Manisha R. Madkaikar,                               M.D. 
                               
                              Scientist D  
                           
                         
                                  
         
                                                    
                                                    
                            National Institute of Immunohaematology 
                           
                                                                              
                            Department of Paediatric Immunology and Leukemia Biology  
                           
                                                                              
                            13th floor, New Multistoreyed Building, KEM Hospital Campus, Parel 
                           
                                                    
                            Mumbai - 400 012                                 
                           
                                                    
                            Maharashtra                                 
                           						  
                                                            
                           
                                                    
                            E-mail: madkaikarm@icmr.org.in 
                           
                                                                              
                            Phone: +91-22-24138518, 24138519, 24111161 
                           
                                                    
                            Fax: +91-22-24138521  
                           
                  
                          
                               
                           
                          
                            URL:   http://niih.org.in/departments/paediatric_immunolo_leukemiabiology/manisha.htm  
                           
                          
                          						  
                              
                           
						  
	                                                       
                            Area of Specialization:  
                           
                          
                          
  
     
    Molecular Biology 
   
     
                          
                        
                           
                           
                         
                         
                                                    
                                                    
                          
                             
                           
                                                    
                             Research Summary:  
                           
                                                    
                            
                                                                
                                   
                                  Haematopoietic stem cells and hematological malignancies  
                                 
                                                                
                                   
                                  Primary immunodeficiency disorders 
                                 
                                                            
 
                           
                          
                              
                           
                                                    
                            Publications:  
                           
                          
                            
	
		
			
				1. 
			
				Madkaikar, M. , Gupta, M., Jijina, F. and Ghosh, K.  Paroxysmal nocturnal haemoglobinuria: diagnostic tests, advantages, & limitations. European Journal of Haematology.  2009.  83, 503-511. [PubMed]  
		 
		
			
				2. 
			
				Swaminathan, S., Madkaikar, M. , Ghosh, K., Vundinti, B. R., Kerketta, L. and Gupta, M.  Novel immunophenotypic and morphologic presentation in acute myeloid leukemia (AML) with JAK2 V617F mutation. European Journal of Haematology.  2010.  84, 180-182. [PubMed]  
		 
		
			
				3. 
			
				Shmukler, B. E., Kedar, P. S., Warang, P., Desai, M., Madkaikar, M. , Ghosh, K., Colah, R. B. and Alper, S. L.  Hemolytic anemia and distal renal tubular acidosis in two Indian patients homozygous for SLC4A1/AE1 mutation A858D. American Journal of Hematology.  2010.  85, 824-828. [PubMed]  
		 
		
			
				4. 
			
				Pereira, W. C., Khushnooma, I., Madkaikar, M.  and Ghosh, K.  Reproducible methodology for the isolation of mesenchymal stem cells from human umbilical cord and its potential for cardiomyocyte generation. Journal of Tissue Engineering and Regenerative Medicine.  2008.  2, 394-399. [PubMed]  
		 
		
			
				5. 
			
				Vundinti, B. R., Kerketta, L., Madkaikar, M.,  Jijina, F. and Ghosh, K.  Three way translocation in a new variant of t(8;21) acute myeloid leukemia involving Xp22. Indian Journal of Cancer.  2008.  45, 30-32. [PubMed]  
		 
		
			
				6. 
			
				Meera, V., Jijina, F., Shrikande, M., Madkaikar, M . and Ghosh, K.  Twin pregnancy in a patient of chronic myeloid leukemia on imatinib therapy. Leukemia Research.  2008.  32, 1620-1622. [PubMed]  
		 
		
			
				7. 
			
				Ghosh, K., Madkaikar, M . and Jijina, F.  Spontaneous resolution of severe aplastic anemia following thymic hemorrhage. Acta Haematologica.  2008.  119, 69-72. [PubMed]  
		 
		
			
				8. 
			
				Madkaikar, M. , Gupta, M., Ghosh, K., Swaminathan, S., Sonawane, L. and Mohanty, D.  Optimising methods of red cell sedimentation from cord blood to maximise nucleated cell recovery prior to cryopreservation. British Journal of Biomedical Science.  2007.  64, 157-159. [PubMed]  
		 
		
			
				9. 
			
				Madkaikar, M. , Ghosh, K., Gupta, M., Swaminathan, S. and Mohanty, D.  Ex vivo expansion of umbilical cord blood stem cells using different combinations of cytokines and stromal cells. Acta Haematologica.  2007.  118, 153-159. [PubMed]  
		 
		
			
				10. 
			
				Ghosh, K., Madkaikar, M. , Jijina, F. and Shetty, S.  Fractures of long bones in severe haemophilia. Haemophilia .  2007.  13, 337-339. [PubMed]  
		 
		
			
				11. 
			
				Nair, A. P., Jijina, F., Ghosh, K., Madkaikar, M., Shrikhande, M. and Nema, M.  Osteoporosis in young haemophiliacs from western India. American Journal of Hematology.  2007.  82, 453-457. [PubMed]  
		 
		
			
				12. 
			
				Babu, R. a. o., Kerketta, L., Madkaikar, M. , Farah, J. and Ghosh, K.  Hybrid cytogenetics of chronic lymphocytic leukemia and follicular cell lymphoma in a case of non-Hodgkin's lymphoma. Acta Haematologica.  2006.  116, 150-152. [PubMed]  
		 
		
			
				13. 
			
				Ghosh, K., Nair, A. P., Jijina, F., Madkaikar, M. , Shetty, S. and Mohanty, D.  Intracranial haemorrhage in severe haemophilia: prevalence and outcome in a developing country. Haemophilia : the Official Journal of the World Federation of Hemophilia.  2005.  11, 459-462. [PubMed]  
		 
		
			
				14. 
			
				Kedar, P. S., Nadkarni, A. H., Phanasgoankar, S., Madkaikar, M. , Ghosh, K., Gorakshakar, A. C., Colah, R. B. and Mohanty, D.  Congenital methemoglobinemia caused by Hb-MRatnagiri (beta-63CAT-->TAT, His-->Tyr) in an Indian family. American Journal of Hematology.  2005.  79, 168-170. [PubMed]  
		 
		
			
				15. 
			
				Madkaikar, M.  and Ghosh, K.  Immunotherapy in benzene-induced aplastic anemia using a biotherapeutic approach--is it durable? Stem Cells and Development.  2004.  13, 161-163. [PubMed]  
		 
		
			
				16. 
			
				Madkaikar, M.  and Ghosh, K.  Treating patients of myelodysplastic syndrome with antithymocytic globulin--should we be more selective? Blood.  2003.  102, 3851-3853. [PubMed]  
		 
		
			
				17. 
			
				Ghosh, K., Vundinti, B. R., Kerketta, L., Madkaikar, M. , Mohanty, D. and Jijina, F.  Severe megakaryocytic dysplasia in a case of myelodysplasia progressing to acute megakaryocytic leukemia presenting with dic(1;16)(q21;p13.3) and t(1;22)(p13;q13). Cancer Genetics and Cytogenetics.  2003.  146, 176-178. [PubMed]  
		 
		
			
				18. 
			
				Ghosh, K., Iyer, Y., Basu, A., Madkaikar, M. , Jijina, F., Shankarkumar, U. and Mohanty, D.  Virological, serological and haemopoietic colony studies and its correlation with the outcome of severe aplastic anemia. The Hematology Journal.  2003.  4, 292-294. [PubMed]  
		 
		
			
				19. 
			
				Vundinti, B. R., Madkaikar, M. , Kerketta, L., Jijina, F., Ghosh, K., Mohanty, D. and Jijina, F.  A novel translocation der(4)t(1;4)(q21;q35) and a marker chromosome in a case of myelodysplastic syndrome. Cancer Genetics and Cytogenetics.  2003.  144, 175-176. [PubMed]  
		 
		
			
				20. 
			
				Ghosh, K., Madkaikar, M. , Jijina, F., Gandhi, S., Shetty, S. and Mohanty, D.  Open heart surgery with mitral valve replacement--ordeal of an undiagnosed haemophilia patient. Clinical and Laboratory Haematology.  2003.  25, 131-133. [PubMed]  
		 
		
			
				21. 
			
				Ghosh, K., Jijina, F., Shetty, S., Madkaikar, M.  and Mohanty, D.  First-time development of FVIII inhibitor in haemophilia patients during the postoperative period. Haemophilia : the Official Journal of the World Federation of Hemophilia.  2002.  8, 776-780. [PubMed]  
		 
		
			
				22. 
			
				Madkaikar, M. , Ghosh, K., Jijina, F., Gupta, M., Rajpurkar, M. and Mohanty, D.  Tuberculosis and immune thrombocytopenia. Haematologica.  2002.  87, ELT38. [PubMed]  
		 
		
			
				23. 
			
				Ghosh, K., Gosavi, S., Pathare, A., Madkaikar, M. , Rao, V. B. and Mohanty, D.  Low cost autologous peripheral blood stem cell transplantation performed in a municipal hospital for a patient with plasma cell leukaemia. Clinical and Laboratory Haematology.  2002.  24, 187-190. [PubMed]  
		 
		
			
				24. 
			
				Ghosh, K., Madkaikar, M. , Iyer, Y., Pathare, A., Jijina, F. and Mohanty, D.  Systemic capillary leak syndrome preceding plasma cell leukaemia. Acta Haematologica.  2001.  106, 118-121. [PubMed]  
		 
		
			
				25. 
			
				Jijina, F., Ghosh, K., Madkaikar, M.  and Mohanty, D.  Ophthalmic surgery in haemophilia. Haemophilia.  2001.  7, 464-467. [PubMed]  
		 
		
			
				26. 
			
				Ghosh, K., Shetty, S., Madkaikar, M. , Pawar, A., Nair, S., Khare, A., Pathare, A., Jijina, F. and Mohanty, D.  Venous thromboembolism in young patients from western India: a study. Clinical and Applied Thrombosis/hemostasis.  2001.  7, 158-165. [PubMed]  
		 
		
			
				27. 
			
				Ghosh, K., Joshi, S. H., Shetty, S., Pawar, A., Chipkar, S., Pujari, V., Madkaikar, M. , Pathare, A. V., Jijina, F. and Mohanty, D.  Transfusion transmitted diseases in haemophilics from western India. The Indian Journal of Medical Research.  2000.  112, 61-64. [PubMed]  
		 
		
			
				28. 
			
				Shetty, S., Madkaikar, M. , Nair, S., Pawar, A., Baindur, S., Pathare, A., Ghosh, K. and Mohanty, D.  Combined factor V and VIII deficiency in Indian population. Haemophilia.  2000.  6, 504-507. [PubMed]  
		 
	 
	 
  
                           
                         
                                                
 
                      
                          
                            
                                                                 
                                   
                             
                            
                                
                             
                            
                              
                                  
                                     
                                   
                                  
                                                                            
                                        
                                                                                    
                                            Education  
 
                                           
                                                                                    
                                            :: 
 
                                            M.D.                                                    in Medicine, 				
				 
                                                    Seth G. S. Medical College,Mumbai,                             1994-1997                                            
 
                                           
                                                                                    
                                            Honors and Awards  
 
                                           
                                                                                    
                                            :: 
 
                                            2005-2006, Awarded Associateship for specialized training of young scientists in niche areas of biotechnology by Department of Biotechnology             
 
                                           
                                                                                    
                                            :: 
 
                                            2009 - Best paper award for paper on ‘Clinical spectrum of Leukocyte Adhesion Deficiency-I from India and antenatal diagnosis for  LAD-I for the first time in India.’ Presented at Mumbai Haematology group annual conference held at Tata Memorial Hospital, Mumbai       
 
                                           
                                                                                    
                                            :: 
 
                                            Dr. N.C. Kelkar award for standing first in M.D. (General Medicine) examination from Seth G.S. Medical College, Mumbai