INCREDB ID : 220
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Asima Bhattacharyya, Ph.D.
Assistant Professor 
 
National Institute of Science Education and Research
School of Biological Sciences
Institute of Physics Campus, Sachivalaya Marg, PO: Sainik School,
Bhubaneswar - 751 005   
Orissa   
 
E-mail: asima@niser.ac.in
Phone: +91-674-2304068
 
URL: http://biology.niser.ac.in/viewfacdetail.php?e=asima
 
Positions Held:
Position Affiliation Time Period
Assistant Professor National Institute of Science Education and Research 2010-Present
Research Associate University of Virginia, USA 2005-2010
 
Area of Specialization:
Cell signaling
Gastrointestinal epithelial cell biology
Research Summary:
Host-pathogen interactions, cell signalling events, immunopathogenesis of infection, inflammation, molecular events in cancer metastasis and apoptosis.
 
Publications:
1. Bhattacharyya, A., Chattopadhyay, R., Hall, E. H., Mebrahtu, S. T., Ernst, P. B. and Crowe, S. E.  Mechanism of hypoxia-inducible factor 1 alpha-mediated Mcl1 regulation in Helicobacter pylori-infected human gastric epithelium. American Journal of Physiology. Gastrointestinal and Liver Physiology. 2010.  299, G1177-86. [PubMed]
2. Chattopadhyay, R., Bhattacharyya, A. and Crowe, S. E.  Dual regulation by apurinic/apyrimidinic endonuclease-1 inhibits gastric epithelial cell apoptosis during Helicobacter pylori infection. Cancer Research. 2010.  70, 2799-2808. [PubMed]
3. O'Hara, A. M., Bhattacharyya, A., Bai, J., Mifflin, R. C., Ernst, P. B., Mitra, S. and Crowe, S. E.  Tumor necrosis factor (TNF)-alpha-induced IL-8 expression in gastric epithelial cells: role of reactive oxygen species and AP endonuclease-1/redox factor (Ref)-1. Cytokine. 2009.  46, 359-369. [PubMed]
4. Bhattacharyya, A., Chattopadhyay, R., Burnette, B. R., Cross, J. V., Mitra, S., Ernst, P. B., Bhakat, K. K. and Crowe, S. E.  Acetylation of apurinic/apyrimidinic endonuclease-1 regulates Helicobacter pylori-mediated gastric epithelial cell apoptosis. Gastroenterology. 2009.  136, 2258-2269. [PubMed]
5. Basu, S., Pathak, S., Pathak, S. K., Bhattacharyya, A., Banerjee, A., Kundu, M. and Basu, J.  Mycobacterium avium-induced matrix metalloproteinase-9 expression occurs in a cyclooxygenase-2-dependent manner and involves phosphorylation- and acetylation-dependent chromatin modification. Cellular Microbiology. 2007.  9, 2804-2816. [PubMed]
6. Pathak, S. K., Basu, S., Basu, K. K., Banerjee, A., Pathak, S., Bhattacharyya, A., Kaisho, T., Kundu, M. and Basu, J.  Direct extracellular interaction between the early secreted antigen ESAT-6 of Mycobacterium tuberculosis and TLR2 inhibits TLR signaling in macrophages. Nature Immunology. 2007.  8, 610-618. [PubMed]
7. Basu, S., Pathak, S. K., Banerjee, A., Pathak, S., Bhattacharyya, A., Yang, Z., Talarico, S., Kundu, M. and Basu, J.  Execution of macrophage apoptosis by PE_PGRS33 of Mycobacterium tuberculosis is mediated by Toll-like receptor 2-dependent release of tumor necrosis factor-alpha. The Journal of Biological Chemistry. 2007.  282, 1039-1050. [PubMed]
8. O'Hara, A. M., Bhattacharyya, A., Mifflin, R. C., Smith, M. F., Ryan, K. A., Scott, K. G., Naganuma, M., Casola, A., Izumi, T., Mitra, S., Ernst, P. B. and Crowe, S. E.  Interleukin-8 induction by Helicobacter pylori in gastric epithelial cells is dependent on apurinic/apyrimidinic endonuclease-1/redox factor-1. Journal of Immunology. 2006.  177, 7990-7999. [PubMed]
9. Pathak, S. K., Basu, S., Bhattacharyya, A., Pathak, S., Banerjee, A., Basu, J. and Kundu, M.  TLR4-dependent NF-kappaB activation and mitogen- and stress-activated protein kinase 1-triggered phosphorylation events are central to Helicobacter pylori peptidyl prolyl cis-, trans-isomerase (HP0175)-mediated induction of IL-6 release from macrophages. Journal of Immunology. 2006.  177, 7950-7958. [PubMed]
10. Pathak, S. K., Basu, S., Bhattacharyya, A., Pathak, S., Kundu, M. and Basu, J.  Mycobacterium tuberculosis lipoarabinomannan-mediated IRAK-M induction negatively regulates Toll-like receptor-dependent interleukin-12 p40 production in macrophages. The Journal of Biological Chemistry. 2005.  280, 42794-42800. [PubMed]
11. Basak, C., Pathak, S. K., Bhattacharyya, A., Pathak, S., Basu, J. and Kundu, M.  The secreted peptidyl prolyl cis,trans-isomerase HP0175 of Helicobacter pylori induces apoptosis of gastric epithelial cells in a TLR4- and apoptosis signal-regulating kinase 1-dependent manner. Journal of Immunology. 2005.  174, 5672-5680. [PubMed]
12. Basak, C., Pathak, S. K., Bhattacharyya, A., Mandal, D., Pathak, S. and Kundu, M.  NF-kappaB- and C/EBPbeta-driven interleukin-1beta gene expression and PAK1-mediated caspase-1 activation play essential roles in interleukin-1beta release from Helicobacter pylori lipopolysaccharide-stimulated macrophages. The Journal of Biological Chemistry. 2005.  280, 4279-4288. [PubMed]
13. Pathak, S. K., Bhattacharyya, A., Pathak, S., Basak, C., Mandal, D., Kundu, M. and Basu, J.  Toll-like receptor 2 and mitogen- and stress-activated kinase 1 are effectors of Mycobacterium avium-induced cyclooxygenase-2 expression in macrophages. The Journal of Biological Chemistry. 2004.  279, 55127-55136. [PubMed]
14. Mandal, D., Baudin-Creuza, V., Bhattacharyya, A., Pathak, S., Delaunay, J., Kundu, M. and Basu, J.  Caspase 3-mediated proteolysis of the N-terminal cytoplasmic domain of the human erythroid anion exchanger 1 (band 3). The Journal of Biological Chemistry. 2003.  278, 52551-52558. [PubMed]
15. Bhattacharyya, A., Pathak, S., Basak, C., Law, S., Kundu, M. and Basu, J.  Execution of macrophage apoptosis by Mycobacterium avium through apoptosis signal-regulating kinase 1/p38 mitogen-activated protein kinase signaling and caspase 8 activation. The Journal of Biological Chemistry. 2003.  278, 26517-26525. [PubMed]
16. Bhattacharyya, A., Pathak, S., Datta, S., Chattopadhyay, S., Basu, J. and Kundu, M.  Mitogen-activated protein kinases and nuclear factor-kappaB regulate Helicobacter pylori-mediated interleukin-8 release from macrophages. The Biochemical Journal. 2002.  368, 121-129. [PubMed]
17. Bhattacharyya, A., Pathak, S., Kundu, M. and Basu, J.  Mitogen-activated protein kinases regulate Mycobacterium avium-induced tumor necrosis factor-alpha release from macrophages. FEMS Immunology and Medical Microbiology. 2002.  34, 73-80. [PubMed]
18. Maiti, D., Bhattacharyya, A. and Basu, J.  Lipoarabinomannan from Mycobacterium tuberculosis promotes macrophage survival by phosphorylating Bad through a phosphatidylinositol 3-kinase/Akt pathway. The Journal of Biological Chemistry. 2001.  276, 329-333. [PubMed]

 
 
Education 
::
Ph.D. Jadavpur University, Kolkata, India
  Last modified on : Mar 4, 2011
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