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Manoj B Mahimkar, Ph.D.
Principal Investigator 
Cancer Research Institute, Advanced Centre for Treatment, Research and Education in Cancer
Manoj Mahimkar Lab
Khanolkar Shodhika 232,Tata Memorial Center, Kharghar
Navi Mumbai - 410 210   
Phone: +91-22-27405049
Fax: + 91-22-27405085
Positions Held:
Position Affiliation Time Period
Principal Investigator Cancer Research Institute, Advanced Centre for Treatment, Research and Education in Cancer Present
Post Doctoral Fellow New York Eye & Ear Infirmary, New York, USA
Area of Specialization:
Molecular Biology
Research Summary:
Molecular cytogenetics of Oral Cancers
Genetic susceptibility factors in oral Cancers and Molecular Epidemiology
Genetic toxicology and Human Bio-monitoring
1. Anantharaman, D., Samant, T. A., Sen, S. and Mahimkar, M. B.  Polymorphisms in tobacco metabolism and DNA repair genes modulate oral precancer and cancer risk. Oral Oncology. 2011.  47, 866-872. [PubMed]
2. Ambatipudi, S., Gerstung, M., Pandey, M., Samant, T., Patil, A., Kane, S., Desai, R.S., Schaffer, A.A., Beerenwinkel, N., Mahimkar, M.B. Genome-wide Expression and Copy Number Analysis Identifies Driver Genes in Gingivobuccal Cancers. Genes Chromosomes Cancer 2011 (In Press)
3. Chuang, S., Agudo, A., Ahrens, W., Anantharaman, D., Benhamou, S., Boccia, S., Chen, C., Conway, D., Fabianova, E., Hayes, R.B., Healy, C., Holcatova, I., Kjaerheim, K., Lagiou, P., Lazarus, P., Macfarlane, G. J., Mahimkar, M.B., Mates, D., Matsuo, K., Merletti, F., Metspalu, A., Morgenstern, H., Muscat, J., Nicolotti, N., Olshan, A.F., Purdue, M., Ramroth, H., Rudnai, P., Schwartz, S.M., Simonato, L., Smith, E., Sturgis, E.M., Szeszenia-Dabrowska, N., Talamini, R., Thomson, P., Wei, Q., Zaridze, D., Zhang, Z., Znaor, A., Brennan, P., Boffetta, P., Hashibe, M. Sequence variants and the risk of head and neck cancer: pooled analysis in the INHANCE consortium. Frontiers in Oncology Cancer Epidemiology and Prevention 2011 1:13. doi: 10.3389/fonc.2011.00013
4. Pathare, S., Gerstung, M.,  Beerenwinkel, B. Schäffer, A, A., Kannan, S, Pai P, K. Alok Pathak A.K., Borges, A.M. and Mahimkar, M.B.  Clinicopathological and prognostic implications of genetic alterations in oral cancers. Oncology Letters. 2011.  2: 445-451
5. Ambatipudi, S., Gerstung, M., Gowda, R., Pai, P., Borges, A. M., Schaffer, A. A., Beerenwinkel, N. and Mahimkar, M. B.  Genomic profiling of advanced-stage oral cancers reveals chromosome 11q alterations as markers of poor clinical outcome. PloS One. 2011. 6, e17250. [PubMed]
6. Mahimkar, M. B., Samant, T. A., Kannan, S. and Patil, T.  Influence of genetic polymorphisms on frequency of micronucleated buccal epithelial cells in leukoplakia patients. Oral Oncology. 2010.  46, 761-766. [PubMed]
7. Pathare, S., Schaffer, A. A., Beerenwinkel, N. and Mahimkar, M.  Construction of oncogenetic tree models reveals multiple pathways of oral cancer progression. International Journal of Cancer. Journal. 2009. 124, 2864-2871. [PubMed]
8. Varela-Lema, L., Taioli, E., Ruano-Ravina, A., Barros-Dios, J. M., Anantharaman, D., Benhamou, S., Boccia, S., Bhisey, R. A., Cadoni, G., Capoluongo, E., Chen, C. J., Foulkes, W., Goloni-Bertollo, E. M., Hatagima, A., Hayes, R. B., Katoh, T., Koifman, S., Lazarus, P., Manni, J. J., Mahimkar, M., Morita, S., Park, J., Park, K. K., Pavarino, B., de, S., Roy, B., Spitz, M. R., Strange, R. C., Wei, Q. and Ragin, C. C.  Meta-analysis and pooled analysis of GSTM1 and CYP1A1 polymorphisms and oral and pharyngeal cancers: a HuGE-GSEC review. Genetics in Medicine. 2008. 10, 369-384. [PubMed]
9. Anantharaman, D., Chaubal, P. M., Kannan, S., Bhisey, R. A. and Mahimkar, M. B.  Susceptibility to oral cancer by genetic polymorphisms at CYP1A1, GSTM1 and GSTT1 loci among Indians: tobacco exposure as a risk modulator. Carcinogenesis. 2007.  28, 1455-1462. [PubMed]
10. Huang, Q., Yu, G. P., McCormick, S. A., Mo, J., Datta, B., Mahimkar, M., Lazarus, P., Schaffer, A. A., Desper, R. and Schantz, S. P.  Genetic differences detected by comparative genomic hybridization in head and neck squamous cell carcinomas from different tumor sites: construction of oncogenetic trees for tumor progression. Genes, Chromosomes & Cancer. 2002.  34, 224-233. [PubMed]
11. Mahimkar, M. B., Buch, S. C., Samant, T. A., Kapoor, M. D. and Bhisey, R. A.  Influence of smokeless tobacco exposure on detoxification status and chromosomal damage in male and female habitues. Mutation Research. 2001.  491, 111-117. [PubMed]
12. Shah, M. D., Ramchandani, A. G., Mahimkar, M. B., Potdar, P. D., Bhisey, A. N. and Bhisey, R. A.  Effects of an aqueous extract of processed bidi tobacco on the growth of hamster tracheal epithelial cells. Toxicology Letters. 2001.  119, 1-9. [PubMed]
13. Bhisey, R. A., Bagwe, A. N., Mahimkar, M. B. and Buch, S. C.  Biological monitoring of bidi industry workers occupationally exposed to tobacco. Toxicology Letters. 1999.  108, 259-265. [PubMed]
14. Mulherkar, R., Goud, A. P., Wagle, A. S., Naresh, K. N., Mahimkar, M. B., Thomas, S. M., Pradhan, S. A. and Deo, M. G.  Establishment of a human squamous cell carcinoma cell line of the upper aero-digestive tract. Cancer Letters. 1997.  118, 115-121. [PubMed]
15. Mahimkar, M. B. and Bhisey, R. A.  Occupational exposure to bidi tobacco increases chromosomal aberrations in tobacco processors. Mutation Research. 1995.  334, 139-144. [PubMed]


Book Chapters:
Bagwe, A.N, Buch, S.C., Mahimkar, M.B, Karthikeyan, S., Bhisey, R.A.: (2000) Environmental, biological and health monitoring of tobacco processing factory workers. Proceedings of World Assembly on Tobacco Counters Health - WATCH 2000, Publ. Macmillan India, pp. 160-163
Mahimkar, M.B., Bhisey, R.A. (1997) Genotoxic effects of occupational tobacco exposure in bidi industry workers. In H. Prasad & PP Reddy, eds Environmental Pollution and Genetic Risk, Institute of Genetics, Osmania University, Hyderabad , pp 103-110
Bhisey, R.A., Govekar, R.B., Bagwe, A.N., Mahimkar, M.B.(1991) Biological risk assessment in tobacco chewers: a population at high risk for oral cancer. In: RS Rao & PB Desai, eds. Oral Cancer, Tata Memorial Centre Publ., Bombay, pp.191-199
Ph.D. in Biosciences, University of Mumbai
International Head and Neck Cancer Epidemiology, IARC, Lyon, France
International Collaborative Study on Genetic Susceptibility to Environmental Carcinogens, University of Pittsburgh Cancer Center, USA
Editorial Board: Oral Oncology
  Last modified on : Oct 28, 2011
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