INCREDB ID : 193
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Abhijit De, Ph.D.
Principal Investigator 
 
Molecular Functional Imaging Laboratory, DE LAB
KS-325, 326, ACTREC,
Tata Memorial Centre, Kharghar, Sector 22
Navi Mumbai - 410 210   
Maharashtra   
 
E-mail: ade@actrec.gov.in, de.lab@actrec.gov.in
Phone: +91-022-2740 5038
Fax: +91-22-27405085
 
URL: http://actrec.gov.in/pi-webpages/AbhijitDe/abhijit-index-1.html
 
Positions Held:
Position Affiliation Time Period
Principal Investigator Molecular Functional Imaging Laboratory, DE LAB 2009-Present
Research Associate Department of Radiology and Bioengineering, Stanford University, California, USA 2005-2009
Post Doctoral Fellow Department of Radiology and Bioengineering, Stanford University, California, USA 2003-2005
Post Doctoral Fellow Department of Pharmacology, University of Californa, Los Angeles, California, USA 2000-2003
Post Doctoral Fellow Center for Cellular and Molecular Biology, Hyderabad, India 1998-2000
 
Area of Specialization:
Molecular Oncology
Molecular Imaging
Small Animal Model
Research Summary:
Molecular imaging of human sodium iodide symporter based gene targeted radiotherapy in breast cancer
Bioluminescence resonance energy transfer based sensor development for visualizing intracellular protein activity in vivo
Targeted Nanomedicine in breast cancer
 
Publications:
1. Shete, H., Chatterjee, S., De, A. and Patravale, V.  Long chain lipid based tamoxifen NLC. Part II: pharmacokinetic, biodistribution and in vitro anticancer efficacy studies. International Journal of Pharmaceutics. 2013.  454, 584-592. [PubMed]
2. Chatterjee, S., Malhotra, R., Varghese, F., Bukhari, A. B., Patil, A., Budrukkar, A., Parmar, V., Gupta, S. and De, A.  Quantitative immunohistochemical analysis reveals association between sodium iodide symporter and estrogen receptor expression in breast cancer. PloS One. 2013.  8, e54055. [PubMed]
3. Srivastava, M., Nambiar, M., Sharma, S., Karki, S. S., Goldsmith, G., Hegde, M., Kumar, S., Pandey, M., Singh, R. K., Ray, P., Natarajan, R., Kelkar, M., De, A., Choudhary, B. and Raghavan, S. C.  An inhibitor of nonhomologous end-joining abrogates double-strand break repair and impedes cancer progression. Cell. 2012.  151, 1474-1487. [PubMed]
4. van, d. e., Elias, S. G., Chan, C. T., Miao, Z., Cheng, Z., De, A. and Gambhir, S. S.  Optical imaging with her2-targeted affibody molecules can monitor hsp90 treatment response in a breast cancer xenograft mouse model. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 2012.  18, 1073-1081. [PubMed]
5. Dragulescu-Andrasi, A., Chan, C. T., De, A., Massoud, T. F. and Gambhir, S. S.  Bioluminescence resonance energy transfer (BRET) imaging of protein-protein interactions within deep tissues of living subjects. Proceedings of the National Academy of Sciences of the United States of America. 2011.  108, 12060-12065. [PubMed]
6. Rufaihah, A. J., Huang, N. F., Jame, S., Lee, J. C., Nguyen, H. N., Byers, B., De, A., Okogbaa, J., Rollins, M., Reijo-Pera, R., Gambhir, S. S. and Cooke, J. P.  Endothelial cells derived from human iPSCS increase capillary density and improve perfusion in a mouse model of peripheral arterial disease. Arteriosclerosis, Thrombosis, and Vascular Biology. 2011.  31, e72-9. [PubMed]
7. Smith, B. R., Cheng, Z., De, A., Rosenberg, J. and Gambhir, S. S.  Dynamic visualization of RGD-quantum dot binding to tumor neovasculature and extravasation in multiple living mouse models using intravital microscopy. Small. 2010.  6, 2222-2229. [PubMed]
8. Pendharkar, A. V., Chua, J. Y., Andres, R. H., Wang, N., Gaeta, X., Wang, H., De, A., Choi, R., Chen, S., Rutt, B. K., Gambhir, S. S. and Guzman, R.  Biodistribution of neural stem cells after intravascular therapy for hypoxic-ischemia. Stroke; A Journal of Cerebral Circulation. 2010.  41, 2064-2070. [PubMed]
9. Huang, N. F., Niiyama, H., Peter, C., De, A., Natkunam, Y., Fleissner, F., Li, Z., Rollins, M. D., Wu, J. C., Gambhir, S. S. and Cooke, J. P.  Embryonic stem cell-derived endothelial cells engraft into the ischemic hindlimb and restore perfusion. Arteriosclerosis, Thrombosis, and Vascular Biology. 2010.  30, 984-991. [PubMed]
10. Cheng, Z., De, J., Kramer, D. J., De, A., Webster, J. M., Gheysens, O., Levi, J., Namavari, M., Wang, S., Park, J. M., Zhang, R., Liu, H., Lee, B., Syud, F. A. and Gambhir, S. S.  64Cu-labeled affibody molecules for imaging of HER2 expressing tumors. Molecular Imaging and Biology. 2010.  12, 316-324. [PubMed]
11. Wang, H., Cao, F., De, A., Cao, Y., Contag, C., Gambhir, S. S., Wu, J. C. and Chen, X.  Trafficking mesenchymal stem cell engraftment and differentiation in tumor-bearing mice by bioluminescence imaging. Stem Cells. 2009.  27, 1548-1558. [PubMed]
12. De, A., Ray, P., Loening, A. M. and Gambhir, S. S.  BRET3: a red-shifted bioluminescence resonance energy transfer (BRET)-based integrated platform for imaging protein-protein interactions from single live cells and living animals. The FASEB Journal. 2009.  23, 2702-2709. [PubMed]
13. Namavari, M., Cheng, Z., Zhang, R., De, A., Levi, J., Hoerner, J. K., Yaghoubi, S. S., Syud, F. A. and Gambhir, S. S.  A novel method for direct site-specific radiolabeling of peptides using [18F]FDG. Bioconjugate Chemistry. 2009.  20, 432-436. [PubMed]
14. Ray, P., De, A., Patel, M. and Gambhir, S. S.  Monitoring caspase-3 activation with a multimodality imaging sensor in living subjects. Clinical Cancer Research. 2008.  14, 5801-5809. [PubMed]
15. Namavari, M., Padilla, D. e., Cheng, Z., De, A., Kovacs, E., Levi, J., Zhang, R., Hoerner, J. K., Grade, H., Syud, F. A. and Gambhir, S. S.  Direct site-specific radiolabeling of an Affibody protein with 4-[18F]fluorobenzaldehyde via oxime chemistry. Molecular Imaging and Biolog. 2008.  10, 177-181. [PubMed]
16. Cheng, Z., De, J., Namavari, M., De, A., Levi, J., Webster, J. M., Zhang, R., Lee, B., Syud, F. A. and Gambhir, S. S.  Small-animal PET imaging of human epidermal growth factor receptor type 2 expression with site-specific 18F-labeled protein scaffold molecules. Journal of Nuclear Medicine. 2008.  49, 804-813. [PubMed]
17. Smith, B. R., Cheng, Z., De, A., Koh, A. L., Sinclair, R. and Gambhir, S. S.  Real-time intravital imaging of RGD-quantum dot binding to luminal endothelium in mouse tumor neovasculature. Nano Letters. 2008.  8, 2599-2606. [PubMed]
18. Levi, J., De, A., Cheng, Z. and Gambhir, S. S.  Bisdeoxycoelenterazine derivatives for improvement of bioluminescence resonance energy transfer assays. Journal of the American Chemical Society. 2007.  129, 11900-11901. [PubMed]
19. De, A., Loening, A. M. and Gambhir, S. S.  An improved bioluminescence resonance energy transfer strategy for imaging intracellular events in single cells and living subjects. Cancer Research. 2007.  67, 7175-7183. [PubMed]
20. Massoud, T. F., Paulmurugan, R., De, A., Ray, P. and Gambhir, S. S.  Reporter gene imaging of protein-protein interactions in living subjects. Current Opinion in Biotechnology. 2007.  18, 31-37. [PubMed]
21. De, A. and Gambhir, S. S.  Noninvasive imaging of protein-protein interactions from live cells and living subjects using bioluminescence resonance energy transfer. The FASEB Journal. 2005.  19, 2017-2019. [PubMed]
22. Craft, N., Bruhn, K. W., Nguyen, B. D., Prins, R., Liau, L. M., Collisson, E. A., De, A., Kolodney, M. S., Gambhir, S. S. and Miller, J. F.  Bioluminescent imaging of melanoma in live mice. The Journal of Investigative Dermatology. 2005.  125, 159-165. [PubMed]
23. Ray, P., De, A., Min, J. J., Tsien, R. Y. and Gambhir, S. S.  Imaging tri-fusion multimodality reporter gene expression in living subjects. Cancer Research. 2004.  64, 1323-1330. [PubMed]
24. Collisson, E. A., Kleer, C., Wu, M., De, A., Gambhir, S. S., Merajver, S. D. and Kolodney, M. S.  Atorvastatin prevents RhoC isoprenylation, invasion, and metastasis in human melanoma cells. Molecular Cancer Therapeutics. 2003.  2, 941-948. [PubMed]
25. Wu, J. C., Chen, I. Y., Sundaresan, G., Min, J. J., De, Abhijit, Qiao, J. H., Fishbein, M. C. and Gambhir, S. S.  Molecular imaging of cardiac cell transplantation in living animals using optical bioluminescence and positron emission tomography. Circulation. 2003.  108, 1302-1305. [PubMed]
26. De, Abhijit, Lewis, X. Z. and Gambhir, S. S.  Noninvasive imaging of lentiviral-mediated reporter gene expression in living mice. Molecular Therapy. 2003.  7, 681-691. [PubMed]
27. J.P. Gupta and Abhijit De. 2000. Genetic diversity in Polypedilum nubifer (Chironomidae): A comparative study of differences between two groups of widely separated geographic populations. In: The 20th century Chironomids: systematics and cytogenetics. Editor: Odwin Hoffrichter.
28. Abhijit De and J.P. Gupta.  Female heterogenity in Indian populations of Polypedilum nubifer (Diptera: Chironomidae). Current Science, India. 1998. 75(10): 1068-70.
29. Abhijit De and J.P. Gupta. Records of Drosophilidae from Bhutan. Drosophila Information Service, USA. 1996. 77: 98.
30. J.P. Gupta and Abhijit De. Records of Drosophilidae with the description of two new species from Bhutan  (Insecta: Diptera). Entomon, India. 1996. 21(2): 177-186.
31. Abhijit De and J.P. Gupta. Records of Drosophilid species from West Bengal with description of one new and two previously unrecorded species from India (Diptera: Insecta). Senckenbergiana Biologica, Frankfurt. 1996. 76(1/2): 134-139.
32. Abhijit De and J.P. Gupta.  A review of the genus Mulgravea with the description of four new species from Bhutan (Diptera: Drosophilidae). Oriental Insects, USA. 1995. 29: 359-369.
33. Abhijit De and J.P. Gupta. Karyological characterization of Chironomus niger (Diptera: Chironomidae). Cytobios, Cambridge. 1994. 80: 55-62.
34. Abhijit De and J.P. Gupta. Further record of three new species of Microdrosophila from India (Insecta: Diptera: Drosophilidae). Senckenbergiana Biologica, Frankfurt. 1994. 74(1/2): 153-156.
35. Abhijit De and J.P. Gupta. The genus Hypselothyrea from India (Diptera: Drosophilidae). Proceedings of the Zoological Society, Calcutta. 1994. 47(1): 53-56.

 
Book Chapters:
Abhijit De. New era of bioluminescence resonance energy transfer technology. Current Pharmaceutical Biotechnology. Invited Review. 2011. 12(4):558-568.
Tarik F Massoud, Ramasamy Paulmurugan, Pritha Ray, Abhijit De, Carmel Chan, Hua Fan-Minogue and Sanjiv S Gambhir. Molecular imaging of protein–protein interactions. In: Molecular Imaging: Principles and Practice. Editors: R. Weissleder, B. Ross, A. Rehemtulla, S. S. Gambhir. University of Michigan Press. 2010. USA. Pp. 781-807.
Abhijit De, Shahriar Shah Yaghoubi and Sanjiv Sam Gambhir. Applications of Lentiviral Vectors in Non-invasive Molecular Imaging. In: Methods in Molecular Biology: Gene therapy Protocols. Vol. 1. Editor: Joseph LeDoux. 3rd edition. Humana Press. 2008. pp 177-202
Tarik F Massoud, Ramasamy Paulmurugan, Abhijit De, Pritha Ray and Sanjiv S Gambhir. Reporter gene imaging of protein–protein interactions in living subjects. Current Opinion in Biotechnology. 2007. 18. 1–7
R. Paulmurugan, P Ray, Abhijit De, C.T. Chan and S.S. Gambhir. Protocol for imaging protein-protein interactions in living subjects. In: Protein-protein interactions, Cold Spring Harbor Laboratory. 2005. Pp.695-713
R. Paulmurugan, P Ray, Abhijit De, C.T. Chan and S.S. Gambhir., Imaging protein-protein interactions in living subjects. Trends in Analytical Chemistry. 24. 5. 2005. 446-458.
Abhijit De and S.S. Gambhir. PET as a Tool in Multimodality Imaging of Gene Expression and Therapy. In: Positron Emission Tomography: Basic Sciences. Editors: Peter Valk et al. Springer-Verlag Inc. 2004. Pp. 343-367
Abhijit De and S. S. Gambhir. PET as an imaging tool in therapy. In: Positron Emission Tomography: Basic sciences and clinical practices. Editors: Peter Valk et al. Springer-Verlag Inc. 2002. Pp. 845-868
 
 
Education 
::
M.Sc. Burdwan University, Burdwan, India
::
M.Phil. Burdwan University, Burdwan, India
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Ph.D. Banaras Hindu University, Varanasi, India
Honors and Awards
::
2006, Young Investigator Travel Scholarship from Academy of Molecular Imaging
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2005, Young Investigator Travel Scholarship from Academy of Molecular Imaging
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1998, Department of Biotechnology Post Doctoral Fellowship
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1997, Travel Award, Council of Scientific and Industrial Research, New Delhi, India
Member
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Life member, Indian Society of Cell Biology
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Annual member, Academy of Molecular Imaging
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2011, Expert reviewer Department of BioTechnology BIPP program
  Last modified on : Jan 10, 2016
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