INCREDB ID : 170
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Paturu Kondaiah, Ph.D.
Professor 
 
Indian Institute of Science
Department of Molecular Reproduction, Development and Genetics
Bangalore - 560 012   
Karnataka   
 
E-mail: paturu@mrdg.iisc.ernet.in
Phone: +91-80-2932688
 
URL: http://www.mrdg.iisc.ernet.in/PK.htm
 
Positions Held:
Position Affiliation Time Period
Professor Indian Institute of Science, Bangalore, India Present
Post Doctoral Fellowship Laboratory of Chemoprevention, National Cancer Institute, USA 1983-1990
 
Area of Specialization:
Genetics
Research Summary:
Understanding the mechanism of estrogen regulated gene expression mediated by ERE half sites
Regulation of a TGF-beta gene by muscle specific transcription factor, MyoD and heart specific transcription factor, NKx 2.5
The identification of several novel genes regulated by androgens in the rat ventral prostate
Differential regulation of gene expression by testosterone and anti-androgen, flutamide
Characterization of modified novel triterpenoids from plant sources for their anti inflammatory and anti growth potential
 
Publications:
1. Prasad, P., Khan, I., Sasmal, P. K., Koley, D., Kondaiah, P. and Chakravarty, A. R.  Planar triazinium cations from VO(2+)-assisted ring cyclizations: a remarkably efficient thiazole species for nuclear staining, PDT and anaerobic photocleavage of DNA. Chemical Communications. 2011.  [PubMed]
2. Polisetti, N., Agarwal, P., Khan, I., Kondaiah, P., Sangwan, V. S. and Vemuganti, G. K.  Gene expression profile of epithelial cells and mesenchymal cells derived from limbal explant culture. Molecular Vision. 2010.  16, 1227-1240. [PubMed]
3. Ladha, J., Donakonda, S., Agrawal, S., Thota, B., Srividya, M. R., Sridevi, S., Arivazhagan, A., Thennarasu, K., Balasubramaniam, A., Chandramouli, B. A., Hegde, A. S., Kondaiah, P., Somasundaram, K., Santosh, V. and Rao, S. M.  Glioblastoma-specific protein interaction network identifies PP1A and CSK21 as connecting molecules between cell cycle-associated genes. Cancer Research. 2010.  70, 6437-6447. [PubMed]
4. Sreekanthreddy, P., Srinivasan, H., Kumar, D. M., Nijaguna, M. B., Sridevi, S., Vrinda, M., Arivazhagan, A., Balasubramaniam, A., Hegde, A. S., Chandramouli, B. A., Santosh, V., Rao, M. R., Kondaiah, P. and Somasundaram, K.  Identification of potential serum biomarkers of glioblastoma: serum osteopontin levels correlate with poor prognosis. Cancer Epidemiology, Biomarkers & Prevention : A Publication of the American Association For Cancer Research, Cosponsored By the American Society Of. 2010.  19, 1409-1422. [PubMed]
5. Santosh, V., Arivazhagan, A., Sreekanthreddy, P., Srinivasan, H., Thota, B., Srividya, M. R., Vrinda, M., Sridevi, S., Shailaja, B. C., Samuel, C., Prasanna, K. V., Thennarasu, K., Balasubramaniam, A., Chandramouli, B. A., Hegde, A. S., Somasundaram, K., Kondaiah, P. and Rao, M. R.  Grade-specific expression of insulin-like growth factor-binding proteins-2, -3, and -5 in astrocytomas: IGFBP-3 emerges as a strong predictor of survival in patients with newly diagnosed glioblastoma. Cancer Epidemiology, Biomarkers & Prevention : A Publication of the American Association For Cancer Research, Cosponsored By the American Society Of. 2010.  19, 1399-1408. [PubMed]
6. Thangjam, G. S., Agarwal, P., Balapure, A. K., Rao, S. G. and Kondaiah, P.  Regulation of extracellular matrix genes by arecoline in primary gingival fibroblasts requires epithelial factors. Journal of Periodontal Research. 2009.  44, 736-743. [PubMed]
7. Thangjam, G. S. and Kondaiah, P.  Regulation of oxidative-stress responsive genes by arecoline in human keratinocytes. Journal of Periodontal Research. 2009.  44, 673-682. [PubMed]
8. Thangjam, G. S., Agarwal, P., Khan, I., Verma, U. P., Balapure, A. K., Rao, S. G. and Kondaiah, P.  Transglutaminase-2 regulation by arecoline in gingival fibroblasts. Journal of Dental Research. 2009.  88, 170-175. [PubMed]
9. Subba, R. a. o., Kondaiah, P., Singh, S. K., Ravanan, P. and Sporn, M. B.  Chemical modifications of natural triterpenes - glycyrrhetinic and boswellic acids: evaluation of their biological activity. Tetrahedron. 2008.  64, 11541-11548. [PubMed]
10. Padmavathi, V., Sudhakar, R., Padmaja, A. and Kondaiah, P.  Synthesis, antimicrobial and cytotoxic activities of 1,3,4-oxadiazoles, 1,3,4-thiadiazoles and 1,2,4-triazoles. European Journal of Medicinal Chemistry. 2009.  44, 2106-2112. [PubMed]
11. Reddy, P. S., Umesh, S., Thota, B., Tandon, A., Pandey, P., Hegde, A. S., Balasubramaniam, A., Chandramouli, B. A., Santosh, V., Rao, M. R., Kondaiah, P. and Somasundaram, K.  PBEF1/NAmPRTase/Visfatin: a potential malignant astrocytoma/glioblastoma serum marker with prognostic value. Cancer Biology & Therapy. 2008.  7, 663-668. [PubMed]
12. Limaye, A. M., Desai, K. V., Chavalmane, A. K. and Kondaiah, P.  Regulation of mRNAs encoding MMP-9 and MMP-2, and their inhibitors TIMP-1 and TIMP-2 by androgens in the rat ventral prostate. Molecular and Cellular Endocrinology. 2008.  294, 10-18. [PubMed]
13. Bajaj, A., Kondaiah, P. and Bhattacharya, S.  Synthesis and gene transfection efficacies of PEI-cholesterol-based lipopolymers. Bioconjugate Chemistry. 2008.  19, 1640-1651. [PubMed]
14. Limaye, A. M., Asangani, I., Kalyani, T. and Kondaiah, P.  Changes in gene expression following androgen receptor blockade is not equivalent to androgen ablation by castration in the rat ventral prostate. Journal of Biosciences. 2008.  33, 209-220. [PubMed]
15. Bajaj, A., Paul, B., Kondaiah, P. and Bhattacharya, S.  Structure-activity investigation on the gene transfection properties of cardiolipin mimicking gemini lipid analogues. Bioconjugate Chemistry. 2008.  19, 1283-1300. [PubMed]
16. Reddy, S. P., Britto, R., Vinnakota, K., Aparna, H., Sreepathi, H. K., Thota, B., Kumari, A., Shilpa, B. M., Vrinda, M., Umesh, S., Samuel, C., Shetty, M., Tandon, A., Pandey, P., Hegde, S., Hegde, A. S., Balasubramaniam, A., Chandramouli, B. A., Santosh, V., Kondaiah, P., Somasundaram, K. and Rao, M. R.  Novel glioblastoma markers with diagnostic and prognostic value identified through transcriptome analysis. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 2008.  14, 2978-2987. [PubMed]
17. Bajaj, A., Kondaiah, P. and Bhattacharya, S.  Effect of the nature of the spacer on gene transfer efficacies of novel thiocholesterol derived gemini lipids in different cell lines: a structure-activity investigation. Journal of Medicinal Chemistry. 2008.  51, 2533-2540. [PubMed]
18. Bajaj, A., Kondaiah, P. and Bhattacharya, S.  Gene transfection efficacies of novel cationic gemini lipids possessing aromatic backbone and oxyethylene spacers. Biomacromolecules. 2008.  9, 991-999. [PubMed]
19. Bajaj, A., Mishra, S. K., Kondaiah, P. and Bhattacharya, S.  Effect of the headgroup variation on the gene transfer properties of cholesterol based cationic lipids possessing ether linkage. Biochimica et Biophysica Acta. 2008.  1778, 1222-1236. [PubMed]
20. Bajaj, A., Paul, B., Indi, S. S., Kondaiah, P. and Bhattacharya, S.  Effect of the hydrocarbon chain and polymethylene spacer lengths on gene transfection efficacies of gemini lipids based on aromatic backbone. Bioconjugate Chemistry. 2007.  18, 2144-2158. [PubMed]
21. Arany, P. R., Nayak, R. S., Hallikerimath, S., Limaye, A. M., Kale, A. D. and Kondaiah, P.  Activation of latent TGF-beta1 by low-power laser in vitro correlates with increased TGF-beta1 levels in laser-enhanced oral wound healing. Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society. 2007.  15, 866-874. [PubMed]
22. Limaye, A. M., Asangani, I., Bora, N. and Kondaiah, P.  Novel flutamide regulated genes in the rat ventral prostate: differential modulation of their expression by castration and flutamide treatments. Asian Journal of Andrology. 2007.  9, 801-808. [PubMed]
23. Bajaj, A., Kondaiah, P. and Bhattacharya, S.  Synthesis and gene transfer activities of novel serum compatible cholesterol-based gemini lipids possessing oxyethylene-type spacers. Bioconjugate Chemistry. 2007.  18, 1537-1546. [PubMed]
24. Ranganathan, P., Agrawal, A., Bhushan, R., Chavalmane, A. K., Kalathur, R. K., Takahashi, T. and Kondaiah, P.  Expression profiling of genes regulated by TGF-beta: differential regulation in normal and tumour cells. BMC Genomics. 2007.  8, 98. [PubMed]
25. Somasundaram, K., Reddy, S. P., Vinnakota, K., Britto, R., Subbarayan, M., Nambiar, S., Hebbar, A., Samuel, C., Shetty, M., Sreepathi, H. K., Santosh, V., Hegde, A. S., Hegde, S., Kondaiah, P. and Rao, M. R.  Upregulation of ASCL1 and inhibition of Notch signaling pathway characterize progressive astrocytoma. Oncogene. 2005.  24, 7073-7083. [PubMed]
26. Haldar, J., Kondaiah, P. and Bhattacharya, S.  Synthesis and antibacterial properties of novel hydrolyzable cationic amphiphiles. Incorporation of multiple head groups leads to impressive antibacterial activity. Journal of Medicinal Chemistry. 2005.  48, 3823-3831. [PubMed]
27. Bahadur, U., Ganjam, G. K., Vasudevan, N. and Kondaiah, P.  Estrogen regulation of chicken riboflavin carrier protein gene is mediated by ERE half sites without direct binding of estrogen receptor. Molecular and Cellular Endocrinology. 2005.  231, 1-11. [PubMed]
28. Desai, K. V., Michalowska, A. M., Kondaiah, P., Ward, J. M., Shih, J. H. and Green, J. E.  Gene expression profiling identifies a unique androgen-mediated inflammatory/immune signature and a PTEN (phosphatase and tensin homolog deleted on chromosome 10)-mediated apoptotic response specific to the rat ventral prostate. Molecular Endocrinology. 2004.  18, 2895-2907. [PubMed]
29. Kondaiah P.  Bone marrow stromal cells and multi-lineage differentiation. Journal of Biosciences. 2003.  28, 651. [PubMed]
30. Goswami, M. T., Desai, K. V. and Kondaiah, P.  Comparative functional analysis of rat TGF-beta1 and Xenopus laevis TGF-beta5 promoters suggest differential regulations. Journal of Molecular Evolution. 2003.  57, 44-51. [PubMed]
31. Subramanian, S., Kondaiah, P. and Radhakantha, A.  Expression, purification, and characterization of minimized chicken riboflavin carrier protein from a synthetic gene in Escherichia coli. Protein Expression and Purification. 2002.  26, 284-289. [PubMed]
32. Roy, N., Guruprasad, M. R., Kondaiah, P., Mann, E. A., Giannella, R. A. and Visweswariah, S. S.  Protein kinase C regulates transcription of the human guanylate cyclase C gene. European Journal of Biochemistry / FEBS. 2001.  268, 2160-2171. [PubMed]
33. Vasudevan, N., Bahadur, U. and Kondaiah, P.  Characterization of chicken riboflavin carrier protein gene structure and promoter regulation by estrogen. Journal of Biosciences. 2001.  26, 39-46. [PubMed]
34. Dhanasekaran, S. M., Vempati, U. D. and Kondaiah, P.  Isolation and characterization of a transforming growth factor-beta Type II receptor cDNA from Xenopus laevis. Gene. 2001.  263, 171-178. [PubMed]
35. Kondaiah, P., Taira, M., Vempati, U. D. and Dawid, I. B.  Transforming growth factor-beta5 expression during early development of Xenopus laevis. Mechanisms of Development. 2000.  95, 207-209. [PubMed]
36. Desai, K. V. and Kondaiah, P.  Androgen ablation results in differential regulation of transforming growth factor-beta isoforms in rat male accessory sex organs and epididymis. Journal of Molecular Endocrinology. 2000.  24, 253-260. [PubMed]
37. Desai, K. V., Flanders, K. C. and Kondaiah, P.  Expression of transforming growth factor-beta isoforms in the rat male accessory sex organs and epididymis. Cell and Tissue Research. 1998.  294, 271-277. [PubMed]
38. Vempati, U. D. and Kondaiah, P.  Molecular organization of the gene encoding Xenopus laevis transforming growth factor-beta 5. Biochemistry and Molecular Biology International. 1998.  45, 997-1003. [PubMed]
39. Devi, K. S., Devi, A. R. and Kondaiah, P.  Amplification of phenylalanine hydroxylase and cystathionine beta-synthase transcripts in human peripheral lymphocytes by RT-PCR. Biochemistry and Molecular Biology International. 1998.  45, 643-650. [PubMed]
40. Vempati, U. D. and Kondaiah, P.  Characterization of the 5' flanking region of the Xenopus laevis transforming growth factor-beta 5 (TGF-beta 5) gene. Gene. 1998.  208, 323-329. [PubMed]
41. Sumathy, K., Desai, K. V. and Kondaiah, P.  Isolation of transforming growth factor-beta2 cDNA from a fish, Cyprinus carpio by RT-PCR. Gene. 1997.  191, 103-107. [PubMed]
42. Romeo, D., Allison, R. S., Kondaiah, P. and Wakefield, L. M.  Recharacterization of the start sites for the major human transforming growth factor-beta 1 mRNA. Gene. 1997.  189, 289-295. [PubMed]
43. Sanderson, N., Factor, V., Nagy, P., Kopp, J., Kondaiah, P., Wakefield, L., Roberts, A. B., Sporn, M. B. and Thorgeirsson, S. S.  Hepatic expression of mature transforming growth factor beta 1 in transgenic mice results in multiple tissue lesions. Proceedings of the National Academy of Sciences of the United States of America. 1995.  92, 2572-2576. [PubMed]
44. Flanders, K. C., Ludecke, G., Engels, S., Cissel, D. S., Roberts, A. B., Kondaiah, P., Lafyatis, R., Sporn, M. B. and Unsicker, K.  Localization and actions of transforming growth factor-beta s in the embryonic nervous system. Development. 1991.  113, 183-191. [PubMed]
45. Qian, S. W., Kondaiah, P., Casscells, W., Roberts, A. B. and Sporn, M. B.  A second messenger RNA species of transforming growth factor beta 1 in infarcted rat heart. Cell Regulation. 1991.  2, 241-249. [PubMed]
46. Wakefield, L. M., Kondaiah, P., Hollands, R. S., Winokur, T. S. and Sporn, M. B.  Addition of a C-terminal extension sequence to transforming growth factor-beta 1 interferes with biosynthetic processing and abolishes biological activity. Growth Factors. 1991.  5, 243-253. [PubMed]
47. Qian, S. W., Kondaiah, P., Roberts, A. B. and Sporn, M. B.  cDNA cloning by PCR of rat transforming growth factor beta-1. Nucleic Acids Research. 1990.  18, 3059. [PubMed]
48. Roberts, A. B., Flanders, K. C., Heine, U. I., Jakowlew, S., Kondaiah, P., Kim, S. J. and Sporn, M. B.  Transforming growth factor-beta: multifunctional regulator of differentiation and development. Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences. 1990.  327, 145-154. [PubMed]
49. Kondaiah, P., Sands, M. J., Smith, J. M., Fields, A., Roberts, A. B., Sporn, M. B. and Melton, D. A.  Identification of a novel transforming growth factor-beta (TGF-beta 5) mRNA in Xenopus laevis. The Journal of Biological Chemistry. 1990.  265, 1089-1093. [PubMed]
50. Fitzpatrick, D. R., Denhez, F., Kondaiah, P. and Akhurst, R. J.  Differential expression of TGF beta isoforms in murine palatogenesis. Development. 1990.  109, 585-595. [PubMed]
51. Millan, F. A., Denhez, F., Kondaiah, P. and Akhurst, R. J.  Embryonic gene expression patterns of TGF beta 1, beta 2 and beta 3 suggest different developmental functions in vivo. Development. 1991.  111, 131-143. [PubMed]
52. Samuel, S. K., Hurta, R. A., Kondaiah, P., Khalil, N., Turley, E. A., Wright, J. A. and Greenberg, A. H.  Autocrine induction of tumor protease production and invasion by a metallothionein-regulated TGF-beta 1 (Ser223, 225). The EMBO Journal. 1992.  11, 1599-1605. [PubMed]
53. Jacobsen, S. E., Keller, J. R., Ruscetti, F. W., Kondaiah, P., Roberts, A. B. and Falk, L. A.  Bidirectional effects of transforming growth factor beta (TGF-beta) on colony-stimulating factor-induced human myelopoiesis in vitro: differential effects of distinct TGF-beta isoforms. Blood. 1991.  78, 2239-2247. [PubMed]
54. Casscells, W., Bazoberry, F., Speir, E., Thompson, N., Flanders, K., Kondaiah, P., Ferrans, V. J., Epstein, S. E. and Sporn, M.  Transforming growth factor-beta 1 in normal heart and in myocardial infarction. Annals of the New York Academy of Sciences. 1990.  593, 148-160. [PubMed]
55. Roberts, A. B., Rosa, F., Roche, N. S., Coligan, J. E., Garfield, M., Rebbert, M. L., Kondaiah, P., Danielpour, D., Kehrl, J. H., Wahl, S. M. and et, a. l. ..  Isolation and characterization of TGF-beta 2 and TGF-beta 5 from medium conditioned by Xenopus XTC cells. Growth Factors. 1990.  2, 135-147. [PubMed]
56. Roberts, A. B., Kondaiah, P., Rosa, F., Watanabe, S., Good, P., Danielpour, D., Roche, N. S., Rebbert, M. L., Dawid, I. B. and Sporn, M. B.  Mesoderm induction in Xenopus laevis distinguishes between the various TGF-beta isoforms. Growth Factors. 1990.  3, 277-286. [PubMed]
57. Denhez, F., Lafyatis, R., Kondaiah, P., Roberts, A. B. and Sporn, M. B.  Cloning by polymerase chain reaction of a new mouse TGF-beta, mTGF-beta 3. Growth Factors. 1990.  3, 139-146. [PubMed]
58. Roberts, A. B., Kim, S. J., Kondaiah, P., Jakowlew, S. B., Denhez, F., Glick, A. B., Geiser, A. G., Watanabe, S., Noma, T., Lechleider, R. and et, a. l. ..  Transcriptional control of expression of the TGF-betas. Annals of the New York Academy of Sciences. 1990.  593, 43-50. [PubMed]
59. Kondaiah, P., Van, O., Ludwig, R. L., Dhar, R., Sporn, M. B. and Roberts, A. B.  cDNA cloning of porcine transforming growth factor-beta 1 mRNAs. Evidence for alternate splicing and polyadenylation. The Journal of Biological Chemistry. 1988.  263, 18313-18317. [PubMed]
60. Jakowlew, S. B., Kondaiah, P., Dillard, P. J., Sporn, M. B. and Roberts, A. B.  A novel low molecular weight ribonucleic acid (RNA) related to transforming growth factor alpha messenger RNA. Molecular Endocrinology. 1988.  2, 1056-1063. [PubMed]
61. Jakowlew, S. B., Dillard, P. J., Kondaiah, P., Sporn, M. B. and Roberts, A. B.  Complementary deoxyribonucleic acid cloning of a novel transforming growth factor-beta messenger ribonucleic acid from chick embryo chondrocytes. Molecular Endocrinology. 1988.  2, 747-755. [PubMed]
62. Jakowlew, S. B., Kondaiah, P., Flanders, K. C., Thompson, N. L., Dillard, P. J., Sporn, M. B. and Roberts, A. B.  Increased expression of growth factor mRNAs accompanies viral transformation of rodent cells. Oncogene Research. 1988.  2, 135-148. [PubMed]
63. Thompson, N. L., Bazoberry, F., Speir, E. H., Casscells, W., Ferrans, V. J., Flanders, K. C., Kondaiah, P., Geiser, A. G. and Sporn, M. B.  Transforming growth factor beta-1 in acute myocardial infarction in rats. Growth Factors. 1988.  1, 91-99. [PubMed]
64. Van, O., Kondaiah, P., Ludwig, R. L., Sporn, M. B. and Baker, C. C.  Complementary deoxyribonucleic acid cloning of bovine transforming growth factor-beta 1. Molecular Endocrinology. 1987.  1, 693-698. [PubMed]
65. Roberts, A. B., Flanders, K. C., Kondaiah, P., Thompson, N. L., Van, O., Wakefield, L., Rossi, P., de, C., Heine, U. and Sporn, M. B.  Transforming growth factor beta: biochemistry and roles in embryogenesis, tissue repair and remodeling, and carcinogenesis. Recent Progress in Hormone Research. 1988.  44, 157-197. [PubMed]
66. Robey, P. G., Young, M. F., Flanders, K. C., Roche, N. S., Kondaiah, P., Reddi, A. H., Termine, J. D., Sporn, M. B. and Roberts, A. B.  Osteoblasts synthesize and respond to transforming growth factor-type beta (TGF-beta) in vitro. The Journal of Cell Biology. 1987.  105, 457-463. [PubMed]

 

 
 
Education 
::
Ph.D. in Genetics, Osmania University, Hyderabad, India
Type of Neoplasms
 
Head and Neck
Central nervous system
  Last modified on : Mar 4, 2011
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