INCREDB ID : 459
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K. Muniyappa, Ph.D.
Professor 
 
Indian Institute of Science
Department of Biochemistry
Bangalore - 560 012   
Karnataka   
 
E-mail: kmbc@biochem.iisc.ernet.in, kmbc@rediffmail.com
Phone: +91-80-2293 2235, 91-80-2260 0278
Fax: 91-80-2360-0814 91-80-2360-0683
 
URL: http://biochem.iisc.ernet.in/MuniyappaLab/
 
Area of Specialization:
chromosome synapsis
homologous recombination
double stranded break repair and Fanconi anemia
Research Summary:
Fanconi anemia and Homologous Recombination
Synaptonemal complex proteins of Saccharomyces cerevisiae
DNA Double Strand Break Repair (DSBR) of Saccharomyces cerevisiae
Mechanistic aspects of homologous pairing and stand exchange
 
Publications:

 

1. Sharadamma, N., Harshavardhana, Y., Ravishankar, A., Anand, P., Chandra, N. and Muniyappa, K.  Molecular Dissection of Mycobacterium tuberculosis Integration Host Factor Reveals Novel Insights into the Mode of DNA Binding and Nucleoid Compaction. Biochemistry. 2015.  54, 4142-4160. [PubMed]
2. Thakur, R. S., Basavaraju, S., Khanduja, J. S., Muniyappa, K. and Nagaraju, G.  Mycobacterium tuberculosis RecG Protein but Not RuvAB or RecA Protein Is Efficient at Remodeling the Stalled Replication Forks: IMPLICATIONS FOR MULTIPLE MECHANISMS OF REPLICATION RESTART IN MYCOBACTERIA. The Journal of Biological Chemistry. 2015.  290, 24119-24139. [PubMed]
3. Ujaoney, A. K., Basu, B., Muniyappa, K. and Apte, S. K.  Functional roles of N-terminal and C-terminal domains in the overall activity of a novel single-stranded DNA binding protein of Deinococcus radiodurans. FEBS Open Bio. 2015.  5, 378-387. [PubMed]
4. Maji, B., Kumar, K., Muniyappa, K. and Bhattacharya, S.  New dimeric carbazole-benzimidazole mixed ligands for the stabilization of human telomeric G-quadruplex DNA and as telomerase inhibitors. A remarkable influence of the spacer. Organic & Biomolecular Chemistry. 2015.  13, 8335-8348. [PubMed]
5. Chandran, A. V., Prabu, J. R., Nautiyal, A., Patil, K. N., Muniyappa, K. and Vijayan, M.  Structural studies on Mycobacterium tuberculosis RecA: molecular plasticity and interspecies variability. Journal of Biosciences. 2015.  40, 13-30. [PubMed]
6. Dewhare, S. S., Umesh, T. G. and Muniyappa, K.  Molecular and Functional Characterization of RecD, a Novel Member of the SF1 Family of Helicases, from Mycobacterium tuberculosis. The Journal of Biological Chemistry. 2015.  290, 11948-11968. [PubMed]
7. Le, S., Chen, H., Zhang, X., Chen, J., Patil, K. N., Muniyappa, K. and Yan, J.  Mechanical force antagonizes the inhibitory effects of RecX on RecA filament formation in Mycobacterium tuberculosis. Nucleic Acids Research. 2014.  42, 11992-11999. [PubMed]
8. Maji, B., Kumar, K., Kaulage, M., Muniyappa, K. and Bhattacharya, S.  Design and synthesis of new benzimidazole-carbazole conjugates for the stabilization of human telomeric DNA, telomerase inhibition, and their selective action on cancer cells. Journal of Medicinal Chemistry. 2014.  57, 6973-6988. [PubMed]
9. Muniyappa, K., Kshirsagar, R. and Ghodke, I.  The HORMA domain: an evolutionarily conserved domain discovered in chromatin-associated proteins, has unanticipated diverse functions. Gene. 2014.  545, 194-197. [PubMed]
10. Nautiyal, A., Patil, K. N. and Muniyappa, K.  Suramin is a potent and selective inhibitor of Mycobacterium tuberculosis RecA protein and the SOS response: RecA as a potential target for antibacterial drug discovery. The Journal of Antimicrobial Chemotherapy. 2014.  69, 1834-1843. [PubMed]
11. Gupta, S., De, S., Srivastava, V., Hussain, M., Kumari, J., Muniyappa, K. and Sengupta, S.  RECQL4 and p53 potentiate the activity of polymerase gamma and maintain the integrity of the human mitochondrial genome. Carcinogenesis. 2014.  35, 34-45. [PubMed]
12. Ghodke, I. and Muniyappa, K. Processing of DNA double-stranded breaks and intermediates of recombination and repair by Saccharomyces cerevisiae Mre11 and its stimulation by Rad50, Xrs2, and Sae2 proteins. The Journal of Biological Chemistry. 2013.  288, 11273-11286. [PubMed]
13. Khan, K., Madhavan, T. P., Kshirsagar, R., Boosi, K. N., Sadhale, P. and Muniyappa, K.  N-terminal disordered domain of Saccharomyces cerevisiae Hop1 protein is dispensable for DNA binding, bridging, and synapsis of double-stranded DNA molecules but is necessary for spore formation. Biochemistry. 2013.  52, 5265-5279. [PubMed]
14. Raj, S. M., Halebeedu, P., Kadandale, J. S., Mirazon, L., Gallego, R., Yadhav, J. R., Iliescu, M., Rai, N., Crivellaro, F., Chaubey, G., Villems, R., Thangaraj, K., Muniyappa, K., Chandra, H. S. and Kivisild, T.  Variation at diabetes- and obesity-associated Loci may mirror neutral patterns of human population diversity and diabetes prevalence in India. Annals of Human Genetics. 2013.  77, 392-408. [PubMed]
15. Fu, H., Le, S., Chen, H., Muniyappa, K. and Yan, J.  Force and ATP hydrolysis dependent regulation of RecA nucleoprotein filament by single-stranded DNA binding protein. Nucleic Acids Research. 2013.  41, 924-932. [PubMed]
16. Fu, H., Le, S., Muniyappa, K. and Yan, J.  Dynamics and Regulation of RecA Polymerization and De-Polymerization on Double-Stranded DNA. PloS One. 2013.  8, e66712. [PubMed]
17. Thakur, R. S., Basavaraju, S., Somyajit, K., Jain, A., Subramanya, S., Muniyappa, K. and Nagaraju, G.  Evidence for the role of Mycobacterium tuberculosis RecG helicase in DNA repair and recombination. The FEBS Journal. 2013.  280, 1841-1860. [PubMed]
18. Jain, A. K., Paul, A., Maji, B., Muniyappa, K. and Bhattacharya, S.  Dimeric 1,3-phenylene-bis(piperazinyl benzimidazole)s: synthesis and structure-activity investigations on their binding with human telomeric G-quadruplex DNA and telomerase inhibition properties. Journal of Medicinal Chemistry. 2012.  55, 2981-2993. [PubMed]
19. Khan, K., Karthikeyan, U., Li, Y., Yan, J. and Muniyappa, K.  Single-molecule DNA analysis reveals that yeast Hop1 protein promotes DNA folding and synapsis: implications for condensation of meiotic chromosomes. ACS Nano. 2012.  6, 10658-10666. [PubMed]
20. Khanduja, J. S. and Muniyappa, K.  Functional analysis of DNA replication fork reversal catalyzed by Mycobacterium tuberculosis RuvAB proteins. The Journal of Biological Chemistry. 2012.  287, 1345-1360. [PubMed]
21. Paul, A., Jain, A. K., Misra, S. K., Maji, B., Muniyappa, K. and Bhattacharya, S.  Binding of gemini bisbenzimidazole drugs with human telomeric G-quadruplex dimers: effect of the spacer in the design of potent telomerase inhibitors. PloS One. 2012.  7, e39467. [PubMed]
22. Paul, A., Maji, B., Misra, S. K., Jain, A. K., Muniyappa, K. and Bhattacharya, S.  Stabilization and structural alteration of the G-quadruplex DNA made from the human telomeric repeat mediated by Troger's base based novel benzimidazole derivatives. Journal of Medicinal Chemistry. 2012.  55, 7460-7471. [PubMed]
23. Patil, K. N., Singh, P., Harsha, S. and Muniyappa, K.  Mycobacterium leprae RecA is structurally analogous but functionally distinct from Mycobacterium tuberculosis RecA protein. Biochimica et Biophysica Acta. 2011.  1814, 1802-1811. [PubMed]
24. Sharadamma, N., Khan, K., Kumar, S., Patil, K. N., Hasnain, S. E. and Muniyappa, K.  Synergy between the N-terminal and C-terminal domains of Mycobacterium tuberculosis HupB is essential for high-affinity binding, DNA supercoiling and inhibition of RecA-promoted strand exchange. The FEBS Journal. 2011.  278, 3447-3462. [PubMed]
25. Patil, K. N., Singh, P. and Muniyappa, K.  DNA binding, coprotease, and strand exchange activities of mycobacterial RecA proteins: implications for functional diversity among RecA nucleoprotein filaments. Biochemistry. 2011.  50, 300-311. [PubMed]
26. Rossi, F., Khanduja, J. S., Bortoluzzi, A., Houghton, J., Sander, P., Guthlein, C., Davis, E. O., Springer, B., Bottger, E. C., Relini, A., Penco, A., Muniyappa, K. and Rizzi, M.  The biological and structural characterization of Mycobacterium tuberculosis UvrA provides novel insights into its mechanism of action. Nucleic Acids Research. 2011.  39, 7316-7328. [PubMed]
27. Chandran, A. V., Prabu, J. R., Manjunath, G. P., Patil, K. N., Muniyappa, K. and Vijayan, M.  Crystallization and preliminary X-ray studies of the C-terminal domain of Mycobacterium tuberculosis LexA. Acta Crystallographica. Section F, Structural Biology and Crystallization Communications. 2010.  66, 1093-1095. [PubMed]
28. Kaushal, P. S., Singh, P., Sharma, A., Muniyappa, K. and Vijayan, M.  X-ray and molecular-dynamics studies on Mycobacterium leprae single-stranded DNA-binding protein and comparison with other eubacterial SSB structures. Acta Crystallographica. Section D, Biological Crystallography. 2010.  66, 1048-1058. [PubMed]
29. Kavitha, C. V., Choudhary, B., Raghavan, S. C. and Muniyappa, K.  Differential regulation of MRN (Mre11-Rad50-Nbs1) complex subunits and telomerase activity in cancer cells. Biochemical and Biophysical Research Communications. 2010.  399, 575-580. [PubMed]
30. Khan, K., Madhavan, T. P. and Muniyappa, K.  Cloning, overexpression and purification of functionally active Saccharomyces cerevisiae Hop1 protein from Escherichia coli. Protein Expression and Purification. 2010.  72, 42-47. [PubMed]
31. Kumar, S., Sardesai, A. A., Basu, D., Muniyappa, K. and Hasnain, S. E.  DNA clasping by mycobacterial HU: the C-terminal region of HupB mediates increased specificity of DNA binding. PloS One. 2010.  5. [PubMed]
32. Sharadamma, N., Harshavardhana, Y., Singh, P. and Muniyappa, K.  Mycobacterium tuberculosis nucleoid-associated DNA-binding protein H-NS binds with high-affinity to the Holliday junction and inhibits strand exchange promoted by RecA protein. Nucleic Acids Research. 2010.  38, 3555-3569. [PubMed]
33. Singh, P., Patil, K. N., Khanduja, J. S., Kumar, P. S., Williams, A., Rossi, F., Rizzi, M., Davis, E. O. and Muniyappa, K.  Mycobacterium tuberculosis UvrD1 and UvrA proteins suppress DNA strand exchange promoted by cognate and noncognate RecA proteins. Biochemistry. 2010.  49, 4872-4883. [PubMed]
34. Singh, P., Tripathi, P. and Muniyappa, K.  Mutational analysis of active-site residues in the Mycobacterium leprae RecA intein, a LAGLIDADG homing endonuclease: Asp(122) and Asp(193) are crucial to the double-stranded DNA cleavage activity whereas Asp(218) is not. Protein Science : A Publication of the Protein Society. 2010.  19, 111-123. [PubMed]
35. Khanduja, J. S., Tripathi, P. and Muniyappa, K.  Mycobacterium tuberculosis RuvA induces two distinct types of structural distortions between the homologous and heterologous Holliday junctions. Biochemistry. 2009.  48, 27-40. [PubMed]
36. Prabu, J. R., Thamotharan, S., Khanduja, J. S., Chandra, N. R., Muniyappa, K. and Vijayan, M.  Crystallographic and modelling studies on Mycobacterium tuberculosis RuvA Additional role of RuvB-binding domain and inter species variability. Biochimica et Biophysica Acta. 2009.  1794, 1001-1009. [PubMed]
37. Jain, A. K., Reddy, V. V., Paul, A., Muniyappa, K. and Bhattacharya, S.  Synthesis and evaluation of a novel class of G-quadruplex-stabilizing small molecules based on the 1,3-phenylene-bis(piperazinyl benzimidazole) system. Biochemistry. 2009.  48, 10693-10704. [PubMed]
38. Kavitha, C. V., Nambiar, M., Ananda, K., Choudhary, B., Muniyappa, K. Rangappa, K. S. and Raghavan, S. C.  Novel derivatives of spirohydantoin induce growth inhibition followed by apoptosis in leukemia cells. Biochemical Pharmacology. 2009.  77, 348-363. [PubMed]
39. Singh, P., Tripathi, P., Silva, G. H., Pingoud, A. and Muniyappa, K. Characterization of Mycobacterium leprae RecA intein, a LAGLIDADG homing endonuclease, reveals a unique mode of DNA binding, helical distortion, and cleavage compared with a canonical LAGLIDADG homing endonuclease. The Journal of Biological Chemistry. 2009.  284, 25912-25928. [PubMed]
40. Prabu, J. R., Manjunath, G. P., Chandra, N. R., Muniyappa, K. and Vijayan, M.  Functionally important movements in RecA molecules and filaments: studies involving mutation and environmental changes. Acta Crystallographica. Section D, Biological Crystallography. 2008.  64, 1146-1157. [PubMed]
41. Ghosal, G. and Muniyappa, K.  The characterization of Saccharomyces cerevisiae Mre11/Rad50/Xrs2 complex reveals that Rad50 negatively regulates Mre11 endonucleolytic but not the exonucleolytic activity. Journal of Molecular Biology. 2007.  372, 864-882. [PubMed]
42. Krishna, R., Prabu, J. R., Manjunath, G. P., Datta, S., Chandra, N. R., Muniyappa, K. and Vijayan, M.  Snapshots of RecA protein involving movement of the C-domain and different conformations of the DNA-binding loops: crystallographic and comparative analysis of 11 structures of Mycobacterium smegmatis RecA. Journal of Molecular Biology. 2007.  367, 1130-1144. [PubMed]
43. Tripathi, P., Pal, D. and Muniyappa, K.  Saccharomyces cerevisiae Hop1 protein zinc finger motif binds to the Holliday junction and distorts the DNA structure: implications for holliday junction migration. Biochemistry. 2007.  46, 12530-12542. [PubMed]
44. Ghosal, G. and Muniyappa, K.  Hoogsteen base-pairing revisited: resolving a role in normal biological processes and human diseases. Biochemical and Biophysical Research Communications. 2006.  343, 1-7. [PubMed]
45. Krishna, R., Manjunath, G. P., Kumar, P., Surolia, A., Chandra, N. R., Muniyappa, K. and Vijayan, M.  Crystallographic identification of an ordered C-terminal domain and a second nucleotide-binding site in RecA: new insights into allostery. Nucleic Acids Research. 2006.  34, 2186-2195. [PubMed]
46. Prabu, J. R., Thamotharan, S., Khanduja, J. S., Alipio, E. Z., Kim, C. Y., Waldo, G. S., Terwilliger, T. C., Segelke, B., Lekin, T., Toppani, D., Hung, L. W., Yu, M., Bursey, E., Muniyappa, K., Chandra, N. R. and Vijayan, M.  Structure of Mycobacterium tuberculosis RuvA, a protein involved in recombination. Acta Crystallographica. Section F, Structural Biology and Crystallization Communications. 2006.  62, 731-734. [PubMed]
47. Tripathi, P., Anuradha, S., Ghosal, G. and Muniyappa, K.  Selective binding of meiosis-specific yeast Hop1 protein to the holliday junctions distorts the DNA structure and its implications for junction migration and resolution. Journal of Molecular Biology. 2006.  364, 599-611. [PubMed]
48. Anuradha, S. and Muniyappa, K.  Molecular aspects of meiotic chromosome synapsis and recombination. Progress in Nucleic Acid Research and Molecular Biology. 2005.  79, 49-132. [PubMed]
49. Anuradha, S., Tripathi, P., Mahajan, K. andMuniyappa, K.  Meiosis-specific yeast Hop1 protein promotes pairing of double-stranded DNA helices via G/C isochores. Biochemical and Biophysical Research Communications. 2005.  336, 934-941. [PubMed]
50. Ghosal, G. and Muniyappa, K.  Saccharomyces cerevisiae Mre11 is a high-affinity G4 DNA-binding protein and a G-rich DNA-specific endonuclease: implications for replication of telomeric DNA. Nucleic Acids Research. 2005.  33, 4692-4703. [PubMed]
51. Saikrishnan, K., Manjunath, G. P., Singh, P., Jeyakanthan, J., Dauter, Z., Sekar, K., Muniyappa, K. and Vijayan, M.  Structure of Mycobacterium smegmatis single-stranded DNA-binding protein and a comparative study involving homologus SSBs: biological implications of structural plasticity and variability in quaternary association. Acta Crystallographica. Section D, Biological Crystallography. 2005.  61, 1140-1148. [PubMed]
52. Anuradha, S. and Muniyappa, K.  Meiosis-specific yeast Hop1 protein promotes synapsis of double-stranded DNA helices via the formation of guanine quartets. Nucleic Acids Research. 2004.  32, 2378-2385. [PubMed]
53. Anuradha, S. and Muniyappa, K.  Saccharomyces cerevisiae Hop1 zinc finger motif is the minimal region required for its function in vitro. The Journal of Biological Chemistry. 2004.  279, 28961-28969. [PubMed]
54. Datta, S., Ganesh, N., Chandra, N. R., Muniyappa, K. and Vijayan, M.  Structural studies on MtRecA-nucleotide complexes: insights into DNA and nucleotide binding and the structural signature of NTP recognition. Proteins. 2003.  50, 474-485. [PubMed]
55. Datta, S., Krishna, R., Ganesh, N., Chandra, N. R., Muniyappa, K. and Vijayan, M.  Crystal structures of Mycobacterium smegmatis RecA and its nucleotide complexes. Journal of Bacteriology. 2003.  185, 4280-4284. [PubMed]
56. Ganesh, N. and Muniyappa, K.  Characterization of DNA strand transfer promoted by Mycobacterium smegmatis RecA reveals functional diversity with Mycobacterium tuberculosis RecA. Biochemistry. 2003.  42, 7216-7225. [PubMed]
57. Ganesh, N. and Muniyappa, K.  Mycobacterium smegmatis RecA protein is structurally similar to but functionally distinct from Mycobacterium tuberculosis RecA. Proteins. 2003.  53, 6-17. [PubMed]
58. Guhan, N. and Muniyappa, K.  Mycobacterium tuberculosis RecA intein, a LAGLIDADG homing endonuclease, displays Mn(2+) and DNA-dependent ATPase activity. Nucleic Acids Research. 2003.  31, 4184-4191. [PubMed]
59. Guhan, N. and Muniyappa, K.  Structural and functional characteristics of homing endonucleases. Critical Reviews in Biochemistry and Molecular Biology. 2003.  38, 199-248. [PubMed]
60. Guhan, N. and Muniyappa, K.  Mycobacterium tuberculosis RecA intein possesses a novel ATP-dependent site-specific double-stranded DNA endonuclease activity. The Journal of Biological Chemistry. 2002.  277, 16257-16264. [PubMed]
61. Guhan, N. and Muniyappa, K. The RecA intein of Mycobacterium tuberculosis promotes cleavage of ectopic DNA sites. Implications for the dispersal of inteins in natural populations. The Journal of Biological Chemistry. 2002.  277, 40352-40361. [PubMed]
62. Venkatesh, R., Ganesh, N., Guhan, N., Reddy, M. S., Chandrasekhar, T. and Muniyappa, K. RecX protein abrogates ATP hydrolysis and strand exchange promoted by RecA: insights into negative regulation of homologous recombination. Proceedings of the National Academy of Sciences of the United States of America. 2002.  99, 12091-12096. [PubMed]
63. Bakshi, R., Galande, S. and Muniyappa, K.  Substrate specificity plays an important role in uncoupling the catalytic and scaffolding activities of rat testis DNA topoisomerase IIalpha. Journal of Biomolecular Structure & Dynamics. 2001.  18, 749-760. [PubMed]
64. Bakshi, R. P., Galande, S., Bali, P., Dighe, R. and Muniyappa, K. Developmental and hormonal regulation of type II DNA topoisomerase in rat testis. Journal of Molecular Endocrinology. 2001.  26, 193-206. [PubMed]
65. Bakshi, R. P., Galande, S. and Muniyappa, K.  Functional and regulatory characteristics of eukaryotic type II DNA topoisomerase. Critical Reviews in Biochemistry and Molecular Biology. 2001.  36, 1-37. [PubMed]
66. Reddy, M. S., Guhan, N. and Muniyappa, K.  Characterization of single-stranded DNA-binding proteins from Mycobacteria. The carboxyl-terminal of domain of SSB is essential for stable association with its cognate RecA protein. The Journal of Biological Chemistry. 2001.  276, 45959-45968. [PubMed]
67. Datta, S., Prabu, M. M., Vaze, M. B., Ganesh, N., Chandra, N. R., Muniyappa, K. and Vijayan, M.  Crystal structures of Mycobacterium tuberculosis RecA and its complex with ADP-AlF(4): implications for decreased ATPase activity and molecular aggregation. Nucleic Acids Research. 2000.  28, 4964-4973. [PubMed]
68. Muniyappa, K., Anuradha, S. and Byers, B.  Yeast meiosis-specific protein Hop1 binds to G4 DNA and promotes its formation. Molecular and Cellular Biology. 2000.  20, 1361-1369. [PubMed]
69. Muniyappa, K., Vaze, M. B., Ganesh, N., Sreedhar, R., Guhan, N. and Venkatesh, R.  Comparative genomics of Mycobacterium tuberculosis and Escherichia coli for recombination (rec) genes. Microbiology. 2000.  146 ( Pt 9), 2093-2095. [PubMed]
70. Reddy, M. S., Vaze, M. B., Madhusudan, K. and Muniyappa, K.  Binding of SSB and RecA protein to DNA-containing stem loop structures: SSB ensures the polarity of RecA polymerization on single-stranded DNA. Biochemistry. 2000.  39, 14250-14262. [PubMed]
 
71. Vaze, M. B. and Muniyappa, K.  RecA protein of Mycobacterium tuberculosis possesses pH-dependent homologous DNA pairing and strand exchange activities: implications for allele exchange in mycobacteria. Biochemistry. 1999.  38, 3175-3186. [PubMed]
72. Kironmai, K. M., Muniyappa, K., Friedman, D. B., Hollingsworth, N. M. and Byers, B.  DNA-binding activities of Hop1 protein, a synaptonemal complex component from Saccharomyces cerevisiae. Molecular and Cellular Biology. 1998.  18, 1424-1435. [PubMed]
73. Muniyappa, K. and Kironmai, K. M.  Telomere structure, replication and length maintenance. Critical Reviews in Biochemistry and Molecular Biology. 1998.  33, 297-336. [PubMed]
74. Galande, S. and Muniyappa, K.  Effects of nucleosomes and anti-tumor drugs on the catalytic activity of type II DNA topoisomerase from rat testis. Biochemical Pharmacology. 1997.  53, 1229-1238. [PubMed]
75. Kironmai, K. M. and Muniyappa, K.  Alteration of telomeric sequences and senescence caused by mutations in RAD50 of Saccharomyces cerevisiae. Genes To Cells : Devoted To Molecular & Cellular Mechanisms. 1997.  2, 443-455. [PubMed]
76. Galande, S. and Muniyappa, K.  Purification and functional characterization of type II DNA topoisomerase from rat testis and comparison with topoisomerase II from liver. Biochimica et Biophysica Acta. 1996.  1308, 58-66. [PubMed]
77. Kumar, R. A., Vaze, M. B., Chandra, N. R., Vijayan, M. and Muniyappa, K.  Functional characterization of the precursor and spliced forms of RecA protein of Mycobacterium tuberculosis. Biochemistry. 1996.  35, 1793-1802. [PubMed]
78. Mythili, E., Kumar, K. A. and Muniyappa, K.  Characterization of the DNA-binding domain of beta protein, a component of phage lambda red-pathway, by UV catalyzed cross-linking. Gene. 1996.  182, 81-87. [PubMed]
79. Ramdas, J. and Muniyappa, K.  Recognition and alignment of homologous DNA sequences between minichromosomes and single-stranded DNA promoted by RecA protein. Molecular & General Genetics : MGG. 1995.  249, 336-348. [PubMed]
80. Ramdas, J. and Muniyappa, K.  Recognition and alignment of homologous DNA sequences between minichromosomes and single-stranded DNA promoted by RecA protein. Molecular & General Genetics : MGG. 1995.  249, 336-348. [PubMed]
81. Muniyappa, K. and Mythili, E.  Phage lambda beta protein, a component of general recombination, is associated with host ribosomal S1 protein. Biochemistry and Molecular Biology International. 1993.  31, 1-11. [PubMed]
82. Mythili, E. and Muniyappa, K.  Formation of linear plasmid multimers promoted by the phage lambda Red-system in lon mutants of Escherichia coli. Journal of General Microbiology. 1993.  139, 2387-2397. [PubMed]
83. Kumar, K. A. and Muniyappa, K.  Use of structure-directed DNA ligands to probe the binding of recA protein to narrow and wide grooves of DNA and on its ability to promote homologous pairing. The Journal of Biological Chemistry. 1992.  267, 24824-24832. [PubMed]
84. Rould, E., Muniyappa, K. and Radding, C. M.  Unwinding of heterologous DNA by RecA protein during the search for homologous sequences. Journal of Molecular Biology. 1992.  226, 127-139. [PubMed]
85. Muniyappa, K., Ramdas, J., Mythili, E. and Galande, S.  Homologous pairing between nucleosome cores on a linear duplex DNA and nucleoprotein filaments of RecA protein-single stranded DNA. Biochimie. 1991.  73, 187-190. [PubMed]
86. Ramdas, J., Mythili, E. and Muniyappa, K.  Nucleosomes on linear duplex DNA allow homologous pairing but prevent strand exchange promoted by RecA protein. Proceedings of the National Academy of Sciences of the United States of America. 1991.  88, 1344-1348. [PubMed]
87. Muniyappa, K., Williams, K., Chase, J. W. and Radding, C. M.  Active nucleoprotein filaments of single-stranded binding protein and recA protein on single-stranded DNA have a regular repeating structure. Nucleic Acids Research. 1990.  18, 3967-3973. [PubMed]
88. Ramdas, J., Mythili, E. and Muniyappa, K.  RecA protein promoted homologous pairing in vitro. Pairing between linear duplex DNA bound to HU Protein (nucleosome cores) and nucleoprotein filaments of recA protein-single-stranded DNA. The Journal of Biological Chemistry. 1989.  264, 17395-17400. [PubMed]
89. Muniyappa, K. and Radding, C. M.  The homologous recombination system of phage lambda. Pairing activities of beta protein. The Journal of Biological Chemistry. 1986.  261, 7472-7478. [PubMed]
90. Tsang, S. S., Muniyappa, K., Azhderian, E., Gonda, D. K., Radding, C. M., Flory, J. and Chase, J. W.  Intermediates in homologous pairing promoted by recA protein. Isolation and characterization of active presynaptic complexes. Journal of Molecular Biology. 1985.  185, 295-309. [PubMed]
91. Flory, J., Tsang, S. S. and Muniyappa, K.  Isolation and visualization of active presynaptic filaments of recA protein and single-stranded DNA. Proceedings of the National Academy of Sciences of the United States of America. 1984.  81, 7026-7030. [PubMed]
92. Flory, S. S., Tsang, J., Muniyappa, K., Bianchi, M., Gonda, D., Kahn, R., Azhderian, E., Egner, C., Shaner, S. and Radding, C. M.  Intermediates in homologous pairing promoted by RecA protein and correlations of recombination in vitro and in vivo. Cold Spring Harbor Symposia On Quantitative Biology. 1984.  49, 513-523. [PubMed]
93. Mascarenhas, C., Rajanna, B., Muniyappa, K. and Desiraju, T.  Efficacy of a commercial rat feed & three other constituted diets in sustaining the body growth of rats. The Indian Journal of Medical Research. 1984.  80, 218-227. [PubMed]
94. Muniyappa, K. and Mendicino, J.  Binding and regulatory properties of phosphofructokinase from swine kidney. Molecular and Cellular Biochemistry. 1984.  63, 21-32. [PubMed]
95. Muniyappa, K., Shaner, S. L., Tsang, S. S. and Radding, C. M.  Mechanism of the concerted action of recA protein and helix-destabilizing proteins in homologous recombination. Proceedings of the National Academy of Sciences of the United States of America. 1984.  81, 2757-2761. [PubMed]
96. Muniyappa, K., Leibach, F. H. and Mendicino, J.  Characterization and comparison of the soluble and membrane-bound cyclic AMP-dependent protein kinase from swine kidney. Molecular and Cellular Biochemistry. 1983.  50, 157-171. [PubMed]
97. Muniyappa, K., Leibach, F. H. and Mendicino, J.  Reciprocal regulation of fructose 1,6-bisphosphatase and phosphofructokinase by fructose 2,6-bisphosphate in swine kidney. Life Sciences. 1983.  32, 271-278. [PubMed]
98. Muniyappa, K. and Mendicino, J.  Purification and properties of swine kidney phosphoprotein phosphatase. Molecular and Cellular Biochemistry. 1983.  51, 177-189. [PubMed]
99. Mendicino, J., Muniyappa, K. and Leibach, F. H.  cAMP-dependent protein kinase, soluble and particulate, from swine kidney. Methods in Enzymology. 1982.  90 Pt E, 200-206. [PubMed]
100. Muniyappa, K., Leibach, F. and Mendicino, J.  Phosphoprotein phosphatase from swine kidney. Methods in Enzymology. 1982.  90 Pt E, 407-413. [PubMed]
101. Muniyappa, K. and Adiga, P. R.  Nature of the thiamin-binding protein from chicken egg yolk. The Biochemical Journal. 1981.  193, 679-685. [PubMed]
102. Muniyappa, K. and Adiga, P. R.  Isolation and characterization of riboflavin-binding protein from pregnant-rat serum. The Biochemical Journal. 1980.  187, 537-540. [PubMed]
103. Muniyappa, K. and Adiga, P. R.  Occurrence and functional importance of a riboflavin-carrier protein in the pregnant rat. FEBS Letters. 1980.  110, 209-212. [PubMed]
104. Muniyappa, K. and Adiga, P. R.  Oestrogen-induced synthesis of thiamin-binding protein in immature chicks. Kinetics of induction, hormonal specificity and modulation. The Biochemical Journal. 1980.  186, 201-210. [PubMed]
105. Muniyappa, K. and Adiga, P. R.  Purification and properties of riboflavin-binding protein from the egg white of the duck (Anas platyrhynckos). Biochimica et Biophysica Acta. 1980.  623, 339-347. [PubMed]
106. Muniyappa, K. and Adiga, P. R.  Isolation and characterization of thiamin-binding protein from chicken egg white. The Biochemical Journal. 1979.  177, 887-894. [PubMed]
 

 
 
Education 
::
Ph.D. Indian Institute of Science, Bangalore, India
::
M.Sc. University of Mysore
Honors and Awards
::
IISc Alumni Award (2007); and Kempe Gowda Award (2007).
::
Professor Vishwanath Memorial Lecture (2001) of INSA; Anima Sen Memorial Award (2002); JC Bose National Fellowship (2006-11);
::
SS Bhatnagar Prize (1995); Eleanor Roosevelt Award of the American Cancer Society (1995); Yamagiwa International Cancer Fellowship Award, Switzerland (1999);
::
Hanumantha Rao Memorial Medal (1980); Rockefeller Foundation Career Development Award (1990-92); M Sreenivasaya Memorial Award (1994)
  Last modified on : Dec 14, 2015
India Cancer Research Database has been developed by the Institute of Bioinformatics with funding from the Department of Biotechnology, Government of India.