INCREDB ID : 162
Home >> Investigator Page Previous      Next
Ravi Sirdeshmukh, Ph.D.
Associate Director & Distinguished Scientist 
 
Institute of Bioinformatics
Discoverer Building, International Tech Park, Whitefield
Bangalore - 560 066   
Karnataka   
 
E-mail: ravi@ibioinformatics.org
Phone: +91-80-28416140
Fax: +91-80-28416132
 
URL: http://www.ibioinformatics.org/team.htm
 
Positions Held:
Position Affiliation Time Period
Associate Director & Distinguished Scientist Institute of Bioinformatics, Bangalore, India 2010-Present
Scientist G Center for Cellular and Molecular Biology, Hyderabad, India 2007-2009
Scientist F Center for Cellular and Molecular Biology, Hyderabad, India 2002-2007
Visiting Scientist National Cancer Institute, National Institutes of Health, MD, USA 2006
Scientist E-II Center for Cellular and Molecular Biology, Hyderabad, India 1996-2002
Scientist E1 Center for Cellular and Molecular Biology, Hyderabad, India 1992-1996
Visiting Scientist National Institute of Neurological Disorders and Stroke, NIH, USA 1996
Scientist C Center for Cellular and Molecular Biology, Hyderabad, India 1987-1992
Post Doctoral Fellow Washington University Medical School, St Louis, USA 1982-1987
 
Area of Specialization:
Proteomics
Transcriptomics
Oncology
Publications:
1. Peng, L., Kapp, E. A., Fenyo, D., Kwon, M. S., Jiang, P., Wu, S., Jiang, Y., Aguilar, M. I., Ahmed, N., Baker, M. S., Cai, Z., Chen, Y. J., Van, C. h. i., Chung, M. C., He, F., Len, A. C., Liao, P. C., Nakamura, K., Ngai, S. M., Paik, Y. K., Pan, T. L., Poon, T. C., Salekdeh, G. H., Simpson, R. J., Sirdeshmukh, R., Srisomsap, C., Svasti, J., Tyan, Y. C., Dreyer, F. S., McLauchlan, D., Rawson, P. and Jordan, T. W.  The Asia Oceania Human Proteome Organisation Membrane Proteomics Initiative. Preparation and characterisation of the carbonate-washed membrane standard. Proteomics. 2010.  10, 4142-4148. [PubMed]
2. Govekar, R. B., D'Cruz, A. K., Alok, P., Agarwal, J., Dinshaw, K. A., Chinoy, R. F., Gadewal, N., Kannan, S., Sirdeshmukh, R., Sundaram, C. S., Malgundkar, S. A., Kane, S. V. and Zingde, S. M.  Proteomic profiling of cancer of the gingivo-buccal complex: Identification of new differentially expressed markers. Proteomics - Clinical Applications. 2009.  3, 1451-1462. [PubMed]
3. Govekar, R. B., D'Cruz, A. K., Alok, P., Agarwal, J., Dinshaw, K. A., Chinoy, R. F., Gadewal, N., Kannan, S., Sirdeshmukh, R., Sundaram, C. S., Malgundkar, S. A., Kane, S. V. and Zingde, S. M.  Proteomic profiling of cancer of the gingivo-buccal complex: Identification of new differentially expressed markers. Proteomics - Clinical Applications. 2009.  3, 1451-1462. [PubMed]
4. Gautam, P., Shankar, J., Madan, T., Sirdeshmukh, R., Sundaram, C. S., Gade, W. N., Basir, S. F. and Sarma, P. U.  Proteomic and transcriptomic analysis of Aspergillus fumigatus on exposure to amphotericin B. Antimicrobial Agents and Chemotherapy. 2008.  52, 4220-4227. [PubMed]
5. Sirdeshmukh R.  Proteomics in India: an overview. Molecular & Cellular Proteomics. 2008.  7, 1406-1407. [PubMed]
6. Mathivanan, S., Ahmed, M., Ahn, N. G., Alexandre, H., Amanchy, R., Andrews, P. C., Bader, J. S., Balgley, B. M., Bantscheff, M., Bennett, K. L., Bjorling, E., Blagoev, B., Bose, R., Brahmachari, S. K., Burlingame, A. S., Bustelo, X. R., Cagney, G., Cantin, G. T., Cardasis, H. L., Celis, J. E., Chaerkady, R., Chu, F., Cole, P. A., Costello, C. E., Cotter, R. J., Crockett, D., DeLany, J. P., De, M., DeSouza, L. V., Deutsch, E. W., Dransfield, E., Drewes, G., Droit, A., Dunn, M. J., Elenitoba-Johnson, K., Ewing, R. M., Van, E. y. k., Faca, V., Falkner, J., Fang, X., Fenselau, C., Figeys, D., Gagne, P., Gelfi, C., Gevaert, K., Gimble, J. M., Gnad, F., Goel, R., Gromov, P., Hanash, S. M., Hancock, W. S., Harsha, H. C., Hart, G., Hays, F., He, F., Hebbar, P., Helsens, K., Hermeking, H., Hide, W., Hjerno, K., Hochstrasser, D. F., Hofmann, O., Horn, D. M., Hruban, R. H., Ibarrola, N., James, P., Jensen, O. N., Jensen, P. H., Jung, P., Kandasamy, K., Kheterpal, I., Kikuno, R. F., Korf, U., Korner, R., Kuster, B., Kwon, M. S., Lee, H. J., Lee, Y. J., Lefevre, M., Lehvaslaiho, M., Lescuyer, P., Levander, F., Lim, M. S., Lobke, C., Loo, J. A., Mann, M., Martens, L., Martinez-Heredia, J., McComb, M., McRedmond, J., Mehrle, A., Menon, R., Miller, C. A., Mischak, H., Mohan, S. S., Mohmood, R., Molina, H., Moran, M. F., Morgan, J. D., Moritz, R., Morzel, M., Muddiman, D. C., Nalli, A., Navarro, J. D., Neubert, T. A., Ohara, O., Oliva, R., Omenn, G. S., Oyama, M., Paik, Y. K., Pennington, K., Pepperkok, R., Periaswamy, B., Petricoin, E. F., Poirier, G. G., Prasad, T. S., Purvine, S. O., Rahiman, B. A., Ramachandran, P., Ramachandra, Y. L., Rice, R. H., Rick, J., Ronnholm, R. H., Salonen, J., Sanchez, J. C., Sayd, T., Seshi, B., Shankari, K., Sheng, S. J., Shetty, V., Shivakumar, K., Simpson, R. J., Sirdeshmukh, R., Siu, K. W., Smith, J. C., Smith, R. D., States, D. J., Sugano, S., Sullivan, M., Superti-Furga, G., Takatalo, M., Thongboonkerd, V., Trinidad, J. C., Uhlen, M., Vandekerckhove, J., Vasilescu, J., Veenstra, T. D., Vidal-Taboada, J. M., Vihinen, M., Wait, R., Wang, X., Wiemann, S., Wu, B., Xu, T., Yates, J. R., Zhong, J., Zhou, M., Zhu, Y., Zurbig, P. and Pandey, A.  Human Proteinpedia enables sharing of human protein data. Nature Biotechnology. 2008.  26, 164-167. [PubMed]
7. Shukla, S., Govekar, R. B., Sirdeshmukh, R., Sundaram, C. S., D'Cruz, A. K., Pathak, K. A., Kane, S. V. and Zingde, S. M.  Tumor antigens eliciting autoantibody response in cancer of gingivo-buccal complex. Proteomics - Clinical Applications. 2007.  1, 1592-1604. [PubMed]
8. Suhasini, A. N. and Sirdeshmukh, R.  Onconase action on tRNA(Lys3), the primer for HIV-1 reverse transcription. Biochemical and Biophysical Research Communications. 2007.  363, 304-309. [PubMed]
9. Gautam, P., Sundaram, C. S., Madan, T., Gade, W. N., Shah, A., Sirdeshmukh, R. and Sarma, P. U.  Identification of novel allergens of Aspergillus fumigatus using immunoproteomics approach. Clinical and Experimental Allergy : Journal of the British Society for Allergy. 2007.  37, 1239-1249. [PubMed]
10. Sirdeshmukh R.  Fostering proteomics in India. Journal of Proteome Research. 2006.  5, 2879. [PubMed]
11. Sharma, S., Sundaram, C. S., Luthra, P. M., Singh, Y., Sirdeshmukh, R. and Gade, W. N.  Role of proteins in resistance mechanism of Pseudomonas fluorescens against heavy metal induced stress with proteomics approach. Journal of Biotechnology. 2006.  126, 374-382. [PubMed]
12. Suhasini, A. N. and Sirdeshmukh, R.  Transfer RNA cleavages by onconase reveal unusual cleavage sites. The Journal of Biological Chemistry. 2006.  281, 12201-12209. [PubMed]
13. Chumbalkar, V. C., Subhashini, C., Dhople, V. M., Sundaram, C. S., Jagannadham, M. V., Kumar, K. N., Srinivas, P. N., Mythili, R., Rao, M. K., Kulkarni, M. J., Hegde, S., Hegde, A. S., Samual, C., Santosh, V., Singh, L. and Sirdeshmukh, R.  Differential protein expression in human gliomas and molecular insights. Proteomics. 2005.  5, 1167-1177. [PubMed]
14. Chandra, H., Gupta, P. K., Sharma, K., Mattoo, A. R., Garg, S. K., Gade, W. N., Sirdeshmukh, R., Maithal, K. and Singh, Y.  Proteome analysis of mouse macrophages treated with anthrax lethal toxin. Biochimica et Biophysica Acta. 2005.  1747, 151-159. [PubMed]
15. Saxena, S. K., Sirdeshmukh, R., Ardelt, W., Mikulski, S. M., Shogen, K. and Youle, R. J.  Entry into cells and selective degradation of tRNAs by a cytotoxic member of the RNase A family. The Journal of Biological Chemistry. 2002.  277, 15142-15146. [PubMed]
16. Murthy, B. S., De, L., Piccoli, R., D'Alessio, G. and Sirdeshmukh, R.  Effects of protein RNase inhibitor and substrate on the quaternary structures of bovine seminal RNase. Biochemistry. 1996.  35, 3880-3885. [PubMed]
17. Tharun, S. and Sirdeshmukh, R.  Specific endonucleolytic cleavages of mouse albumin mRNA and their modulation during liver development. Nucleic Acids Research. 1995.  23, 641-646. [PubMed]
18. Rao, K. S., Sirdeshmukh, R. and Gupta, P. D.  Modulation of cytosolic RNase activity by endogenous RNase inhibitor in rat vaginal epithelial cells on estradiol administration. FEBS Letters. 1994.  343, 11-14. [PubMed]
19. Murthy, B. S. and Sirdeshmukh, R.  Sensitivity of monomeric and dimeric forms of bovine seminal ribonuclease to human placental ribonuclease inhibitor. The Biochemical Journal. 1992.  281 ( Pt 2), 343-348. [PubMed]
20. Krych, M., Sirdeshmukh, R., Gourse, R. and Schlessinger, D.  Processing of Escherichia coli 16S rRNA with bacteriophage lambda leader sequences. Journal of Bacteriology. 1987.  169, 5523-5529. [PubMed]
21. Schlessinger, D., Thomas, J. R., Krych, M., Sirdeshmukh, R. and Little, R. D.  Ribosomal RNA processing in Escherichia coli and cultured mammalian cells. Biochemical Society Transactions. 1986.  14, 811-813. [PubMed]
22. Sirdeshmukh, R. and Schlessinger, D.  Why is processing of 23 S ribosomal RNA in Escherichia coli not obligate for its function? Journal of Molecular Biology. 1985.  186, 669-672. [PubMed]
23. Sirdeshmukh, R. and Schlessinger, D.  Ordered processing of Escherichia coli 23S rRNA in vitro. Nucleic Acids Research. 1985.  13, 5041-5054. [PubMed]
24. Schlessinger, D., Bolla, R. I., Sirdeshmukh, R. and Thomas, J. R.  Spacers and processing of large ribosomal RNAs in Escherichia coli and mouse cells. BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology. 1985.  3, 14-18. [PubMed]
25. Sirdeshmukh, R., Krych, M. and Schlessinger, D.  Escherichia coli 23S ribosomal RNA truncated at its 5' terminus. Nucleic Acids Research. 1985.  13, 1185-1192. [PubMed]
26. Sirdeshmukh, R., Vijayarangam, D. and Bhargava, P. M.  E. coli RNA entrapped in large unilamellar liposomes is partially exposed. Indian Journal of Biochemistry & Biophysics. 1984.  21, 293-298. [PubMed]
27. King, T. C., Sirdeshmukh, R. and Schlessinger, D.  RNase III cleavage is obligate for maturation but not for function of Escherichia coli pre-23S rRNA. Proceedings of the National Academy of Sciences of the United States of America. 1984.  81, 185-188. [PubMed]
28. Sirdeshmukh, R. B. and Bhargava, P. M.  Uptake of exogenous RNA by rat-liver parenchymal cells in suspension prepared by the collagenase method. Indian Journal of Biochemistry & Biophysics. 1983.  20, 121-126. [PubMed]
29. Sirdeshmukh, R. and Bhargava, P. M.  Evidence for the presence of a cell-surface ribonuclease in mechanically prepared rat-liver cells in suspension. Bioscience Reports. 1982.  2, 751-760. [PubMed]

 
Grant Support:
Project Title Role Funding Agency Sanction Number Sanction Date
Identification of new biomarkers using genomics and proteomics Principal Investigator Council of Scientific and Industrial Research, Government of India
Proteomics of the effect of alkylating agents on mouse liver Principal Investigator Defence Research and Development Organisation, New Delhi, India
New insights in cancer biology- Proteomics of glioma Principal Investigator Council of Scientific and Industrial Research, Government of India
Plasma proteomics for health and disease Principal Investigator Council of Scientific and Industrial Research, Government of India
Medically important fungus Aspergillus fumigatus Co-PI Department of Science & Technology, Government of India
Identification and functional analysis of genes for yield in rice Co-PI Department of Biotechnology, Government of India

 
 
My CV:   Download
 
Education 
::
M.Sc. in Biochemistry, Osmania University, Hyderabad, India
::
Ph.D. in Biochemistry, Centre for Cellular and Molecular Biology, Hyderabad, India
Member
::
SAC, Institute Of Cytology and Preventive Medicine, ICMR, Noida
::
Program Advisory Committee, National Facility for Advanced Proteomics and Protein Research, IICB, Kolkata
::
SAC, Institute of Pathology, ICMR, New Delhi
::
Board of Studies in Biotechnology, Osmania University, Hyderabad
::
2007-2008, Consortium manager of CSIR Proteomics Network for International Collaborations
::
Nodal scientist, EFYP CSIR Plasma Proteomics Network Project
::
Invited/elected member of the Council of Human Proteome Organization
::
Invited member of the Council of Asian Oceanean HUPO
::
Advisory Panel for Protein and Glycoprotein analysis, US Pharmacopeia, USA
::
Editorial Board Member - Journal of Proteomics and Bioinformatics
::
Reviewer - Proteomics, Annals of Neurology, Proteomics - Clinical Applications, Journal of Proteome Research
Type of Neoplasms
 
Head and Neck
Central nervous system, Oral cavity
  Last modified on : Mar 4, 2011
India Cancer Research Database has been developed by the Institute of Bioinformatics with funding from the Department of Biotechnology, Government of India.