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Rajiv D. Kalraiya, Ph.D.
Principal Investigator 
Advanced Centre for Treatment Research and Education in Cancer
Kalraiya Lab
Khanolkar Shodhika 121, Tata Memorial Centre, Kharghar
Navi Mumbai - 410 208   
Phone: +91-22-2740 5008
Fax: +91-22-2740 5085
Area of Specialization:
Molecular Oncology
Research Summary:
Studies on the role of cell surface glycosylation in the cascade of events involved in organ specific metastasis
Role of ß1,6 branched N-oligosaccharides in regulating the key cellular processes involved in cancer cell invasion
Role of O-linked N-acetylglucosamine modification on cytokeratins 8 and 18 in epithelial cell transformation


1. Srikanth, B., Vaidya, M. M. and Kalraiya, R. D.  O-GlcNAcylation determines the solubility, filament organization, and stability of keratins 8 and 18. The Journal of Biological Chemistry. 2010.  285, 34062-34071. [PubMed]
2. Srinivasan, N., Bane, S. M., Ahire, S. D., Ingle, A. D. and Kalraiya, R. D.  Poly N-acetyllactosamine substitutions on N- and not O-oligosaccharides or Thomsen-Friedenreich antigen facilitate lung specific metastasis of melanoma cells via galectin-3. Glycoconjugate Journal. 2009.  26, 445-456. [PubMed]
3. Reddy, B. V. and Kalraiya, R. D.  Sialilated beta1,6 branched N-oligosaccharides modulate adhesion, chemotaxis and motility of melanoma cells: Effect on invasion and spontaneous metastasis properties. Biochimica et Biophysica Acta. 2006.  1760, 1393-1402. [PubMed]
4. Krishnan, V., Bane, S. M., Kawle, P. D., Naresh, K. N. and Kalraiya, R. D.  Altered melanoma cell surface glycosylation mediates organ specific adhesion and metastasis via lectin receptors on the lung vascular endothelium. Clinical & Experimental Metastasis. 2005.  22, 11-24. [PubMed]
5. Bhanushali, A. A., Raghunathan, R., Kalraiya, R. D. and Mehta, N. G.  Cancer-related anemia in a rat model: alpha2-macroglobulin from Yoshida sarcoma shortens erythrocyte survival. European Journal of Haematology. 2002.  68, 42-48. [PubMed]
6. Sanjay, A., Kalraiya, R. D. and Mehta, N. G.  Modification of the erythrocyte surface in rats bearing Yoshida ascites sarcoma is brought about by a tumour variant of alpha2-macroglobulin. The Biochemical Journal. 1997.  322 ( Pt 2), 379-384. [PubMed]
7. Kalraiya, R. D., Sanjay, A. and Mehta, N. G.  Isolation of a glycoprotein responsible for the enhanced concanavalin A agglutinability of erythrocytes in Yoshida-ascites-sarcoma-bearing rats: the mechanism of paraneoplastic syndromes. The Biochemical Journal. 1993.  292 ( Pt 1), 163-170. [PubMed]
8. Kalraiya, R. D., Iyer, S. S., Chati, A. and Mehta, N. G.  Mechanism of host cell membrane modification by tumour: a model for paraneoplastic syndromes. Indian Journal of Biochemistry & Biophysics. 1990.  27, 460-463. [PubMed]
9. Kalraiya, R. D. and Mehta, N. G.  N-ethylmaleimide causes mechanical fragility and accumulation of spectrin dimers in the rat erythrocyte membrane. Biochemical and Biophysical Research Communications. 1985.  130, 157-162. [PubMed]


Ph.D. in Life Sciences, University of Mumbai, Mumbai, India
  Last modified on : Dec 10, 2015
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