treated with differentiation inducers. Cell Biology International. 2006.  30, 210-213. [PubMed]
5. Patole, J., Padhye, S., Moodbidri, M. S. and Shirsat, N.  Antiproliferative activities of iron and platinum conjugates of salicylaldehyde semi-/thiosemicarbazones against C6 glioma cells. European Journal of Medicinal Chemistry. 2005.  40, 1052-1055. [PubMed]
6. Moodbidri, M. S. and Shirsat, N. V.  Activated JNK brings about accelerated apoptosis of Bcl-2-overexpressing C6 glioma cells on treatment with tamoxifen. Journal of Neurochemistry. 2005.  92, 1-9. [PubMed]
7. Shirsat, N. V. and Shaikh, S. A.  Overexpression of the immediate early gene fra-1 inhibits proliferation, induces apoptosis, and reduces tumourigenicity of c6 glioma cells. Experimental Cell Research. 2003.  291, 91-100. [PubMed]
8. Shirsat, N. V., Kayal, J. J., Shaikh, S. and Mehta, A.  Growth inhibition and differentiation of C6 glioma cells on treatment with hmba. Cell Biology International. 2001.  25, 621-627. [PubMed]
9. Shirsat N. V.  HMBA inhibits growth and induces differentiation of astrocytes from neonatal rat brain. Neuroreport. 1999.  10, 3755-3758. [PubMed]


Grant Support:
Project Title Role Funding Agency Sanction Number Sanction Date
Role of LLGL1, a gene controlling asymmetric cell division of stem cells in pathogenesis of medulloblastoma a pediatric malignant brain tumor
Studies on the molecular mechanism of Tamoxifen - induced apoptosis pf astrocutoma cells Principal Investigator Indian Council of Medical Research, Goverment of India 2003-2006


Type of Neoplasms
Head and Neck
Central nervous system
  Last modified on : Mar 4, 2011
India Cancer Research Database has been developed by the Institute of Bioinformatics with funding from the Department of Biotechnology, Government of India.