INCREDB ID : 195
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Sujit Nair, M.Pharm., Ph.D.
Assistant Professor 
 
Amrita Institute of Medical Sciences and Research Centre
Amrita Lane, AIMS, Ponekkara
Kochi - 682 041   
Kerala   
 
E-mail: brdrsujit@aims.amrita.edu, sujit108@gmail.com
 
URL: http://www.amrita.edu/acns/faculty.php
 
Positions Held:
Position Affiliation Time Period
Assistant Professor Amrita Institute of Medical Sciences and Research Center, Kochi, India 2008-Present
 
Area of Specialization:
Cancer Chemoprevention
Pharmacogenomics
Pharmacology
Drug Metabolism
Pharmacokinetics
Research Summary:
Cancer biology, signal transduction and pharmacogenomics
Biomarker discovery and screening of candidate drug molecules
Drug metabolism and pharmacokinetics of anti-cancer agents
 
Publications:
1. Nair, S., Barve, A., Khor, T. O., Shen, G. X., Lin, W., Chan, J. Y., Cai, L. and Kong, A. N.  Regulation of Nrf2- and AP-1-mediated gene expression by epigallocatechin-3-gallate and sulforaphane in prostate of Nrf2-knockout or C57BL/6J mice and PC-3 AP-1 human prostate cancer cells. Acta Pharmacologica Sinica. 2010.  31, 1223-1240. [PubMed]
2. Barve, A., Khor, T. O., Nair, S., Reuhl, K., Suh, N., Reddy, B., Newmark, H. and Kong, A. N.  Gamma-tocopherol-enriched mixed tocopherol diet inhibits prostate carcinogenesis in TRAMP mice. International Journal of Cancer. 2009.  124, 1693-1699. [PubMed]
3. Nair, S., Doh, S. T., Chan, J. Y., Kong, A. N. and Cai, L.  Regulatory potential for concerted modulation of Nrf2- and Nfkb1-mediated gene expression in inflammation and carcinogenesis. British Journal of Cancer. 2008.  99, 2070-2082. [PubMed]
4. Barve, A., Khor, T. O., Nair, S., Lin, W., Yu, S., Jain, M. R., Chan, J. Y. and Kong, A. N.  Pharmacogenomic profile of soy isoflavone concentrate in the prostate of Nrf2 deficient and wild-type mice. Journal of Pharmaceutical Sciences. 2008.  97, 4528-4545. [PubMed]
5. Nair, S., Hebbar, V., Shen, G., Gopalakrishnan, A., Khor, T. O., Yu, S., Xu, C. and Kong, A. N.  Synergistic effects of a combination of dietary factors sulforaphane and (-) epigallocatechin-3-gallate in HT-29 AP-1 human colon carcinoma cells. Pharmaceutical Research. 2008.  25, 387-399. [PubMed]
6. Prawan, A., Keum, Y. S., Khor, T. O., Yu, S., Nair, S., Li, W., Hu, L. and Kong, A. N.  Structural influence of isothiocyanates on the antioxidant response element (ARE)-mediated heme oxygenase-1 (HO-1) expression. Pharmaceutical Research. 2008.  25, 836-844. [PubMed]
7. Shen, G., Khor, T. O., Hu, R., Yu, S., Nair, S., Ho, C. T., Reddy, B. S., Huang, M. T., Newmark, H. L. and Kong, A. N.  Chemoprevention of familial adenomatous polyposis by natural dietary compounds sulforaphane and dibenzoylmethane alone and in combination in ApcMin/+ mouse. Cancer Research. 2007.  67, 9937-9944. [PubMed]
8. Nair, S., Li, W. and Kong, A. N.  Natural dietary anti-cancer chemopreventive compounds: redox-mediated differential signaling mechanisms in cytoprotection of normal cells versus cytotoxicity in tumor cells. Acta Pharmacologica Sinica. 2007.  28, 459-472. [PubMed]
9. Nair, S., Xu, C., Shen, G., Hebbar, V., Gopalakrishnan, A., Hu, R., Jain, M. R., Liew, C., Chan, J. Y. and Kong, A. N.  Toxicogenomics of endoplasmic reticulum stress inducer tunicamycin in the small intestine and liver of Nrf2 knockout and C57BL/6J mice. Toxicology Letters. 2007.  168, 21-39. [PubMed]
10. Hu, R., Shen, G., Yerramilli, U. R., Lin, W., Xu, C., Nair, S. and Kong, A. N.  In vivo pharmacokinetics, activation of MAPK signaling and induction of phase II/III drug metabolizing enzymes/transporters by cancer chemopreventive compound BHA in the mice. Archives of Pharmacal Research. 2006.  29, 911-920. [PubMed]
11. Nair, S., Xu, C., Shen, G., Hebbar, V., Gopalakrishnan, A., Hu, R., Jain, M. R., Lin, W., Keum, Y. S., Liew, C., Chan, J. Y. and Kong, A. N.  Pharmacogenomics of phenolic antioxidant butylated hydroxyanisole (BHA) in the small intestine and liver of Nrf2 knockout and C57BL/6J mice. Pharmaceutical Research. 2006.  23, 2621-2637. [PubMed]
12. Gopalakrishnan, A., Xu, C. J., Nair, S. S., Chen, C., Hebbar, V. and Kong, A. N.  Modulation of activator protein-1 (AP-1) and MAPK pathway by flavonoids in human prostate cancer PC3 cells. Archives of Pharmacal Research. 2006.  29, 633-644. [PubMed]
13. Khor, T. O., Hu, R., Shen, G., Jeong, W. S., Hebbar, V., Chen, C., Xu, C., Nair, S., Reddy, B., Chada, K. and Kong, A. N.  Pharmacogenomics of cancer chemopreventive isothiocyanate compound sulforaphane in the intestinal polyps of ApcMin/+ mice. Biopharmaceutics & Drug Disposition. 2006.  27, 407-420. [PubMed]
14. Shen, G., Xu, C., Hu, R., Jain, M. R., Gopalkrishnan, A., Nair, S., Huang, M. T., Chan, J. Y. and Kong, A. N.  Modulation of nuclear factor E2-related factor 2-mediated gene expression in mice liver and small intestine by cancer chemopreventive agent curcumin. Molecular Cancer Therapeutics. 2006.  5, 39-51. [PubMed]
15. Xu, C., Shen, G., Yuan, X., Kim, J. H., Gopalkrishnan, A., Keum, Y. S., Nair, S. and Kong, A. N.  ERK and JNK signaling pathways are involved in the regulation of activator protein 1 and cell death elicited by three isothiocyanates in human prostate cancer PC-3 cells. Carcinogenesis. 2006.  27, 437-445. [PubMed]
16. Shen, G., Xu, C., Hu, R., Jain, M. R., Nair, S., Lin, W., Yang, C. S., Chan, J. Y. and Kong, A. N.  Comparison of (-)-epigallocatechin-3-gallate elicited liver and small intestine gene expression profiles between C57BL/6J mice and C57BL/6J/Nrf2 (-/-) mice. Pharmaceutical Research. 2005.  22, 1805-1820. [PubMed]
17. Chen, C., Pung, D., Leong, V., Hebbar, V., Shen, G., Nair, S., Li, W. and Kong, A. N.  Induction of detoxifying enzymes by garlic organosulfur compounds through transcription factor Nrf2: effect of chemical structure and stress signals. Free Radical Biology & Medicine. 2004.  37, 1578-1590. [PubMed]
18. Shen, G., Hebbar, V., Nair, S., Xu, C., Li, W., Lin, W., Keum, Y. S., Han, J., Gallo, M. A. and Kong, A. N.  Regulation of Nrf2 transactivation domain activity. The differential effects of mitogen-activated protein kinase cascades and synergistic stimulatory effect of Raf and CREB-binding protein. The Journal of Biological Chemistry. 2004.  279, 23052-23060. [PubMed]
19. Kim, B. R., Hu, R., Keum, Y. S., Hebbar, V., Shen, G., Nair, S. S. and Kong, A. N.  Effects of glutathione on antioxidant response element-mediated gene expression and apoptosis elicited by sulforaphane. Cancer Research. 2003.  63, 7520-7525. [PubMed]

 
Grant Support:
Project Title Role Funding Agency Sanction Number Sanction Date
Modulation of microRNA and protein signatures in hepatocellular carcinoma by chemopreventive phytochemicals Principal Investigator Department of Biotechnology, Government of India 2010
Fusion transcripts in cancer and the potential to inhibit by RNA interference Co-PI Department of Biotechnology, Government of India 2010

 
 
 
Education 
::
M.Pharm. Principal K. M. Kundnani College of Pharmacy, University of Mumbai, Mumbai, India
::
Ph.D. in Pharmaceutical Sciences, , Center for Cancer Prevention Research and the Ernest Mario School of Pharmacy at Rutgers, The State University of New Jersey, USA.
Honors and Awards
::
2010, Faculty Award for Excellence from Amrita University
::
2009, Rapid Grant for Young Investigators from the Department of Biotechnology, Government of India
::
2005, Outstanding Head-Teaching Assistant award from the Graduate School at Rutgers University
::
1997, First Rank in the University of Mumbai Pharmacy Examination
Member
::
American Association for Cancer Research
::
Indian Association for Cancer Research
::
American Association of Pharmaceutical Scientists
  Last modified on : Mar 4, 2011
India Cancer Research Database has been developed by the Institute of Bioinformatics with funding from the Department of Biotechnology, Government of India.