INCREDB ID : 155
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Rakesh Kumar Tyagi, Ph.D.
Associate Professor 
 
Special Centre for Molecular Medicine
Jawaharlal Nehru University
New Delhi - 110 067   
 
E-mail: rktyagi@yahoo.com, rkt2300@mail.jnu.ac.in
Phone: +91-11-26738741, 26704559
Fax: +91-11-26731781
 
URL: http://www.jnu.ac.in/Faculty/rtyagi
 
Positions Held:
Position Affiliation Time Period
Assistant Professor Special Centre for Molecular Medicine, Jawaharlal Nehru University, New Delhi, India 2009
Chairman Centre for Molecular Medicine, Jawaharlal Nehru University, New Delhi, India 2007-2009
Visiting Scientist Department of Biomedical Sciences, Bharathidasan University, Tiruchirappalli, India 2006
Assistant Professor Special Centre for Molecular Medicine, Jawaharlal Nehru University, New Delhi, India 2001-2005
Visiting Fellow University of Texas Health Science Center, Texas, USA 1998-2001
French Medical Research Fellow Foundation pour la Recherche Medicale, France 1997-1998
INSERM International Fellow Institut National de la Santé et de la Recherche Médicale (INSERM), Paris, France 1995-1997
Feinberg fellow The Weizmann Institute of Science, Israel 1993-1995
 
Area of Specialization:
Molecular Biology
Publications:
1. Chaturvedi, N. K., Kumar, S., Negi, S. and Tyagi, R. K.  Endocrine disruptors provoke differential modulatory responses on androgen receptor and pregnane and xenobiotic receptor: potential implications in metabolic disorders. Molecular and Cellular Biochemistry. 2010.  345, 291-308. [PubMed]
2. Kumar, S., Jaiswal, B., Kumar, S., Negi, S. and Tyagi, R. K.  Cross-talk between androgen receptor and pregnane and xenobiotic receptor reveals existence of a novel modulatory action of anti-androgenic drugs. Biochemical Pharmacology. 2010.  80, 964-976. [PubMed]
3. Pondugula, S. R., Brimer-Cline, C., Wu, J., Schuetz, E. G., Tyagi, R. K. and Chen, T.  A phosphomimetic mutation at threonine-57 abolishes transactivation activity and alters nuclear localization pattern of human pregnane x receptor. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 2009.  37, 719-730. [PubMed]
4. Kumar, S., Chaturvedi, N. K., Kumar, S. and Tyagi, R. K.  Agonist-mediated docking of androgen receptor onto the mitotic chromatin platform discriminates intrinsic mode of action of prostate cancer drugs. Biochimica et Biophysica Acta. 2008.  1783, 59-73. [PubMed]
5. Sharma, M., Hanchate, N. K., Tyagi, R. K. and Sharma, P.  Cyclin dependent kinase 5 (Cdk5) mediated inhibition of the MAP kinase pathway results in CREB down regulation and apoptosis in PC12 cells. Biochemical and Biophysical Research Communications. 2007.  358, 379-384. [PubMed]
6. Gupta, M. K., Neelakantan, T. V., Sanghamitra, M., Tyagi, R. K., Dinda, A., Maulik, S., Mukhopadhyay, C. K. and Goswami, S. K.  An assessment of the role of reactive oxygen species and redox signaling in norepinephrine-induced apoptosis and hypertrophy of H9c2 cardiac myoblasts. Antioxidants & Redox Signaling. 2006.  8, 1081-1093. [PubMed]
7. Kumar, S., Saradhi, M., Chaturvedi, N. K. and Tyagi, R. K.  Intracellular localization and nucleocytoplasmic trafficking of steroid receptors: an overview. Molecular and Cellular Endocrinology. 2006.  246, 147-156. [PubMed]
8. Saradhi, M., Sengupta, A., Mukhopadhyay, G. and Tyagi, R. K.  Pregnane and Xenobiotic Receptor (PXR/SXR) resides predominantly in the nuclear compartment of the interphase cell and associates with the condensed chromosomes during mitosis. Biochimica et Biophysica Acta. 2005.  1746, 85-94. [PubMed]
9. Saradhi, M., Krishna, B., Mukhopadhyay, G. and Tyagi, R. K.  Purification of full-length human pregnane and xenobiotic receptor: polyclonal antibody preparation for immunological characterization. Cell Research. 2005.  15, 785-795. [PubMed]
10. Sengupta, A., Banerjee, B., Tyagi, R. K. and Datta, K.  Golgi localization and dynamics of hyaluronan binding protein 1 (HABP1/p32/C1QBP) during the cell cycle. Cell Research. 2005.  15, 183-186. [PubMed]
11. Kumar, S., Chaturvedi, N. K., Nishi, M., Kawata, M. and Tyagi, R. K.  Shuttling components of nuclear import machinery involved in nuclear translocation of steroid receptors exit nucleus via exportin-1/CRM-1* independent pathway. Biochimica et Biophysica Acta. 2004.  1691, 73-77. [PubMed]
12. Sengupta, A., Tyagi, R. K. and Datta, K.  Truncated variants of hyaluronan-binding protein 1 bind hyaluronan and induce identical morphological aberrations in COS-1 cells. The Biochemical Journal. 2004.  380, 837-844. [PubMed]
13. Tyagi R. K.  Dynamics of subcellular compartmentalization of steroid receptors in living cells as a strategic screening method to determine the biological impact of suspected endocrine disruptors. Medical Hypotheses. 2003.  60, 501-504. [PubMed]
14. Tyagi, R. K. and Datta, K.  A rapid, high-yield purification of L-alanine:4,5-dioxovalerate transaminase from rat kidney mitochondria using an improved enzyme assay method. Protein Expression and Purification. 1994.  5, 527-533. [PubMed]
15. Tyagi, R. K., Babu, B. R. and Datta, K.  Simultaneous determination of native and subunit molecular weights of proteins by pore limit electrophoresis and restricted use of sodium dodecyl sulfate. Electrophoresis. 1993.  14, 826-828. [PubMed]
16. Tyagi, R. K. and Datta, K.  In vitro translocation of L-alanine:4,5-dioxovalerate transaminase into rat kidney mitochondria. Journal of Biochemistry. 1993.  113, 557-562. [PubMed]
17. Singh, N. K., Tyagi, R. K. and Datta, K.  Cytosolic L-alanine:4,5-dioxovalerate transaminase differs from the mitochondrial form. European Journal of Biochemistry / FEBS. 1991.  198, 581-587. [PubMed]
18. Tyagi, R. K. and Datta, K.  Localization of L-alanine: 4,5-dioxovalerate transaminase in the matrix of the rat kidney mitochondria. Biochemistry International. 1991.  23, 999-1006. [PubMed]
19. Tyagi, R. K., Azrad, A., Degani, H. and Salomon, Y.  Simultaneous extraction of cellular lipids and water-soluble metabolites: evaluation by NMR spectroscopy. Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine. 1996.  35, 194-200. [PubMed]
20. Tyagi, R. K., Amazit, L., Lescop, P., Milgrom, E. and Guiochon-Mantel, A.  Mechanisms of progesterone receptor export from nuclei: role of nuclear localization signal, nuclear export signal, and ran guanosine triphosphate. Molecular Endocrinology. 1998.  12, 1684-1695. [PubMed]
21. Tyagi, R. K., Lavrovsky, Y., Ahn, S. C., Song, C. S., Chatterjee, B. and Roy, A. K.  Dynamics of intracellular movement and nucleocytoplasmic recycling of the ligand-activated androgen receptor in living cells. Molecular Endocrinology. 2000.  14, 1162-1174. [PubMed]
22. Roy, A. K., Tyagi, R. K., Song, C. S., Lavrovsky, Y., Ahn, S. C., Oh, T. S. and Chatterjee, B.  Androgen receptor: structural domains and functional dynamics after ligand-receptor interaction. Annals of the New York Academy of Sciences. 2001.  949, 44-57. [PubMed]

 
Grant Support:
Project Title Role Funding Agency Sanction Number Sanction Date
Role of pregnanae X receptor (PXR) in lung cancer Bangalore Science Foundation, Bangalore, India 2004-2006
Mechanisms of inhibition of transcriptional activity of androgen receptor by antagonists/endocrine disruptors Council of Scientific and Industrial Research, Government of India 2003-2006
Investigation into androgen-independent activation of androgen receptor in prostate cancer Indian Council of Medical Research, Goverment of India 2003-2006

 
 
 
Education 
::
Ph.D.
Honors and Awards
::
2009, Awarded Fellow in Reproduction and Endocrinology by Society of Reproductive Biology and Comparative Endocrinology
::
1997, Awarded French Medical Research Fellowship by Foundation pour la Recherche Medicale
::
1995, Awarded INSERM (post verte) International Fellowship, France
::
1993, Awarded Feinberg fellowship of The Weizmann Institute of Science, Israel
::
1992, Recipient of S.R.V. Rao award to Young Scientist by Indian Society of Cell Biology
Member
::
Editorial Board member: Journal of Endocrinology and Reproduction
::
Ad hoc Reviewer for- Journal of Histochemistry and Cytochemistry, Biochimica Biophysica Acta, Molecular Cell Research, FEBS Letters, BMC Cancer, Indian Journal of Pharmacology
::
Indian Society of Cell Biology
::
Ph.D. admission committees, National Institute of Immunology, National Institute for Plant Genome Research, New Delhi
::
Society of Reproduction Biology and Comparative Endocrinology, India
::
Society of Biological Chemists, India
  Last modified on : Mar 4, 2011
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