Kakoli Bose, Ph.D.
Advanced Centre for Treatment Research and Education in Cancer, Tata Memorial Centre
Kharghar
Navi Mumbai - 410 210
E-mail: kbose@actrec.gov.in, bose.lab@actrec.gov.in
Phone: +91-22-2740 5109
Fax: +91-22-2740 5085
URL: http://www.actrec.gov.in/pi-webpages/KakoliBose/
Positions Held:
Position Affiliation Time Period
Post Doctoral Fellowship
Tufts University School of Medicine, Boston, USA
Area of Specialization:
Oncology
Publications:
1.
Chaganti, L. K., Kuppili, R. R. and Bose, K. Intricate structural coordination and domain plasticity regulate activity of serine protease HtrA2. FASEB Journal : Official Publication of the Federation of American Societies For Experimental Biology. 2013. 27, 3054-3066. [PubMed]
2.
Bejugam, P. R., Kuppili, R. R., Singh, N., Gadewal, N., Chaganti, L. K., Sastry, G. M. and Bose, K. Allosteric regulation of serine protease HtrA2 through novel non-canonical substrate binding pocket. PloS One. 2013. 8, e55416. [PubMed]
3.
Singh, N., Kuppili, R. R. and Bose, K. The structural basis of mode of activation and functional diversity: a case study with HtrA family of serine proteases. Archives of Biochemistry and Biophysics. 2011. 516, 85-96. [PubMed]
4.
Bose, K., Meinke, G., Bohm, A. and Baleja, J. D. Design and characterization of an enhanced repressor of human papillomavirus E2 protein. FASEB Journal : Official Publication of the Federation of American Societies For Experimental Biology. 2011. 25, 2354-2361. [PubMed]
5.
Wei, J., Liu, Y., Bose, K. , Henry, G. D. and Baleja, J. D. Disorder and structure in the Rab11 binding domain of Rab11 family interacting protein 2. Biochemistry. 2009. 48, 549-557. [PubMed]
6.
Bose, K. , Yoder, N. C., Kumar, K. and Baleja, J. D. The role of conserved histidines in the structure and stability of human papillomavirus type 16 E2 DNA-binding domain. Biochemistry. 2007. 46, 1402-1411. [PubMed]
7.
Bose, K. and Clark, A. C. pH effects on the stability and dimerization of procaspase-3. Protein Science. 2005. 14, 24-36. [PubMed]
8.
Bose, K. Pop, C., Feeney, B. and Clark, A. C. An uncleavable procaspase-3 mutant has a lower catalytic efficiency but an active site similar to that of mature caspase-3. Biochemistry. 2003. 42, 12298-12310. [PubMed]
9.
Bose, K. and Clark, A. C. Dimeric procaspase-3 unfolds via a four-state equilibrium process. Biochemistry. 2001. 40, 14236-14242. [PubMed]
10.
Pop, C., Chen, Y. R., Smith, B., Bose, K. , Bobay, B., Tripathy, A., Franzen, S. and Clark, A. C. Removal of the pro-domain does not affect the conformation of the procaspase-3 dimer. Biochemistry. 2001. 40, 14224-14235. [PubMed]
Grant Support:
Project Title Role Funding Agency Sanction Number Sanction Date
Structural and functional characterization of proapoptotic proteins: Human papillomavirus E2 and serine protease HtrA2
Understanding protein-protein interactions involved in papillomavirus E2 induced apoptosis
Proapoptotic serine protease HtrA2/Omi: structural determinants of its mechanism of action
Education
::
Ph.D. in Biochemistry,
North Carolina State University, Department of Biochemistry, Raleigh, USA
::
M.Sc. in Chemistry
Honors and Awards
::
Designed a papillomaviral inhibitor that is currently being developed by the Tufts University for Technology Transfer for turning it into a patent application and being evaluated by a company to license the technology
::
2005, Received Natalie Zucker Research Grant Award
::
2005, Received honorable mention in Tufts Dean’s letter
::
2002, Received award for best poster presentation in the Research Triangle Park Annual Conference on Biochemistry, NC
::
Obtained full Scholarship from NC State University for Doctoral study
Member
::
Member, American Chemical Society
::
Member, American Association for the Advancement of Science
::
Member, The Protein Society