INCREDB ID : 111
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Jackson James, Ph.D.
Scientist C 
 
Rajiv Gandhi Centre for Biotechnology
Neuro-Stem Cell Biology Laboratory
Thycaud P.O. box, Poojappura
Thiruvananthapuram - 695 014   
Kerala   
 
E-mail: jjames@rgcb.res.in
Phone: 0471-2529480
 
URL: http://rgcb.res.in/departments/neural_stem_cell_biology/jackson-james/profile.html
 
Positions Held:
Position Affiliation Time Period
Post Doctoral Fellowship University of Nebraska Medical Center, Omaha, USA 2000-2003
Post Doctoral Fellowship Sree Chitra Tirunal Institute for Medical Sciences & Technology, Kerala, India 1999-2000
 
Area of Specialization:
Molecular Neurobiology
Research Summary:
Transplantation of embryonic stem cells engineered to produce GABA into hippocampus of rats with temporal lobe epilepsy for possible control of seizures
Identify the role of notch and other signaling pathways in formation of new excitatory neural circuits through differentiation of in vivo hippocampal stem cells during temporal lobe epilepsy
Development of a cell therapy strategy to treat glaucoma using retinal ganglion cells generated from embryonic stem cells
Role of notch signaling in proliferation and maintenance of neural progenitors
Development of a biodegradable scaffold for transplanting cells into retina
Development of neuronal cell lines for drug screening
 
Publications:
1. Sanalkumar, R., Dhanesh, S. B. and James, J.  Non-canonical activation of Notch signaling/target genes in vertebrates. Cellular and Molecular Life Sciences : CMLS. 2010.  67, 2957-2968. [PubMed]
2. Indulekha, C. L., Sanalkumar, R., Thekkuveettil, A. and James, J.  Seizure induces activation of multiple subtypes of neural progenitors and growth factors in hippocampus with neuronal maturation confined to dentate gyrus. Biochemical and Biophysical Research Communications. 2010.  393, 864-871. [PubMed]
3. Sanalkumar, R., Indulekha, C. L., Divya, T. S., Divya, M. S., Anto, R. J., Vinod, B., Vidyanand, S., Jagatha, B., Venugopal, S. and James, J.  ATF2 maintains a subset of neural progenitors through CBF1/Notch independent Hes-1 expression and synergistically activates the expression of Hes-1 in Notch-dependent neural progenitors. Journal of Neurochemistry. 2010.  113, 807-818. [PubMed]
4. Sanalkumar, R., Vidyanand, S., Lalitha, I. and James, J.  Neuronal vs. glial fate of embryonic stem cell-derived neural progenitors (ES-NPs) is determined by FGF2/EGF during proliferation. Journal of Molecular Neuroscience : MN. 2010.  42, 17-27. [PubMed]
5. Raveendran, R., Devi, S., Mayadevi, M., Steephan, M., Santhoshkumar, T. R., Cheriyan, J., Sanalkumar, R., Pradeep, K. K., James, J. and Omkumar, R. V.  Phosphorylation status of the NR2B subunit of NMDA receptor regulates its interaction with calcium/calmodulin-dependent protein kinase II. Journal of Neurochemistry. 2009.  110, 92-105. [PubMed]
6. Jagatha, B., Divya, M. S., Sanalkumar, R., Indulekha, C. L., Vidyanand, S., Divya, T. S., Das, A. V. and James, J.  In vitro differentiation of retinal ganglion-like cells from embryonic stem cell derived neural progenitors. Biochemical and Biophysical Research Communications. 2009.  380, 230-235. [PubMed]
7. Saju, K. K., Reshmi, R., Jayadas, N. H., James, J. and Jayaraj, M. K.  Polycrystalline coating of hydroxyapatite on TiAl6V4 implant material grown at lower substrate temperatures by hydrothermal annealing after pulsed laser deposition. Proceedings of the Institution of Mechanical Engineers. Part H, Journal of Engineering in Medicine. 2009.  223, 1049-1057. [PubMed]
8. Das, A. V., James, J., Bhattacharya, S., Imbalzano, A. N., Antony, M. L., Hegde, G., Zhao, X., Mallya, K., Ahmad, F., Knudsen, E. and Ahmad, I.  SWI/SNF chromatin remodeling ATPase Brm regulates the differentiation of early retinal stem cells/progenitors by influencing Brn3b expression and Notch signaling. The Journal of Biological Chemistry. 2007.  282, 35187-35201. [PubMed]
9. Hegde, G. V., James, J., Das, A. V., Zhao, X., Bhattacharya, S. and Ahmad, I.  Characterization of early retinal progenitor microenvironment: presence of activities selective for the differentiation of retinal ganglion cells and maintenance of progenitors. Experimental Eye Research. 2007.  84, 577-590. [PubMed]
10. Das, A. V., Zhao, X., James, J., Kim, M., Cowan, K. H. and Ahmad, I.  Neural stem cells in the adult ciliary epithelium express GFAP and are regulated by Wnt signaling. Biochemical and Biophysical Research Communications. 2006.  339, 708-716. [PubMed]
11. Sanalkumar, R., Indulekha, C. L., Divya, T. S., Divya, M. S., Anto, R. J., Vinod, B., Vidyanand, S., Jagatha, B., Venugopal, S. and James, J.  ATF2 maintains a subset of neural progenitors through CBF1/Notch independent Hes-1 expression and synergistically activates the expression of Hes-1 in Notch-dependent neural progenitors. Journal of Neurochemistry. 2010.  113, 807-818. [PubMed]
12. Das, A. V., James, J., Zhao, X., Rahnenfuhrer, J. and Ahmad, I.  Identification of c-Kit receptor as a regulator of adult neural stem cells in the mammalian eye: interactions with Notch signaling. Developmental Biology. 2004.  273, 87-105. [PubMed]
13. Ahmad, I., Das, A. V., James, J., Bhattacharya, S. and Zhao, X.  Neural stem cells in the mammalian eye: types and regulation. Seminars in Cell & Developmental Biology. 2004.  15, 53-62. [PubMed]
14. James, J., Das, A. V., Bhattacharya, S., Chacko, D. M., Zhao, X. and Ahmad, I.  In vitro generation of early-born neurons from late retinal progenitors. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 2003.  23, 8193-8203. [PubMed]
15. Dooley, C. M., James, J., Jane, M. and Ahmad, I.  Involvement of numb in vertebrate retinal development: evidence for multiple roles of numb in neural differentiation and maturation. Journal of Neurobiology. 2003.  54, 313-325. [PubMed]
16. Chacko, D. M., Das, A. V., Zhao, X., James, J., Bhattacharya, S. and Ahmad, I.  Transplantation of ocular stem cells: the role of injury in incorporation and differentiation of grafted cells in the retina. Vision Research. 2003.  43, 937-946. [PubMed]
17. Bhattacharya, S., Jackson, J. D., Das, A. V., Thoreson, W. B., Kuszynski, C., James, J., Joshi, S. and Ahmad, I.  Direct identification and enrichment of retinal stem cells/progenitors by Hoechst dye efflux assay. Investigative Ophthalmology & Visual Science. 2003.  44, 2764-2773. [PubMed]
18. Zhao, X., Das, A. V., Thoreson, W. B., James, J., Wattnem, T. E., Rodriguez-Sierra, J. and Ahmad, I.  Adult corneal limbal epithelium: a model for studying neural potential of non-neural stem cells/progenitors. Developmental Biology. 2002.  250, 317-331. [PubMed]
19. K.K. Saju., Vidyanand S., Jayadas N.H. and Jackson James, M.K. Jayaraj: Effect of surface characteristics of Anodized Ti-6Al-4V implant material on Osteoblast attachment and proliferation.J.Orthopaedics.2009
20. Ani V. Das, Sreekumaran Edakkot, Wallace B. Thoreson, Jackson James, Sumitra Bhattacharya, and Iqbal Ahmad: Membrane properties of retinal stem cells/progenitors.Progress in Retinal and Eye Research.2005
21. Ani V. Das, Jackson James, J�rg Rahnenf�hrer, Wallace B. Thoreson, Sumitra Bhattacharya, Xing Zhao, and Iqbal Ahmad: Retinal properties and potential of the adult mammalian ciliary epithelium stem cells.Vision Research 2005
22. J.Jackson and C.S. Paulose; Brain 5HT2A receptor regulation by tryptophan supplementation in streptozotocin diabetic rats. J. Biochemistry Molecular Biology & Biophysics.2000
23. Jackson .J and Paulose C.S; Enhancement of [m-methoxy 3H] MDL100907 binding to 5-HT2A receptors in cerebral cortex and brain stem of streptozotocin induced diabetic rats. Molecular & Cellular Biochemistry.1999
24. Jackson James, Pius S. Padayatti, Thomas Paul and C.S. Paulose; Platelet monoamine changes in diabetic patients and streptozotocin induced diabetic rats. Current Science.1997
 
Education 
::
Ph.D. in Biotechnology, Cochin University of Science and Technology, 1994-1999
Honors and Awards
::
DST young scientist award Department of Science & Technology, 2004.
::
1994 M.Sc. Biotechnology 4th Rank Cochin University of Science & Technology.
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April 2000 -Dec 2000 Research Associate ship Council for Scientific and Industrial Research.
::
Dec 2003 – Not availed Pool officer ship Council for Scientific and Industrial Research.
Member
::
Society for Biotechnologists,India
::
Indian Academy of Neuroscience, India
::
Association for Research in Vision and Ophthalmology, USA
::
Society for Neuroscience, USA.
::
Society for Neurochemistry, India
  Last modified on : Mar 4, 2011
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