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Ruby John Anto, Ph.D.
Scientist E-II 
Rajiv Gandhi Centre for Biotechnology
Thycaud, Poojappura
Thiruvananthapuram - 695 014   
Phone: +91-471-2529473
Positions Held:
Position Affiliation Time Period
Scientist E-II Rajiv Gandhi Centre for Biotechnology, Thiruvananthapuram, India 2009-Present
Scientist E-I Rajiv Gandhi Centre for Biotechnology, Thiruvananthapuram, India 2004-2009
Scientist C Rajiv Gandhi Centre for Biotechnology, Thiruvananthapuram, India 2000-2004
Visiting Scientist Department of Bioimmunotherapy, MD Anderson Cancer Center, Houston, Texas, USA 2000-2001
Research Associate Rajiv Gandhi Centre for Biotechnology, Thiruvananthapuram, India 1996-2000
Area of Specialization:
Cell Signaling
Chemo Sensitization
Chemo Prevention
1. Sreekanth, C. N., Bava, S. V., Sreekumar, E. and Anto, R. J.  Molecular evidences for the chemosensitizing efficacy of liposomal curcumin in paclitaxel chemotherapy in mouse models of cervical cancer. Oncogene. 2011.  [PubMed]
2. Bava, S. V., Sreekanth, C. N., Thulasidasan, A. K., Anto, N. P., Cheriyan, V. T., Puliyappadamba, V. T., Menon, S. G., Ravichandran, S. D. and Anto, R. J.  Akt is upstream and MAPKs are downstream of NF-kappaB in paclitaxel-induced survival signaling events, which are down-regulated by curcumin contributing to their synergism. The International Journal of Biochemistry & Cell Biology. 2010.  [PubMed]
3. Puliyappadamba, V. T., Cheriyan, V. T., Thulasidasan, A. K., Bava, S. V., Vinod, B. S., Prabhu, P. R., Varghese, R., Bevin, A., Venugopal, S. and Anto, R. J.  Nicotine-induced survival signaling in lung cancer cells is dependent on their p53 status while its down-regulation by curcumin is independent. Molecular Cancer. 2010.  9, 220. [PubMed]
4. Sanalkumar, R., Indulekha, C. L., Divya, T. S., Divya, M. S., Anto, R. J., Vinod, B., Vidyanand, S., Jagatha, B., Venugopal, S. and James, J.  ATF2 maintains a subset of neural progenitors through CBF1/Notch independent Hes-1 expression and synergistically activates the expression of Hes-1 in Notch-dependent neural progenitors. Journal of Neurochemistry. 2010.  113, 807-818. [PubMed]
5. Laladhas, K. P., Cheriyan, V. T., Puliappadamba, V. T., Bava, S. V., Unnithan, R. G., Vijayammal, P. L. and Anto, R. J.  A novel protein fraction from Sesbania grandiflora shows potential anticancer and chemopreventive efficacy, in vitro and in vivo. Journal of Cellular and Molecular Medicine. 2010.  14, 636-646. [PubMed]
6. Venkatraman, M., Anto, R. J., Nair, A., Varghese, M. and Karunagaran, D.  Biological and chemical inhibitors of NF-kappaB sensitize SiHa cells to cisplatin-induced apoptosis. Molecular Carcinogenesis. 2005.  44, 51-59. [PubMed]
7. Bava, S. V., Puliappadamba, V. T., Deepti, A., Nair, A., Karunagaran, D. and Anto, R. J.  Sensitization of taxol-induced apoptosis by curcumin involves down-regulation of nuclear factor-kappaB and the serine/threonine kinase Akt and is independent of tubulin polymerization. The Journal of Biological Chemistry. 2005.  280, 6301-6308. [PubMed]
8. Maliekal, T. T., Anto, R. J. and Karunagaran, D.  Differential activation of Smads in HeLa and SiHa cells that differ in their response to transforming growth factor-beta. The Journal of Biological Chemistry. 2004.  279, 36287-36292. [PubMed]
9. Oommen, S., Anto, R. J., Srinivas, G. and Karunagaran, D.  Allicin (from garlic) induces caspase-mediated apoptosis in cancer cells. European Journal of Pharmacology. 2004.  485, 97-103. [PubMed]
10. Srinivas, G., Anto, R. J., Srinivas, P., Vidhyalakshmi, S., Senan, V. P. and Karunagaran, D.  Emodin induces apoptosis of human cervical cancer cells through poly(ADP-ribose) polymerase cleavage and activation of caspase-9. European Journal of Pharmacology. 2003.  473, 117-125. [PubMed]
11. Anto, R. J., Venkatraman, M. and Karunagaran, D.  Inhibition of NF-kappaB sensitizes A431 cells to epidermal growth factor-induced apoptosis, whereas its activation by ectopic expression of RelA confers resistance. The Journal of Biological Chemistry. 2003.  278, 25490-25498. [PubMed]
12. Anto, R. J., Mukhopadhyay, A., Shishodia, S., Gairola, C. G. and Aggarwal, B. B.  Cigarette smoke condensate activates nuclear transcription factor-kappaB through phosphorylation and degradation of IkappaB(alpha): correlation with induction of cyclooxygenase-2. Carcinogenesis. 2002.  23, 1511-1518. [PubMed]
13. Anto, R. J., Mukhopadhyay, A., Denning, K. and Aggarwal, B. B.  Curcumin (diferuloylmethane) induces apoptosis through activation of caspase-8, BID cleavage and cytochrome c release: its suppression by ectopic expression of Bcl-2 and Bcl-xl. Carcinogenesis. 2002.  23, 143-150. [PubMed]
14. Anto, R. J., Maliekal, T. T. and Karunagaran, D.  L-929 cells harboring ectopically expressed RelA resist curcumin-induced apoptosis. The Journal of Biological Chemistry. 2000.  275, 15601-15604. [PubMed]
15. Anto, R. J., George, J., Babu, K. V., Rajasekharan, K. N. and Kuttan, R.  Antimutagenic and anticarcinogenic activity of natural and synthetic curcuminoids. Mutation Research. 1996.  370, 127-131. [PubMed]
16. Anto, R. J., Sukumaran, K., Kuttan, G., Rao, M. N., Subbaraju, V. and Kuttan, R.  Anticancer and antioxidant activity of synthetic chalcones and related compounds. Cancer Letters. 1995.  97, 33-37. [PubMed]
17. Ruby John Anto, Asok Mukhopadyay, Kate Denning and Bharat B. Aggarwal. Curcumin (Diferuloylmethane) induces apoptosis through activation of caspase-8, BID cleavage and cytochrome C Release: Its Suppression by ectopic expression of Bcl-2 and Bcl-xLs. Carcinogenesis. 2002.  143-150.
18. Ruby John Anto, Girija Kuttan, Dinesh Babu K.V., Rajasekharan K.N. and Kuttan R. Synthetic curcuminoids as anticancer agents and as free radical scavangers. International Journal of Pharmaceutics.s1991 , 131, 1-8.
19. P. L. Anto, Ruby John Anto, HT Varghese, C.Y. Panicker and Daizy Philip. Vibrational spectroscopic studies and ab initio calculations of phenyl phosphate disodium salt.. Journal of Raman Spectroscopy. 2010, 41,113-119.
20. Rajendran G., Amritha C. S., Ruby John Anto and Vino T. Cheriyan. Synthesis, thermal and antitumor studies of thorium (IV) complexes with furan-2- aldehyde-N-phenyl thiosemicarbazone. Journal of Serbian Chemical Society .2010, 75, 1-13.
21. M.S.R. Murty, Kesur R. Ram, Rayudu Venkateswara Rao, J.S. Yadav, Janapala Venkateswara Rao, Vino. T. Cheriyan and  Ruby John Anto. Synthesis and preliminary evaluation of 2-substituted-1,3- benzoxazole and 3-[(3-substituted)propyl]-1,3-benzoxazol- 2(3H)-one derivatives as potent anticancer agents, In press 2010.
22. P. L. Anto, Ruby John Anto, T. Varghese, C. Y. Panicker, D. Philip, and A. G. Brolo. FT-IR, FT-Raman and SERS spectra of Anilinium Sulfate .Journal of Raman Spectroscopy. 2009.
23. Ruby John Anto, Josely George, Dinesh Babu K.V., Rajasekharan K.N. and Kuttan R. Antimutagenic and anticarcinogenic activities of natural and synthetic curcuminoids. Mutation Reserch. 1996 , 370, 127- 131. ,


Book Chapters:
Ruby John Anto, Smitha V.B., Vinesh Kumar T.P., Sreekanth C.N., Vinod B.S., Vino T. Cherian, Priya R Prabhu and Gayathri L.T. Phenolics of the functional foods – “Curcumin- A nutraceuticals with potential chemosensitive property”, p-202-208, Role of dietary fibers and nutraceuticals in preventing diseases, Pubd -Pharma Med Press
Grant Support:
Project Title Role Funding Agency Sanction Number Sanction Date
Isolation and identification of anticancer principle from Mistletoes(Viscum album) growing on various host trees Indian Council of Medical Research, Goverment of India 2006-2009
Development of High Specific and High Affinity monoclonal antibody against human IgM TreeLand Biotech 2006-2009
Isolation and identification of anticancer principle from the indigenous medicinal plant, Wrightia tinctoria Council of Scientific and Industrial Research, Government of India 2006-2009
Antineoplastic molecules associated with bacteria from entomopathogenic nematodes Co-PI Kerala State Council for Science Technology and Environment, Government of Kerala, India 2007-2010
Novel polymer nanoparticle based drug releasing systems for improving the efficacy of drug administration in cancer chemotherapy Co-PI Department of Biotechnology, Government of India 2008-2011
Synergistic effect of taxol and curcumin in inducing apoptosis of cancer cells Kerala State Council for Science Technology and Environment, Government of Kerala, India 2003-2006
Potential role of curcumin in regulating the effects induced by the major carcinogens in cigarette smoke, such as nicotine, NNK and B(a)P in normal and cancerous lung cells. Department of Science & Technology, Government of India 2004-2007


My CV:   Download
M.Sc. in Chemistry, University of Calicut, Kerala, India, 1983-1985
Ph.D. in Biochemistry, Amala Cancer Research Centre, Thrissur, India, 1991-1995
Honors and Awards
2004, National Young Woman Bio-Scientist Award, DBT, Government of India
1995, Fr. Gabriel Golden Jubilee Award, Amala Cancer Research Centre, Thrissur
American Society For Biochemistry And Molecular Biology
  Last modified on : Mar 4, 2011
India Cancer Research Database has been developed by the Institute of Bioinformatics with funding from the Department of Biotechnology, Government of India.