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Anjali Shiras,
Scientific Officer F 
National Centre for Cell Science
NCCS Complex, Pune University Campus
Pune - 411 007   
Phone: +91-020-25708052
Fax: +91-020-25692259
Research Summary:
Understanding the role of cellular signaling pathways involved in cancer stemness and malignant behavior of Central Nervous System (CNS) tumors
1.Murawala, P., Tirmale, A., Shiras, A. and Prasad, B. L.  In situ synthesized BSA capped gold nanoparticles: Effective carrier of anticancer drug Methotrexate to MCF-7 breast cancer cells. Materials Science & Engineering. C, Materials For Biological Applications. 2014.  34, 158-167. [PubMed]
2.Rani, S. B., Rathod, S. S., Karthik, S., Kaur, N., Muzumdar, D. and Shiras, A. S.  MiR-145 functions as a tumor-suppressive RNA by targeting Sox9 and adducin 3 in human glioma cells. Neuro-oncology. 2013.  15, 1302-1316. [PubMed]
3.Gupta, M. K., Polisetty, R. V., Ramamoorthy, K., Tiwary, S., Kaur, N., Uppin, M. S., Shiras, A. and Sirdeshmukh, R.  Secretome analysis of Glioblastoma cell line--HNGC-2. Molecular BioSystems. 2013.  9, 1390-1400. [PubMed]
4.Kaur, N., Chettiar, S., Rathod, S., Rath, P., Muzumdar, D., Shaikh, M. L. and Shiras, A.  Wnt3a mediated activation of Wnt/beta-catenin signaling promotes tumor progression in glioblastoma. Molecular and Cellular Neurosciences. 2013.  54, 44-57. [PubMed]
5.Polisetty, R. V., Gupta, M. K., Nair, S. C., Ramamoorthy, K., Tiwary, S., Shiras, A., Chandak, G. R. and Sirdeshmukh, R.  Glioblastoma cell secretome: analysis of three glioblastoma cell lines reveal 148 non-redundant proteins. Journal of Proteomics. 2011.  74, 1918-1925. [PubMed]
6.Mruthyunjaya, S., Rumma, M., Ravibhushan, G., Anjali, S. and Padma, S.  c-Jun/AP-1 transcription factor regulates laminin-1-induced neurite outgrowth in human bone marrow mesenchymal stem cells: role of multiple signaling pathways. FEBS Letters. 2011.  585, 1915-1922. [PubMed]
7.Das, G., Shiras, A., Shanmuganandam, K. and Shastry, P.  Rictor regulates MMP-9 activity and invasion through Raf-1-MEK-ERK signaling pathway in glioma cells. Molecular Carcinogenesis. 2011.  50, 412-423. [PubMed]
8.Joshi-Navare, K., Shiras, A. and Prabhune, A.  Differentiation-inducing ability of sophorolipids of oleic and linoleic acids using a glioma cell line. Biotechnology Journal. 2011.  6, 509-512. [PubMed]
9.Venkatpurwar, V., Shiras, A. and Pokharkar, V.  Porphyran capped gold nanoparticles as a novel carrier for delivery of anticancer drug: in vitro cytotoxicity study. International Journal of Pharmaceutics. 2011.  409, 314-320. [PubMed]
10.Rajendran, G., Shanmuganandam, K., Bendre, A., Muzumdar, D., Goel, A. and Shiras, A.  Epigenetic regulation of DNA methyltransferases: DNMT1 and DNMT3B in gliomas. Journal of Neuro-oncology. 2011.  104, 483-494. [PubMed]
11.Dhar, S., Mali, V., Bodhankar, S., Shiras, A., Prasad, B. L. and Pokharkar, V.  Biocompatible gellan gum-reduced gold nanoparticles: cellular uptake and subacute oral toxicity studies. Journal of Applied Toxicology : JAT. 2011.  31, 411-420. [PubMed]
12.Dhar, S., Reddy, E. M., Prabhune, A., Pokharkar, V., Shiras, A. and Prasad, B. L.  Cytotoxicity of sophorolipid-gellan gum-gold nanoparticle conjugates and their doxorubicin loaded derivatives towards human glioma and human glioma stem cell lines. Nanoscale. 2011.  3, 575-580. [PubMed]
13.Reddy, E. M., Chettiar, S. T., Kaur, N., Shepal, V. and Shiras, A.  Dlxin-1, a MAGE family protein, induces accelerated neurite outgrowth and cell survival by enhanced and early activation of MEK and Akt signalling pathways in PC12 cells. Experimental Cell Research. 2010.  316, 2220-2236. [PubMed]
14.Mruthyunjaya, S., Manchanda, R., Godbole, R., Pujari, R., Shiras, A. and Shastry, P.  Laminin-1 induces neurite outgrowth in human mesenchymal stem cells in serum/differentiation factors-free conditions through activation of FAK-MEK/ERK signaling pathways. Biochemical and Biophysical Research Communications. 2010.  391, 43-48. [PubMed]
15.Dhar, S., Reddy, E. M., Shiras, A., Pokharkar, V. and Prasad, B. L.  Natural gum reduced/stabilized gold nanoparticles for drug delivery formulations. Chemistry. 2008.  14, 10244-10250. [PubMed]
16.Sudheerkumar, P., Shiras, A., Das, G., Jagtap, J. C., Prasad, V. and Shastry, P.  Independent activation of Akt and NF-kappaB pathways and their role in resistance to TNF-alpha mediated cytotoxicity in gliomas. Molecular Carcinogenesis. 2008.  47, 126-136. [PubMed]
17.Kumar, P. S., Shiras, A., Das, G., Jagtap, J. C., Prasad, V. and Shastry, P.  Differential expression and role of p21cip/waf1 and p27kip1 in TNF-alpha-induced inhibition of proliferation in human glioma cells. Molecular Cancer. 2007.  6, 42. [PubMed]
18.Shiras, A., Chettiar, S. T., Shepal, V., Rajendran, G., Prasad, G. R. and Shastry, P.  Spontaneous transformation of human adult nontumorigenic stem cells to cancer stem cells is driven by genomic instability in a human model of glioblastoma. Stem Cells. 2007.  25, 1478-1489. [PubMed]
19.Shiras, A., Bhosale, A., Shepal, V., Shukla, R., Baburao, V. S., Prabhakara, K. and Shastry, P.  A unique model system for tumor progression in GBM comprising two developed human neuro-epithelial cell lines with differential transforming potential and coexpressing neuronal and glial markers. Neoplasia. 2003.  5, 520-532. [PubMed]
20.Shiras, A., Bhosale, A., Patekar, A., Shepal, V. and Shastry, P.  Differential expression of CD44(S) and variant isoforms v3, v10 in three-dimensional cultures of mouse melanoma cell lines. Clinical & Experimental Metastasis. 2002.  19, 445-455. [PubMed]
  Last modified on : Dec 3, 2013
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