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ManojKumar Bhattacharyya, Ph.D.
Scientist F 
National Centre for Cell Science
NCCS Complex, Pune University Campus
Pune - 411 007   
Phone: +91-020-25708066
Research Summary:
Cell Biology and Cancer Biology
1.Meena, A. S., Sharma, A., Kumari, R., Mohammad, N., Singh, S. V. and Bhat, M. K.  Inherent and acquired resistance to paclitaxel in hepatocellular carcinoma: molecular events involved. PloS One. 2013.  8, e61524. [PubMed]
2.Vijayakumar, M. V. and Bhat, M. K.  Real time qualitative and quantitative GLUT4 translocation assay. Methods in Enzymology. 2012.  505, 257-271. [PubMed]
3.Sharma, A. and Bhat, M. K.  Enhancement of carboplatin- and quercetin-induced cell death by roscovitine is Akt dependent and p53 independent in hepatoma cells. Integrative Cancer Therapies. 2011.  10, NP4-14. [PubMed]
4.Kumar, A., Chinta, J. P., Ajay, A. K., Bhat, M. K. and Rao, C. P.  Synthesis, characterization, plasmid cleavage and cytotoxicity of cancer cells by a copper(II) complex of anthracenyl-terpyridine. Dalton Transactions. 2011.  40, 10865-10872. [PubMed]
5.Pandey, V., Chaube, B. and Bhat, M. K.  Hyperglycemia regulates MDR-1, drug accumulation and ROS levels causing increased toxicity of carboplatin and 5-fluorouracil in MCF-7 cells. Journal of Cellular Biochemistry. 2011.  112, 2942-2952. [PubMed]
6.Pandey, V., Vijayakumar, M. V., Ajay, A. K., Malvi, P. and Bhat, M. K.  Diet-induced obesity increases melanoma progression: involvement of Cav-1 and FASN. International Journal of Cancer. Journal International Du Cancer. 2012.  130, 497-508. [PubMed]
7.Vijayakumar, M. V., Ajay, A. K. and Bhat, M. K.  Demonstration of a visual cell-based assay for screening glucose transporter 4 translocation modulators in real time. Journal of Biosciences. 2010.  35, 525-531. [PubMed]
8.Sharma, A., Meena, A. S. and Bhat, M. K.  Hyperthermia-associated carboplatin resistance: differential role of p53, HSF1 and Hsp70 in hepatoma cells. Cancer Science. 2010.  101, 1186-1193. [PubMed]
9.Sharma, A., Upadhyay, A. K. and Bhat, M. K.  Inhibition of Hsp27 and Hsp40 potentiates 5-fluorouracil and carboplatin mediated cell killing in hepatoma cells. Cancer Biology & Therapy. 2009.  8, 2106-2113. [PubMed]
10.Kumari, R., Sharma, A., Ajay, A. K. and Bhat, M. K.  Mitomycin C induces bystander killing in homogeneous and heterogeneous hepatoma cellular models. Molecular Cancer. 2009.  8, 87. [PubMed]
11.Upadhyay, A. K., Ajay, A. K., Singh, S. and Bhat, M. K.  Cell cycle regulatory protein 5 (Cdk5) is a novel downstream target of ERK in carboplatin induced death of breast cancer cells. Current Cancer Drug Targets. 2008.  8, 741-752. [PubMed]
12.Pandey, V., Vijayakumar, M. V., Kaul-Ghanekar, R., Mamgain, H., Paknikar, K. and Bhat, M. K.  Atomic force microscopy, biochemical analysis of 3T3-L1 cells differentiated in the absence and presence of insulin. Biochimica et Biophysica Acta. 2009.  1790, 57-64. [PubMed]
13.Vijayakumar, M. V. and Bhat, M. K.  Hypoglycemic effect of a novel dialysed fenugreek seeds extract is sustainable and is mediated, in part, by the activation of hepatic enzymes. Phytotherapy Research : PTR. 2008.  22, 500-505. [PubMed]
14.Chhipa, R. R., Kumari, R., Upadhyay, A. K. and Bhat, M. K.  Abrogation of p53 by its antisense in MCF-7 breast carcinoma cells increases cyclin D1 via activation of Akt and promotion of cell proliferation. Experimental Cell Research. 2007.  313, 3945-3958. [PubMed]
15.Gholap, A. R., Toti, K. S., Shirazi, F., Kumari, R., Bhat, M. K., Deshpande, M. V. and Srinivasan, K. V.  Synthesis and evaluation of antifungal properties of a series of the novel 2-amino-5-oxo-4-phenyl-5,6,7,8-tetrahydroquinoline-3-carbonitrile and its analogues. Bioorganic & Medicinal Chemistry. 2007.  15, 6705-6715. [PubMed]
16.Chhipa, R. R. and Bhat, M. K.  Bystander killing of breast cancer MCF-7 cells by MDA-MB-231 cells exposed to 5-fluorouracil is mediated via Fas. Journal of Cellular Biochemistry. 2007.  101, 68-79. [PubMed]
17.Singh, S., Upadhyay, A. K., Ajay, A. K. and Bhat, M. K.  p53 regulates ERK activation in carboplatin induced apoptosis in cervical carcinoma: a novel target of p53 in apoptosis. FEBS Letters. 2007.  581, 289-295. [PubMed]
18.Singh, S., Upadhyay, A. K., Ajay, A. K. and Bhat, M. K.  Gadd45alpha does not modulate the carboplatin or 5-fluorouracil-induced apoptosis in human papillomavirus-positive cells. Journal of Cellular Biochemistry. 2007.  100, 1191-1199. [PubMed]
19.Upadhyay, A. K., Singh, S., Chhipa, R. R., Vijayakumar, M. V., Ajay, A. K. and Bhat, M. K.  Methyl-beta-cyclodextrin enhances the susceptibility of human breast cancer cells to carboplatin and 5-fluorouracil: involvement of Akt, NF-kappaB and Bcl-2. Toxicology and Applied Pharmacology. 2006.  216, 177-185. [PubMed]
20.Singh, S., Chhipa, R. R., Vijayakumar, M. V. and Bhat, M. K.  DNA damaging drugs-induced down-regulation of Bcl-2 is essential for induction of apoptosis in high-risk HPV-positive HEp-2 and KB cells. Cancer Letters. 2006.  236, 213-221. [PubMed]
21.Vijayakumar, M. V., Singh, S., Chhipa, R. R. and Bhat, M. K.  The hypoglycaemic activity of fenugreek seed extract is mediated through the stimulation of an insulin signalling pathway. British Journal of Pharmacology. 2005.  146, 41-48. [PubMed]
22.Chhipa, R. R., Singh, S., Surve, S. V., Vijayakumar, M. V. and Bhat, M. K.  Doxycycline potentiates antitumor effect of cyclophosphamide in mice. Toxicology and Applied Pharmacology. 2005.  202, 268-277. [PubMed]
23.Singh, S. and Bhat, M. K.  Carboplatin induces apoptotic cell death through downregulation of constitutively active nuclear factor-kappaB in human HPV-18 E6-positive HEp-2 cells. Biochemical and Biophysical Research Communications. 2004.  318, 346-353. [PubMed]
24.Salunke, D. B., Hazra, B. G., Pore, V. S., Bhat, M. K., Nahar, P. B. and Deshpande, M. V.  New steroidal dimers with antifungal and antiproliferative activity. Journal of Medicinal Chemistry. 2004.  47, 1591-1594. [PubMed]
25.Kaul, R., Mukherjee, S., Ahmed, F., Bhat, M. K., Chhipa, R., Galande, S. and Chattopadhyay, S.  Direct interaction with and activation of p53 by SMAR1 retards cell-cycle progression at G2/M phase and delays tumor growth in mice. International Journal of Cancer. Journal International Du Cancer. 2003.  103, 606-615. [PubMed]
Ph.D. in Biochemistry
M.Sc. in Biochemistry
Fellow, National Academy of Sciences, India, 2011
Indian Association for Cancer Research
Indian Society of Cell Biology
  Last modified on : Dec 3, 2013
India Cancer Research Database has been developed by the Institute of Bioinformatics with funding from the Department of Biotechnology, Government of India.