INCREDB ID : 203
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Murali Dharan Bashyam, Ph.D.
Head 
 
Centre for DNA Fingerprinting and Diagnostics
Molecular Oncology Lab
Bldg. 7, Gruhakalpa, 5-4-399 / B, Nampally
Hyderabad - 500 001   
Andhra Pradesh   
 
E-mail: bashyam@cdfd.org.in
Phone: +91-40-24749383
Fax: +91-40-24749448
 
URL: http://www.cdfd.org.in/labpages/murali_bashyam.html
 
Positions Held:
Position Affiliation Time Period
Visiting Fellow Stanford University School of Medicine, California, USA
Post Doctoral Fellowship National Institute of Immunology, New Delhi, India
 
Area of Specialization:
Molecular Biology
Oncology
Research Summary:
Molecular characterization of sporadic colorectal cancer in the young from India
Identification of novel ESCC genes by using a combination of array based CGH and gene expression microarrays
Identification and characterization of pancreatic cancer genes located within novel localized copy number alterations
Molecular studies on genetic disorders
 
Publications:
1. RamaDevi, A. R., Reddy, E. C., Ranjan, S. and Bashyam, M. D.  Molecular genetic analysis of patients from India with hypohidrotic ectodermal dysplasia reveals novel mutations in the EDA and EDAR genes. The British Journal of Dermatology. 2008.  158, 163-167. [PubMed]
1. Yabaluri, N. and Bashyam, M. D.  Hormonal regulation of gluconeogenic gene transcription in the liver. Journal of Biosciences. 2010.  35, 473-484. [PubMed]
2. Purushotham, G., Madhumohan, K., Anwaruddin, M., Nagarajaram, H., Hariram, V., Narasimhan, C. and Bashyam, M. D.  The MYH7 p.R787H mutation causes hypertrophic cardiomyopathy in two unrelated families. Experimental and Clinical Cardiology. 2010.  15, e1-4. [PubMed]
3. Bashyam, M. D., Chaudhary, A. K., Reddy, E. C., Devi, A. R., Savithri, G. R., Ratheesh, R., Bashyam, L., Mahesh, E., Sen, D., Puri, R., Verma, I. C., Nampoothiri, S., Vaidyanathan, S., Chandrashekar, M. D. and Kantheti, P.  Phenylalanine hydroxylase gene mutations in phenylketonuria patients from India: identification of novel mutations that affect PAH RNA. Molecular Genetics and Metabolism. 2010.  100, 96-99. [PubMed]
4. Angalena, R., Prabitha, K. N., Chaudhary, A. K., Bashyam, M. D., Jain, S. and Dalal, A. B.  A novel homozygous point mutation at codon 82 (HBB:c.247A > T) in the beta-globin gene leads to thalassemia major. International Journal of Laboratory Hematology. 2010.  32, 548-549. [PubMed]
5. Bashyam M. D.  Nonsense-mediated decay: linking a basic cellular process to human disease. Expert Review of Molecular Diagnostics. 2009.  9, 299-303. [PubMed]
6. Kumar, M. S., Ramachandran, A., Hasnain, S. E. and Bashyam, M. D.  Octamer and heat shock elements regulate transcription from the AcMNPV polyhedrin gene promoter. Archives of Virology. 2009.  154, 445-456. [PubMed]
7. Bashyam M. D.  Studies on nonsense mediated decay reveal novel therapeutic options for genetic diseases. Recent Patents On DNA & Gene Sequences. 2009.  3, 7-15. [PubMed]
8. Kwei, K. A., Bashyam, M. D., Kao, J., Ratheesh, R., Reddy, E. C., Kim, Y. H., Montgomery, K., Giacomini, C. P., Choi, Y. L., Chatterjee, S., Karikari, C. A., Salari, K., Wang, P., Hernandez-Boussard, T., Swarnalata, G., van, d. e., Maitra, A. and Pollack, J. R.  Genomic profiling identifies GATA6 as a candidate oncogene amplified in pancreatobiliary cancer. PLoS Genetics. 2008.  4, e1000081. [PubMed]
9. RamaDevi, A. R., Reddy, E. C., Ranjan, S. and Bashyam, M. D.  Molecular genetic analysis of patients from India with hypohidrotic ectodermal dysplasia reveals novel mutations in the EDA and EDAR genes. The British Journal of Dermatology. 2008.  158, 163-167. [PubMed]
10. Bashyam, M. D., Savithri, G. R., Gopikrishna, M. and Narasimhan, C.  A p.R870H mutation in the beta-cardiac myosin heavy chain 7 gene causes familial hypertrophic cardiomyopathy in several members of an Indian family. The Canadian Journal of Cardiology. 2007.  23, 788-790. [PubMed]
11. Bashyam, M. D., Bair, R., Kim, Y. H., Wang, P., Hernandez-Boussard, T., Karikari, C. A., Tibshirani, R., Maitra, A. and Pollack, J. R.  Array-based comparative genomic hybridization identifies localized DNA amplifications and homozygous deletions in pancreatic cancer. Neoplasia. 2005.  7, 556-562. [PubMed]
12. Bashyam, M. D. and Hasnain, S. E.  The extracytoplasmic function sigma factors: role in bacterial pathogenesis. Infection, Genetics and Evolution. 2004.  4, 301-308. [PubMed]
13. Bashyam, M. D., Bashyam, L., Savithri, G. R., Gopikrishna, M., Sangal, V. and Devi, A. R.  Molecular genetic analyses of beta-thalassemia in South India reveals rare mutations in the beta-globin gene. Journal of Human Genetics. 2004.  49, 408-413. [PubMed]
14. Viswanathan, P., Venkaiah, B., Kumar, M. S., Rasheedi, S., Vrati, S., Bashyam, M. D. and Hasnain, S. E.  The homologous region sequence (hr1) of Autographa californica multinucleocapsid polyhedrosis virus can enhance transcription from non-baculoviral promoters in mammalian cells. The Journal of Biological Chemistry. 2003.  278, 52564-52571. [PubMed]
15. Bashyam, M. D. and Hasnain, S. E.  The human genome sequence: impact on health care. The Indian Journal of Medical Research. 2003.  117, 43-65. [PubMed]
16. Bashyam, M. D., Savithri, G. R., Kumar, M. S., Narasimhan, C. and Nallari, P.  Molecular genetics of familial hypertrophic cardiomyopathy (FHC). Journal of Human Genetics. 2003.  48, 55-64. [PubMed]
17. Bashyam M. D.  Understanding cancer metastasis: an urgent need for using differential gene expression analysis. Cancer. 2002.  94, 1821-1829. [PubMed]
18. Ramachandran, A., Jain, A., Arora, P., Bashyam, M. D., Chatterjee, U., Ghosh, S., Parnaik, V. K. and Hasnain, S. E.  Novel Sp family-like transcription factors are present in adult insect cells and are involved in transcription from the polyhedrin gene initiator promoter. The Journal of Biological Chemistry. 2001.  276, 23440-23449. [PubMed]
19. Bashyam, M. D. and Tyagi, A. K.  Identification and analysis of "extended -10" promoters from mycobacteria. Journal of Bacteriology. 1998.  180, 2568-2573. [PubMed]
20. Bashyam, M. D., Kaushal, D., Dasgupta, S. K. and Tyagi, A. K.  A study of mycobacterial transcriptional apparatus: identification of novel features in promoter elements. Journal of Bacteriology. 1996.  178, 4847-4853. [PubMed]
21. Bashyam, M. D. and Tyagi, A.  An efficient and high-yielding method for isolation of RNA from mycobacteria. BioTechniques. 1994.  17, 834-836. [PubMed]
22. Das, G., Bashyam, M. D. and Tyagi, A. K.  Cloning and assessment of mycobacterial promoters by using a plasmid shuttle vector. Journal of Bacteriology. 1993.  175, 5186-5192. [PubMed]
23. Angalena, R., Chaudhary, A., Murali, D., Bashyam, Dalal, A., Hemoglobin D masquerading as Hemoglobin E: An interesting case report. Newsletter of Genetics Chapter of Indian Academy of Pediatrics, 2009, Vol 2, Issue 1.
24. Bashyam M. D.  Studies on nonsense mediated decay reveal novel therapeutic options for genetic diseases. Recent Patents On DNA & Gene Sequences. 2009. 3, 7-15. [PubMed]
25. Murali D Bashyam and R Ratheesh. Genetic instability in colorectal cancer. ICFAI Journal of Biotechnology, 2008, 2:13-26.
26. Devi, A. R., Gopikrishna, M., Ratheesh, R., Savithri, G., Swarnalata, G. and Bashyam, M.  Farber lipogranulomatosis: clinical and molecular genetic analysis reveals a novel mutation in an Indian family. Journal of Human Genetics. 2006. 51, 811-814. [PubMed]
27. RamaDevi, A. R., Reddy, E. C., Ranjan, S. and Bashyam, M. D.  Molecular genetic analysis of patients from India with hypohidrotic ectodermal dysplasia reveals novel mutations in the EDA and EDAR genes. The British Journal of Dermatology. 2008. 158, 163-167. [PubMed]
28. Bashyam, M., D., Prokaryotic Genomes. Book Review, Current Science, 2003, 84:1366-1367.
29. Bashyam, M., D., Microarrays for the Neurosciences : An essential guide. Daniel H. Geschwind and Jeffery P. Gregg (eds.). Book Review, Current Science, 2002, 83:649-650.
30. Ramachandran, A., Bashyam, M., D., Viswanathan, P., Ghosh, S., Kumar, M., S., Hasnain, S., E., The bountiful and baffling baculovirus: The story of polyhedrin transcription. Current Science, 2001,  81:998-1010.
31. Bashyam, M., D., Ghosh, S., Ramachandran, A., Viswanathan, P., Hasnain, S., E. Multiple regulatory circuits for transcription from the polyhedrin gene promoter of the Autographa californica  multiple nucleocapsid nuclear polyhedrosis  virus. Proceeding. Indian National. Science Academy.2000, B66 Nos 2&3 pp 83-96.
32. Bashyam, M. D., Kaushal, D., Dasgupta, S., K. and Tyagi, A., K., A study of the mycobacterial transcriptional apparatus: identification of novel features in promoter elements. Journal of Bacteriology.1996, 178:4847-4853.

 
Book Chapters:
Angalena R, Ajay Chaudhary, Murali D Bashyam, Ashwin Dalal. Hemoglobin D (Iran) masquerading as Hemoglobin E: An interesting case report. Newsletter of Genetics Chapter of Indian Academy of Pediatrics, Vol 2, Issue 1. Jan-Mar 2009.
 
Grant Support:
Project Title Role Funding Agency Sanction Number Sanction Date
Molecular characterization of sporadic colorectal cancer in the young from India Fogarty International Research Collaboration Award, National Institutes of Health, Maryland, USA
Identification of novel esophageal squamous cell carcinoma (ESCC) genes by using a combination of array based CGH and gene expression microarrays Department of Biotechnology, Government of India
Identification and characterization of pancreatic cancer genes located within novel localized copy number alterations Department of Science & Technology, Government of India
Molecular genetic analyses of Familial Hypertrophic Cardiomyopathy in Andhra Pradesh Department of Biotechnology, Government of India
Molecular studies on genetic disorders in Andhra Pradesh

 
 
 
Education 
::
Ph.D. in Biochemistry, Delhi University
Honors and Awards
::
2010, Faculty from developing countries award from American Association for Cancer Research from the laboratory to the clinic, Jordan
::
2009, Awarded the National Cancer Institute, USA Fellowship
::
2008, American Association for Cancer Research National Cancer Institute International investigator opportunity grant
::
2008, Selected as a member of the multidisciplinary young scientist team, by the Indian National Science Academy and Department of Science and Technology, Government of India
::
2008, Fogarty International Research Collaboration Award, Fogarty International Center, National Institutes of Health, USA
::
2006, Indian National Science Academy, Govt of India, travel grant to present abstract at the Cold Spring Harbor Meeting on Mechanisms and Models of Cancer
::
2005, International Cancer Technology Transfer Fellowship of the International Union Against Cancer
::
2005, Sir Dorabji Tata Trust travel award
::
2003, The Overseas Associateship Award of the Department of Biotechnology
::
2001, Young Scientist Award of the Department of Science and Technology
::
2000, Sir Jamsetji Tata Trust Award for training in Microarray Technology at the Memorial Sloan Kettering Cancer Center, New York, USA
::
2000, Sir Dorabji Tata Trust Award for training in Microarray Technology at the Memorial Sloan Kettering Cancer Center, New York, USA
::
1998, Young scientist medal of the Indian National Science Academy
::
1995, Young scientist award of the Association of Microbiologists of India
Member
::
The National Academy of Sciences, Allahabad
  Last modified on : Mar 4, 2011
India Cancer Research Database has been developed by the Institute of Bioinformatics with funding from the Department of Biotechnology, Government of India.