INCREDB ID : 21
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Vaijayanti P. Kale, Ph.D.
Scientist F 
 
National Centre for Cell Science
NCCS Complex, Pune University Campus, Ganeshkhind
Pune - 411 007   
Maharashtra   
 
E-mail: vpkale@nccs.res.in, vaijayanti.kale@gmail.com
Phone: +91-20-25708077, +91-20-25708000, Extn. 8077
Fax: +91-20-25692259
 
URL: http://www.nccs.res.in/DrKale/DrKale.html
 
Area of Specialization:
Molecular Biology
Research Summary:
Regulation of stem cell fate by its microenvironment
Identification of signaling mechanisms involved in the regulation of hematopoietic stem cells
Creation of an in vitro model of the BM niche and studies on its impact on the Hematopoietic Stem Cells
Comparative gene and protein profiling of mesenchymal stem cells of human and mouse origin to identify the species-specific HSC-supportive factors secreted by them
Effect of hematopoiesis-regulatory factors/signaling molecules expressed in the stromal cells on the fate of the HSCs interacting with them
Studies on the regulation of hematopoiesis by the micro-environment-mediated signalling mechanisms
Enrichment and characterization of pluri-potent embryonic like stem cells from bone marrow and assessment of their capacity to differentiate towards neuronal, pancreatic and cardiac lineages
Nitric oxide signaling and its role in cancer progression
Infusion of autologous mesenchymal stem cells rendered into an Artificial Bone Marrow Environment in vitro during autologous hematopoietic stem cell transplantations
Application of autologous Mesenchymal Stem Cells rendered into an Artificial Bone Marrow Environment in vitro in diabetic wound healing
 
Publications:
1. Kale, V. P., Bhat, A. V. and Bapat, C. V.  Comparison of biochemical characterisation of ICRC bacilli with M. leprae: effect of substrate alteration in the medium. Indian Journal of Leprosy. 1984.  56, 212-218. [PubMed]
2. Mandock, O., Ibegbu, C., Kale, V. and Navalkar, R. G.  Studies on the antigenic specificity of Mycobacterium leprae. II. Immunological characterization. Zentralblatt Fur Bakteriologie, Mikrobiologie, Und Hygiene. Series A, Medical Microbiology, Infectious Diseases, Virology, Parasitology. 1987.  265, 12-19. [PubMed]
3. Kale, V. P., Bhat, A. V. and Bapat, C. V.  Dopa-oxidase activity on ICRC bacilli. Indian Journal of Leprosy. 1984.  56, 58-62. [PubMed]
4. Kale, V. P. and Bapat, C. V.  Antigeneic cross-reactivity between ICRC-bacilli and M. leprae--"in vitro" evaluation. Indian Journal of Leprosy. 1984.  56, 219-231. [PubMed]
5. Bajaj, M., Hinge, A., Limaye, L. S., Gupta, R. K., Surolia, A. and Kale, V. P.  Mannose-binding dietary lectins induce adipogenic differentiation of the marrow-derived mesenchymal cells via an active insulin-like signaling mechanism. Glycobiology. 2010.  [PubMed]
6. Sangeetha, V. M., Kale, V. P. and Limaye, L. S.  Expansion of cord blood CD34 cells in presence of zVADfmk and zLLYfmk improved their in vitro functionality and in vivo engraftment in NOD/SCID mouse. PloS One. 2010.  5, e12221. [PubMed]
7. Balan, S., Kale, V. P. and Limaye, L. S.  A large number of mature and functional dendritic cells can be efficiently generated from umbilical cord blood-derived mononuclear cells by a simple two-step culture method. Transfusion. 2010.  50, 2413-2423. [PubMed]
8. Hinge, A. S., Limaye, L. S., Surolia, A. and Kale, V. P.  In vitro protection of umbilical cord blood-derived primitive hematopoietic stem progenitor cell pool by mannose-specific lectins via antioxidant mechanisms. Transfusion. 2010.  50, 1815-1826. [PubMed]
9. Siddiqui, N. F., Shabrani, N. C., Kale, V. P. and Limaye, L. S.  Enhanced generation of megakaryocytes from umbilical cord blood-derived CD34(+) cells expanded in the presence of two nutraceuticals, docosahexanoic acid and arachidonic acid, as supplements to the cytokine-containing medium. Cytotherapy. 2011.  13, 114-128. [PubMed]
10. Balan, S., Kale, V. P. and Limaye, L. S.  A simple two-step culture system for the large-scale generation of mature and functional dendritic cells from umbilical cord blood CD34+ cells. Transfusion. 2009.  49, 2109-2121. [PubMed]
11. Vaidya, A. A., Sharma, M. B. and Kale, V. P.  Suppression of p38-stress kinase sensitizes quiescent leukemic cells to anti-mitotic drugs by inducing proliferative responses in them. Cancer Biology & Therapy. 2008.  7, 1232-1240. [PubMed]
12. Sasnoor, L. M., Kale, V. P. and Limaye, L. S.  Prevention of apoptosis as a possible mechanism behind improved cryoprotection of hematopoietic cells by catalase and trehalose. Transplantation. 2005.  80, 1251-1260. [PubMed]
13. Sasnoor, L. M., Kale, V. P. and Limaye, L. S.  A combination of catalase and trehalose as additives to conventional freezing medium results in improved cryoprotection of human hematopoietic cells with reference to in vitro migration and adhesion properties. Transfusion. 2005.  45, 622-633. [PubMed]
14. Sasnoor, L. M., Kale, V. P. and Limaye, L. S.  Supplementation of conventional freezing medium with a combination of catalase and trehalose results in better protection of surface molecules and functionality of hematopoietic cells. Journal of Hematotherapy & Stem Cell Research. 2003.  12, 553-564. [PubMed]
15. Kale V. P.  MAP kinase: a switch in fate determination of stem cells. Stem Cells and Development. 2005.  14, 248-251. [PubMed]
16. Sasnoor, L. M., Kale, V. P. and Limaye, L. S.  A combination of catalase and trehalose as additives to conventional freezing medium results in improved cryoprotection of human hematopoietic cells with reference to in vitro migration and adhesion properties. Transfusion. 2005.  45, 622-633. [PubMed]
17. Kale V. P.  Differential activation of MAPK signaling pathways by TGF-beta1 forms the molecular mechanism behind its dose-dependent bidirectional effects on hematopoiesis. Stem Cells and Development. 2004.  13, 27-38. [PubMed]
18. Raju, G. M., Guha, S., Mukhopadhyay, A., Kumar, L., Kale, V. P., Mittal, S., Deka, D., Mohanty, S. and Kochupillai, V.  Colony-stimulating activity of fetal liver cells: synergistic role of stem cell factor in bone marrow recovery from aplastic anemia. Journal of Hematotherapy & Stem Cell Research. 2003.  12, 491-497. [PubMed]
19. Limaye, L. S. and Kale, V. P.  Cryopreservation of human hematopoietic cells with membrane stabilizers and bioantioxidants as additives in the conventional freezing medium. Journal of Hematotherapy & Stem Cell Research. 2001.  10, 709-718. [PubMed]
20. Kale, V. P. and Limaye, L. S.  Stimulation of adult human bone marrow by factors secreted by fetal liver hematopoietic cells: in vitro evaluation using semisolid clonal assay system. Stem Cells. 1999.  17, 107-116. [PubMed]
21. Hinge, A.S., Limaye, L.S., Surolia, A. and Kale, V.P. In vitro protection of umbilical cord blood-derived primitive hematopoietic stem progenitor cell pool by mannose-specific lectins via anti-oxidant mechanisms. Transfusion. In press.
22. Hinge, A., Bajaj, M., Limaye, L., Surolia, A. and Kale, V.P. Oral administration of insulin receptor-interacting lectins leads to an enhancement in the hematopoietic stem and progenitor cell pool of mice. Stem Cells and Development. In press.

 
Grant Support:
Project Title Role Funding Agency Sanction Number Sanction Date
Identification of signaling mechanisms involved in the regulation of hematopoietic stem cells Department of Biotechnology, Government of India
Creation of an in vitro model of the BM niche and studies on its impact on the Hematopoietic Stem Cells Department of Biotechnology, Government of India
Harnessing the potential of multipotent adult stem cells Development of three-dimensional cultures with mesenchymal cells to examine their effect on development of hematopoietic cells Department of Biotechnology, Government of India
Identification of biochemical pathways involved in the Hematopoietic Stem Cell regulation Department of Biotechnology, Government of India
Identification of molecular mechanisms involved in the adipogenic conversion of hematopoietic cells by mannose specific dietary lectins namely, banana lectin and garlic lectin Department of Biotechnology, Government of India
Assessment of caveolin-1 mutations as possible risk factors in the development of human breast carcinoma Department of Science & Technology, Government of India

 
 
 
Education 
::
Ph.D. University of Pune, Pune, India
Member
::
International Society of Experimental Hematologists
::
International Society of Stem Cell Research
::
Indian Association of Cell Biology
::
Indian Association of Biotechnology
::
Associate Editor - Stem Cells and Development, Annals of Neurosciences
  Last modified on : Mar 4, 2011
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