Sandip K. Mishra,                               Ph.D. 
                               
                              Scientist D  
                           
                         
                                  
         
                                                    
                                                    
                            Institute of Life Sciences 
                           
                                                                                                        
                            Nalco Square 
                           
                                                    
                            Bhubaneswar - 751 023                                 
                           
                                                    
                            Orissa                                 
                           						  
                                                            
                           
                                                    
                            E-mail: sandipkmishra@ils.res.in, sandipkmishra@hotmail.com 
                           
                                                                              
                            Phone: +91-674-2300702, +91-674-2300137, 2301476, Extn: 234 
                           
                                                    
                            Fax: +91-674-2300728  
                           
                  
                          
                               
                           
                          
                            URL:   http://ils.res.in/skmishra.htm  
                           
                          
                          						  
                              
                           
						  
	                             
                            Positions Held:  
                           
                                                    
                            
                                
                                  Position  
                                  Affiliation  
                                  Time Period   
                                 
                                                                
                                  Scientist D  
                                  Institute of Life Sciences, Bhubaneswar, India 
                                  
								  2007-Present 
                                 
                                                                
                                  Instructor  
                                  Department of Neurosurgery,University of Texas, MD Anderson Cancer Center, Houston, USA 
                                  
								  2004-2007 
                                 
                                                                
                                  Reader  
                                  Institute of Life Sciences, Bhubaneswar, India 
                                  
								  2004 
                                 
                                                                
                                  Post Doctoral Fellow  
                                  Dept. Molecular and Cellular Oncology, University of Texas, MD Anderson Cancer Center, Houston, USA 
                                  
								  2000-2004 
                                 
                                                                
                                  Project Associate  
                                  National Institute of Immunology, New Delhi, India 
                                  
								  1998-1999 
                                 
                                                            
 
                           
                          
                              
                           
                                                                              
                            Area of Specialization:  
                           
                          
                          
                          
  
     
    Molecular Oncology  
   
    
                          
                        
                           
                           
                         
                         
                                                    
                                                    
                          
                             
                           
                                                    
                             Research Summary:  
                           
                                                    
                            
                                                                
                                   
                                  Chromatin remodeling in breast cancer 
                                 
                                                            
 
                           
                          
                              
                           
                                                    
                            Publications:  
                           
                          
                            
	
		
			
				1. 
			
				Mishra, S. K. , Mandal, M., Mazumdar, A. and Kumar, R.  Dynamic chromatin remodeling on the HER2 promoter in human breast cancer cells. FEBS Letters.  2001.  507, 88-94. [PubMed]  
		 
		
			
				2. 
			
				Mazumdar, A., Wang, R. A., Mishra, S. K. , Adam, L., Bagheri-Yarmand, R., Mandal, M., Vadlamudi, R. K. and Kumar, R.  Transcriptional repression of oestrogen receptor by metastasis-associated protein 1 corepressor. Nature Cell Biology.  2001.  3, 30-37. [PubMed]  
		 
		
			
				3. 
			
				Talukder, A. H., Jorgensen, H. F., Mandal, M., Mishra, S. K. , Vadlamudi, R. K., Clark, B. F., Mendelsohn, J. and Kumar, R.  Regulation of elongation factor-1alpha expression by growth factors and anti-receptor blocking antibodies. The Journal of Biological Chemistry.  2001.  276, 5636-5642. [PubMed]  
		 
		
			
				4. 
			
				Prithivirajsingh, S., Mishra, S. K.  and Mahadevan, A.  Functional analysis of a chromosomal arsenic resistance operon in Pseudomonas fluorescens strain MSP3. Molecular Biology Reports.  2001.  28, 63-72. [PubMed]  
		 
		
			
				5. 
			
				Prithivirajsingh, S., Mishra, S. K.  and Mahadevan, A.  Detection and analysis of chromosomal arsenic resistance in Pseudomonas fluorescens strain MSP3. Biochemical and Biophysical Research Communications.  2001.  280, 1393-1401. [PubMed]  
		 
		
			
				6. 
			
				Li, F., Mandal, M., Mishra, S. K. , Barnes, C. J. and Kumar, R.  Heregulin promotes expression and subcellular redistribution of ADP-ribosylation factor 3. FEBS Letters.  2002.  524, 49-53. [PubMed]  
		 
		
			
				7. 
			
				Talukder, A. H., Mishra, S. K. , Mandal, M., Balasenthil, S., Mehta, S., Sahin, A. A., Barnes, C. J. and Kumar, R.  MTA1 interacts with MAT1, a cyclin-dependent kinase-activating kinase complex ring finger factor, and regulates estrogen receptor transactivation functions. The Journal of Biological Chemistry.  2003.  278, 11676-11685. [PubMed]  
		 
		
			
				8. 
			
				Mishra, S. K. , Mazumdar, A., Vadlamudi, R. K., Li, F., Wang, R. A., Yu, W., Jordan, V. C., Santen, R. J. and Kumar, R.  MICoA, a novel metastasis-associated protein 1 (MTA1) interacting protein coactivator, regulates estrogen receptor-alpha transactivation functions. The Journal of Biological Chemistry.  2003.  278, 19209-19219. [PubMed]  
		 
		
			
				9. 
			
				Cheema, S. K., Mishra, S. K. , Rangnekar, V. M., Tari, A. M., Kumar, R. and Lopez-Berestein, G.  Par-4 transcriptionally regulates Bcl-2 through a WT1-binding site on the bcl-2 promoter. The Journal of Biological Chemistry.  2003.  278, 19995-20005. [PubMed]  
		 
		
			
				10. 
			
				Barnes, C. J., Vadlamudi, R. K., Mishra, S. K. , Jacobson, R. H., Li, F. and Kumar, R.  Functional inactivation of a transcriptional corepressor by a signaling kinase. Nature Structural Biology.  2003.  10, 622-628. [PubMed]  
		 
		
			
				11. 
			
				Mishra, S. K. , Yang, Z., Mazumdar, A., Talukder, A. H., Larose, L. and Kumar, R.  Metastatic tumor antigen 1 short form (MTA1s) associates with casein kinase I-gamma2, an estrogen-responsive kinase. Oncogene.  2004.  23, 4422-4429. [PubMed]  
		 
		
			
				12. 
			
				Mishra, S. K. , Balasenthil, S., Nguyen, D. and Vadlamudi, R. K.  Cloning and functional characterization of PELP1/MNAR promoter. Gene.  2004.  330, 115-122. [PubMed]  
		 
		
			
				13. 
			
				Mishra, S. K. , Talukder, A. H., Gururaj, A. E., Yang, Z., Singh, R. R., Mahoney, M. G., Franci, C., Vadlamudi, R. K. and Kumar, R.  Upstream determinants of estrogen receptor-alpha regulation of metastatic tumor antigen 3 pathway. The Journal of Biological Chemistry.  2004.  279, 32709-32715. [PubMed]  
		 
		
			
				14. 
			
				Talukder, A. H., Gururaj, A., Mishra, S. K. , Vadlamudi, R. K. and Kumar, R.  Metastasis-associated protein 1 interacts with NRIF3, an estrogen-inducible nuclear receptor coregulator. Molecular and Cellular Biology.  2004.  24, 6581-6591. [PubMed]  
		 
		
			
				15. 
			
				Nair, S. S., Mishra, S. K. , Yang, Z., Balasenthil, S., Kumar, R. and Vadlamudi, R. K.  Potential role of a novel transcriptional coactivator PELP1 in histone H1 displacement in cancer cells. Cancer Research.  2004.  64, 6416-6423. [PubMed]  
		 
		
			
				16. 
			
				Amano, T., Nakamizo, A., Mishra, S. K. , Gumin, J., Shinojima, N., Sawaya, R. and Lang, F. F.  Simultaneous phosphorylation of p53 at serine 15 and 20 induces apoptosis in human glioma cells by increasing expression of pro-apoptotic genes. Journal of Neuro-oncology.  2009.  92, 357-371. [PubMed]  
		 
		
			
				17. 
			
				Sar, P., Peter, R., Rath, B., Das, M. and Mishra, S. K.  3, 3'5 Triiodo L thyronine induces apoptosis in human breast cancer MCF-7 cells, repressing SMP30 expression through negative thyroid response elements. PloS One.  2011.  6, e20861. [PubMed]  
		 
		
			
				18. 
			
				Sar, P., Bhargava, D. K., Sengupta, D., Rath, B., Chaudhary, S., and Mishra, S. K.  In Human Breast Cancer Cells TRβ Competes with ERα for Altering Bcl2/Bax ratio through SMP30-Mediated P53 Induction. Journal of Cancer Science & Therapy . 2012. In press.  
		 
		
			
				19. 
			
				Chaudhary, S., Panda, A. K.,Mishra, D. K. and Mishra, S. K.  Association of +331G/A PgR polymorphism with susceptibility to female reproductive cancer: Evidence from a meta-analysis. PloS One.  2013. In press.  
		 
		
			
				20. 
			
				Mishra, S. K. , Sengupta, D., Sar, P. and Bhargava, D. Molecular Basis of Aging and Breast Cancer. J  ournal of Cancer Science & Therapy.  2013. In press. Invited review.  
		 
		
			
				21. 
			
				Mishra, S. K. , Kumari, K. and Bhargava, D. A Review on EZH2 and its Epigenetic Association with Breast Cancer.  Journal of Cancer Research Updates.  2013. In press. Invited review.  
		 
	 
	 
  
                           
                         
                                                
 
                      
                          
                            
                                                                 
                                   
                             
                            
                                
                             
                            
                              
                                  
                                     
                                   
                                  
                                                                            
                                        
                                                                                    
                                            Education  
 
                                           
                                                                                    
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                                            Ph.D.                                                    				
				 
                                                                                                                            
 
                                           
                                                                                    
                                            Honors and Awards  
 
                                           
                                                                                    
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                                            2003, Amgen award in Basic Science Research at UT MD Anderson Cancer Center, Houston, Texas.                          
 
                                           
                                                                                    
                                            Member 
 
                                           
                                                                                    
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                                            Associate Editor - World Journal of Cancer Research  (American Scientific Publishers)  
 
                                           
                                                                                    
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                                            Editor - Journal of Cancer Science and Therapy