Arun Kumar Trivedi, Ph.D.
Scientist C
Central Drug Research Institute
DTDD Division
Lucknow - 226 001
Uttar Pradesh
E-mail: arun3vedi@cdri.res.in
URL: http://www.cdriindia.org/aruntrivedi.htm
Positions Held:
Position
Affiliation
Time Period
Scientist C
Central Drug Research Institute, Lucknow, India
Present
Area of Specialization:
Molecular Oncology
Research Summary:
Molecular biology of acute myeloid leukemia and role of C/EBPalpha in leukemogenesis
Molecular biology and pathogenesis of breast cancer: mechanism of action of anti-cancer drugs and compounds using mass spectrometry based proteomics approach
Publications:
1.
Bararia, D., Trivedi, A. K. , Zada, A. A., Greif, P. A., Mulaw, M. A., Christopeit, M., Hiddemann, W., Bohlander, S. K. and Behre, G. Proteomic identification of the MYST domain histone acetyltransferase TIP60 (HTATIP) as a co-activator of the myeloid transcription factor C/EBPalpha. Leukemia 2008. 22, 800-807. [PubMed]
2.
Trivedi, A. K. , Pal, P., Behre, G. and Singh, S. M. Multiple ways of C/EBPalpha inhibition in myeloid leukaemia. European Journal of Cancer. 2008. 44, 1516-1523. [PubMed]
3.
Singh, S. M., Trivedi, A. K. and Behre, G. C/EBPalpha S248A mutation reduces granulocytic differentiation in human leukemic K562 cells. Biochemical and Biophysical Research Communications. 2008. 369, 692-694. [PubMed]
4.
Geletu, M., Balkhi, M. Y., Peer, Z., Christopeit, M., Pulikkan, J. A., Trivedi, A. K. , Tenen, D. G. and Behre, G. Target proteins of C/EBPalphap30 in AML: C/EBPalphap30 enhances sumoylation of C/EBPalphap42 via up-regulation of Ubc9. Blood. 2007. 110, 3301-3309. [PubMed]
5.
Trivedi, A. K. , Bararia, D., Christopeit, M., Peerzada, A. A., Singh, S. M., Kieser, A., Hiddemann, W., Behre, H. M. and Behre, G. Proteomic identification of C/EBP-DBD multiprotein complex: JNK1 activates stem cell regulator C/EBPalpha by inhibiting its ubiquitination. Oncogene. 2007. 26, 1789-1801. [PubMed]
6.
Balkhi, M. Y., Trivedi, A. K. , Geletu, M., Christopeit, M., Bohlander, S. K., Behre, H. M. and Behre, G. Proteomics of acute myeloid leukaemia: Cytogenetic risk groups differ specifically in their proteome, interactome and post-translational protein modifications. Oncogene. 2006. 25, 7041-7058. [PubMed]
7.
Zada, A. A., Pulikkan, J. A., Bararia, D., Geletu, M., Trivedi, A. K. , Balkhi, M. Y., Hiddemann, W. D., Tenen, D. G., Behre, H. M. and Behre, G. Proteomic discovery of Max as a novel interacting partner of C/EBPalpha: a Myc/Max/Mad link. Leukemia 2006. 20, 2137-2146. [PubMed]
Education
::
M.Sc.
Banaras Hindu University, Varanasi, Uttar Pradesh, India
::
Ph.D.
Ludwig Maximilians University, Munich, Germany