INCREDB ID : 18
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Sharmila A. Bapat, Ph.D.
Scientist D 
 
National Centre for Cell Science
NCCS Complex, Pune University Campus, Ganeshkhind
Pune - 411 007   
Maharashtra   
 
E-mail: sabapat@nccs.res.in, sabapat@hotmail.com
Phone: +91-20-25708074, 25708089, 25708000
Fax: +91-20-25692259
 
URL: http://www.nccs.res.in/DrBapat/DrBapat.html
 
Area of Specialization:
Molecular Biology
Research Summary:
Ovarian cancer stem cells
Epigenetic changes in ovarian cancer
Combination of bioinformatics and biological approaches to identify transcription factor binding site
Systems network modeling in ovarian cancer
 
Publications:
1. Sharma, N., Mali, A. M. and Bapat, S. A.  Spectrum of CREBBP mutations in Indian patients with Rubinstein-Taybi syndrome. Journal of Biosciences. 2010.  35, 187-202. [PubMed]
2. Bapat, S. A., Jin, V., Berry, N., Balch, C., Sharma, N., Kurrey, N., Zhang, S., Fang, F., Lan, X., Li, M., Kennedy, B., Bigsby, R. M., Huang, T. H. and Nephew, K. P.  Multivalent epigenetic marks confer microenvironment-responsive epigenetic plasticity to ovarian cancer cells. Epigenetics . 2010.  5, 716-729. [PubMed]
3. Bapat, S. A., Krishnan, A., Ghanate, A. D., Kusumbe, A. P. and Kalra, R. S.  Gene expression: protein interaction systems network modeling identifies transformation-associated molecules and pathways in ovarian cancer. Cancer Research. 2010.  70, 4809-4819. [PubMed]
4. Bapat S. A.  Human ovarian cancer stem cells. Reproduction. 2010.  140, 33-41. [PubMed]
5. Sharma, N., Jadhav, S. P. and Bapat, S. A.  CREBBP re-arrangements affect protein function and lead to aberrant neuronal differentiation. Differentiation. 2010.  79, 218-231. [PubMed]
6. Kusumbe, A. P. and Bapat, S. A.  Cancer stem cells and aneuploid populations within developing tumors are the major determinants of tumor dormancy. Cancer Research. 2009.  69, 9245-9253. [PubMed]
7. Kurrey, N. K., Jalgaonkar, S. P., Joglekar, A. V., Ghanate, A. D., Chaskar, P. D., Doiphode, R. Y. and Bapat, S. A.  Snail and slug mediate radioresistance and chemoresistance by antagonizing p53-mediated apoptosis and acquiring a stem-like phenotype in ovarian cancer cells. Stem Cells. 2009.  27, 2059-2068. [PubMed]
8. Kusumbe, A. P., Mali, A. M. and Bapat, S. A.  CD133-expressing stem cells associated with ovarian metastases establish an endothelial hierarchy and contribute to tumor vasculature. Stem Cells. 2009.  27, 498-508. [PubMed]
9. Berry, N. B. and Bapat, S. A.  Ovarian cancer plasticity and epigenomics in the acquisition of a stem-like phenotype. Journal of Ovarian Research. 2008.  1, 8. [PubMed]
10. Wani, A. A., Rangrez, A. Y., Kumar, H., Bapat, S. A., Suresh, C. G., Barnabas, S., Patole, M. S. and Shouche, Y. S.  Analysis of reactive oxygen species and antioxidant defenses in complex I deficient patients revealed a specific increase in superoxide dismutase activity. Free Radical Research. 2008.  42, 415-427. [PubMed]
11. Wani, A. A., Ahanger, S. H., Bapat, S. A., Rangrez, A. Y., Hingankar, N., Suresh, C. G., Barnabas, S., Patole, M. S. and Shouche, Y. S.  Analysis of mitochondrial DNA sequences in childhood encephalomyopathies reveals new disease-associated variants. PloS One. 2007.  2, e942. [PubMed]
12. Bapat S. A.  Evolution of cancer stem cells. Seminars in Cancer Biology. 2007. 17, 204-213. [PubMed]
13. Balch, C., Nephew, K. P., Huang, T. H. and Bapat, S. A.  Epigenetic "bivalently marked" process of cancer stem cell-driven tumorigenesis. BioEssays. 2007.  29, 842-845. [PubMed]
14. Wani, A. A., Sharma, N., Shouche, Y. S. and Bapat, S. A.  Nuclear-mitochondrial genomic profiling reveals a pattern of evolution in epithelial ovarian tumor stem cells. Oncogene. 2006. 25, 6336-6344. [PubMed]
15. Bapat, S. A. and Mishra, G. C.  Stem cell pharmacogenomics: a reality check on stem cell therapy. Current Opinion in Molecular Therapeutics. 2005.  7, 551-556. [PubMed]
16. Bapat, S. and Galande, S.  Association by guilt: identification of DLX5 as a target for MeCP2 provides a molecular link between genomic imprinting and Rett syndrome. BioEssays. 2005. 27, 676-680. [PubMed]
17. Bapat, S. A., Mali, A. M., Koppikar, C. B. and Kurrey, N. K.  Stem and progenitor-like cells contribute to the aggressive behavior of human epithelial ovarian cancer. Cancer Research. 2005.  65, 3025-3029. [PubMed]
18. Bapat, S. A. and Mishra, G. C.  Stem cell pharmacogenomics. Current Topics in Medicinal Chemistry. 2004. 4, 1371-1383. [PubMed]

 
Book Chapters:
Bapat, S.A., Cancer Stem Cells: Identification And Targets, Editor. John Wiley & Sons, New York, USA.
 
 
Education 
::
Ph.D. in Biochemistry, University of Pune, Pune, India, 1987-1992
Honors and Awards
::
2008, Senior National Woman Bioscientist Award
  Last modified on : Mar 4, 2011
India Cancer Research Database has been developed by the Institute of Bioinformatics with funding from the Department of Biotechnology, Government of India.