Samir K. Brahmachari, Ph.D.
Council of Scientific and Industrial Research
Anusandhan Bhawan
Rafi Ahmed Kidwai Marg
New Delhi - 110 001
E-mail: dgcsir@csir.res.in, dg@csir.res.in
Phone: +91-11-23710472, 23717053
Fax: +91-11-23710618
URL: http://www.cecri.res.in/krc/skb/index.html
Positions Held:
Position Affiliation Time Period
Secretary
Department of Scientific and Industrial Research, New Delhi, India
2007-Present
Director General
Council of Scientific and Industrial Research, New Delhi, India
2007-Present
Adjunct Professor
University of Pune, India
2003-Present
Visiting Professor
Dr. B.R. Ambedkar Center for Biomedical Research, New Delhi, India
1998-Present
Director
Institute of Genomics and Integrative Biology, New Delhi, India
1997-2007
Professor
Molecular Biophysics Unit, Indian Institute of Science, Bangalore, India
1997-2001
Associate Professor
Molecular Biophysics Unit, Indian Institute of Science, Bangalore, India
1992-1997
Assistant Professor
Molecular Biophysics Unit, Indian Institute of Science, Bangalore, India
1986-1992
Lecturer
Molecular Biophysics Unit, Indian Institute of Science, Bangalore, India
1981-1986
Research Associate
Molecular Biophysics Unit, Indian Institute of Science, Bangalore, India
1979-1981
Research Associate
Molecular Biophysics Unit, Indian Institute of Science, Bangalore, India
1979-1981
Visiting Professor
Max. Planck Institute of Biophysical Chemistry, Goettingen, Germany
1997-1997
Associated Faculty
Centre for Genetic Engineering, Indian Institute of Science, Bangalore, India
1989-1995
Assistant Professor
Molecular Biophysics Unit, Indian Institute of Science, Bangalore, India
1986-1992
Lecturer
Molecular Biophysics Unit, Indian Institute of Science, Bangalore, India
1981-1986
Research Associate
Molecular Biophysics Unit, Indian Institute of Science, Bangalore, India
1979-1981
Area of Specialization:
Cancer Genomics
Research Summary:
Functional genomics
Pharmacogenomics
Publications:
1.
Grover, S., Gourie-Devi, M., Baghel, R., Sharma, S., Bala, K., Gupta, M., Narayanasamy, K., Varma, B., Gupta, M., Kaur, K., Talwar, P., Kaur, H., Giddaluru, S., Sharma, A., Brahmachari, S. K. , Indian, G. and Kukreti, R. Genetic profile of patients with epilepsy on first-line antiepileptic drugs and potential directions for personalized treatment. Pharmacogenomics. 2010. 11, 927-941. [PubMed]
2.
Abdulla, M. A., Ahmed, I., Assawamakin, A., Bhak, J., Brahmachari, S. K. , Calacal, G. C., Chaurasia, A., Chen, C. H., Chen, J., Chen, Y. T., Chu, J., Cutiongco-de, l. a., De, U., Delfin, F. C., Edo, J., Fuchareon, S., Ghang, H., Gojobori, T., Han, J., Ho, S. F., Hoh, B. P., Huang, W., Inoko, H., Jha, P., Jinam, T. A., Jin, L., Jung, J., Kangwanpong, D., Kampuansai, J., Kennedy, G. C., Khurana, P., Kim, H. L., Kim, K., Kim, S., Kim, W. Y., Kimm, K., Kimura, R., Koike, T., Kulawonganunchai, S., Kumar, V., Lai, P. S., Lee, J. Y., Lee, S., Liu, E. T., Majumder, P. P., Mandapati, K. K., Marzuki, S., Mitchell, W., Mukerji, M., Naritomi, K., Ngamphiw, C., Niikawa, N., Nishida, N., Oh, B., Oh, S., Ohashi, J., Oka, A., Ong, R., Padilla, C. D., Palittapongarnpim, P., Perdigon, H. B., Phipps, M. E., Png, E., Sakaki, Y., Salvador, J. M., Sandraling, Y., Scaria, V., Seielstad, M., Sidek, M. R., Sinha, A., Srikummool, M., Sudoyo, H., Sugano, S., Suryadi, H., Suzuki, Y., Tabbada, K. A., Tan, A., Tokunaga, K., Tongsima, S., Villamor, L. P., Wang, E., Wang, Y., Wang, H., Wu, J. Y., Xiao, H., Xu, S., Yang, J. O., Shugart, Y. Y., Yoo, H. S., Yuan, W., Zhao, G. and Zilfalil, B. A. Mapping human genetic diversity in Asia. Science. 2009. 326, 1541-1545. [PubMed]
3.
Hariharan, M., Scaria, V. and Brahmachari, S. K. dbSMR: a novel resource of genome-wide SNPs affecting microRNA mediated regulation. BMC Bioinformatics. 2009. 10, 108. [PubMed]
4.
Gupta, M., Bhatnagar, P., Grover, S., Kaur, H., Baghel, R., Bhasin, Y., Chauhan, C., Verma, B., Manduva, V., Mukherjee, O., Purushottam, M., Sharma, A., Jain, S., Brahmachari, S. K. and Kukreti, R. Association studies of catechol-O-methyltransferase (COMT) gene with schizophrenia and response to antipsychotic treatment. Pharmacogenomics. 2009. 10, 385-397. [PubMed]
5.
Taneja, B., Yadav, J., Chakraborty, T. K. and Brahmachari, S. K. An Indian effort towards affordable drugs: "generic to designer drugs". Biotechnology Journal. 2009. 4, 348-360. [PubMed]
6.
Gupta, M., Chauhan, C., Bhatnagar, P., Gupta, S., Grover, S., Singh, P. K., Purushottam, M., Mukherjee, O., Jain, S., Brahmachari, S. K. and Kukreti, R. Genetic susceptibility to schizophrenia: role of dopaminergic pathway gene polymorphisms. Pharmacogenomics. 2009. 10, 277-291. [PubMed]
7.
Thorisson, G. A., Lancaster, O., Free, R. C., Hastings, R. K., Sarmah, P., Dash, D., Brahmachari, S. K. and Brookes, A. J. HGVbaseG2P: a central genetic association database. Nucleic Acids Research. 2009. 37, D797-802. [PubMed]
8.
Soni, K; Ahluwalia, JK; Khan, SZ; Pillai, B; Mitra, D; and Brahmachari, S.K. Human miRNAs: an antiviral defense mechanism
9.
Ahluwalia, J. K., Khan, S. Z., Soni, K., Rawat, P., Gupta, A., Hariharan, M., Scaria, V., Lalwani, M., Pillai, B., Mitra, D. and Brahmachari, S. K. Human cellular microRNA hsa-miR-29a interferes with viral nef protein expression and HIV-1 replication. Retrovirology. 2008. 5, 117. [PubMed]
10.
Anbazhagan, P., Purushottam, M., Kumar, H. B., Kubendran, S., Mukherjee, O., Brahmachari, S. K. , Jain, S. and Sowdhamini, R. Evolutionary analysis of PHLPP1 gene in humans and non-human primates. Bioinformation. 2008. 2, 471-474. [PubMed]
11.
Hardy, B. J., Seguin, B., Singer, P. A., Mukerji, M., Brahmachari, S. K. and Daar, A. S. From diversity to delivery: the case of the Indian Genome Variation initiative. Nature Reviews. Genetics. 2008. 9 Suppl 1, S9-14. [PubMed]
12.
Prasher, B., Negi, S., Aggarwal, S., Mandal, A. K., Sethi, T. P., Deshmukh, S. R., Purohit, S. G., Sengupta, S., Khanna, S., Mohammad, F., Garg, G., Brahmachari, S. K. and Mukerji, M. Whole genome expression and biochemical correlates of extreme constitutional types defined in Ayurveda. Journal of Translational Medicine. 2008. 6, 48. [PubMed]
13.
Sundaramoorthy, E., Maiti, S., Brahmachari, S. K. and Sengupta, S. Predicting protein homocysteinylation targets based on dihedral strain energy and pKa of cysteines. Proteins. 2008. 71, 1475-1483. [PubMed]
14.
Mathivanan, S., Ahmed, M., Ahn, N. G., Alexandre, H., Amanchy, R., Andrews, P. C., Bader, J. S., Balgley, B. M., Bantscheff, M., Bennett, K. L., Bjorling, E., Blagoev, B., Bose, R., Brahmachari, S. K. , Burlingame, A. S., Bustelo, X. R., Cagney, G., Cantin, G. T., Cardasis, H. L., Celis, J. E., Chaerkady, R., Chu, F., Cole, P. A., Costello, C. E., Cotter, R. J., Crockett, D., DeLany, J. P., De, M., DeSouza, L. V., Deutsch, E. W., Dransfield, E., Drewes, G., Droit, A., Dunn, M. J., Elenitoba-Johnson, K., Ewing, R. M., Van, E. y. k., Faca, V., Falkner, J., Fang, X., Fenselau, C., Figeys, D., Gagne, P., Gelfi, C., Gevaert, K., Gimble, J. M., Gnad, F., Goel, R., Gromov, P., Hanash, S. M., Hancock, W. S., Harsha, H. C., Hart, G., Hays, F., He, F., Hebbar, P., Helsens, K., Hermeking, H., Hide, W., Hjerno, K., Hochstrasser, D. F., Hofmann, O., Horn, D. M., Hruban, R. H., Ibarrola, N., James, P., Jensen, O. N., Jensen, P. H., Jung, P., Kandasamy, K., Kheterpal, I., Kikuno, R. F., Korf, U., Korner, R., Kuster, B., Kwon, M. S., Lee, H. J., Lee, Y. J., Lefevre, M., Lehvaslaiho, M., Lescuyer, P., Levander, F., Lim, M. S., Lobke, C., Loo, J. A., Mann, M., Martens, L., Martinez-Heredia, J., McComb, M., McRedmond, J., Mehrle, A., Menon, R., Miller, C. A., Mischak, H., Mohan, S. S., Mohmood, R., Molina, H., Moran, M. F., Morgan, J. D., Moritz, R., Morzel, M., Muddiman, D. C., Nalli, A., Navarro, J. D., Neubert, T. A., Ohara, O., Oliva, R., Omenn, G. S., Oyama, M., Paik, Y. K., Pennington, K., Pepperkok, R., Periaswamy, B., Petricoin, E. F., Poirier, G. G., Prasad, T. S., Purvine, S. O., Rahiman, B. A., Ramachandran, P., Ramachandra, Y. L., Rice, R. H., Rick, J., Ronnholm, R. H., Salonen, J., Sanchez, J. C., Sayd, T., Seshi, B., Shankari, K., Sheng, S. J., Shetty, V., Shivakumar, K., Simpson, R. J., Sirdeshmukh, R., Siu, K. W., Smith, J. C., Smith, R. D., States, D. J., Sugano, S., Sullivan, M., Superti-Furga, G., Takatalo, M., Thongboonkerd, V., Trinidad, J. C., Uhlen, M., Vandekerckhove, J., Vasilescu, J., Veenstra, T. D., Vidal-Taboada, J. M., Vihinen, M., Wait, R., Wang, X., Wiemann, S., Wu, B., Xu, T., Yates, J. R., Zhong, J., Zhou, M., Zhu, Y., Zurbig, P. and Pandey, A. Human Proteinpedia enables sharing of human protein data. Nature Biotechnology. 2008. 26, 164-167. [PubMed]
15.
Scaria, V., Hariharan, M., Pillai, B., Maiti, S. and Brahmachari, S. K. Host-virus genome interactions: macro roles for microRNAs. Cellular Microbiology. 2007. 9, 2784-2794. [PubMed]
16.
Ghosh, T., Pandey, N., Maitra, A., Brahmachari, S. K. and Pillai, B. A role for voltage-dependent anion channel Vdac1 in polyglutamine-mediated neuronal cell death. PloS One. 2007. 2, e1170. [PubMed]
17.
Kumar, H. B., Purushottam, M., Kubendran, S., Gayathri, P., Mukherjee, O., Murthy, A. R., Ghosh, S., Chandra, P., Reddy, Y. C., Benegal, V., Brahmachari, S. K. and Jain, S. Serotonergic candidate genes and puerperal psychosis: an association study. Psychiatric Genetics. 2007. 17, 253-260. [PubMed]
18.
Prakash, T., Sandhu, K. S., Singh, N. K., Bhasin, Y., Ramakrishnan, C. and Brahmachari, S. K. Structural assessment of glycyl mutations in invariantly conserved motifs. Proteins. 2007. 69, 617-632. [PubMed]
19.
Sharma, V. K., Kumar, N., Brahmachari, S. K. and Ramachandran, S. Abundance of dinucleotide repeats and gene expression are inversely correlated: a role for gene function in addition to intron length. Physiological Genomics. 2007. 31, 96-103. [PubMed]
20.
Scaria, V., Hariharan, M., Brahmachari, S. K. , Maiti, S. and Pillai, B. microRNA: an emerging therapeutic. ChemMedChem. 2007. 2, 789-792. [PubMed]
21.
Ganapathi, M., Singh, G. P., Sandhu, K. S., Brahmachari, S. K. and Brahmachari, V. A whole genome analysis of 5' regulatory regions of human genes for putative cis-acting modulators of nucleosome positioning. Gene. 2007. 391, 242-251. [PubMed]
22.
Gupta, S., Bisht, S. S., Kukreti, R., Jain, S. and Brahmachari, S. K. Boolean network analysis of a neurotransmitter signaling pathway. Journal of Theoretical Biology. 2007. 244, 463-469. [PubMed]
23.
Appelbe W, Auerbach AD, Becker K, Bodmer W, Boone DJ , Boulyjenkov V, Brahmachari S , Brody L, Brookes A, Brown AF, Byers P, Cantu JM, Cassiman JJ, Claustres M,Concannon P, Cotton RG, den Dunnen JT, Flicek P, Gibbs R, Hall J, Hasler J, Katz M, Kwok PY, Laradi S, Lindblom A, Maglott D, Marsh S, Masimirembwa CM, Minoshima S, de Ramirez AM, Pagon R, Ramesar R, Ravine D, Richards S, Rimoin D, Ring HZ, Scriver CR, Sherry S, Shimizu N, Stein L, Tadmouri GO, Taylor G, Watson M. Recommendations of the 2006 Human Variome Project meeting. Nature Genetics . 2007. 39, 433-436.
24.
Sharma, V. K., Sharma, A., Kumar, N., Khandelwal, M., Mandapati, K. K., Horn-Saban, S., Strichman-Almashanu, L., Lancet, D., Brahmachari, S. K. and Ramachandran, S. Expoldb: expression linked polymorphism database with inbuilt tools for analysis of expression and simple repeats. BMC Genomics. 2006. 7, 258. [PubMed]
25.
Scaria, V., Hariharan, M., Maiti, S., Pillai, B. and Brahmachari, S. K. Host-virus interaction: a new role for microRNAs. Retrovirology. 2006. 3, 68. [PubMed]
26.
Mukherjee, O., Meera, P., Ghosh, S., Kubendran, S., Kiran, K., Manjunath, K. R., Subhash, M. N., Benegal, V., Brahmachari, S. K., Majumder, P. P. and Jain, S. Evidence of linkage and association on 18p11.2 for psychosis. American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics. 2006. 141B, 868-873. [PubMed]
27.
Guzman, M. R., Liquier, J., Brahmachari, S. K. and Taillandier, E. Characterization of parallel and antiparallel G-tetraplex structures by vibrational spectroscopy. Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy. 2006. 64, 495-503. [PubMed]
28.
Gupta, S., Jain, S., Brahmachari, S. K. and Kukreti, R. Pharmacogenomics: a path to predictive medicine for schizophrenia. Pharmacogenomics. 2006. 7, 31-47. [PubMed]
29.
Kukreti, R., Tripathi, S., Bhatnagar, P., Gupta, S., Chauhan, C., Kubendran, S., Janardhan, R., Jain, S. and Brahmachari, S. K. Association of DRD2 gene variant with schizophrenia. Neuroscience Letters. 2006. 392, 68-71. [PubMed]
30.
Bagga, R. and Brahmachari, S. K. Polypurine-polypyrimidine sequences adopt unwound structure in pBR322 form V DNA as probed by single-hit analysis of HpaII sites. Journal of Biomolecular Structure & Dynamics. 1993. 10, 879-890. [PubMed]
31.
Sarkar, P. S. and Brahmachari, S. K. Intramolecular triplex potential sequence within a gene down regulates its expression in vivo. Nucleic Acids Research. 1992. 20, 5713-5718. [PubMed]
32.
Balagurumoorthy, P., Brahmachari, S. K. , Mohanty, D., Bansal, M. and Sasisekharan, V. Hairpin and parallel quartet structures for telomeric sequences. Nucleic Acids Research. 1992. 20, 4061-4067. [PubMed]
33.
Brahmachari, S. K. , Sarkar, P. S., Balagurumoorthy, P., Burma, P. K. and Bagga, R. Synthetic gene design to investigate the role of cis-acting DNA structural elements in regulation of gene expression in vivo. Nucleic Acids Symposium Series. 1991. , 163-166. [PubMed]
34.
Tripathi, J. and Brahmachari, S. K. Distribution of simple repetitive (TG/CA)n and (CT/AG)n sequences in human and rodent genomes. Journal of Biomolecular Structure & Dynamics. 1991. 9, 387-397. [PubMed]
35.
Bagga, R., Ramesh, N. and Brahmachari, S. K. Supercoil-induced unusual DNA structures as transcriptional block. Nucleic Acids Research. 1990. 18, 3363-3369. [PubMed]
36.
Shouche, Y. S., Ramesh, N. and Brahmachari, S. K. Probing of unusual DNA structures in topologically constrained form V DNA: use of restriction enzymes as structural probe. Nucleic Acids Research. 1990. 18, 267-275. [PubMed]
37.
Rao, K. E., Ramesh, N., Choudhury, D., Brahmachari, S. K. and Sasisekharan, V. Role of the environment in the interaction of nonintercalators with Z-DNA. Journal of Biomolecular Structure & Dynamics. 1989. 7, 335-345. [PubMed]
38.
Brahmachari, S. K., Mishra, R. K., Bagga, R. and Ramesh, N. DNA duplex with the potential to change handedness after every half a turn. Nucleic Acids Research. 1989. 17, 7273-7281. [PubMed]
39.
Meera, G., Ramesh, N. and Brahmachari, S. K. Zintrons in rat alpha-lactalbumin gene. FEBS Letters. 1989. 251, 245-249. [PubMed]
40.
Ramesh, N. and Brahmachari, S. K. Structural alteration from non-B to B-form could reflect DNase I hypersensitivity. Journal of Biomolecular Structure & Dynamics. 1989. 6, 899-906. [PubMed]
41.
Majumder, K. and Brahmachari, S. K. Sequence specificity in spermine-induced structural changes in CG-oligomers. Biochemistry International. 1989. 18, 455-465. [PubMed]
42.
Majumder, K., Mishra, R. K., Bansal, M. and Brahmachari, S. K. Sequence criteria for Z-DNA formation: studies on poly d(ACGT). Nucleic Acids Research. 1989. 17, 450. [PubMed]
43.
Ramesh, N. and Brahmachari, S. K. Dynamic nature of B to Z transition: role of DNA supercoiling and Z-DNA binding protein. Indian Journal of Biochemistry & Biophysics. 1988. 25, 542-547. [PubMed]
44.
Mishra, R. K., Latha, P. K. and Brahmachari, S. K. Interruptions of (CG)n sequences by GG, TG and CA need not prevent B to Z transition in solution. Nucleic Acids Research. 1988. 16, 4651-4665. [PubMed]
45.
Kadalayil, L. P., Majumder, K., Mishra, R. K. and Brahmachari, S. K. Sequence specificity of Z-DNA formation in oligonucleotides. Biochemistry International. 1988. 17, 121-131. [PubMed]
46.
Brahmachari, S. K. , Shouche, Y. S., Cantor, C. R. and McClelland, M. Sequences that adopt non-B-DNA conformation in form V DNA as probed by enzymic methylation. Journal of Molecular Biology. 1987. 193, 201-211. [PubMed]
47.
Conrad, M., Brahmachari, S. K. and Sasisekharan, V. DNA structural variability as a factor in gene expression and evolution. Bio Systems. 1986. 19, 123-126. [PubMed]
48.
Ramesh, N., Shouche, Y. S. and Brahmachari, S. K. Recognition of B and Z forms of DNA by Escherichia coli DNA polymerase I. Journal of Molecular Biology. 1986. 190, 635-638. [PubMed]
49.
Brahmachari, S. K . Ramesh, N., Das, M. R. and Parnaik, V. K. Poly(dG-dC) in the Z-form inhibits E. coli DNA polymerase I and AMV DNA polymerase activity. Biochemistry International. 1985. 11, 281-290. [PubMed]
50.
Latha, P. K. and Brahmachari, S. K. A novel structural transition in poly(dG-Me5dC):Z in equilibrium B in equilibrium Z. FEBS Letters. 1985. 182, 315-318. [PubMed]
51.
Rao, B. J., Brahmachari, S. K. and Rao, M. R. Structural organization of the meiotic prophase chromatin in the rat testis. The Journal of Biological Chemistry. 1983. 258, 13478-13485. [PubMed]
52.
Rajagopalan, M., Brahmachari, S. K. , Sasisekharan, V. and Srivastava, R. X-ray diffraction studies on Mycobacterium smegmatis DNA. Biopolymers. 1983. 22, 1633-1635. [PubMed]
53.
Ramesh, N. and Brahmachari, S. K. Critical cation balance in B leads to Z transition: role of Li+. FEBS Letters. 1983. 164, 33-37. [PubMed]
54.
Brahms, S., Brahmachari, S. K., Angelier, N. and Brahms, J. G. Conformation of DNA in chromatin reconstituted from poly [d(A-T)] and the core histones. Nucleic Acids Research. 1981. 9, 4879-4893. [PubMed]
55.
Couppez, M., Sautiere, P., Brahmachari, S. K., Brahms, J., Liquier, J. and Taillandier, E. Site and role of the N-terminal fragment of the nucleosomal core histones in their binding to deoxyribonucleic acid as determined by vibrational spectroscopy. Biochemistry. 1980. 19, 3358-3363. [PubMed]
56.
Ananthanarayanan, V. S., Brahmachari, S. K. and Pattabiraman, N. Proline-containing beta-turns in peptides and proteins: analysis of structural data on globular proteins. Archives of Biochemistry and Biophysics. 1984. 232, 482-495. [PubMed]
57.
Brahmachari, S. K. , Ananthanarayanan, V. S., Brahms, S., Brahms, J., Rapaka, R. S. and Bhatnagar, R. S. Vacuum ultraviolet circular dichroism spectrum of beta-turn in solution. Biochemical and Biophysical Research Communications. 1979. 86, 605-612. [PubMed]
58.
Brahmachari, S. K. and Ananthanarayanan, V. S. Beta-turns in nascent procollagen are sites of posttranslational enzymatic hydroxylation of proline. Proceedings of the National Academy of Sciences of the United States of America. 1979. 76, 5119-5123. [PubMed]
59.
Brahmachari, S. K. , Ananthanarayanan, V. S., Rapaka, R. S. and Bhatnagar, R. S. Polypeptide models of collagen. II. Solution properties of (Pro-Gly-Phe)n. Biopolymers. 1978. 17, 2096-2105. [PubMed]
60.
Ananthanarayanan, V. S., Brahmachari, S. K. , Rapaka, R. S. and Bhatnagar, R. S. Polypeptide models of collagen. Solution properties of (Gly-Pro-Sar)n and (Gly-Sar-Pro)n. Biopolymers. 1976. 15, 707-716. [PubMed]
61.
Brahmachari, S. K. , Ananthanarayanan, V. S., Brahms, S., Brahms, J., Rapaka, R. S. and Bhatnagar, R. S. Vacuum ultraviolet circular dichroism spectrum of beta-turn in solution. Biochemical and Biophysical Research Communications. 1979. 86, 605-612. [PubMed]
62.
Nandi, T., Dash, D., Ghai, R., B-Rao, C., Kannan, K., Brahmachari, S. K. , Ramakrishnan, C. and Ramachandran, S. A novel complexity measure for comparative analysis of protein sequences from complete genomes. Journal of Biomolecular Structure & Dynamics. 2003. 20, 657-668. [PubMed]
63.
Pillai, B., Verma, J., Abraham, A., Francis, P., Kumar, Y., Tatu, U., Brahmachari, S. K. and Sadhale, P. P. Whole genome expression profiles of yeast RNA polymerase II core subunit, Rpb4, in stress and nonstress conditions. The Journal of Biological Chemistry. 2003. 278, 3339-3346. [PubMed]
64.
Saleem, Q., Roy, S., Murgood, U., Saxena, R., Verma, I. C., Anand, A., Muthane, U., Jain, S. and Brahmachari, S. K. Molecular analysis of Huntington's disease and linked polymorphisms in the Indian population. Acta Neurologica Scandinavica. 2003. 108, 281-286. [PubMed]
65.
Pasha, M. A., Khan, A. P., Kumar, R., Ram, R. B., Grover, S. K., Srivastava, K. K., Selvamurthy, W. and Brahmachari, S. K. Variations in angiotensin-converting enzyme gene insertion/deletion polymorphism in Indian populations of different ethnic origins. Journal of Biosciences. 2002. 27, 67-70. [PubMed]
66.
Brahmachari S. K. Keynote: Functional genomics and DNA chips. Applied Biochemistry and Biotechnology. 2001. 96, 9-12. [PubMed]
67.
Saleem, Q., Muthane, U., Verma, I. C., Brahmachari, S. K. and Jain, S. Expanding colonies and expanding repeats. Lancet. 2002. 359, 895-896. [PubMed]
68.
Qadar, P., Khan, A. P., Kumar, R., Grover, S. K., Ram, R. B., Norboo, T., Srivastava, K. K., Selvamurthy, W. and Brahmachari, S. K. Angiotensin converting enzyme insertion allele in relation to high altitude adaptation. Annals of Human Genetics. 2001. 65, 531-536. [PubMed]
69.
Kukreti, R., B-Rao, C., Das, S. K., De, M., Talukder, G., Vaz, F., Verma, I. C. and Brahmachari, S. K. Study of the single nucleotide polymorphism (SNP) at the palindromic sequence of hypersensitive site (HS)4 of the human beta-globin locus control region (LCR) in Indian population. American Journal of Hematology. 2002. 69, 77-79. [PubMed]
70.
Murgod, U. A., Saleem, Q., Anand, A., Brahmachari, S. K. , Jain, S. and Muthane, U. B. A clinical study of patients with genetically confirmed Huntington's disease from India. Journal of the Neurological Sciences. 2001. 190, 73-78. [PubMed]
71.
Maiti, A. K. and Brahmachari, S. K. Poly purine.pyrimidine sequences upstream of the beta-galactosidase gene affect gene expression in Saccharomyces cerevisiae. BMC Molecular Biology. 2001. 2, 11. [PubMed]
72.
Choudhry, S., Mukerji, M., Srivastava, A. K., Jain, S. and Brahmachari, S. K. CAG repeat instability at SCA2 locus: anchoring CAA interruptions and linked single nucleotide polymorphisms. Human Molecular Genetics. 2001. 10, 2437-2446. [PubMed]
73.
Saleem, Q., Anand, A., Jain, S. and Brahmachari, S. K. The polyglutamine motif is highly conserved at the Clock locus in various organisms and is not polymorphic in humans. Human Genetics. 2001. 109, 136-142. [PubMed]
74.
Pataskar, S. S., Dash, D. and Brahmachari, S. K. Intramolecular i-motif structure at acidic pH for progressive myoclonus epilepsy (EPM1) repeat d(CCCCGCCCCGCG)n. Journal of Biomolecular Structure & Dynamics. 2001. 19, 307-313. [PubMed]
75.
Srivastava, A. K., Choudhry, S., Gopinath, M. S., Roy, S., Tripathi, M., Brahmachari, S. K. and Jain, S. Molecular and clinical correlation in five Indian families with spinocerebellar ataxia 12. Annals of Neurology. 2001. 50, 796-800. [PubMed]
76.
Pataskar, S. S., Dash, D. and Brahmachari, S. K. Progressive myoclonus epilepsy [EPM1] repeat d(CCCCGCCCCGCG)n forms folded hairpin structures at physiological pH. Journal of Biomolecular Structure & Dynamics. 2001. 19, 293-305. [PubMed]
77.
Saleem, Q., Dash, D., Gandhi, C., Kishore, A., Benegal, V., Sherrin, T., Mukherjee, O., Jain, S. and Brahmachari, S. K. Association of CAG repeat loci on chromosome 22 with schizophrenia and bipolar disorder. Molecular Psychiatry. 2001. 6, 694-700. [PubMed]
78.
Brahmachari, S. K. , Sharma, D., Sharma, S., Pasha, S., Sen, S. and Saleem, Q. Probing the polyglutamine puzzle in neurological disorders. FEBS Letters. 2000. 472, 167-168. [PubMed]
79.
Saleem, Q., Ganesh, S., Vijaykumar, M., Reddy, Y. C., Brahmachari, S. K. and Jain, S. Association analysis of 5HT transporter gene in bipolar disorder in the Indian population. American Journal of Medical Genetics. 2000. 96, 170-172. [PubMed]
80.
Saleem, Q., Choudhry, S., Mukerji, M., Bashyam, L., Padma, M. V., Chakravarthy, A., Maheshwari, M. C., Jain, S. and Brahmachari, S. K. Molecular analysis of autosomal dominant hereditary ataxias in the Indian population: high frequency of SCA2 and evidence for a common founder mutation. Human Genetics. 2000. 106, 179-187. [PubMed]
81.
Saleem, Q., Sreevidya, V. S., Sudhir, J., Savithri, J. V., Gowda, Y., B-Rao, C., Benegal, V., Majumder, P. P., Anand, A., Brahmachari, S. K. and Jain, S. Association analysis of CAG repeats at the KCNN3 locus in Indian patients with bipolar disorder and schizophrenia. American Journal of Medical Genetics. 2000. 96, 744-748. [PubMed]
82.
Raghavan, S., Hariharan, R. and Brahmachari, S. K. Polypurine.polypyrimidine sequences in complete bacterial genomes: preference for polypurines in protein-coding regions. Gene. 2000. 242, 275-283. [PubMed]
83.
Sharma, D., Sharma, S., Pasha, S. and Brahmachari, S. K. Peptide models for inherited neurodegenerative disorders: conformation and aggregation properties of long polyglutamine peptides with and without interruptions. FEBS Letters. 1999. 456, 181-185. [PubMed]
84.
Saleem, Q., Vijayakumar, M., Mutsuddi, M., Chowdhary, N., Jain, S. and Brahmachari, S. K . American Journal of Medical Genetics. 1998. 81, 440-442. [PubMed]
85.
Chatterji, S., Jain, S., Brahmachari, S. K. , Majumder, P. and Reich, T. International collaboration in genetics research. Nature Genetics. 1997. 15, 124. [PubMed]
86.
Raghavan, S., Burma, P. K. and Brahmachari, S. K. Positional preferences of polypurine/polypyrimidine tracts in Saccharomyces cerevisiae genome: implications for cis regulation of gene expression. Journal of Molecular Evolution. 1997. 45, 485-498. [PubMed]
87.
Brahmachari, S. K. , Sarkar, P. S., Raghavan, S., Narayan, M. and Maiti, A. K. Polypurine/polypyrimidine sequences as cis-acting transcriptional regulators. Gene. 1997. 190, 17-26. [PubMed]
88.
Balagurumoorthy, P. and Brahmachari, S. K. Intra- and interloop interactions in the folded G quartet structure of Oxytricha telomeric sequence. Indian Journal of Biochemistry & Biophysics. 1995. 32, 385-390. [PubMed]
89.
Brahmachari, S. K. , Meera, G., Sarkar, P. S., Balagurumoorthy, P., Tripathi, J., Raghavan, S., Shaligram, U. and Pataskar, S. Simple repetitive sequences in the genome: structure and functional significance. Electrophoresis. 1995. 16, 1705-1714. [PubMed]
90.
Balagurumoorthy, P. and Brahmachari, S. K. Structure and stability of human telomeric sequence. The Journal of Biological Chemistry. 1994. 269, 21858-21869. [PubMed]
91.
Nagaich, A. K., Bhattacharyya, D., Brahmachari, S. K. and Bansal, M. CA/TG sequence at the 5' end of oligo(A)-tracts strongly modulates DNA curvature. The Journal of Biological Chemistry. 1994. 269, 7824-7833. [PubMed]
92.
Kukreti, R., Bhatnagar, P., B-Rao, C., Gupta, S., Madan, B., Das, C., Guleria, R., Athavale, A. U., Brahmachari, S. K. and Ghosh, B. Beta(2)-adrenergic receptor polymorphisms and response to salbutamol among Indian asthmatics*. Pharmacogenomics. 2005. 6, 399-410. [PubMed]
93.
Sharma, V. K., Brahmachari, S. K. and Ramachandran, S. (TG/CA)n repeats in human gene families: abundance and selective patterns of distribution according to function and gene length. BMC Genomics. 2005. 6, 83. [PubMed]
94.
Ganapathi, M., Srivastava, P., Das, S., Kumar, K., Dasgupta, D., Pal, S., Brahmachari, V. and Brahmachari, S. K. Comparative analysis of chromatin landscape in regulatory regions of human housekeeping and tissue specific genes. BMC Bioinformatics. 2005. 6, 126. [PubMed]
95.
Sharma, A., Sharma, V. K., Horn-Saban, S., Lancet, D., Ramachandran, S. and Brahmachari, S. K. Assessing natural variations in gene expression in humans by comparing with monozygotic twins using microarrays. Physiological Genomics. 2005. 21, 117-123. [PubMed]
96.
Padiath, Q. S., Srivastava, A. K., Roy, S., Jain, S. and Brahmachari, S. K. Identification of a novel 45 repeat unstable allele associated with a disease phenotype at the MJD1/SCA3 locus. American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics. 2005. 133B, 124-126. [PubMed]
97.
Prakash, T., Ramakrishnan, C., Dash, D. and Brahmachari, S. K. Conformational analysis of invariant peptide sequences in bacterial genomes. Journal of Molecular Biology. 2005. 345, 937-955. [PubMed]
98.
Nandi, T., Brahmachari, S. K., Kannan, K. and Ramachandran, S. Clusters of proteins in archaeal and bacterial proteomes using compositional analysis. In Silico Biology. 2004. 4, 573-591. [PubMed]
99.
Shankar, R., Grover, D., Brahmachari, S. K. and Mukerji, M. Evolution and distribution of RNA polymerase II regulatory sites from RNA polymerase III dependant mobile Alu elements. BMC Evolutionary Biology. 2004. 4, 37. [PubMed]
100.
Prakash, T., Khandelwal, M., Dasgupta, D., Dash, D. and Brahmachari, S. K. CoPS: Comprehensive Peptide Signature database. Bioinformatics. 2004. 20, 2886-2888. [PubMed]
101.
Verma, R., Chauhan, C., Saleem, Q., Gandhi, C., Jain, S. and Brahmachari, S. K. A nonsense mutation in the synaptogyrin 1 gene in a family with schizophrenia. Biological Psychiatry. 2004. 55, 196-199. [PubMed]
102.
Grover, D., Mukerji, M., Bhatnagar, P., Kannan, K. and Brahmachari, S. K. Alu repeat analysis in the complete human genome: trends and variations with respect to genomic composition. Bioinformatics. 2004. 20, 813-817. [PubMed]
103.
Sharma, R., Maheshwari, J. K., Prakash, T., Dash, D. and Brahmachari, S. K. Recognition and analysis of protein-coding genes in severe acute respiratory syndrome associated coronavirus. Bioinformatics. 2004. 20, 1074-1080. [PubMed]
104.
Kaushik, M., Kukreti, R., Grover, D., Brahmachari, S. K . Nucleic Acids Research. 2003. 31, 6904-6915. [PubMed]
105.
Sharma, V. K., B-Rao, C., Sharma, A., Brahmachari, S. K. and Ramachandran, S. (TG:CA)(n) repeats in human housekeeping genes. Journal of Biomolecular Structure & Dynamics. 2003. 21, 303-310. [PubMed]
106.
Grover, D., Majumder, P. P., B, R. a. o., Brahmachari, S. K. and Mukerji, M. Nonrandom distribution of alu elements in genes of various functional categories: insight from analysis of human chromosomes 21 and 22. Molecular Biology and Evolution. 2003. 20, 1420-1424. [PubMed]
107.
Sen, S., Dash, D., Pasha, S. and Brahmachari, S. K. Role of histidine interruption in mitigating the pathological effects of long polyglutamine stretches in SCA1: A molecular approach. Protein Science : A Publication of the Protein Society. 2003. 12, 953-962. [PubMed]
108.
Verma, R., Kubendran, S., Das, S. K., Jain, S. and Brahmachari, S. K. SYNGR1 is associated with schizophrenia and bipolar disorder in southern India. Journal of Human Genetics. 2005. 50, 635-640. [PubMed]
109.
Hariharan, M., Scaria, V., Pillai, B. and Brahmachari, S. K . Biochemical and Biophysical Research Communications. 2005. 337, 1214-1218. [PubMed]
110.
Grover, D., Kannan, K., Brahmachari, S. K. and Mukerji, M. ALU-ring elements in the primate genomes. Genetica. 2005. 124, 273-289. [PubMed]
111.
Verma, R., Mukerji, M., Grover, D., B-Rao, C., Das, S. K., Kubendran, S., Jain, S. and Brahmachari, S. K. MLC1 gene is associated with schizophrenia and bipolar disorder in Southern India. Biological Psychiatry. 2005. 58, 16-22. [PubMed]
112.
Kumar, R., Pasha, Q. M. A., Khan, A. P., Gupta, V., Grover, S. K., Norboo, T., Srivastava, K. K., Selvamurthy, W., Brahmachari, S.K. Association of high-altitude systemic hypertension with the deletion allele-of the angiotensin- converting enzyme (ACE) gene. International Journal of Biometeorology. 2003. 48, 10-14.
113.
Pasha, Q. M. A., Kocherlakota, K. S., Khan, A. P., Norboo, T., Grover, S. K., Baig, M. A., Selvamurthy, W. and Brahmachari, S. K. Arterial oxygen saturation under hypoxic environment of high altitude associates with routine physical activities of natives. Current Science. 2003. 85, 502-506
114.
Pillai, B., Brahmachari, S.K. and Sadhale, P.P. Genome-wide expression profile of RNA polymerase II subunit mutant of yeast using microarray technology. Current Science . 2001. 81, 574-578
115.
Ramachandran, S., Dash, D., Brahmachari, S.K. The multitude of ‘omics’ and ‘omes’: Evolution of scientific terms in molecular biology in the new millennium. Current Science . 1999. 77, 846-847
116.
Gourie-Devi, M., Chaydhari, J.Ray., Vasanth, A., Saleem, Q., Mutsuddi, M., Gopinath, M., Sarkar, P.S. and Brahmachari, S.K. Correlation of Clinical Profile of Mytonic dystrophy with CTG repeats in Mtotonin Protein kinase gene. The Indian Journal of Medical Research.
117.
Sivaramjani, T.R. and Brahmachari, S.K. Human genome studies and intellectual property rights: Whither national interest? Current Science. 1997. 72, 708.
118.
Bhandari, R. and Brahmachari, S.K. Analysis of CAG/CTG triplet repeats in the human genome: Implication in transcription factor gene regulation. Journal of Biosciences . 1995. 20, 613.
119.
Baranidharan, S., Sankaranarayanan, B. and Brahmachari, S.K. Chaos game representations of similarities and differences between genomic sequences. International Journal of Genome Research . 1994. 1, 309.
120.
Burma, P.K., Raj, A., Deb, J.K. and Brahmachari, S.K. Genome Analysis I: A new approach for visualization of sequence organization in genomes. Journal of Biosciences. 1992. 17, 395.
121.
Sarkar, P.S., Bagga R., Balagurumoorthy, P. and Brahmachari, S.K. A novel approach to design cis-acting DNA structural elements for regulation of gene expression in vivo. Current Science . 1991. 60, 586.
122.
Brahmachari, V., Nagasuma, R. and Brahmachari, S.K. Preparation of Megabase DNA from adult insects and mammalian spleen for pulse field gel electrophoresis. Journal of Genetics . 1989. 68, 185.
123.
Mishra, R.K. and Brahmachari, S.K. Synthesis of novel polynucleotide: Potential R-L model. Current Science . 1988.57, 574-907.
124.
Sasiskharan, V. and Brahmachari, S.K. B to Z transition in a DNA fibre: The question of handedness of the duplex. Current Science . 1981. 50, 10
125.
Brahmachari, S.K. , Ananthanaryanan, V.S., Rao, S.R. and Bhatnagar, R.S. Proline containing β-turns in –peptides and proteins. I. Physico-chemical studies on N-acetyl- Pro-Gly-X-OH tri- peptides. Biopolymers . 1982. 21, 1208.
126.
Brahmachari, S.K. , Ananthanaryanan, V.S., Bhat, T.N., Sudhakar, V., Vijayan, M., Rapaka, Rao, S.R. and Bhatnagar, R.S. Crystal structure and solution studies on N-acetyle-Pro-Gly- Phe-OH. Journal of the American Chemical Society. 1981. 103, 1703.
127.
Ananthanaryanan, V.S., Brahmachari, S.K. and Vijayan, M. β-turn conformation of N-acetyl-Pro-Gly-Phe-OH in crystal and solution and its relevance to collagen. Federation Proceedings . 1980. 39, 1788
128.
Brahmachari, S.K. and Ananthanaryanan, V.S. Conformational criteria for the enzymatic hydroxylation of proline in collagen. Current Science. 1978. 47, 107.
129.
Brahmachari, S.K. , Bansal, M., Ananthanaryanan, V.S, Sasisekharan, V. Structural investigations on Poly-4-hydroxy-L-proline. II. Physico-chemical and X-ray studies. Macromolecules. 1978. 12, 23.
130.
Bansal, M., Brahmachari, S.K and Sasisekharan, V. Structural investigations on Poly-4-hydroxy-L-proline I.Theoretical studies. Macromolecules . 1979. 12, 19.
131.
Genetic landscape of the people of India: a canvas for disease gene exploration. Journal of Genetics. 2008. 87, 3-20. [PubMed]
132.
The Indian Genome Variation database (IGVdb): a project overview. Human Genetics. 2005. 118, 1-11. [PubMed]
Book Chapters:
Mukerji, M., Pillai, B., Sen, S. and Brahmachari, S. K. Genomics and Functional Genomics. In. Textbook of Biotechnology, Das, H.K. Editor. Wiley Dreamtech Pvt. Ltd, Delhi. 2005. pp 1349-1409.
Brahmachari, S.K. , Ramesh, N., Souche, Y.S., Mishra, R.K., Bagga, R. and Meera, G. Unusual DNA structures:Sequence requirements and role in transcriptional control. In. Structures & Methods, R.H.Sarma & M.H. Sarma. Editor. Adenine press, 1990. Volume 2. pp 32-47
Brahmachari, S. K. , Paulus, E.T., Krishnamachary, N.and Ramesh, N. Z-DNA Binding Protein Mediated Stabilization of the Z-conformation. In Protein Structure-Function, Zaidi, Abbasi & Smith. Editors. TWEL Publishers. 1990. pp-135.
My CV: Download
Education
::
M.Sc. in Chemistry,
University of Calcutta, Kolkata, India, 1973-1974
::
Ph.D. in Molecular Biophysics,
Indian Institute of Science, Bangalore, India
Honors and Awards
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2010, D.Sc. (Honoris causa), Kalyani University
::
2010, Nayadumma Awards
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2009, D.Sc. (Honoris causa), Vidyasagar University, West Bengal
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2009, 2008 Shri Om Prakash Bhasin Award for S&T (Biotechnology), Shri O. P. B.Foundation for S&T
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2009, The Jagadis Chandra Bose Medal (2007), INSA
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2009, SS Bhatnagar Memorial Award and Gold Medal
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2008, Distinguished Alumni IISc, IISc Alumni Association
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2008, 6th Biospectrum person of the year-2008, Biospectrum
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2008, Prof. M.V. Pylee Lifetime Achievement Award
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2008, 2005 VASVIK Award for Biological S&T, Vividhlaxi Audyogik Samshodhan Vikas Kendra
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2007, Chemcon Distinguished Speaker Award
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2007, Padma Bhushan Dr. R.A.Mashelkar Medal, Asian Paints
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2007, Dhirubhai Ambani Oration Award
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2007, H. K. Firodia Awards For Excellence In Science and Technology, H.K. Firodia Memorial Foundation
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2005, Dr. B.R. Ambedkar Centenary Award for excellence in biomedical research, Indian Council of Medical Research
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2004, Prof. P.K. Bose Memorial Award, Indian Chemical Society
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2003, C. R. Krishnamurthy Oration Award, CDRI
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2003, B. K. Bachhawat Oration Lecture Award, JNU
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2003, Goyal Prize 2001, Life Sciences, Kurukshetra University
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2002, Ranbaxy Research Award for The Year 2001 in the field of Medical Sciences – Medical Research, Ranbaxy Science Foundation
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2000, Millennium Medal, Indian Science Congress
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1999, FICCI Award 1998-99 in recognition of individual initiative in Life Sciences including agriculture, Federation of Indian Chambers of Commerce and Industry
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1998, C. R. Krishnamurthy Oration Award, Society of Biological Chemists,India
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1990, Shanti Swarup Bhatnagar Award in Biological Sciences, Council of Scientific & Industrial Research, India
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1990, Cama Memorial Award, Society of Biological Chemists, India
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1981, Kani medal, National Cancer Research Centre,Tokyo, Japan
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1979, Young scientist medal, Indian National Science Academy
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1968, National Science Talent Search Scholarship, NCERT, India
Member
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2009-2011, Member of the international Advisory Panel on Biotechnology Development of Malaysia
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2010, Fellow of Indian National Academy of Engineering, Indian National Academy of Engineering, New Delhi
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2010, International Panel Reviewer for the Malaysian Cohort project of the Ministry of Science, Technology and Innovation, Malaysia
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2010, Member of the Board of Advisors of Journal of Biomolecular Structure and Dynamics
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2006-till date, Regional Editor for South Asian Countries for the Journal Genomic Medicine
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2006, Advisory Committee of Special Centre for Molecular Medicine, Jawaharlal Nehru University, New Delhi
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2005, Fellow of Biotech Research Society of India, Regional Research Laboratory, Trivandrum
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2005-till date, Chairman, Working Group on Bioinformatics Research and Development, Ministry of Communication and Information Technology, Government of India
::
2005, Medical Biotechnology Development Board, Ministry of S & T, Department of Biotechnology, India
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2005, CSIR Working Group for the formulation of XI th Five Year Plan
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2004, Elected Council Member, Human Genome Organisation
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2004-2007, Research Council, Central Drug Research Institute, Lucknow
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2004, Steering Committee on Technology Financing in India – A National Initiative, Department of Science & Technology, India
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2004-2007, Elected Member of the Human Genome Organisation Council
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2001-2007, Research Council, Centre for Cellular and Molecular Biology, Hyderabad
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2000, Fellowship of the National Academy of Sciences, Allahabad, National Academy of Sciences
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1995, Elected Council Member Biochemistry and Molecular Biology, Federation of Asian & Oceanic
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1995, Fellowship of the Indian National Science Academy, Indian National Science Academy
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1994, Task Force on Human Genetics, Department of Biotechnology, Government of India
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1994, National Organizing Committee, XVI IUBMB Congress, New Delhi
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1993-1995 & 1987-1989, General Secretary, Society of Biological Chemists, India
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1993-1998, Chemical Sciences and Technology Research Committee, CSIR
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1991, Elected member, Human Genome Organization
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1991-1997, Editorial Board, Journal of Biosciences
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1991, Fellowship of the Indian Academy of Sciences, Indian Academy of Sciences
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1991, Human Genome Organization
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1990-1994, Task Force on Medical Biotechnology, Dept. of Biotechnology, Government of India
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1987, Executive committee member, Society of Biological Chemists, India
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1986, Elected member, Guha Research Conference, India
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Animal Ethics Committee, Delhi University South Campus
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Management Council, Institute of Microbial Technology, Chandigarh
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Research Council, National Institute of Science, Technology and Development Studies, New Delhi
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Academic Committee, National Institute of Immunology, New Delhi
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Advisory Committee of the Biotechnology Teaching Programme, Ambedkar Centre for Biomedical Research, Delhi
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Society, Governing Body, and Finance Committee, National Brain Research Centre, New Delhi
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Board of Governors, National Institute of Pharmaceutical Education & Research, Punjab
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Sectional Committee-IX of Indian National Science Academy. INSA Medal for Young Scientists, New Delhi
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Performance Appraisal Board, Council of Scientific & Industrial Research, New Delhi
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Advisory Committee, CSIR Young Scientists Award on Biological Sciences for the year 2000, New Delhi
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Chairman, Research Advisory Committee, National Bureau of Animal Genetic Resources, Karnal
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Visitors nominee, Selection committee for teaching post, Centre for Molecular Medicine, Jawaharlal Nehru University, New Delhi
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Recombinant Drug advisory Panel, Ministry of Health and Family welfare, Government of India
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Task Force Madhya Pradesh Expert Committee for Life Sciences
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Maharashtra Biotech Commission
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Kelkar high power Committee of CSIR
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Task Force Himachal Pradesh
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Area Coordinator, Life Sciences, Integrated Long Term Programme, Department of Science and Technology, New Delhi
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Chairman, CSIR Committee for Optimising the CSIR support staff in various streams in the global context
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CSIR Change Team for the implementation of recommendation of Kelkar Committee
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Indian Council of medical Research for preparing the XI th Five Year Plan document
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Committees for preparing plan and budget of Biology & Biotechnology and Drug, Pharma & Healthcare Sectors of CSIR, India
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Advisory Board Member, Journal of Biochemistry, Molecular Biology & Biophysics. The official journal of FAOBMB
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Advisory group on Biotechnology & Human Rights to H. R. High Commission, Geneva
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India-European Commission S&T Steering Committee responsible for Genomics & Biotechnology for Health
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Advisory Board member for Archon-X prize for genomics, X-Prize foundation, USA