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Tessy Thomas Maliekal, Ph.D.
Visiting Scientist 
Rajiv Gandhi Center for Biotechnology
Thycaud Post, Poojappura
Thiruvananthapuram - 695 014   
Positions Held:
Position Affiliation Time Period
Research Associate Regional Cancer Center, Thiruvananthapuram 2002-2004
Research Associate National Centre for Biological Sciences 2004-2005
Visiting Fellow National Centre for Biological Sciences 2008-2010
Research Summary:
Characterizing the signaling network that sustains oral cancer stem cells for developing a targeted therapy
1. Vinod, B. S., Maliekal, T. T. and Anto, R. J.  Phytochemicals as chemosensitizers: from molecular mechanism to clinical significance. Antioxidants & Redox Signaling. 2013.  18, 1307-1348. [PubMed]
2. Anto, R. J., Maliekal, T. T. and Karunagaran, D.  L-929 cells harboring ectopically expressed RelA resist curcumin-induced apoptosis. The Journal of Biological Chemistry. 2000.  275, 15601-15604. [PubMed]
3. Maliekal, T. T., Anto, R. J. and Karunagaran, D.  Differential activation of Smads in HeLa and SiHa cells that differ in their response to transforming growth factor-beta. The Journal of Biological Chemistry. 2004.  279, 36287-36292. [PubMed]
4. Maliekal, T. T., Bajaj, J., Giri, V., Subramanyam, D. and Krishna, S.  The role of Notch signaling in human cervical cancer: implications for solid tumors. Oncogene. 2008.  27, 5110-5114. [PubMed]
5. Maliekal, T. T., Antony, M. L., Nair, A., Paulmurugan, R. and Karunagaran, D.  Loss of expression, and mutations of Smad 2 and Smad 4 in human cervical cancer. Oncogene. 2003.  22, 4889-4897. [PubMed]
6. Bajaj, J., Maliekal, T. T., Vivien, E., Pattabiraman, C., Srivastava, S., Krishnamurthy, H., Giri, V., Subramanyam, D. and Krishna, S.  Notch signaling in CD66+ cells drives the progression of human cervical cancers. Cancer Research. 2011.  71, 4888-4897. [PubMed]
7. Ramdass, B., Maliekal, T. T., Lakshmi, S., Rehman, M., Rema, P., Nair, P., Mukherjee, G., Reddy, B. K., Krishna, S. and Radhakrishna, P.  Coexpression of Notch1 and NF-kappaB signaling pathway components in human cervical cancer progression. Gynecologic Oncology. 2007.  104, 352-361. [PubMed]
8. Nair, A., Venkatraman, M., Maliekal, T. T., Nair, B. and Karunagaran, D.  NF-kappaB is constitutively activated in high-grade squamous intraepithelial lesions and squamous cell carcinomas of the human uterine cervix. Oncogene. 2003.  22, 50-58. [PubMed]
9. Maliekal, T. T., Sudha, B. and Paulose, C. S.  Kinetic parameters of Thymidine kinase and DNA synthesis during liver regeneration: role of thyroid hormones. Life Sciences. 1997.  60, 1867-1874. [PubMed]


Ph.D. in Biotechnology
M.Sc. in Biotechnology, Cochin University of Science and Technology, 2000-2002
Honors and Awards
Indo-French Scientific Co-operation Programme, 2008
Type of Neoplasms
Head and Neck
  Last modified on : Dec 2, 2013
India Cancer Research Database has been developed by the Institute of Bioinformatics with funding from the Department of Biotechnology, Government of India.