Home >> Investigator Page Previous      Next
Sorab N. Dalal, Ph.D.
Principal Investigator 
Advanced Centre for Treatment Research and Education in Cancer
Sorab’s Lab
Khanolkar Shodhika, Tata Memorial Centre, Kharghar
Navi Mumbai - 410 210    
Phone: +91-22-27405007
Fax: +91-22-27405085
Positions Held:
Position Affiliation Time Period
Principal Investigator Tata Memorial Hospital, Mumbai, India Present
Post Doctoral Fellowship Dana Farber Cancer Institute, Harvard Medical School
Area of Specialization:
Molecular Biology
Research Summary:
Identification of pathways that regulate metastatic progression and cell-cell adhesion
Regulation of cellular checkpoint pathways by 14-3-3 proteins
Generation of knockdown or over-expression transgenic mouse models to study human disease
1. Telles, E., Gurjar, M., Ganti, K., Gupta, D. and Dalal, S. N.  Filamin A stimulates cdc25C function and promotes entry into mitosis. Cell Cycle. 2011.  10. [PubMed]
2. Gosavi, P., Kundu, S. T., Khapare, N., Sehgal, L., Karkhanis, M. S. and Dalal, S. N.  E-cadherin and plakoglobin recruit plakophilin3 to the cell border to initiate desmosome assembly. Cellular and Molecular Life Sciences : CMLS. 2010.  [PubMed]
3. Telles, E., Hosing, A. S., Kundu, S. T., Venkatraman, P. and Dalal, S. N.  A novel pocket in 14-3-3epsilon is required to mediate specific complex formation with cdc25C and to inhibit cell cycle progression upon activation of checkpoint pathways. Experimental Cell Research. 2009.  315, 1448-1457. [PubMed]
4. Hosing, A. S., Kundu, S. T. and Dalal, S. N.  14-3-3 Gamma is required to enforce both the incomplete S phase and G2 DNA damage checkpoints. Cell Cycle. 2008.  7, 3171-3179. [PubMed]
5. Kundu, S. T., Gosavi, P., Khapare, N., Patel, R., Hosing, A. S., Maru, G. B., Ingle, A., Decaprio, J. A. and Dalal, S. N.  Plakophilin3 downregulation leads to a decrease in cell adhesion and promotes metastasis. International Journal of Cancer.  2008.  123, 2303-2314. [PubMed]
6. Dalal, S. N. and Volkening, M.  CDC25 dual-specificity protein phosphatases: detection and activity measurements. Methods in Molecular Biology. 2005.  296, 329-344. [PubMed]
7. Dalal, S. N., Yaffe, M. B. and DeCaprio, J. A.  14-3-3 family members act coordinately to regulate mitotic progression. Cell Cycle. 2004.  3, 672-677. [PubMed]
8. Brunet, A., Kanai, F., Stehn, J., Xu, J., Sarbassova, D., Frangioni, J. V., Dalal, S. N., DeCaprio, J. A., Greenberg, M. E. and Yaffe, M. B.  14-3-3 transits to the nucleus and participates in dynamic nucleocytoplasmic transport. The Journal of Cell Biology. 2002.  156, 817-828. [PubMed]
9. Dalal, S. N., Schweitzer, C. M., Gan, J. and DeCaprio, J. A.  Cytoplasmic localization of human cdc25C during interphase requires an intact 14-3-3 binding site. Molecular and Cellular Biology. 1999.  19, 4465-4479. [PubMed]



Ph.D. Tufts University
  Last modified on : Mar 4, 2011
India Cancer Research Database has been developed by the Institute of Bioinformatics with funding from the Department of Biotechnology, Government of India.