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Shekhar Krishnan, M.B.B.S., M.R.C.P., F.R.C.Path, Ph.D.
Senior Consultant 
Tata Medical Center, Kolkata, India
Paediatric Haematology-Oncology, Major Arterial Road (E-W)
New Town, Rajarhat
Kolkata - 700 156    
West Bengal   
Area of Specialization:


1. Hurley, E. H., Krishnan, S., Parton, L. A. and Dozor, A. J.  Differences in perspective on prognosis and treatment of children with trisomy 18. American Journal of Medical Genetics. Part A. 2014.  164A, 2551-2556. [PubMed]
2. Krishnan, S. and Prasadarao, N. V.  Identification of minimum carbohydrate moiety in N-glycosylation sites of brain endothelial cell glycoprotein 96 for interaction with Escherichia coli K1 outer membrane protein A. Microbes and Infection / Institut Pasteur. 2014.  16, 540-552. [PubMed]
3. Shanmuganathan, M. V., Krishnan, S., Fu, X. and Prasadarao, N. V.  Escherichia coli K1 induces pterin production for enhanced expression of Fcgamma receptor I to invade RAW 264.7 macrophages. Microbes and Infection / Institut Pasteur. 2014.  16, 134-141. [PubMed]
4. Chaudhary, Z., Krishnan, S., Sharma, P., Sharma, R. and Kumar, P.  A review of literature on ameloblastoma in children and adolescents and a rare case report of ameloblastoma in a 3-year-old child. Craniomaxillofacial Trauma & Reconstruction. 2012.  5, 161-168. [PubMed]
5. Rajagopal, R., Lum, S. H., Jalaludin, M. Y., Krishnan, S., Abdullah, W. A. and Ariffin, H.  Hypercalcaemia: an unusual presenting feature of childhood acute lymphoblastic leukaemia. British Journal of Haematology. 2013.  163, 147. [PubMed]
6. Blackett, P., Tryggestad, J., Krishnan, S., Li, S., Xu, W., Alaupovic, P., Quiroga, C. and Copeland, K.  Lipoprotein abnormalities in compound heterozygous lipoprotein lipase deficiency after treatment with a low-fat diet and orlistat. Journal of Clinical Lipidology. 2013.  7, 132-139. [PubMed]
7. Shanmuganathan, M. V., Krishnan, S., Fu, X. and Prasadarao, N. V.  Attenuation of biopterin synthesis prevents Escherichia coli K1 invasion of brain endothelial cells and the development of meningitis in newborn mice. The Journal of Infectious Diseases. 2013.  207, 61-71. [PubMed]
8. de, l. a., Krishnan, S. and Dozor, A. J.  Relationship between exhaled nitric oxide and exposure to low-level environmental tobacco smoke in children with asthma on inhaled corticosteroids. The Journal of Asthma : Official Journal of the Association For the Care of Asthma. 2012.  49, 673-678. [PubMed]
9. Krishnan, S., Fields, D. A., Copeland, K. C., Blackett, P. R., Anderson, M. P. and Gardner, A. W.  Sex differences in cardiovascular disease risk in adolescents with type 1 diabetes. Gender Medicine. 2012.  9, 251-258. [PubMed]
10. Krishnan, S., Fernandez, G. E., Sacks, D. B. and Prasadarao, N. V.  IQGAP1 mediates the disruption of adherens junctions to promote Escherichia coli K1 invasion of brain endothelial cells. Cellular Microbiology. 2012.  14, 1415-1433. [PubMed]
11. Lim, L., Chen, K. S., Krishnan, S., Gole, L. and Ariffin, H.  Mature B-cell acute lymphoblastic leukaemia associated with a rare MLL-FOXO4 fusion gene. British Journal of Haematology. 2012.  157, 651. [PubMed]
12. Krishnan, S., Mali, R. S., Ramdas, B., Sims, E., Ma, P., Ghosh, J., Munugalavadla, V., Hanneman, P., Beane, J. D. and Kapur, R.  p85beta regulatory subunit of class IA PI3 kinase negatively regulates mast cell growth, maturation, and leukemogenesis. Blood. 2012.  119, 3951-3961. [PubMed]
13. Setty, B. N., Key, N. S., Rao, A. K., Gayen-Betal, S., Krishnan, S., Dampier, C. D. and Stuart, M. J.  Tissue factor-positive monocytes in children with sickle cell disease: correlation with biomarkers of haemolysis. British Journal of Haematology. 2012.  157, 370-380. [PubMed]
14. Krishnan, S. and Prasadarao, N. V.  Outer membrane protein A and OprF: versatile roles in Gram-negative bacterial infections. The FEBS Journal. 2012.  279, 919-931. [PubMed]
15. Krishnan, S., Mali, R. S., Koehler, K. R., Vemula, S., Chatterjee, A., Ghosh, J., Ramdas, B., Ma, P., Hashino, E. and Kapur, R.  Class I(A) PI3Kinase regulatory subunit, p85alpha, mediates mast cell development through regulation of growth and survival related genes. PloS One. 2012.  7, e28979. [PubMed]
16. Ma, P., Mali, R. S., Munugalavadla, V., Krishnan, S., Ramdas, B., Sims, E., Martin, H., Ghosh, J., Li, S., Chan, R. J., Krystal, G., Craig, A. W., Takemoto, C. and Kapur, R.  The PI3K pathway drives the maturation of mast cells via microphthalmia transcription factor. Blood. 2011.  118, 3459-3469. [PubMed]
17. Krishnan, S., Copeland, K. C., Bright, B. C., Gardner, A. W., Blackett, P. R. and Fields, D. A.  Impact of type 1 diabetes and body weight status on cardiovascular risk factors in adolescent children. Journal of Clinical Hypertension. 2011.  13, 351-356. [PubMed]
18. Forghani, N., Lum, C., Krishnan, S., Wang, J., Wilson, D. M., Blackett, P. R., Malloy, P. J. and Feldman, D.  Two new unrelated cases of hereditary 1,25-dihydroxyvitamin D-resistant rickets with alopecia resulting from the same novel nonsense mutation in the vitamin D receptor gene. Journal of Pediatric Endocrinology & Metabolism : JPEM. 2010.  23, 843-850. [PubMed]
19. Mittal, R., Krishnan, S., Gonzalez-Gomez, I. and Prasadarao, N. V.  Deciphering the roles of outer membrane protein A extracellular loops in the pathogenesis of Escherichia coli K1 meningitis. The Journal of Biological Chemistry. 2011.  286, 2183-2193. [PubMed]
20. Krishnan, S., Setty, Y., Betal, S. G., Vijender, V., Rao, K., Dampier, C. and Stuart, M.  Increased levels of the inflammatory biomarker C-reactive protein at baseline are associated with childhood sickle cell vasocclusive crises. British Journal of Haematology. 2010.  148, 797-804. [PubMed]
21. Fields, D. A., Krishnan, S. and Wisniewski, A. B.  Sex differences in body composition early in life. Gender Medicine. 2009.  6, 369-375. [PubMed]
22. Krishnan, S. and Short, K. R.  Prevalence and significance of cardiometabolic risk factors in children with type 1 diabetes. Journal of the Cardiometabolic Syndrome. 2009.  4, 50-56. [PubMed]
23. Munugalavadla, V., Vemula, S., Sims, E. C., Krishnan, S., Chen, S., Yan, J., Li, H., Niziolek, P. J., Takemoto, C., Robling, A. G., Yang, F. C. and Kapur, R.  The p85alpha subunit of class IA phosphatidylinositol 3-kinase regulates the expression of multiple genes involved in osteoclast maturation and migration. Molecular and Cellular Biology. 2008.  28, 7182-7198. [PubMed]
24. Ooi, M. H., Lewthwaite, P., Lai, B. F., Mohan, A., Clear, D., Lim, L., Krishnan, S., Preston, T., Chieng, C. H., Tio, P. H., Wong, S. C., Cardosa, J. and Solomon, T.  The epidemiology, clinical features, and long-term prognosis of Japanese encephalitis in central sarawak, malaysia, 1997-2005. Clinical Infectious Diseases : An Official Publication of the Infectious Diseases Society of America. 2008.  47, 458-468. [PubMed]
25. Krishnan, S., Siegel, J., Pullen, G., Hevelow, M., Dampier, C. and Stuart, M.  Increased von Willebrand factor antigen and high molecular weight multimers in sickle cell disease associated with nocturnal hypoxemia. Thrombosis Research. 2008.  122, 455-458. [PubMed]
26. Yusuf, S., Piedimonte, G., Auais, A., Demmler, G., Krishnan, S., Van, C., Singleton, R., Broor, S., Parveen, S., Avendano, L., Parra, J., Chavez-Bueno, S., Murguia, D. e., Simoes, E. A., Shaha, S. and Welliver, R.  The relationship of meteorological conditions to the epidemic activity of respiratory syncytial virus. Epidemiology and Infection. 2007.  135, 1077-1090. [PubMed]
27. Krishnan, S., Banquet, A., Newman, L., Katta, U., Patil, A. and Dozor, A. J.  Lung lesions in children with Crohn's disease presenting as nonresolving pneumonias and response to infliximab therapy. Pediatrics. 2006.  117, 1440-1443. [PubMed]
28. Krishnan S.  Evaluation and management of the febrile infant in the emergency department. Indian Journal of Pediatrics. 2003.  70 Suppl 1, S45-50. [PubMed]
29. Ooi, M. H., Wong, S. C., Clear, D., Perera, D., Krishnan, S., Preston, T., Tio, P. H., Willison, H. J., Tedman, B., Kneen, R., Cardosa, M. J. and Solomon, T.  Adenovirus type 21-associated acute flaccid paralysis during an outbreak of hand-foot-and-mouth disease in Sarawak, Malaysia. Clinical Infectious Diseases : An Official Publication of the Infectious Diseases Society of America. 2003.  36, 550-559. [PubMed]
30. Prabha, P. C., Hussain, M. J., Bhat, B. V. and Krishnan, S. G.  CHARGE association--need for choanostomy. Indian Pediatrics. 2000.  37, 1129-1133. [PubMed]
31. Hajjar, K. A. and Krishnan, S.  Annexin II: a mediator of the plasmin/plasminogen activator system. Trends in Cardiovascular Medicine. 1999.  9, 128-138. [PubMed]
32. Deyrup, A. T., Singh, B., Krishnan, S., Lyle, S. and Schwartz, N. B.  Chemical modification and site-directed mutagenesis of conserved HXXH and PP-loop motif arginines and histidines in the murine bifunctional ATP sulfurylase/adenosine 5'-phosphosulfate kinase. The Journal of Biological Chemistry. 1999.  274, 28929-28936. [PubMed]
33. Deyrup, A. T., Krishnan, S., Singh, B. and Schwartz, N. B.  Activity and stability of recombinant bifunctional rearranged and monofunctional domains of ATP-sulfurylase and adenosine 5'-phosphosulfate kinase. The Journal of Biological Chemistry. 1999.  274, 10751-10757. [PubMed]
34. Kurima, K., Warman, M. L., Krishnan, S., Domowicz, M., Krueger, R. C., Deyrup, A. and Schwartz, N. B.  A member of a family of sulfate-activating enzymes causes murine brachymorphism. Proceedings of the National Academy of Sciences of the United States of America. 1998.  95, 8681-8685. [PubMed]
35. Deyrup, A. T., Krishnan, S., Cockburn, B. N. and Schwartz, N. B.  Deletion and site-directed mutagenesis of the ATP-binding motif (P-loop) in the bifunctional murine ATP-sulfurylase/adenosine 5'-phosphosulfate kinase enzyme. The Journal of Biological Chemistry. 1998.  273, 9450-9456. [PubMed]
36. Krishnan, S. S., Stewart, J., Amin, N., Griffin, R. T. and Dozer, A. J.  Electrocardiographic prediction of hyperinflation in children. American Journal of Respiratory and Critical Care Medicine. 1997.  156, 2011-2014. [PubMed]
37. Krishnan, S., Amin, N., Dozor, A. J. and Stringel, G.  Urokinase in the management of complicated parapneumonic effusions in children. Chest. 1997.  112, 1579-1583. [PubMed]
38. HADDAD, G. G., WYMAN, R. J., MOHSENIN, A., SUN, Y. and KRISHNAN, S. N.  Behavioral and Electrophysiologic Responses of Drosophila melanogaster to Prolonged Periods of Anoxia. Journal of Insect Physiology. 1997.  43, 203-210. [PubMed]
39. Kooh, S. W., Brnjac, L., Ehrlich, R. M., Qureshi, R. and Krishnan, S.  Bone mass in children with congenital hypothyroidism treated with thyroxine since birth. Journal of Pediatric Endocrinology & Metabolism : JPEM. 1996.  9, 59-62. [PubMed]
40. Krishnan, S. N., Desai, T., Ward, D. C. and Haddad, G. G.  Isolation and chromosomal localization of a human ATP-regulated potassium channel. Human Genetics. 1995.  96, 155-160. [PubMed]
41. Krishnan, S. N. and Haddad, G. G.  Cloning of glucose transporter-3 (GLUT3) cDNA from rat brain. Life Sciences. 1995.  56, 1193-1197. [PubMed]


Book Chapters:
Krishnan S, Masurekar A, Saha V. Identifying targets for new therapies in children with acute lymphoblastic leukaemia. New Agents for the Treatment of Acute Lymphoblastic Leukemia, Saha V, Kearns P (Eds.), Springer Science, 2011 (ISBN: 978-1-4419-8458-6)
Author of chapters on the Varicella Vaccine and the Pneumococcal polysaccharide vaccine as part of the Childhood Vaccinations Report and Recommendations of the Health Technology Unit, Division of Medical Development, Ministry of Health, Malaysia (2000)
My CV:   Download
M.B.B.S. in Medicine
M.R.C.P. in Paediatrics
F.R.C.Path in Haematology
European Haematology Association
Malaysian Society of Paediatric Haematology-Oncology
  Last modified on : Dec 11, 2015
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