INCREDB ID : 430
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Uttam Pati, Ph.D., D. Phil
Professor 
 
School of Biotechnology, Jawaharlal Nehru University
Transcription and Human Biology Laboratory
New Delhi - 110 067   
New Delhi   
 
E-mail: uttam@mail.jnu.ac.in
Phone: 26704081
Mobile: 9312401811
Fax: 26167261
 
URL: http://www.jnu.ac.in/Faculty/ukpati
 
Positions Held:
Position Affiliation Time Period
Dean School of Biotechnology, Jawaharlal Nehru University 2006-2007
Chairman Center for Biotechnology, Jawaharlal Nehru University 2005-2006
Professor Center for Biotechnology, Jawaharlal Nehru University 2002
Chairman Center for Biotechnology, Jawaharlal Nehru University 1999-2001
Associate Professor Center for Biotechnology, Jawaharlal Nehru University 1991-1994
 
Area of Specialization:
Transcriptomics
Oncology
Research Summary:
Cancer Biology, Gene regulation in hypoxia, Re-oxygenation, p53 and HIF1a and their role in hypoxic tumor, Molecular chaperones and gene regulation.
 
Publications:
1. Madan, E., Gogna, R., Kuppusamy, P., Bhatt, M., Mahdi, A. A. and Pati, U.  SCO2 induces p53-mediated apoptosis by Thr845 phosphorylation of ASK-1 and dissociation of the ASK-1-Trx complex. Molecular and Cellular Biology. 2013.  33, 1285-1302. [PubMed]
2. Madan, E., Gogna, R. and Pati, U.  p53 Ser15 phosphorylation disrupts the p53-RPA70 complex and induces RPA70-mediated DNA repair in hypoxia. The Biochemical Journal. 2012.  443, 811-820. [PubMed]
3. Gogna, R., Madan, E., Kuppusamy, P. and Pati, U.  Re-oxygenation causes hypoxic tumor regression through restoration of p53 wild-type conformation and post-translational modifications. Cell Death & Disease. 2012.  3, e286. [PubMed]
4. Gogna, R., Madan, E., Kuppusamy, P. and Pati, U.  Chaperoning of mutant p53 protein by wild-type p53 protein causes hypoxic tumor regression. The Journal of Biological Chemistry. 2012.  287, 2907-2914. [PubMed]
5. Madan, E., Gogna, R., Kuppusamy, P., Bhatt, M., Pati, U. and Mahdi, A. A.  TIGAR induces p53-mediated cell-cycle arrest by regulation of RB-E2F1 complex. British Journal of Cancer. 2012.  107, 516-526. [PubMed]
6. Madan, E., Gogna, R., Bhatt, M., Pati, U., Kuppusamy, P. and Mahdi, A. A.  Regulation of glucose metabolism by p53: emerging new roles for the tumor suppressor. Oncotarget. 2011.  2, 948-957. [PubMed]
7. Gogna, R., Madan, E., Kuppusamy, P. and Pati, U.  Reactive oxygen species-mediated p53 core-domain modifications determine apoptotic or necrotic death in cancer cells. Antioxidants & Redox Signaling. 2012.  16, 400-412. [PubMed]
8. Gogna, R., Madan, E., Keppler, B. and Pati, U.  Gallium compound GaQ(3) -induced Ca(2+) signalling triggers p53-dependent and -independent apoptosis in cancer cells. British Journal of Pharmacology. 2012.  166, 617-636. [PubMed]
9. Shrivastava, M., Vivekanandhan, S., Pati, U., Behari, M. and Das, T. K.  Mitochondrial perturbance and execution of apoptosis in platelet mitochondria of patients with amyotrophic lateral sclerosis. The International Journal of Neuroscience. 2011.  121, 149-158. [PubMed]
10. Shrivastava, M., Das, T. K., Behari, M., Pati, U. and Vivekanandhan, S.  Ultrastructural variations in platelets and platelet mitochondria: a novel feature in amyotrophic lateral sclerosis. Ultrastructural Pathology. 2011.  35, 52-59. [PubMed]
11. Suman, S., Khaitan, D., Pati, U., Seth, R. K. and Chandna, S.  Stress response of a p53 homologue in the radioresistant Sf9 insect cells. International Journal of Radiation Biology. 2009.  85, 238-249. [PubMed]
12. Dubey, S. K., Sharma, A. K., Narain, U., Misra, K. and Pati, U.  Design, synthesis and characterization of some bioactive conjugates of curcumin with glycine, glutamic acid, valine and demethylenated piperic acid and study of their antimicrobial and antiproliferative properties. European Journal of Medicinal Chemistry. 2008.  43, 1837-1846. [PubMed]
13. Tripathi, V., Ali, A., Bhat, R. and Pati, U.  CHIP chaperones wild type p53 tumor suppressor protein. The Journal of Biological Chemistry. 2007.  282, 28441-28454. [PubMed]
14. Kapoor, N., Sharma, A. K., Dwivedi, V., Kumar, A., Pati, U. and Misra, K.  Telomerase targeted anticancer bioactive prodrug by antisense-based approach. Cancer Letters. 2007.  248, 245-250. [PubMed]
15. Chauhan, R., Handa, R., Das, T. P. and Pati, U.  Over-expression of TATA binding protein (TBP) and p53 and autoantibodies to these antigens are features of systemic sclerosis, systemic lupus erythematosus and overlap syndromes. Clinical and Experimental Immunology. 2004.  136, 574-584. [PubMed]
16. Negi, S., Singh, S. K., Pati, N., Handa, V., Chauhan, R. and Pati, U.  A proximal tissue-specific module and a distal negative regulatory module control apolipoprotein(a) gene transcription. The Biochemical Journal. 2004.  379, 151-159. [PubMed]
17. Handa, V., Pati, N. and Pati, U.  Multiple liver-specific factors bind to a 64-bp element and activate apo(a) gene. Biochemical and Biophysical Research Communications. 2002.  292, 243-249. [PubMed]
18. Pati, U. and Pati, N.  Lipoprotein(a), atherosclerosis, and apolipoprotein(a) gene polymorphism. Molecular Genetics and Metabolism. 2000.  71, 87-92. [PubMed]
19. Pati, U. and Gambhir, J. K.  Apolipoprotein(a) polymorphism and plasma lipoprotein(a) levels. Indian Heart Journal. 2000.  52, 171-172. [PubMed]
20. Pati, N., Rouf, A. and Pati, U.  Simultaneous mutations (A/G(-418) and C/T(-384)) in the apo(a) promoter of individuals with low Lp(a) levels. Molecular Genetics and Metabolism. 2000.  69, 165-167. [PubMed]
21. Pati, N. and Pati, U.  Paraoxonase gene polymorphism and coronary artery disease in Indian subjects. International Journal of Cardiology. 1998.  66, 165-168. [PubMed]
22. Pati U. K.  Human RNA polymerase II subunit hRPB14 is homologous to yeast RNA polymerase I, II, and III subunits (AC19 and RPB11) and is similar to a portion of the bacterial RNA polymerase alpha subunit. Gene. 1994.  145, 289-292. [PubMed]
23. Hirakata, M., Okano, Y., Pati, U., Suwa, A., Medsger, T. A., Hardin, J. A. and Craft, J.  Identification of autoantibodies to RNA polymerase II. Occurrence in systemic sclerosis and association with autoantibodies to RNA polymerases I and III. The Journal of Clinical Investigation. 1993.  91, 2665-2672. [PubMed]
24. Pati U. K.  Novel vectors for expression of cDNA encoding epitope-tagged proteins in mammalian cells. Gene. 1992.  114, 285-288. [PubMed]
25. Pati, U. K. and Weissman, S. M.  The amino acid sequence of the human RNA polymerase II 33-kDa subunit hRPB 33 is highly conserved among eukaryotes. The Journal of Biological Chemistry. 1990.  265, 8400-8403. [PubMed]

1. Esha Madan, Rajan Gogna, Bernhard Keppler and Pati U. p53 Increases Intra-cellular calcium release by transcriptional regulation of calcium channel TRPC6 in GaQ3-treated cancer cells. PloS One. 2013. (In press).

2. Rajan Gogna, Esha Madan, Mahmood Khan, Uttam Pati and Periannan Kuppusamy. p53’s choice of myocardial death or survival: Oxygen protects infarct myocardium by recruiting p53 on NOS3 promoter through regulation of p53Lys162acetylation. EMBO Report. 2013. (In press).

3. Mohammad Azam, Saud I. Al-Resayesa, Agata Trzesowska- Kruszynskab, Rafal Kruszynsk, Ambarish Verma and Uttam Pati. Apoptosis induction by chiral anionic binuclear Zn(II) complexes based on (1S,2S)- (+)-Cyclohexanediamine in HCT cells with different p53 status. Inorganic Chemistry. 2013. (In press).

4. Sharma A, Ali A, Gogna R, Singh A and Pati U. The role of p53 amino terminus domain in displaying chaperone like function. PloS One. 2009. 4(10), 7159.

5. Hirakata M, Kanungo J, Pati U.K, Suwa A, Okano Y, and Hardin J.A. The auto-antigenic domain of RNA polymerase II resides at the carboxyl terminal. Arthritis Rheum. 1992. 35, 38-40.

6. Denner L, Hongjun J, Owen R.D, Kato G.L, Clarke C.L, and Pati U.K. Steroid receptors, transcription factors, and gene expression. Cancer. Res. 1990. 50, 6430-6436.

7. Pati U.K and Wiesner K. Synthesis of 17b- (3’-thiphenyl) 15b-androstane- 3b, 14-b-diol 3-bD glucopyranoside, an-antitropic cardiac glucoside. Steroids. 1990. 55,65-68.

8. Pati U.K and Weissman S.M. Converted domains of mammalial RNA polymerase II. Cold Spring Harbor Journal of Cancer Cells. 1989. 65,157.

9. Pati U.K and Weissman S. Isolation and molecular characterization of cDNA encoding the 23 K subunit of human RNA polymerase II complex. J. Biol. Chem. 1989. 264, 13114-13121.

10. Pati U.K and Wiesner K. Synthesis of 5b-androstane-17b-(oxocyclohex- 2’-en-3’-yl)-3b, 14b-diol 3b-D-glucopyranosdie, a potent cardiac glucoside with high safety margin. Heterocycles. 1989. 29, 1275-1282.

11. Pati U.K and Weissmn S.M. Molecular characterization of mammalian RNA polymerase II complex. Cold Spring Harbor Journal of Cancer Cells. 1988. 64,121- 24.

12. Stone K, Pati U, Weissman S, Sebti S, Lazo J and Williams K. Isolation and re-purification of picomole amounts of peptides on microbore HPLC columns. ASBMB Journal of Protein Purification. 1987. 37, 180-81.

13. Ziegler F.E, Klein S.I, Pati U.K and Wang T.F. Acylic Diastereoselection as a synthetic route to quassinoids : A claisen F.E. Ziegler, U.K. Pati, S.C rearrangment based strategy for bruceantin. J. Am. Chem. Soc. 1985. 107(9), 2730-2737.

14. Ziegler F.E, Hwang K.J, Kadow J.F, Klein S.I, Pati U.K, Wang T.F. Practical Routes to 2 functionilized decalones for the synthesis of quassinoids. J. Org. Chem. 1986. 51(24), 4573-4579.

 
Grant Support:
Project Title Role Funding Agency Sanction Number Sanction Date
Role of p53 tumor suppressor as a molecular sensor of oxygen in inducing apoptosis in hypoxic cancer cells Principal Investigator Indian Council of Medical Research, Government of India 2013-2016
Role of triplex DNA in transcriptional regulation of cardio-protective NOS2 gene Principal Investigator Indian Council of Medical Research, Government of India 2012-2015
Role of pentanucleotide repeat sequence (PNR) in triplex formation and apo(a) gene regulation Principal Investigator Indian Council of Medical Research, Government of India 2008-2011
Role of CHIP and p53 in prevention of amyloid-b fibrils Principal Investigator University Grants Commission, India 2008-2011
CVD biomarkers profiling in acute coronary events by antibodies and antigen array Principal Investigator Indian Council of Medical Research, Government of India 2008-2011
Suppression of oral cancer-specific p53 mutant by SiRNA Principal Investigator Department of Biotechnology, Government of India 2006
A transgenic mice model of Homozygous deletion of Tumor suppressor gene p53 for gene therapy Principal Investigator Department of Biotechnology, Government of India 1997-2000

 
 
My CV:   Download
 
Education 
::
Ph.D. in Drug Design and Synthesis
::
D. Phil in Chemistry
Honors and Awards
::
American Cancer Society Award, 1992-95
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MCG (Georgia) Institutional Award, 1991-92
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Swebilus Cancer Research Award, 1990
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American Cancer Society Grant Award, 1991
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American Cancer Society Travel Award, 1990
Member
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Editorial Board Member, International Journal of Pharma & Biological Sciences
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Member, International Advisory Committe, Amity University
::
Member, Technical Advisory Committe, Delhi Cancer Institue
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Member, Project Review Committe, 2013-; Neuorbiology, ICMR, 2013
::
Member, Selection Committe, Naitional Brain Research Center, 2013
  Last modified on : Jul 5, 2013
India Cancer Research Database has been developed by the Institute of Bioinformatics with funding from the Department of Biotechnology, Government of India.