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Rakesh Kumar Tyagi, Ph.D.
Associate Professor 
Special Centre for Molecular Medicine
Jawaharlal Nehru University
New Delhi - 110 067   
Phone: +91-11-26738741, 26704559
Fax: +91-11-26731781
Positions Held:
Position Affiliation Time Period
Assistant Professor Special Centre for Molecular Medicine, Jawaharlal Nehru University, New Delhi, India 2009
Chairman Centre for Molecular Medicine, Jawaharlal Nehru University, New Delhi, India 2007-2009
Visiting Scientist Department of Biomedical Sciences, Bharathidasan University, Tiruchirappalli, India 2006
Assistant Professor Special Centre for Molecular Medicine, Jawaharlal Nehru University, New Delhi, India 2001-2005
Visiting Fellow University of Texas Health Science Center, Texas, USA 1998-2001
French Medical Research Fellow Foundation pour la Recherche Medicale, France 1997-1998
INSERM International Fellow Institut National de la Santé et de la Recherche Médicale (INSERM), Paris, France 1995-1997
Feinberg fellow The Weizmann Institute of Science, Israel 1993-1995
Area of Specialization:
Molecular Biology


1. Amazit, L., Roseau, A., Khan A.J., Chauchereau, A., Tyagi, R.K., Loosfelt, H., Leclerc, P., Lombes, M., Guiochon-Mantel, A. Ligand-dependent Degradation of SRC-1 is Pivotal for Progesterone Receptor Transcriptional Activity. Molecular Endocrinology. 2011 (in press)

Biswas, A., Pasquel, D., Tyagi, R.K., Mani, S. Acetylation of Pregnane X Receptor protein determines selective function independent of ligand activation. Biochemical and biophysical research communications. 2011 (in press)

1. Chaturvedi, N. K., Kumar, S., Negi, S. and Tyagi, R. K.  Endocrine disruptors provoke differential modulatory responses on androgen receptor and pregnane and xenobiotic receptor: potential implications in metabolic disorders. Molecular and Cellular Biochemistry. 2010.  345, 291-308. [PubMed]
2. Kumar, S., Jaiswal, B., Kumar, S., Negi, S. and Tyagi, R. K.  Cross-talk between androgen receptor and pregnane and xenobiotic receptor reveals existence of a novel modulatory action of anti-androgenic drugs. Biochemical Pharmacology. 2010.  80, 964-976. [PubMed]
3. Pondugula, S. R., Brimer-Cline, C., Wu, J., Schuetz, E. G., Tyagi, R. K. and Chen, T.  A phosphomimetic mutation at threonine-57 abolishes transactivation activity and alters nuclear localization pattern of human pregnane x receptor. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 2009.  37, 719-730. [PubMed]
4. Kumar, S., Chaturvedi, N. K., Kumar, S. and Tyagi, R. K.  Agonist-mediated docking of androgen receptor onto the mitotic chromatin platform discriminates intrinsic mode of action of prostate cancer drugs. Biochimica et Biophysica Acta. 2008.  1783, 59-73. [PubMed]
5. Sharma, M., Hanchate, N. K., Tyagi, R. K. and Sharma, P.  Cyclin dependent kinase 5 (Cdk5) mediated inhibition of the MAP kinase pathway results in CREB down regulation and apoptosis in PC12 cells. Biochemical and Biophysical Research Communications. 2007.  358, 379-384. [PubMed]
6. Gupta, M. K., Neelakantan, T. V., Sanghamitra, M., Tyagi, R. K., Dinda, A., Maulik, S., Mukhopadhyay, C. K. and Goswami, S. K.  An assessment of the role of reactive oxygen species and redox signaling in norepinephrine-induced apoptosis and hypertrophy of H9c2 cardiac myoblasts. Antioxidants & Redox Signaling. 2006.  8, 1081-1093. [PubMed]
7. Kumar, S., Saradhi, M., Chaturvedi, N. K. and Tyagi, R. K.  Intracellular localization and nucleocytoplasmic trafficking of steroid receptors: an overview. Molecular and Cellular Endocrinology. 2006.  246, 147-156. [PubMed]
8. Saradhi, M., Sengupta, A., Mukhopadhyay, G. and Tyagi, R. K.  Pregnane and Xenobiotic Receptor (PXR/SXR) resides predominantly in the nuclear compartment of the interphase cell and associates with the condensed chromosomes during mitosis. Biochimica et Biophysica Acta. 2005.  1746, 85-94. [PubMed]
9. Saradhi, M., Krishna, B., Mukhopadhyay, G. and Tyagi, R. K.  Purification of full-length human pregnane and xenobiotic receptor: polyclonal antibody preparation for immunological characterization. Cell Research. 2005.  15, 785-795. [PubMed]
10. Sengupta, A., Banerjee, B., Tyagi, R. K. and Datta, K.  Golgi localization and dynamics of hyaluronan binding protein 1 (HABP1/p32/C1QBP) during the cell cycle. Cell Research. 2005.  15, 183-186. [PubMed]
11. Kumar, S., Chaturvedi, N. K., Nishi, M., Kawata, M. and Tyagi, R. K.  Shuttling components of nuclear import machinery involved in nuclear translocation of steroid receptors exit nucleus via exportin-1/CRM-1* independent pathway. Biochimica et Biophysica Acta. 2004.  1691, 73-77. [PubMed]
12. Sengupta, A., Tyagi, R. K. and Datta, K.  Truncated variants of hyaluronan-binding protein 1 bind hyaluronan and induce identical morphological aberrations in COS-1 cells. The Biochemical Journal. 2004.  380, 837-844. [PubMed]
13. Tyagi R. K.  Dynamics of subcellular compartmentalization of steroid receptors in living cells as a strategic screening method to determine the biological impact of suspected endocrine disruptors. Medical Hypotheses. 2003.  60, 501-504. [PubMed]
14. Tyagi, R. K. and Datta, K.  A rapid, high-yield purification of L-alanine:4,5-dioxovalerate transaminase from rat kidney mitochondria using an improved enzyme assay method. Protein Expression and Purification. 1994.  5, 527-533. [PubMed]
15. Tyagi, R. K., Babu, B. R. and Datta, K.  Simultaneous determination of native and subunit molecular weights of proteins by pore limit electrophoresis and restricted use of sodium dodecyl sulfate. Electrophoresis. 1993.  14, 826-828. [PubMed]
16. Tyagi, R. K. and Datta, K.  In vitro translocation of L-alanine:4,5-dioxovalerate transaminase into rat kidney mitochondria. Journal of Biochemistry. 1993.  113, 557-562. [PubMed]
17. Singh, N. K., Tyagi, R. K. and Datta, K.  Cytosolic L-alanine:4,5-dioxovalerate transaminase differs from the mitochondrial form. European Journal of Biochemistry / FEBS. 1991.  198, 581-587. [PubMed]
18. Tyagi, R. K. and Datta, K.  Localization of L-alanine: 4,5-dioxovalerate transaminase in the matrix of the rat kidney mitochondria. Biochemistry International. 1991.  23, 999-1006. [PubMed]
19. Tyagi, R. K., Azrad, A., Degani, H. and Salomon, Y.  Simultaneous extraction of cellular lipids and water-soluble metabolites: evaluation by NMR spectroscopy. Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine. 1996.  35, 194-200. [PubMed]
20. Tyagi, R. K., Amazit, L., Lescop, P., Milgrom, E. and Guiochon-Mantel, A.  Mechanisms of progesterone receptor export from nuclei: role of nuclear localization signal, nuclear export signal, and ran guanosine triphosphate. Molecular Endocrinology. 1998.  12, 1684-1695. [PubMed]
21. Tyagi, R. K., Lavrovsky, Y., Ahn, S. C., Song, C. S., Chatterjee, B. and Roy, A. K.  Dynamics of intracellular movement and nucleocytoplasmic recycling of the ligand-activated androgen receptor in living cells. Molecular Endocrinology. 2000.  14, 1162-1174. [PubMed]
22. Roy, A. K., Tyagi, R. K., Song, C. S., Lavrovsky, Y., Ahn, S. C., Oh, T. S. and Chatterjee, B.  Androgen receptor: structural domains and functional dynamics after ligand-receptor interaction. Annals of the New York Academy of Sciences. 2001.  949, 44-57. [PubMed]


Grant Support:
Project Title Role Funding Agency Sanction Number Sanction Date
Role of pregnanae X receptor (PXR) in lung cancer Bangalore Science Foundation, Bangalore, India 2004-2006
Mechanisms of inhibition of transcriptional activity of androgen receptor by antagonists/endocrine disruptors Council of Scientific and Industrial Research, Government of India 2003-2006
Investigation into androgen-independent activation of androgen receptor in prostate cancer 2003-2006


Honors and Awards
Gold medal oration award by the Society of Reproductive Biology and Comparative Endocrinology (SRBCE) for significant contribution in the area of Molecular and Cellular Endocrinology.
2010, Fellow of the National Academy of Sciences (NASI), Allahabad
2009, Awarded Fellow in Reproduction and Endocrinology by Society of Reproductive Biology and Comparative Endocrinology
1997, Awarded French Medical Research Fellowship by Foundation pour la Recherche Medicale
1995, Awarded INSERM (post verte) International Fellowship, France
1993, Awarded Feinberg fellowship of The Weizmann Institute of Science, Israel
1992, Recipient of S.R.V. Rao award to Young Scientist by Indian Society of Cell Biology
Editorial Board member: Journal of Endocrinology and Reproduction
Ad hoc Reviewer for- Journal of Histochemistry and Cytochemistry, Biochimica Biophysica Acta, Molecular Cell Research, FEBS Letters, BMC Cancer, Indian Journal of Pharmacology
Indian Society of Cell Biology
Ph.D. admission committees, National Institute of Immunology, National Institute for Plant Genome Research, New Delhi
Society of Reproduction Biology and Comparative Endocrinology, India
Society of Biological Chemists, India
  Last modified on : Dec 16, 2015
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