INCREDB ID : 153
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Pratibha Mehta Luthra, Ph.D.
Associate Professor 
 
Dr. B.R. Ambedkar Center for Biomedical Research
University of Delhi
New Delhi - 110 007   
 
E-mail: pmluthra@acbr.du.ac.in, luthrapratibha@rediffmail.com
Phone: +91-11-27662778
 
URL: http://www.acbrdu.edu/rf.html
 
Positions Held:
Position Affiliation Time Period
Associate Professor Dr. B.R. Ambedkar Center for Biomedical Research, Delhi, India 1997-Present
Pool Officer Central Institute of Medicinal and Aromatic Plants, Lucknow, India 1994-1997
Post Doctoral Fellowship Eppley Institute, Omaha, NE, USA 1990-1993
Post Doctoral Fellowship University College London, UK 1988-1990
Post Doctoral Fellowship University of Liverpool, UK 1987-1988
 
Area of Specialization:
Medicinal Chemistry
Research Summary:
The development of anti-parkinsonian anti-tumor compounds for brain tumors
Anti-microbial and anti-cancer compounds from natural products
Bioassay guided lead identification of compounds from natural products for anti-microbial and anti-cancer activity
 
Publications:

 

1. Kidwai, M., Bhatnagar, D., Kumar, R. and Luthra, P. M.  Synthesis of 2-oxo/thioxooctahydroquinazolin-5-one derivatives and their evaluation as anticancer agents. Chemical & Pharmaceutical Bulletin. 2010.  58, 1320-1323. [PubMed]
2. Kidwai, M., Poddar, R., Bhardwaj, S., Singh, S. and Luthra, P. M.  Aqua mediated synthesis of 2-amino-6-benzothiazol-2-ylsulfanyl-chromenes and its in vitro study, explanation of the structure-activity relationships (SARs) as antibacterial agent. European Journal of Medicinal Chemistry. 2010.  45, 5031-5038. [PubMed]
3. Barodia, S. K., Mishra, C. B., Prakash, A., Senthil, K., Kumari, N. and Luthra, P. M.  Novel 8-(furan-2-yl)-3-benzyl thiazolo [5,4-e][1,2,4] triazolo [1,5-c] pyrimidine-2(3H)-thione as selective adenosine A(2A) receptor antagonist. Neuroscience Letters. 2011.  488, 1-5. [PubMed]
4. Mishra, C. B., Barodia, S. K., Prakash, A., Senthil, K. and Luthra, P. M.  Novel 8-(furan-2-yl)-3-substituted thiazolo [5,4-e][1,2,4] triazolo[1,5-c] pyrimidine-2(3H)-thione derivatives as potential adenosine A(2A) receptor antagonists. Bioorganic & Medicinal Chemistry. 2010.  18, 2491-2500. [PubMed]
5. Luthra, P. M. and Singh, S.  Identification and optimization of tyrosine hydroxylase activity in Mucuna pruriens DC. var. utilis. Planta. 2010.  231, 1361-1369. [PubMed]
6. Luthra, P. M., Mishra, C. B., Jha, P. K. and Barodia, S. K.  Synthesis of novel 7-imino-2-thioxo-3,7-dihydro-2H-thiazolo [4,5-d] pyrimidine derivatives as adenosine A2A receptor antagonists. Bioorganic & Medicinal Chemistry Letters. 2010.  20, 1214-1218. [PubMed]
7. Aneja, R., Luthra, P. M. and Ahuja, S.  High-performance liquid chromatography separation of enantiomers of mandelic acid and its analogs on a chiral stationary phase. Chirality. 2010.  22, 479-485. [PubMed]
8. Luthra, P. M., Prakash, A., Barodia, S. K., Kumari, R., Mishra, C. B. and Kumar, J. B.  In silico study of naphtha [1, 2-d] thiazol-2-amine with adenosine A 2A receptor and its role in antagonism of haloperidol-induced motor impairments in mice. Neuroscience Letters. 2009.  463, 215-218. [PubMed]
9. Luthra, P. M., Kumar, R. and Prakash, A.  Demethoxycurcumin induces Bcl-2 mediated G2/M arrest and apoptosis in human glioma U87 cells. Biochemical and Biophysical Research Communications. 2009.  384, 420-425. [PubMed]
10. Luthra, P. M., Barodia, S. K. and Raghubir, R.  Antagonism of haloperidol-induced swim impairment in L-dopa and caffeine treated mice: a pre-clinical model to study Parkinson's disease. Journal of Neuroscience Methods. 2009.  178, 284-290. [PubMed]
11. Luthra, Pratibha Mehta , Barodia, S.K. and Raghubir, R. Antagonism of haloperidol-induced swim impairment in L-dopa and caffeine treated mice: a pre-clinical model to study Parkinson's disease. Journal of Neuroscience Methods. 2009. 178, 2. 284-90.
12. Sharma, S, Luthra, Pratibha Mehta, Singh, Y., Sirdeshmukh, R., Gade, W.N.Role of proteins in resistance mechanism of Pseudomonas fluorescens against heavy metal induced stress with proteomics approach. Journal of Biotechnology. 2006. 126, 3. 374-82.
13. Gangenahalli, G.U. Singh, V.K., Verma, Y.K., Gupta,P., Sharma, R. K., Chandra, R., and Luthra, Pratibha Mehta. Hematopoietic Stem Cell Antigen CD34: Role in Adhesion or Homing. Stem Cells Development. 2006. 15, 3. 305-13.
14. Gangenahalli, G.U. Singh, V.K., Verma, Y.K., Gupta,P., Sharma, R. K., Chandra, R., Gulati, S. and Luthra, Pratibha Mehta. Three-dimensional structure prediction of the interaction of CD34 with the SH3 domain of Crk-L. Stem Cells Development. 2005. 14, 5. 470-7.
15. R. Singh, R. Chandra, M. Bose, Luthra, Pratibha Mehta. 2002. Antibacterial activity of Curcuma longa rhizome extract on pathogenic bacteria. Current Science. 2002. 83, 6. 737-740.
16. Ganellin, C. R. Bishop, P.B., Bambal, R.B., Chan, S.M.T. Law, J.K. Marabout, B., Luthra Pratibha Mehta, Moore, A.N.J., Peschard, O., Bourgeat, P., Rose, C., Vargas, F. and Schwartz, J-C. Inhibitors of Tripeptidyl peptidase II.2. Generation of first novel lead inhibitor of cholecystokinin-8-inactvating peptidase: a strategy for the design of peptidase inhibitors. Journal of Medical Chemistry. 2000. 43.  664-674.
17. Mehta, Pratibha, Saxena, A. K ., Gulati, A. and Anand, N. . Synthesis of substituted pyrido [3,4-b] indoles-3-carboxamides and related compounds as benzodiazepine receptor agonist and antagonists. Indian Journal of  Chemistry. 1998. B 27, 140-143.
18. Mehta , Pratibha, Church, K., Williams, J., Chen, F-X, Encell, L. , Shuker D.E.G. and Gold B.  The design of agents to control DNA methylaton adducts. Enhanced major groove methylation of DNA by an N-methyl-Nnitrosoureas functionalised phenylneutral red intercalator. Chemical Reserch Toxicology. 1996.  9, 6.  948.
19. Yhang, Y., Chen, Fa-Xian, Mehta, Pratibha and Gold B. Groove and sequence selective alkylation of DNA by sulfonate esters tethered to Lexitropsins. Biochemistry. 1993. 32. 7954-7965.
20. Mehta, Pratibha, Konakahara, T. and Gold, B.  A convenient method to synthesize N [3 H ]methyl-Nnitrosocarbamate transfer reagents. Journal of Labeled Comp. and Radiopharm. 1992. 31, 11.  925-931.
21. Mehta, Pratibha, Kumar, Y., Saxena, A. K ., Gulati, A., Singh, H.K. and Anand, N. Synthesis of cis and trans-1- substituted-1,2,3,4,4a5,6,11a-octahydro-6H-pyrido [3,2-b]carbazoles, 4-substituted-1,2,3,4,4a,5,6,11c-octahydro- 7Hpyrido [2,3-c]carbazole, cis-methyl-1,2,3,4,4a,5,6,12–octahydro-7H-pyrido[2,3-c]acridine and cis-1-methyl- 2,3,4,4a,5,12,12a-octahydro[3,2-b]acridine, A new class of anti-Parkinsonian agents. Indian Journal of Chemistry.  1991.  30, 2. 213-221.

 
Grant Support:
Project Title Role Funding Agency Sanction Number Sanction Date
Synthesis of selective adenosine A2a receptor antagonists as anti-Parkinsonian agents and study their interaction with adenosine A2areceptors Principal Investigator Council of Scientific and Industrial Research, Government of India 2004-2008
Synthesis of 5-substituted octahydropyridocarbazoles, octahydropyrido-pyridocarbazoles and their biological evaluation on dopamine D1 receptor as potential anti-Parkinsonian agents Principal Investigator Department of Biotechnology, Government of India 2006-2010
Synthesis of DNA intercalator ellipticine tethered to DNA alkylating agent N-methyl-N-nitrosourea to study the relationship between groove and sequence selective alkylation of DNA and cyto-toxicity of brain tumors Principal Investigator Department of Science & Technology, Government of India 2007-2010
Synthesis of ar-turmerone and its analogues to study the mechanism of action of anti-fungal activity and Study the molecular mechanism of Chemopreventive and Chemoprotective Activity of Curcumin, A Natural Product From Curcuma longa Principal Investigator Department of Science & Technology, Government of India 2009-2012
Synthesis of selective adenosine A2a receptor antagonists as anti-Parkinsonian agents and study their interaction with adenosine A2a receptors Principal Investigator Council of Scientific and Industrial Research, Government of India 2010-2013
Establishment of High Resolution NMR [400 MHz] Central Facility for Biomedical Research, at Dr. B.R. Ambedkar Centre for Biomedical Research, University of Delhi Principal Investigator Department of Science & Technology, Government of India 2008-2013
Renovation and Modernization of Animal House Facility at Dr. B.R. Ambedkar Center for Biomedical Research, University of Delhi Principal Investigator Department of Science & Technology, Government of India 2009-2014

 
 
My CV:   Download
 
Education 
::
Ph.D. in Medicinal Chemistry, Central Drug Research Institute, Lucknow, India
Honors and Awards
::
1999-2002,Consultant, Central Revenue Control Laboratory, Ministry of Finance, Government of India
::
2007, Visiting Scientist, American Radiochemical Company, St. Louis, USA
Member
::
Society for Biotechnologists, India
::
American Chemical Society
::
Graduate Member, Royal Society of Chemistry
::
Chemical Society for Analytical Scientists, India
  Last modified on : Mar 4, 2011
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