INCREDB ID : 221
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Amitava Chatterjee, Ph.D.
Senior Assistant Director 
 
Chittaranjan National Cancer Institute
Department of Receptor Biology and Tumor Metastasis
37, S. P. Mukherjee Road
Kolkata - 700 026   
West Bengal   
 
E-mail: a_chatterjee84@hotmail.com, amitava_chatter@yahoo.co.in
Phone: +91-33-23350899
Mobile: +91-9830128320
 
URL: http://darwin-newton.com/profile.htm
 
Positions Held:
Position Affiliation Time Period
Senior Assistant Director Chittaranjan National Cancer Institute, Kolkata, India Present
Officer-in-Charge Chittaranjan National Cancer Institute, Kolkata, India Present
Visiting Professor Institute Molecular Oncology, IDIBELL, Barcelona, Spain 2008-2008
Visiting Scientist DKFZ, Heidelberg, Germany 2007-2007
Visiting Scientist DKFZ, Heidelberg, Germany 2002-2002
Senior Assistant Director Chittaranjan National Cancer Institute, Kolkata, India 2001-2002
Visiting Scientist DKFZ, Heidelberg, Germany 2001-2002
Visiting Scientist DKFZ, Heidelberg, Germany 2000-2000
Associate Director Chittaranjan National Cancer Institute, Kolkata, India 1997-2002
Senior Scientific Officer Gr-1 Chittaranjan National Cancer Institute, Kolkata, India 1993-1997
Tumor Biologist Wellman Laboratory of Photomedicine, Harvard Medical School, Boston, USA 1991-1992
Faculty Baylor College of Medicine, Houston, USA 1990-1991
Senior Research Officer Chittaranjan National Cancer Institute, Kolkata, India 1988-1989
Faculty Baylor College of Medicine, Houston, USA 1985-1987
Research Associate Baylor College of Medicine, Houston, USA 1984-1985
Research Associate Bose Institute, Kolkata, India 1980-1983
 
Area of Specialization:
Cancer Biology
Research Summary:
Integrin biology in relation to tumor development especially metastasis
MMPs biology in relation to cancer or metastasis
Integrin mediated regulation of MMPs expression and function
Integrin receptor mediated signaling
Role of EGFR in cancer biology
Discovery of anti-metaststic drugs or compounds
Tumor Microenvironment
 
Publications:
1. Chakraborty, C., Chatterjee, A., Chakraborty, A. K. and Chakraborty, D. P.  Inverse relationship between melanogenesis and endogenous hydroquinone. Experientia. 1984.  40, 829-830. [PubMed]
1. Sen, T. and Chatterjee, A.  Epigallocatechin-3-gallate (EGCG) downregulates EGF-induced MMP-9 in breast cancer cells: involvement of integrin receptor alpha5beta1 in the process. European Journal of Nutrition. 2010.  [PubMed]
2. Maity, G., Choudhury, P. R., Sen, T., Ganguly, K. K., Sil, H. and Chatterjee, A.  Culture of human breast cancer cell line (MDA-MB-231) on fibronectin-coated surface induces pro-matrix metalloproteinase-9 expression and activity. Tumour Biology . 2011.  32, 129-138. [PubMed]
3. Sen, T., Dutta, A., Maity, G. and Chatterjee, A.  Fibronectin induces matrix metalloproteinase-9 (MMP-9) in human laryngeal carcinoma cells by involving multiple signaling pathways. Biochimie. 2010.  92, 1422-1434. [PubMed]
4. Sen, T., Dutta, A. and Chatterjee, A.  Epigallocatechin-3-gallate (EGCG) downregulates gelatinase-B (MMP-9) by involvement of FAK/ERK/NFkappaB and AP-1 in the human breast cancer cell line MDA-MB-231. Anti-cancer Drugs. 2010.  21, 632-644. [PubMed]
5. Maity, G., Sen, T. and Chatterjee, A.  Laminin induces matrix metalloproteinase-9 expression and activation in human cervical cancer cell line (SiHa). Journal of Cancer Research and Clinical Oncology. 2010.  [PubMed]
6. Dutta, A., Sen, T. and Chatterjee, A.  All-trans retinoic acid (ATRA) downregulates MMP-9 by modulating its regulatory molecules. Cell Adhesion & Migration. 2010.  4, 409-418. [PubMed]
7. Dutta, A., Sen, T. and Chatterjee, A.  Culture of K562 human myeloid leukemia cells in presence of fibronectin expresses and secretes MMP-9 in serum-free culture medium. International Journal of Clinical and Experimental Pathology. 2010.  3, 288-302. [PubMed]
8. Maity, G., Fahreen, S., Banerji, A., Roy, C., Sen, T., Dutta, A. and Chatterjee, A.  Fibronectin-integrin mediated signaling in human cervical cancer cells (SiHa). Molecular and Cellular Biochemistry. 2010.  336, 65-74. [PubMed]
9. Dutta, A., Sen, T., Banerji, A., Das, S. and Chatterjee, A.  Studies on Multifunctional Effect of All-Trans Retinoic Acid (ATRA) on Matrix Metalloproteinase-2 (MMP-2) and Its Regulatory Molecules in Human Breast Cancer Cells (MCF-7). Journal of Oncology. 2009.   627840. [PubMed]
10. Sen, T., Moulik, S., Dutta, A., Choudhury, P. R., Banerji, A., Das, S., Roy, M. and Chatterjee, A.  Multifunctional effect of epigallocatechin-3-gallate (EGCG) in downregulation of gelatinase-A (MMP-2) in human breast cancer cell line MCF-7. Life Sciences. 2009.  84, 194-204. [PubMed]
11. Banerji, A., Das, S. and Chatterjee, A.  Culture of human A375 melanoma cells in the presence of fibronectin causes expression of MMP-9 and activation of MMP-2 in culture supernatants. Journal of Environmental Pathology, Toxicology and Oncology . 2008.  27, 135-145. [PubMed]
12. Das, S., Banerji, A., Frei, E. and Chatterjee, A.  Rapid expression and activation of MMP-2 and MMP-9 upon exposure of human breast cancer cells (MCF-7) to fibronectin in serum free medium. Life Sciences. 2008.  82, 467-476. [PubMed]
13. Mitra, A., Chakrabarti, J., Banerji, A., Chatterjee, A. and Das, B. R.  Curcumin, a potential inhibitor of MMP-2 in human laryngeal squamous carcinoma cells HEp2. Journal of Environmental Pathology, Toxicology and Oncology . 2006.  25, 679-690. [PubMed]
14. Chakrabarti, J., Mitra, A., Banerji, A. and Chatterjee, A.  Culture of human fibrosarcoma HT-1080 cells in presence of fibronectin activates MMP-2. Journal of Environmental Pathology, Toxicology and Oncology . 2006.  25, 667-677. [PubMed]
15. Mitra, A., Chakrabarti, J., Banerji, A. and Chatterjee, A.  Cell membrane-associated MT1-MMP dependent activation of MMP-2 in SiHa (human cervical cancer) cells. Journal of Environmental Pathology, Toxicology and Oncology . 2006.  25, 655-666. [PubMed]
16. Mitra, A., Chakrabarti, J., Banerji, A., Das, S. and Chatterjee, A.  Culture of human cervical cancer cells, SiHa, in the presence of fibronectin activates MMP-2. Journal of Cancer Research and Clinical Oncology. 2006.  132, 505-513. [PubMed]
17. Banerji, A., Chakraborti, J., Mitra, A. and Chatterjee, A.  Cell membrane-associated MT1-MMP-dependent activation of pro-MMP-2 in A375 melanoma cells. Journal of Environmental Pathology, Toxicology and Oncology . 2005.  24, 3-17. [PubMed]
18. Ray, S., Chattopadhyay, N., Biswas, N. and Chatterjee, A.  Regulatory molecules in tumor metastasis. Journal of Environmental Pathology, Toxicology and Oncology . 1999.  18, 251-259. [PubMed]
19. Mitra, A., Chakrabarti, J., Banerji, A. and Chatterjee, A.  Binding of alpha2 monoclonal antibody to human cervical tumor cell (SiHa) surface alpha2beta1 integrin modulates MMP-2 activity. Gynecologic Oncology. 2004.  94, 33-39. [PubMed]
20. Banerji, A., Chakrabarti, J., Mitra, A. and Chatterjee, A.  Effect of curcumin on gelatinase A (MMP-2) activity in B16F10 melanoma cells. Cancer Letters. 2004.  211, 235-242. [PubMed]
21. Mitra, A., Chakrabarti, J., Chattopadhyay, N. and Chatterjee, A.  Membrane-associated MMP-2 in human cervical cancer. Journal of Environmental Pathology, Toxicology and Oncology . 2003.  22, 93-100. [PubMed]
22. Mitra, A., Chakrabarti, J. and Chatterjee, A.  Binding of alpha5 monoclonal antibody to cell surface alpha5beta1 integrin modulates MMP-2 and MMP-7 activity in B16F10 melanoma cells. Journal of Environmental Pathology, Toxicology and Oncology . 2003.  22, 167-178. [PubMed]
23. Ray, S., Chattopadhyay, N., Mitra, A., Siddiqi, M. and Chatterjee, A.  Curcumin exhibits antimetastatic properties by modulating integrin receptors, collagenase activity, and expression of Nm23 and E-cadherin. Journal of Environmental Pathology, Toxicology and Oncology. 2003.  22, 49-58. [PubMed]
24. Sengupta, S., Chattopadhyay, N., Mitra, A., Ray, S., Dasgupta, S. and Chatterjee, A.  Role of alphavbeta3 integrin receptors in breast tumor. Journal of Experimental & Clinical Cancer Research : CR. 2001.  20, 585-590. [PubMed]
25. Chatterjee, N. and Chatterjee, A.  Role of alphavbeta3 integrin receptor in the invasive potential of human cervical cancer (SiHa) cells. Journal of Environmental Pathology, Toxicology and Oncology. 2001.  20, 211-221. [PubMed]
26. Ray, S., Chattopadhyay, N., Sanyal, U., Biswas, N. and Chatterjee, A.  Integrin modulating factor: a 30-kD protein that modulates the expression and function of alpha5beta1 integrin receptor. Journal of Environmental Pathology, Toxicology and Oncology. 2001.  20, 199-209. [PubMed]
27. Chattopadhyay, N., Mitra, A., Frei, E. and Chatterjee, A.  Human cervical tumor cell (SiHa) surface alphavbeta3 integrin receptor has associated matrix metalloproteinase (MMP-2) activity. Journal of Cancer Research and Clinical Oncology. 2001.  127, 653-658. [PubMed]
28. Chattopadhyay, N. and Chatterjee, A.  Studies on the expression of alpha(v)beta3 integrin receptors in non-malignant and malignant human cervical tumor tissues. Journal of Experimental & Clinical Cancer Research : CR. 2001.  20, 269-275. [PubMed]
29. Sengupta, S., Ray, S., Chattopadhyay, N., Biswas, N. and Chatterjee, A.  Effect of retinoic acid on integrin receptors of B16F10 melanoma cells. Journal of Experimental & Clinical Cancer Research : CR. 2000.  19, 81-87. [PubMed]
30. Chattopadhyay, N., Ray, S., Biswas, N. and Chatterjee, A.  Effect of all-trans-retinoic acid on integrin receptors of human cervical cancer (SiHa) cells. Gynecologic Oncology. 1999.  75, 215-221. [PubMed]
31. Choudhuri, S. K. and Chatterjee, A.  Reversal of resistance against doxorubicin by a newly developed compound, oxalyl bis(N-phenyl)hydroxamic acid in vitro. Anti-cancer Drugs. 1998.  9, 825-832. [PubMed]
32. Chatterjee A.  Integrins--new frontier in cancer biology. Indian Journal of Experimental Biology. 1996.  34, 923-926. [PubMed]
33. Chatterjee, A., Biswas, N., Choudhuri, S. K., Mazumder, J. and Chowdhury, J. R.  Identification of a 60-kD antigen associated with malignant growth of human breast tissue. Oncology. 1996.  53, 422-425. [PubMed]
34. Chatterjee, A., Busch, R. K., Jung, D., Zhang, W. W. and Busch, H.  Purification of a group of HeLa nuclear proteins that bind to a regulatory element (-1430/-1327) of the human proliferating cell nucleolar protein P120 gene. Biochemical and Biophysical Research Communications. 1991. 180, 805-812. [PubMed]
35. Chatterjee, A., Datta, K. and Roychowdhury, J.  Identification of a novel 80 kDa antigen associated with cell proliferation. Cancer Letters. 1989. 47, 199-204. [PubMed]
36. Reddy, A. B., Chatterjee, A., Rothblum, L. I., Black, A. and Busch, H.  Isolation and characterization of complementary DNA to proliferating cell nucleolar antigen P40. Cancer Research. 1989. 49, 1763-1767. [PubMed]
37. Chatterjee, A., Durban, E. and Busch, H.  Characterization of a nuclear antigen (Mr 150,000) associated with cell proliferation. Cancer Research. 1988. 48, 7159-7163. [PubMed]
38. Chatterjee, A., Freeman, J. W. and Busch, H.  Identification and partial characterization of a Mr 105,000 nucleolar antigen associated with cell proliferation. Cancer Research. 1987. 47, 6329-6334. [PubMed]
39. Busch, H., Busch, R. K., Black, A., Chan, P. K., Chatterjee, A., Durban, E., Freeman, J., Ochs, R., Reichlin, M., Tan, E. M. and et, a. l. ..  Novel nucleolar antigens in autoimmune disease. The Journal of Rheumatology. Supplement. 1987. 14 Suppl 13, 70-77. [PubMed]
40. Freeman, J. W., Chatterjee, A., Ross, B. E. and Busch, H.  Epitope distribution and immunochemical characterization of nucleolar phosphoprotein C23 using ten monoclonal antibodies. Molecular and Cellular Biochemistry. 1985. 68, 87-96. [PubMed]
41. Freeman, J. W., Chatterjee, A. and Busch, H.  Discrimination of epitopes identified by monoclonal antibodies by competitive binding to nitrocellulose bound antigens. Journal of Immunological Methods. 1985. 78, 259-265. [PubMed]
42. Chakraborty, C., Chatterjee, A., Chakraborty, A. K. and Chakraborty, D. P.  Inverse relationship between melanogenesis and endogenous hydroquinone. Experientia. 1984. 40, 829-830. [PubMed]
43. Chakraborty, D., P., Chatterjee, A., Urinary indole profile of B. Melanostictus during hydroquinone induced leucoderma and iots regenaration. Clin Chim. Acta, 1977, 79 399-400.
45. Chakraborty, D., P., Chowdhury, S., K., R., Dey, R., N., Chatterjee, A., Interrelationship of tryptophan pyrrolase in melanogenesis of B. Melanostictus Clin. Chim Acta, 1978, 82, 55- 59.
46. Chakraborty, A., K., Chatterjee, A., Chakraborty, C., Chakraborty, D.,P., Effect of tryptophan on tyrosinase in relation to vitiligo. Experientia, 1980 36, 920.
47. Chakraborty, D.,P., Chatterjee, A., Chakraborty, A., K., Chakraborty, C., A method of bioassay of antivitiligo drugs Science and Culture, 47, 228-230.
48. Chakraborty, D., P., Chatterjee, A., Chakraborty, A., K., Induced depigmentation in B. Melanostictus and ascorbic acid J. Ind. Chem. Soc LVIII, 1981, 608-610.
 

 
Grant Support:
Project Title Role Funding Agency Sanction Number Sanction Date
Studies on Focal Adhesion Kinase in relation to tumor biology Defence Research and Development Organisation, New Delhi, India 2008-2011
Role of alfa5beta1 and alfaVbeta3 integrin in regulation of MMPs Indian Council of Medical Research 2007-2010
Studies on Integrin mediated signaling Department of Science & Technology, Government of India 2005-2008
Anti metastatic efficacy of Tea products National Tea Research Foundation, India 2005-2008
Studies on MMP-2 in tumor biology Defence Research and Development Organisation, New Delhi, India 2004-2007
Role of Matrixmetalloproteinases in tumor biology Council of Scientific and Industrial Research, Government of India 2004-2008
Role of integrin receptors in invasive potential of tumor cells Department of Science & Technology, Government of India 2001-2005
Role of integrin and lectin molecules in tumor metastasis 2000-2003
Role of integrin receptors in tumor metastasis Council of Scientific and Industrial Research, Government of India 1996-2000
Role of integrin receptor in cervical cancer biology Department of Science & Technology, Government of India 1997-2001

 
 
 
Education 
::
M.Sc. in Physiology, , Calcutta University
::
Ph.D. in Biochemistry, Bose Institute, Calcutta, India
Honors and Awards
::
1984, Birla International Fellowship
Member
::
International Metastasis Research Society, London, U.K
::
Indian Association for Cancer Research
::
Department of Science & Technology, Government of India
::
Department of Biotechnology, Government of India
::
Indian Council of Medical Research, Government of India
::
Council of Scientific & Industrial Research, Government of India
::
Academic Advisory Committee, Government of West Bengal
::
Reviewer- Carcinogenesis, Indian Journal of Experimental Biology, Journal of Biosciences, International Journal of Cancer Care, European Journal of Cancer, International Journal of Cancer, UICC, International Journal of Oncology
  Last modified on : Mar 4, 2011
India Cancer Research Database has been developed by the Institute of Bioinformatics with funding from the Department of Biotechnology, Government of India.