INCREDB ID : 429
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Sandeep Singh, Ph.D.
Assistant Professor 
 
National Institute of Biomedical Genomics
Netaji Subhas Sanatorium (T.B. Hospital)
2 nd Floor, P.O.: N.S.S., Kalyani
West Bengal - 741 251   
Kolkata   
 
E-mail: ss5@nibmg.ac.in
Phone: +91-33-25892151
Mobile: +918647868383
 
URL: http://www.nibmg.ac.in/sandeepsingh.php
 
Positions Held:
Position Affiliation Time Period
Post Doctoral Fellow H. Lee Moffitt Cancer Center, Tampa, Florida, USA 2007-2012
 
Area of Specialization:
Genomics
Oncology
Research Summary:
Establishing the platform for isolation, purification and characterization of SLCCs from oral tumors
Understanding the genomic makeup of Oral-SLCCs and its functional consequences
Identification of the genes that govern deregulated self-renewal and differentiation of SLCCS
 
Publications:
1. Singh, S., Bora-Singhal, N., Kroeger, J., Laklai, H. and Chellappan, S. P.  betaArrestin-1 and Mcl-1 modulate self-renewal growth of cancer stem-like side-population cells in non-small cell lung cancer. PloS One. 2013.  8, e55982. [PubMed]
2. Trevino, J. G., Pillai, S., Kunigal, S., Singh, S., Fulp, W. J., Centeno, B. A. and Chellappan, S. P.  Nicotine induces inhibitor of differentiation-1 in a Src-dependent pathway promoting metastasis and chemoresistance in pancreatic adenocarcinoma. Neoplasia. 2012.  14, 1102-1114. [PubMed]
3. Singh, S., Trevino, J., Bora-Singhal, N., Coppola, D., Haura, E., Altiok, S. and Chellappan, S. P.  EGFR/Src/Akt signaling modulates Sox2 expression and self-renewal of stem-like side-population cells in non-small cell lung cancer. Molecular Cancer. 2012.  11, 73. [PubMed]
4. Perumal, D., Singh, S., Yoder, S. J., Bloom, G. C. and Chellappan, S. P.  A novel five gene signature derived from stem-like side population cells predicts overall and recurrence-free survival in NSCLC. PloS One. 2012.  7, e43589. [PubMed]
5. Alamanda, V., Singh, S., Lawrence, N. J. and Chellappan, S. P.  Nicotine-mediated induction of E-selectin in aortic endothelial cells requires Src kinase and E2F1 transcriptional activity. Biochemical and Biophysical Research Communications. 2012.  418, 56-61. [PubMed]
6. Singh, S., Pillai, S. and Chellappan, S.  Nicotinic acetylcholine receptor signaling in tumor growth and metastasis. Journal of Oncology. 2011.  2011, 456743. [PubMed]
7. Singh, S., Davis, R., Alamanda, V., Pireddu, R., Pernazza, D., Sebti, S., Lawrence, N. and Chellappan, S.  Rb-Raf-1 interaction disruptor RRD-251 induces apoptosis in metastatic melanoma cells and synergizes with dacarbazine. Molecular Cancer Therapeutics. 2010.  9, 3330-3341. [PubMed]
8. Ajay, A. K., Upadhyay, A. K., Singh, S., Vijayakumar, M. V., Kumari, R., Pandey, V., Boppana, R. and Bhat, M. K.  Cdk5 phosphorylates non-genotoxically overexpressed p53 following inhibition of PP2A to induce cell cycle arrest/apoptosis and inhibits tumor progression. Molecular Cancer. 2010.  9, 204. [PubMed]
9. Upadhyay, A. K., Ajay, A. K., Singh, S. and Bhat, M. K.  Cell cycle regulatory protein 5 (Cdk5) is a novel downstream target of ERK in carboplatin induced death of breast cancer cells. Current Cancer Drug Targets. 2008.  8, 741-752. [PubMed]
10. Singh, S., Johnson, J. and Chellappan, S.  Small molecule regulators of Rb-E2F pathway as modulators of transcription. Biochimica et Biophysica Acta. 2010.  1799, 788-794. [PubMed]
11. Singh, S., Upadhyay, A. K., Ajay, A. K. and Bhat, M. K.  p53 regulates ERK activation in carboplatin induced apoptosis in cervical carcinoma: a novel target of p53 in apoptosis. FEBS Letters. 2007.  581, 289-295. [PubMed]
12. Singh, S., Upadhyay, A. K., Ajay, A. K. and Bhat, M. K.  Gadd45alpha does not modulate the carboplatin or 5-fluorouracil-induced apoptosis in human papillomavirus-positive cells. Journal of Cellular Biochemistry. 2007.  100, 1191-1199. [PubMed]
13. Upadhyay, A. K., Singh, S., Chhipa, R. R., Vijayakumar, M. V., Ajay, A. K. and Bhat, M. K.  Methyl-beta-cyclodextrin enhances the susceptibility of human breast cancer cells to carboplatin and 5-fluorouracil: involvement of Akt, NF-kappaB and Bcl-2. Toxicology and Applied Pharmacology. 2006.  216, 177-185. [PubMed]
14. Singh, S., Chhipa, R. R., Vijayakumar, M. V. and Bhat, M. K.  DNA damaging drugs-induced down-regulation of Bcl-2 is essential for induction of apoptosis in high-risk HPV-positive HEp-2 and KB cells. Cancer Letters. 2006.  236, 213-221. [PubMed]
15. Vijayakumar, M. V., Singh, S., Chhipa, R. R. and Bhat, M. K.  The hypoglycaemic activity of fenugreek seed extract is mediated through the stimulation of an insulin signalling pathway. British Journal of Pharmacology. 2005.  146, 41-48. [PubMed]
16. Chhipa, R. R., Singh, S., Surve, S. V., Vijayakumar, M. V. and Bhat, M. K.  Doxycycline potentiates antitumor effect of cyclophosphamide in mice. Toxicology and Applied Pharmacology. 2005.  202, 268-277. [PubMed]
17. Singh, S. and Bhat, M. K.  Carboplatin induces apoptotic cell death through downregulation of constitutively active nuclear factor-kappaB in human HPV-18 E6-positive HEp-2 cells. Biochemical and Biophysical Research Communications. 2004.  318, 346-353. [PubMed]
 
Book Chapters:
Singh S, Chellappan S. The Biology of Lung Cancer Stem Cells. (Chapter in a book entitled
 
Grant Support:
Project Title Role Funding Agency Sanction Number Sanction Date
Isolation of human oral cancer stem cells from patient's tumors and establishment of its primary culture. Principal Investigator National Institute of Biomedical Genomics 2012
Understanding the biology of stem-like cancer cells from human oral tumors Principal Investigator Wellcome Trust-DBT India Alliance 2013

 
 
My CV:   Download
 
Education 
::
Ph.D. in Biotechnology, National Center for Cell Science, Pune, 2001-2007
::
M.Sc. in Biotechnology, Himachal Pradesh University, 1999-2001
Honors and Awards
::
2013 - Intermediate Fellow; Wellcome Trust-DBT India Alliance, India
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2007-2012 Awarded Postdoctoral Fellowship from H.Lee Moffitt cancer Center, Tampa, FL, USA
::
2001-2007 Research Fellowship was awarded by NCCS, Pune, India
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1999-2001 Studentship was awarded by Department of Biotechnology, Govt. of India.
Member
::
Life Member; Society of Biological Chemist (SBC), India
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Life Member; Indian Society of Human Genetics (ISHG), India
Type of Neoplasms
 
Head and Neck
  Last modified on : Jul 4, 2013
India Cancer Research Database has been developed by the Institute of Bioinformatics with funding from the Department of Biotechnology, Government of India.