Suparna Sengupta, Ph.D.
Rajiv Gandhi Centre for Biotechnology
Thycaud, Poojappura
Thiruvananthapuram - 695 014
Kerala
E-mail: ssengupta@rgcb.res.in
Phone: +91-471-2529475
URL: http://rgcb.res.in/departments/cancer_research/suparna-sengupta/profile.html
Positions Held:
Position Affiliation Time Period
Scientist E-I
Rajiv Gandhi Centre for Biotechnology, Thiruvananthapuram, India
2000-Present
Pool Officer
National Institute of Immunology, New Delhi, India
1997-2000
Post Doctoral Fellow
University of Kansas, USA
1994-1996
Area of Specialization:
Cytoskeleton Biology
Research Summary:
Microtubule mediated drug development for anticancer therapy
Study of the nucleation stage of microtubule assembly
Drug screening through microtubule assembly
Publications:
1.
Thomas, N. E., Shashikala, S. and Sengupta, S . Cytoplasmic gamma-tubulin complex from brain contains nonerythroid spectrin. Journal of Cellular Biochemistry. 2010. 110, 1334-1341. [PubMed]
2.
Sengupta, S . and Thomas, S. A. Drug target interaction of tubulin-binding drugs in cancer therapy. Expert Review of Anticancer Therapy. 2006. 6, 1433-1447. [PubMed]
3.
Sengupta, S ., Smitha, S. L., Thomas, N. E., Santhoshkumar, T. R., Devi, S. K., Sreejalekshmi, K. G. and Rajasekharan, K. N. 4-Amino-5-benzoyl-2-(4-methoxyphenylamino)thiazole (DAT1): a cytotoxic agent towards cancer cells and a probe for tubulin-microtubule system. British Journal of Pharmacology. 2005. 145, 1076-1083. [PubMed]
4.
Das, L., Datta, A. B., Gupta, S., Poddar, A., Sengupta, S ., Janik, M. E. and Bhattacharyya, B. -NH-dansyl isocolchicine exhibits a significantly improved tubulin-binding affinity and microtubule inhibition in comparison to isocolchicine by binding tubulin through its A and B rings. Biochemistry. 2005. 44, 3249-3258. [PubMed]
5.
Sengupta S. , Puri, K.D., Surolia, A., Roy, S. and Bhattacharyya, B. NBD-Colcemid: A probe for different classes of colchicine binding sites on tubulin. European Journal Biochemistry .1993, 212, 387-393
6.
Sengupta S ., Boge, T.C., Georg, G.I. and Himes, R.H. Interaction of a fluorescent paclitaxel analogue with tubulin. Biochemistry .1995, 34, 11889-11894.
7.
Sengupta S. , Mahapatra, P.K., Chakrabarti, G., Roy, S. and Bhattacharyya, B. Interaction of a fluorescent analog of N-deacetyl-N-methyl colchicine (colcemid) with liver alcohol dehydrogenase. European Journal Biochemistry .1995, 232, 844-848.
8.
Chakrabarti,G.,Sengupta S. and Bhattacharyya, B. Thermodynamics of colchicinoids-tubulin interactions, Role of B-ring and C-7 substituent. Journal of Biological chemistry .1996, 271, 2897-2901
9.
Sengupta S ., Boge, T., Liu, Y.B., Hepperle, H., Georg, G., and Himes, R.H. Probing the environment of tubulin-bound paclitaxel (taxol) using fluorescent paclitaxel analogues. Biochemistry .1997, 36, 5179-5184.
10.
Sengupta S. , Banerjee, S., Chakrabarti, G., Mahapatra, P.K., Roy, S., and Bhattacharyya, B. NBD-Isocolcemid Interaction: A Novel One-Step Reaction Involving No Conformational Adjustments of Reactants. Biochemistry .2000, 39, 2227-2234.
11.
Sengupta S. , Smitha S.L, Thomas, N.E., Santosh, T.R., Devi, C. and Rajasekharan, K.N. DAT1, A Novel Synthetic Microtubule Inhibitor, Exerts Cytotoxicity and Shows Efficacy Towards Multidrug Resistant Cancer Cells. Molecular Biology of the Cell. 2003, 14, 183a.
Education
::
M.Sc. in Chemistry,
University of Calcutta, Kolkata, India
::
Ph.D. in Biochemistry,
Bose Institute, Kolkata, India
Honors and Awards
::
2005, National Young Woman Bioscientist Award Department of Biotechnology
::
2003, Dr. V.B. Kamat Memorial award Indian Association of Cancer Research
::
1996, Fellowship from Kansas Health Foundation,USA
::
1986, CSIR Junior Research Fellowship
Member
::
American Society for Cell Biology
::
Indian Biophysical Society
::
Society of Biotechnologists, India
::
Biotech Research Society of India
::
Society for Biotechnologists, India
::
Third World Organization for Women in Science
::
American Association for Cancer Research