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Bharathi P Salimath, Ph.D.
University of Mysore
Department of Applied Botany and Biotechnology
Mysore - 570 006   
Positions Held:
Position Affiliation Time Period
Professor University of Mysore, Mysore, India Present
Area of Specialization:
Molecular Biology
1. D'Souza, S. S., Gururaj, A. E., Raj, H. M., Rossler, J. and Salimath, B. P.  Inhibition of ascites tumor growth in vivo by sTie-2 is potentiated by a combinatorial therapy with sFLT-1. The Journal of Gene Medicine. 2010.  12, 968-980. [PubMed]
2. Kumar, A., Salimath, B. P., Stark, G. B. and Finkenzeller, G.  Platelet-derived growth factor receptor signaling is not involved in osteogenic differentiation of human mesenchymal stem cells. Tissue Engineering. Part A. 2010.  16, 983-993. [PubMed]
3. Kumar, A., D'Souza, S. S., Nagaraj, S. R., Gaonkar, S. L., Salimath, B. P. and Rai, K. M.  Antiangiogenic and antiproliferative effects of substituted-1,3,4-oxadiazole derivatives is mediated by down regulation of VEGF and inhibition of translocation of HIF-1alpha in Ehrlich ascites tumor cells. Cancer Chemotherapy and Pharmacology. 2009.  64, 1221-1233. [PubMed]
4. Ramachandra, S., D'Souza, S. S., Gururaj, A. E., Shaila, M. S. and Salimath, B. P.  Paracrine action of sFLT-1 secreted by stably-transfected Ehrlich ascites tumor cells and therapy using sFLT-1 inhibits ascites tumor growth in vivo. The Journal of Gene Medicine. 2009.  11, 422-434. [PubMed]
5. Kumar, A., D'Souza, S. S., Tickoo, S., Salimath, B. P. and Singh, H. B.  Antiangiogenic and proapoptotic activities of allyl isothiocyanate inhibit ascites tumor growth in vivo. Integrative Cancer Therapies. 2009.  8, 75-87. [PubMed]
6. Shivakumar, S., Prabhakar, B. T., Jayashree, K., Rajan, M. G. and Salimath, B. P.  Evaluation of serum vascular endothelial growth factor (VEGF) and microvessel density (MVD) as prognostic indicators in carcinoma breast. Journal of Cancer Research and Clinical Oncology. 2009.  135, 627-636. [PubMed]
7. Kumar, P. S., Shilpa, P., Salimath, B. P. Withaferin A suppresses the expression of vascular endothelial growth factor in Ehrlich ascites tumor cells via Sp1 transcription factor. Current Trends in Biotechnology and Pharmacy. 2009. 3, 138-148.
8. Prasanna, K., Thippeswamy, G., Sheela, M. L., Prabhakar, B. T. and Salimath, B. P.  Butyrate-induced phosphatase regulates VEGF and angiogenesis via Sp1. Archives of Biochemistry and Biophysics. 2008.  478, 85-95. [PubMed]
9. Thippeswamy, G., Sheela, M. L. and Salimath, B. P.  Octacosanol isolated from Tinospora cordifolia downregulates VEGF gene expression by inhibiting nuclear translocation of NF-B and its DNA binding activity. European Journal of Pharmacology. 2008.  588, 141-150. [PubMed]
10. Kumar, A., D'Souza, S. S., Gaonkar, S. L., Rai, K. M. and Salimath, B. P.  Growth inhibition and induction of apoptosis in MCF-7 breast cancer cells by a new series of substituted-1,3,4-oxadiazole derivatives. Investigational New Drugs. 2008.  26, 425-435. [PubMed]
11. Kumar, C. A., Swamy, S. N., Gaonkar, S. L., Salimath, B. P. and Rangappa, K. S.  N-Substituted-2-butyl-5-chloro-3H-imidazole-4-carbaldehyde derivatives as anti-tumor agents against Ehrlich ascites tumor cells in vivo. Medicinal Chemistry. 2007.  3, 269-276. [PubMed]
12. Kumar, C. A., Jayarama, S., Salimath, B. P. and Rangappa, K. S.  Pro-apoptotic activity of imidazole derivatives mediated by up-regulation of Bax and activation of CAD in Ehrlich Ascites Tumor cells. Investigational New Drugs. 2007.  25, 343-350. [PubMed]
13. Belakavadi, M., Prabhakar, B. T. and Salimath, B. P.  Purification and characterization of butyrate-induced protein phosphatase involved in apoptosis of Ehrlich ascites tumor cells. Biochimica et Biophysica Acta. 2007.  1770, 39-47. [PubMed]
14. Prabhakar, B. T., Khanum, S. A., Shashikanth, S. and Salimath, B. P.  Antiangiogenic effect of 2-benzoyl-phenoxy acetamide in EAT cell is mediated by HIF-1alpha and down regulation of VEGF of in-vivo. Investigational New Drugs. 2006.  24, 471-478. [PubMed]
15. Sheela, M. L., Ramakrishna, M. K. and Salimath, B. P.  Angiogenic and proliferative effects of the cytokine VEGF in Ehrlich ascites tumor cells is inhibited by Glycyrrhiza glabra. International Immunopharmacology. 2006.  6, 494-498. [PubMed]
16. Deepak, A. V. and Salimath, B. P.  Antiangiogenic and proapoptotic activity of a novel glycoprotein from U. indica is mediated by NF-kappaB and Caspase activated DNase in ascites tumor model. Biochimie. 2006.  88, 297-307. [PubMed]
17. Prabhakar, B. T., Khanum, S. A., Jayashree, K., Salimath, B. P. and Shashikanth, S.  Anti-tumor and proapoptotic effect of novel synthetic benzophenone analogues in Ehrlich ascites tumor cells. Bioorganic & Medicinal Chemistry. 2006.  14, 435-446. [PubMed]
18. Belakavadi, M., Prabhakar, B. T. and Salimath, B. P.  Butyrate-induced proapoptotic and antiangiogenic pathways in EAT cells require activation of CAD and downregulation of VEGF. Biochemical and Biophysical Research Communications. 2005.  335, 993-1001. [PubMed]
19. Belakavadi, M. and Salimath, B. P.  Mechanism of inhibition of ascites tumor growth in mice by curcumin is mediated by NF-kB and caspase activated DNase. Molecular and Cellular Biochemistry. 2005.  273, 57-67. [PubMed]
20. Deepak, A. V., Thippeswamy, G., Shivakameshwari, M. N. and Salimath, B. P.  Isolation and characterization of a 29-kDa glycoprotein with antifungal activity from bulbs of Urginea indica. Biochemical and Biophysical Research Communications. 2003.  311, 735-742. [PubMed]
21. Gururaj, A. E., Belakavadi, M. and Salimath, B. P.  Antiangiogenic effects of butyric acid involve inhibition of VEGF/KDR gene expression and endothelial cell proliferation. Molecular and Cellular Biochemistry. 2003.  243, 107-112. [PubMed]
22. Gururaj, A. E., Belakavadi, M., Venkatesh, D. A., Marme, D. and Salimath, B. P.  Molecular mechanisms of anti-angiogenic effect of curcumin. Biochemical and Biophysical Research Communications. 2002.  297, 934-942. [PubMed]
23. Salimath, B. P., Sharma, R. and Tabassum, A.  Dexamethasone induced expression of phosphatase inhibits generation of reactive oxygen species in Ehrlich ascites tumor cells. Biochemistry and Molecular Biology International. 1998.  46, 559-569. [PubMed]
24. Savitha, G. and Salimath, B. P.  Cross-talk between protein kinase C and protein kinase A down-regulates the respiratory burst in polymorphonuclear leukocytes. Cellular Signalling. 1993.  5, 107-117. [PubMed]
25. Sharma, R. and Salimath, B. P.  A novel role for calcium and membrane-binding proteins in regulation of respiratory burst in Ehrlich ascites tumour cells. Cellular Signalling. 1993.  5, 53-62. [PubMed]
26. Salimath, B. P. and Savitha, G.  Mechanism of inhibition by cyclic AMP of protein kinase C-triggered respiratory burst in Ehrlich ascites tumour cells. Cellular Signalling. 1992.  4, 651-663. [PubMed]
27. Savitha, G., Panchanathan, S. and Salimath, B. P.  Capsaicin inhibits calmodulin-mediated oxidative burst in rat macrophages. Cellular Signalling. 1990.  2, 577-585. [PubMed]
28. Basavarajappa, B. S., Salimath, B. P. Inhibition of calmodulin-dependent enzymes in rat brain by hexachlorocyclohexane. Pest Management Science. 1990. 29, 397-404.
29. Salimath, B. P. and Satyanarayana, M. N.  Inhibition of calcium and calmodulin-dependent phosphodiesterase activity in rats by capsaicin. Biochemical and Biophysical Research Communications. 1987.  148, 292-299. [PubMed]
30. Salimath, B. P., Sundaresh, C. S., Srinivas, L. Dietary components inhibit lipid peroxidation in erythrocyte membrane. Nutrition Research. 1986. 6, 1171-1178.
31. Salimath, B. P., Marmé, D., Protein phosphorylation and its regulation by calcium and calmodulin in membrane fractions from zucchini hypocotyls. Planta. 1983. 158, 560-568.
32. Graziana,  A., Ranjeva, R., Salimath, B. P., Boudet, A. M. The reversible association of quinate:NAD+ oxidoreductase from carrot cells with a putative regulatory subunit depends on light conditions. FEBS Letters. 1983. 163, 306-310.


Grant Support:
Project Title Role Funding Agency Sanction Number Sanction Date
UGC-SAP-DSA University Grants Commission, India 2007-2012
Isolation and mechanism based validation of novel antiangiogenic molecules from medicinal plants: Role in cancer therapy Department of Atomic Energy, Board of Research in Nuclear Sciences, Mumbai, India 2007-2010
Development of radioreceptor binding assay for quantitating angiogenic ligands in sera and effusions of patients with malignant tumors Principal Investigator Department of Atomic Energy, Board of Research in Nuclear Sciences, Mumbai, India


Honors and Awards
2008, Department of Biotechnology, Government of India, Overseas Fellowship
2004, Kalpana Chawla Young Women Scientist Award instituted by Karnataka Council for Science & Technology
1996, Dr. Veerendra B. Kamath Award, Indian Association For Cancer Research
1995, Young Scientist Award, Karnataka State for Advancement of Science
2008-10, Project review & monitoring committee for the project on Information Support System in Science and Mathematics for Rural Higher Secondary Schools
2007-08, NAAC, UGC
2003-05, 2005-07, PAC (Life Sciences), DST
2005-08, PAC, (Health Sciences), DST
Indian Society of Cell Biology
  Last modified on : Mar 4, 2011
India Cancer Research Database has been developed by the Institute of Bioinformatics with funding from the Department of Biotechnology, Government of India.