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Suparna Sengupta, Ph.D.
Scientist E-I 
Rajiv Gandhi Centre for Biotechnology
Thycaud, Poojappura
Thiruvananthapuram - 695 014   
Phone: +91-471-2529475
Positions Held:
Position Affiliation Time Period
Scientist E-I Rajiv Gandhi Centre for Biotechnology, Thiruvananthapuram, India 2000-Present
Pool Officer National Institute of Immunology, New Delhi, India 1997-2000
Post Doctoral Fellow University of Kansas, USA 1994-1996
Area of Specialization:
Cytoskeleton Biology
Research Summary:
Microtubule mediated drug development for anticancer therapy
Study of the nucleation stage of microtubule assembly
Drug screening through microtubule assembly
1. Thomas, N. E., Shashikala, S. and Sengupta, S.  Cytoplasmic gamma-tubulin complex from brain contains nonerythroid spectrin. Journal of Cellular Biochemistry. 2010.  110, 1334-1341. [PubMed]
2. Sengupta, S. and Thomas, S. A.  Drug target interaction of tubulin-binding drugs in cancer therapy. Expert Review of Anticancer Therapy. 2006.  6, 1433-1447. [PubMed]
3. Sengupta, S., Smitha, S. L., Thomas, N. E., Santhoshkumar, T. R., Devi, S. K., Sreejalekshmi, K. G. and Rajasekharan, K. N.  4-Amino-5-benzoyl-2-(4-methoxyphenylamino)thiazole (DAT1): a cytotoxic agent towards cancer cells and a probe for tubulin-microtubule system. British Journal of Pharmacology. 2005.  145, 1076-1083. [PubMed]
4. Das, L., Datta, A. B., Gupta, S., Poddar, A., Sengupta, S., Janik, M. E. and Bhattacharyya, B.  -NH-dansyl isocolchicine exhibits a significantly improved tubulin-binding affinity and microtubule inhibition in comparison to isocolchicine by binding tubulin through its A and B rings. Biochemistry. 2005.  44, 3249-3258. [PubMed]
5. Sengupta S., Puri, K.D., Surolia, A., Roy, S. and Bhattacharyya, B. NBD-Colcemid: A probe for different classes of colchicine binding sites on tubulin. European Journal Biochemistry.1993, 212, 387-393
6. Sengupta S., Boge, T.C., Georg, G.I. and Himes, R.H. Interaction of a fluorescent paclitaxel analogue with tubulin. Biochemistry.1995, 34, 11889-11894.
7. Sengupta S., Mahapatra, P.K., Chakrabarti, G., Roy, S. and Bhattacharyya, B. Interaction of a fluorescent analog of N-deacetyl-N-methyl colchicine (colcemid) with liver alcohol dehydrogenase. European Journal Biochemistry.1995, 232, 844-848.
8. Chakrabarti,G.,Sengupta S. and Bhattacharyya, B. Thermodynamics of colchicinoids-tubulin interactions, Role of B-ring and C-7 substituent. Journal of Biological chemistry.1996, 271, 2897-2901
9. Sengupta S., Boge, T., Liu, Y.B., Hepperle, H., Georg, G., and Himes, R.H. Probing the environment of tubulin-bound paclitaxel (taxol) using fluorescent paclitaxel analogues. Biochemistry.1997, 36, 5179-5184.
10. Sengupta S., Banerjee, S., Chakrabarti, G., Mahapatra, P.K., Roy, S., and Bhattacharyya, B. NBD-Isocolcemid Interaction: A Novel One-Step Reaction Involving No Conformational Adjustments of Reactants. Biochemistry.2000, 39, 2227-2234.
11. Sengupta S., Smitha S.L, Thomas, N.E., Santosh, T.R., Devi, C. and Rajasekharan, K.N. DAT1, A Novel Synthetic Microtubule Inhibitor, Exerts Cytotoxicity and Shows Efficacy Towards Multidrug Resistant Cancer Cells. Molecular Biology of the Cell. 2003, 14, 183a.


M.Sc. in Chemistry, University of Calcutta, Kolkata, India
Ph.D. in Biochemistry, Bose Institute, Kolkata, India
Honors and Awards
2005, National Young Woman Bioscientist Award Department of Biotechnology
2003, Dr. V.B. Kamat Memorial award Indian Association of Cancer Research
1996, Fellowship from Kansas Health Foundation,USA
1986, CSIR Junior Research Fellowship
American Society for Cell Biology
Indian Biophysical Society
Society of Biotechnologists, India
Biotech Research Society of India
Society for Biotechnologists, India
Third World Organization for Women in Science
American Association for Cancer Research
  Last modified on : Mar 4, 2011
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