INCREDB ID : 194
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Chilakapati Murali Krishna, Ph.D.
Principal Investigator 
 
Advanced Centre for Treatment Research and Education in Cancer
Chilakapati Lab
Khanolkar Shodhika, Tata Memorial Centre, Kharghar
Navi Mumbai - 410 210    
Maharashtra   
 
E-mail: mchilakapati@actrec.gov.in
Phone: +91-22-27405039
Fax: +91-22-27412894
 
URL: http://actrec.gov.in/pi-webpages/MuraliChilakapati/murali-people.html
 
Positions Held:
Position Affiliation Time Period
Associate Professor Centre for Laser Spectroscopy, Manipal University, Manipal, India 2003-2007
Assistant Professor Centre for Laser Spectroscopy, Manipal University, Manipal, India 1999-2003
Visiting Scientist Raja Ramanna Centre for Advanced Technology, Indore, India 1998-1999
Visiting Faculty Labo de Biophysique, MNHN, Paris, France 1997
Post Doctoral Fellowship Centre National de la Recherche Scientifique, France 1997
 
Area of Specialization:
Optical Spectroscopy
Research Summary:
Evaluation of the efficacy of in vivo/in situ Raman spectroscopy for routine screening and diagnosis under clinical setting
Developing Raman microspectroscopy for diagnosis / screening using cell smear and tissue microsections
Complementary FTIR spectroscopy to further validate the findings of Raman spectroscopy
 
Publications:
1. Kumar, K. K., Chowdary, M. V., Mathew, S., Rao, L., Krishna, C. M. and Kurien, J.  Protein profile study of breast-tissue homogenates by HPLC-LIF. Journal of Biophotonics. 2009.  2, 313-321. [PubMed]
2. Chowdary, M. V., Mahato, K. K., Kumar, K. K., Mathew, S., Rao, L., Krishna, C. M. and Kurien, J.  Autofluorescence of breast tissues: evaluation of discriminating algorithms for diagnosis of normal, benign, and malignant conditions. Photomedicine and Laser Surgery. 2009.  27, 241-252. [PubMed]
3. Chowdary, M. V., Kalyan, K., Mathew, S., Rao, L., Krishna, C. M. and Kurien, J.  Biochemical correlation of Raman spectra of normal, benign and malignant breast tissues: a spectral deconvolution study. Biopolymers. 2009.  91, 539-546. [PubMed]
4. Krishna, C. M., Kurien, J., Mathew, S., Rao, L., Maheedhar, K., Kumar, K. K. and Chowdary, M. V.  Raman spectroscopy of breast tissues. Expert Review of Molecular Diagnostics. 2008.  8, 149-166. [PubMed]
5. Maheedhar, K., Bhat, R. A., Malini, R., Prathima, N. B., Keerthi, P., Kushtagi, P. and Krishna, C. M.  Diagnosis of ovarian cancer by Raman spectroscopy: a pilot study. Photomedicine and Laser Surgery. 2008.  26, 83-90. [PubMed]
6. Vidyasagar, M. S., Maheedhar, K., Vadhiraja, B. M., Fernendes, D. J., Kartha, V. B. and Krishna, C. M.  Prediction of radiotherapy response in cervix cancer by Raman spectroscopy: a pilot study. Biopolymers. 2008.  89, 530-537. [PubMed]
7. Chowdary, M. V., Kumar, K. K., Thakur, K., Anand, A., Kurien, J., Krishna, C. M. and Mathew, S.  Discrimination of normal and malignant mucosal tissues of the colon by Raman spectroscopy. Photomedicine and Laser Surgery. 2007.  25, 269-274. [PubMed]
8. Krishna, C. M., Sockalingum, G. D., Bhat, R. A., Venteo, L., Kushtagi, P., Pluot, M. and Manfait, M.  FTIR and Raman microspectroscopy of normal, benign, and malignant formalin-fixed ovarian tissues. Analytical and Bioanalytical Chemistry. 2007.  387, 1649-1656. [PubMed]
9. Chowdary, M. V., Kumar, K. K., Kurien, J., Mathew, S. and Krishna, C. M.  Discrimination of normal, benign, and malignant breast tissues by Raman spectroscopy. Biopolymers. 2006.  83, 556-569. [PubMed]
10. Krishna, C. M., Kegelaer, G., Adt, I., Rubin, S., Kartha, V. B., Manfait, M. and Sockalingum, G. D.  Combined Fourier transform infrared and Raman spectroscopic approach for identification of multidrug resistance phenotype in cancer cell lines. Biopolymers. 2006.  82, 462-470. [PubMed]
11. Malini, R., Venkatakrishna, K., Kurien, J., Pai, K. M., Rao, L., Kartha, V. B. and Krishna, C. M.  Discrimination of normal, inflammatory, premalignant, and malignant oral tissue: a Raman spectroscopy study. Biopolymers. 2006.  81, 179-193. [PubMed]
12. Krishna, C. M., Sockalingum, G. D., Venteo, L., Bhat, R. A., Kushtagi, P., Pluot, M. and Manfait, M.  Evaluation of the suitability of ex vivo handled ovarian tissues for optical diagnosis by Raman microspectroscopy. Biopolymers. 2005.  79, 269-276. [PubMed]
13. Krishna, C. M., Sockalingum, G. D., Kurien, J., Rao, L., Venteo, L., Pluot, M., Manfait, M. and Kartha, V. B.  Micro-Raman spectroscopy for optical pathology of oral squamous cell carcinoma. Applied Spectroscopy. 2004.  58, 1128-1135. [PubMed]
14. Manjunath, B. K., Kurein, J., Rao, L., Krishna, C. M., Chidananda, M. S., Venkatakrishna, K. and Kartha, V. B.  Autofluorescence of oral tissue for optical pathology in oral malignancy. Journal of Photochemistry and Photobiology. B, Biology. 2004.  73, 49-58. [PubMed]
Book Chapters:
C. Murali Krishna, R. Malini, K. Venkatakrishna, Aparna Agarwal, Keertilata M. Pai, Betsy Thomas, Lakshmi Rao, V.B. Kartha, Jacob Kurein, Classification of oral cancers, precancers and inflammatory conditions by Raman spectroscopy, Cancer Research Journal. Review-Invited Contribution - Cross Publication. 2008. 15-34
C. Murali Krishna, V.B. Kartha, R. Malini, K. Venkatakrishna, Aparna Agarwal, Keertilata M. Pai, Betsy Thomas, Lakshmi Rao, Jacob Kurein, Raman signatures of tissue biopolymers: Diagnosis of oral cancer and inflammatory conditions: Biopolymer Research Trends (Ed: T. S. Nemeth), Nova Science Publishers, USA. Invited Contribution. 2008. 189-208
 
Grant Support:
Project Title Role Funding Agency Sanction Number Sanction Date
Development of in vivo laser raman spectroscopy methods for diagnosis of oral precancerous and cancerous conditions Department of Biotechnology, Government of India
In vivo raman spectroscopic prediction of radio-sensitivity in oropharyngeal cancers – pilot study Advanced Centre for Treatment Research and Education in Cancer, Mumbai, India
Comparative sequential evaluation of development of carcinogen-induced buccal pouch tumors employing laser raman spectroscopy and histopathology Council of Scientific and Industrial Research, Government of India
Development of Raman Microspectroscopic methods for clinical applications Department of Science & Technology, Government of India
Conventional and Synchrotron FTIR imaging of tissues and cell level
Coherent anti-stokes Raman spectroscopy (CARS) for biomedical applicaions Department of Atomic Energy, Board of Research in Nuclear Sciences, Mumbai, India
Laser spectroscopy as predictor of tumor response to radiation therapy in cervical cancer Department of Atomic Energy, Board of Research in Nuclear Sciences, Mumbai, India

 
 
 
Education 
::
Ph.D. Saha Institute of Nuclear Physics, Calcutta, India
::
M.Sc. in Biochemistry, Osmania University, Hyderabad, India
  Last modified on : Mar 4, 2011
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