INCREDB ID : 392
Home >> Investigator Page Previous      Next
C S Paulose, Ph.D.
Director 
 
Cochin University of Science & Technology, Cochin, India
Centre for Neuroscience
Department of Biotechnology
Kochi - 682 022   
Kerala   
 
E-mail: cspaulose@cusat.ac.in,paulosecs@yahoo.co.in
Phone: 0484 2576267
Fax: 91(0484) 2577595
 
Positions Held:
Position Affiliation Time Period
Head Cochin University of Science & Technology, Cochin, India
 
Area of Specialization:
Neurology
Research Summary:
Neuroscience, Central nervous system regulation of hypertension and diabetes
Neurotransmitter receptor control of diabetes
Neurotransmitter receptors and control of insulin production by pancreatic islets
Molecular studies on neurotransmitter control of cell proliferation in liver regeneration and liver cancers
 
Publications:
1. Anju, T. R., Smijin, S., Chinthu, R. and Paulose, C. S.  Decreased cholinergic function in the cerebral cortex of hypoxic neonatal rats: role of glucose, oxygen and epinephrine resuscitation. Respiratory Physiology & Neurobiology. 2012.  180, 8-13. [PubMed]
2. Anju, T. R., Binoy, J., Anitha, M. and Paulose, C. S.  Striatal GABA receptor alterations in hypoxic neonatal rats: role of glucose, oxygen and epinephrine treatment. Neurochemical Research. 2012.  37, 629-638. [PubMed]
3. Xavier, S., Sadanandan, J., George, N. and Paulose, C. S.  beta(2)-adrenoceptor and insulin receptor expression in the skeletal muscle of streptozotocin induced diabetic rats: antagonism by vitamin D(3) and curcumin. European Journal of Pharmacology. 2012.  687, 14-20. [PubMed]
4. George, N., Kumar, T. P., Antony, S., Jayanarayanan, S. and Paulose, C. S.  Effect of vitamin D3 in reducing metabolic and oxidative stress in the liver of streptozotocin-induced diabetic rats. The British Journal of Nutrition. 2012.  108, 1410-1418. [PubMed]
5. Sherin, A., Anu, J., Peeyush, K. T., Smijin, S., Anitha, M., Roshni, B. T. and Paulose, C. S.  Cholinergic and GABAergic receptor functional deficit in the hippocampus of insulin-induced hypoglycemic and streptozotocin-induced diabetic rats. Neuroscience. 2012.  202, 69-76. [PubMed]
6. Shilpa, J., Naijil, G., Nandhu, M. S. and Paulose, C. S.  Evaluation of GABA-chitosan nanoparticle induced cell signaling activation during liver regeneration after partial hepatectomy. Journal of Nanoscience and Nanotechnology. 2012.  12, 6145-6155. [PubMed]
7. Tanikawa, K. and Matsushita, K.  [Bladder metastasis from renal cell carcinoma three years after nephrectomy]. Hinyokika Kiyo. Acta Urologica Japonica. 1990.  36, 927-929. [PubMed]
8. Mathew, J., Balakrishnan, S., Antony, S., Abraham, P. M. and Paulose, C. S.  Decreased GABA receptor in the cerebral cortex of epileptic rats: effect of Bacopa monnieri and Bacoside-A. Journal of Biomedical Science. 2012.  19, 25. [PubMed]
9. Anju, T. R., Anitha, M., Chinthu, R. and Paulose, C. S.  Cerebellar GABA(A) receptor alterations in hypoxic neonatal rats: Role of glucose, oxygen and epinephrine supplementation. Neurochemistry International. 2012.  61, 302-309. [PubMed]
10. Soman, S., Korah, P. K., Jayanarayanan, S., Mathew, J. and Paulose, C. S.  Oxidative stress induced NMDA receptor alteration leads to spatial memory deficits in temporal lobe epilepsy: ameliorative effects of Withania somnifera and Withanolide A. Neurochemical Research. 2012.  37, 1915-1927. [PubMed]
11. Shilpa, J., Roshni, B. T., Chinthu, R. and Paulose, C. S.  Role of GABA and serotonin coupled chitosan nanoparticles in enhanced hepatocyte proliferation. Journal of Materials Science. Materials in Medicine. 2012.  23, 2913-2921. [PubMed]
12. Shilpa, J., Pretty, M. A., Anitha, M. and Paulose, C. S.  Gamma aminobutyric acid B and 5-hydroxy tryptamine 2A receptors functional regulation during enhanced liver cell proliferation by GABA and 5-HT chitosan nanoparticles treatment. European Journal of Pharmacology. 2013.  715, 154-163. [PubMed]
13. Anitha, M., Abraham, P. M. and Paulose, C. S.  Striatal dopamine receptors modulate the expression of insulin receptor, IGF-1 and GLUT-3 in diabetic rats: effect of pyridoxine treatment. European Journal of Pharmacology. 2012.  696, 54-61. [PubMed]
14. Raveendran, A. T. and Skaria, P. C.  Learning and cognitive deficits in hypoxic neonatal rats intensified by BAX mediated apoptosis: protective role of glucose, oxygen, and epinephrine. The International Journal of Neuroscience. 2013.  123, 80-88. [PubMed]
15. Romeo, C., Raveendran, A. T., Sobha, N. M. and Paulose, C. S.  Cholinergic receptor alterations in the brain stem of spinal cord injured rats. Neurochemical Research. 2013.  38, 389-397. [PubMed]
16. Jayanarayanan, S., Smijin, S., Peeyush, K. T., Anju, T. R. and Paulose, C. S.  NMDA and AMPA receptor mediated excitotoxicity in cerebral cortex of streptozotocin induced diabetic rat: ameliorating effects of curcumin. Chemico-biological Interactions. 2013.  201, 39-48. [PubMed]
17. Anju, T. R., Ajayan, M. S. and Paulose, C. S.  Disruption of cerebellar cholinergic system in hypoxic neonatal rats and its regulation with glucose, oxygen and epinephrine resuscitations. Neuroscience. 2013.  236, 253-261. [PubMed]
18. Soman, S., Anju, T. R., Jayanarayanan, S., Antony, S. and Paulose, C. S.  Impaired motor learning attributed to altered AMPA receptor function in the cerebellum of rats with temporal lobe epilepsy: ameliorating effects of Withania somnifera and withanolide A. Epilepsy & Behavior : E&B. 2013.  27, 484-491. [PubMed]
19. Shilpa, J., Anitha, M. and Paulose, C. S.  Increased neuronal survival in the brainstem during liver injury: role of gamma-aminobutyric acid and serotonin chitosan nanoparticles. Journal of Neuroscience Research. 2013.  91, 1203-1214. [PubMed]
20. Anju, T. R. and Paulose, C. S.  Striatal cholinergic functional alterations in hypoxic neonatal rats: role of glucose, oxygen, and epinephrine resuscitation. Biochemistry and Cell Biology = Biochimie et Biologie Cellulaire. 2013.  91, 350-356. [PubMed]
21. Kumar, P. T., George, N., Antony, S. and Paulose, C. S.  Curcumin restores diabetes induced neurochemical changes in the brain stem of Wistar rats. European Journal of Pharmacology. 2013.  702, 323-331. [PubMed]
22. Shilpa, J., Pretty, M. A., Anitha, M. and Paulose, C. S.  Gamma aminobutyric acid B and 5-hydroxy tryptamine 2A receptors functional regulation during enhanced liver cell proliferation by GABA and 5-HT chitosan nanoparticles treatment. European Journal of Pharmacology. 2013.  715, 154-163. [PubMed]
23. Shilpa, J. and Paulose, C. S.  GABA and 5-HT chitosan nanoparticles decrease striatal neuronal degeneration and motor deficits during liver injury. Journal of Materials Science. Materials in Medicine. 2014.  25, 1721-1735. [PubMed]
24. Shilpa, J., Anju, T. R., Ajayan, M. S. and Paulose, C. S.  Increased cortical neuronal survival during liver injury: effect of gamma aminobutyric acid and 5-HT chitosan nanoparticles. Journal of Biomedical Nanotechnology. 2014.  10, 622-631. [PubMed]
25. Anju, T. R. and Paulose, C. S.  Cortical cholinergic dysregulation as a long-term consequence of neonatal hypoglycemia. Biochemistry and Cell Biology = Biochimie et Biologie Cellulaire. 2015.  93, 47-53. [PubMed]
26. Anju, T. R. and Paulose, C. S.  Long term effects of neonatal hypoglycaemia on pancreatic function. Archives of Physiology and Biochemistry. 2015.  121, 1-12. [PubMed]
27. Krishnakumar, A., Anju, T. R., Abraham, P. M. and Paulose, C. S.  Alteration in 5-HT(2)C, NMDA receptor and IP3 in cerebral cortex of epileptic rats: restorative role of Bacopa monnieri. Neurochemical Research. 2015.  40, 216-225. [PubMed]
29. Tr, A., Ms, N., P, J. and Cs, P.  Endocrine regulation of neonatal hypoxia: role of glucose, oxygen, and epinephrine supplementation. Fetal and Pediatric Pathology. 2011.  30, 338-349. [PubMed]
30. Sherin, A., Peeyush, K. T., Jayanarayanan, S., Amee, K. K. and Paulose, C. S.  Decreased Cholinergic Receptor Expression in the Striatum: Motor Function Deficit in Hypoglycemic and Diabetic Rats. Cellular and Molecular Neurobiology. 2011.  [PubMed]
31. Peeyush, K., Paul, J., Antony, S. and Paulose, C. S.  Expression of Cholinergic, Insulin, Vitamin D Receptors and GLUT 3 in the Brainstem of Streptozotocin Induced Diabetic Rats: Effect of Treatment with Vitamin D(3). Neurochemical Research. 2011.  [PubMed]
32. Anju, T. R. and Paulose, C. S.  Amelioration of hypoxia-induced striatal 5-HT(2A) receptor, 5-HT transporter and HIF1 alterations by glucose, oxygen and epinephrine in neonatal rats. Neuroscience Letters. 2011.  502, 129-132. [PubMed]
33. Anju, T. R., Jayanarayanan, S. and Paulose, C. S.  Decreased GABAB receptor function in the cerebellum and brain stem of hypoxic neonatal rats: role of glucose, oxygen and epinephrine resuscitation. Journal of Biomedical Science. 2011.  18, 31. [PubMed]
34. Anju, T. R., Korah, P. K., Jayanarayanan, S. and Paulose, C. S.  Enhanced brain stem 5HTA receptor function under neonatal hypoxic insult: role of glucose, oxygen, and epinephrine resuscitation. Molecular and Cellular Biochemistry. 2011.  354, 151-160. [PubMed]
35. Nandhu, M. S., Paul, J., Kuruvila, K. P., Abraham, P. M., Antony, S. and Paulose, C. S.  Glutamate and NMDA receptors activation leads to cerebellar dysfunction and impaired motor coordination in unilateral 6-hydroxydopamine lesioned Parkinson's rat: functional recovery with bone marrow cells, serotonin and GABA. Molecular and Cellular Biochemistry. 2011.  353, 47-57. [PubMed]
36. Paul, J., Kuruvilla, K. P., Mathew, J., Kumar, P. and Paulose, C. S.  Dopamine D and D receptor subtypes functional regulation in cerebral cortex of unilateral rotenone lesioned Parkinson's rat model: Effect of serotonin, dopamine and norepinephrine. Parkinsonism & Related Disorders. 2011.  17, 255-259. [PubMed]
37. Nandhu, M. S., Paul, J., Kuruvilla, K. P., Malat, A., Romeo, C. and Paulose, C. S.  Enhanced glutamate, IP3 and cAMP activity in the cerebral cortex of unilateral 6-hydroxydopamine induced Parkinson's rats: effect of 5-HT, GABA and bone marrow cell supplementation. Journal of Biomedical Science. 2011.  18, 5. [PubMed]
38. Sherin, A., Peeyush, K. T., Naijil, G., Nandhu, M. S., Jayanarayanan, S., Jes, P. and Paulose, C. S.  The effects of abnormalities of glucose homeostasis on the expression and binding of muscarinic receptors in cerebral cortex of rats. European Journal of Pharmacology. 2011.  651, 128-136. [PubMed]
39. Savitha, B., Kumar, P., Pretty, M. A., Naijil, G. and Paulose, C. S.  Muscarinic M, M receptor modulation in the corpus striatum of streptozotocin induced diabetic rats as a function of age. The Journal of Pharmacy and Pharmacology. 2010.  62, 1768-1775. [PubMed]
40. Anitha, M., Nandhu, M. S., Anju, T. R., Jes, P. and Paulose, C. S.  Targeting glutamate mediated excitotoxicity in Huntington's disease: neural progenitors and partial glutamate antagonist--memantine. Medical Hypotheses. 2011.  76, 138-140. [PubMed]
41. Paul, J., Nandhu, M. S., Kuruvilla, K. P. and Paulose, C. S.  Dopamine D and D receptor subtypes functional regulation in corpus striatum of unilateral rotenone lesioned Parkinson's rat model: effect of serotonin, dopamine and norepinephrine. Neurological Research. 2010.  32, 918-924. [PubMed]
42. Abraham, P. M., Kuruvilla, K. P., Mathew, J., Malat, A., Joy, S. and Paulose, C. S.  Alterations in hippocampal serotonergic and INSR function in streptozotocin induced diabetic rats exposed to stress: neuroprotective role of pyridoxine and Aegle marmelose. Journal of Biomedical Science. 2010.  17, 78. [PubMed]
43. Anju, T. R., Smijin, S., Korah, P. K. and Paulose, C. S.  Cortical 5HT 2A receptor function under hypoxia in neonatal rats: role of glucose, oxygen, and epinephrine resuscitation. Journal of Molecular Neuroscience : MN. 2011.  43, 350-357. [PubMed]
44. Sherin, A., Peeyush, K. T., Naijil, G., Chinthu, R. and Paulose, C. S.  Hypoglycemia induced behavioural deficit and decreased GABA receptor, CREB expression in the cerebellum of streptozoticin induced diabetic rats. Brain Research Bulletin. 2010.  83, 360-366. [PubMed]
45. Mathew, J., Gangadharan, G., Kuruvilla, K. P. and Paulose, C. S.  Behavioral deficit and decreased GABA receptor functional regulation in the hippocampus of epileptic rats: effect of Bacopa monnieri. Neurochemical Research. 2011.  36, 7-16. [PubMed]
46. Nandhu, M. S., Naijil, G., Smijin, S., Jayanarayanan, S. and Paulose, C. S.  Opioid system functional regulation in neurological disease management. Journal of Neuroscience Research. 2010.  88, 3215-3221. [PubMed]
47. John, P., Paulose, C. and Sreekanth, R.  Effect of neurotransmitters and bone marrow cells for neuronal regeneration in iatrogenic spinal cord injury: An experimental study. Indian Journal of Orthopaedics. 2010.  44, 252-256. [PubMed]
48. Kumar, P. T., Antony, S., Nandhu, M. S., Sadanandan, J., Naijil, G. and Paulose, C. S.  Vitamin D3 restores altered cholinergic and insulin receptor expression in the cerebral cortex and muscarinic M3 receptor expression in pancreatic islets of streptozotocin induced diabetic rats. The Journal of Nutritional Biochemistry. 2011.  22, 418-425. [PubMed]
49. Abraham, P. M., Anju, T. R., Jayanarayanan, S. and Paulose, C. S.  Serotonergic receptor upregulation in cerebral cortex and down regulation in brainstem of streptozotocin induced diabetic rats: antagonism by pyridoxine and insulin. Neuroscience Letters. 2010.  483, 23-27. [PubMed]
50. Peeyush, K., Antony, S., Soman, S., Kuruvilla, K. P., George, N. and Paulose, C. S.  Role of curcumin in the prevention of cholinergic mediated cortical dysfunctions in streptozotocin-induced diabetic rats. Molecular and Cellular Endocrinology. 2011.  331, 1-10. [PubMed]
51. Antony, S., Kumar, T. P., Kuruvilla, K. P., George, N. and Paulose, C. S.  Decreased GABA receptor binding in the cerebral cortex of insulin induced hypoglycemic and streptozotocin induced diabetic rats. Neurochemical Research. 2010.  35, 1516-1521. [PubMed]
52. Kumar, T. P., Antony, S., Gireesh, G., George, N. and Paulose, C. S.  Curcumin modulates dopaminergic receptor, CREB and phospholipase C gene expression in the cerebral cortex and cerebellum of streptozotocin induced diabetic rats. Journal of Biomedical Science. 2010.  17, 43. [PubMed]
53. George, A. K., Paul, J., Kaimal, S. B. and Paulose, C. S.  Decreased cerebral cortex and liver 5-HT2A receptor gene expression and enhanced ALDH activity in ethanol-treated rats and hepatocyte cultures. Neurological Research. 2010.  32, 510-518. [PubMed]
54. Anju, T. R., Abraham, P. M., Antony, S. and Paulose, C. S.  Alterations in cortical GABAB receptors in neonatal rats exposed to hypoxic stress: role of glucose, oxygen, and epinephrine resuscitation. Molecular and Cellular Biochemistry. 2010.  343, 1-11. [PubMed]
55. Anju, T. R., Mathew, J., Jayanarayanan, S. and Paulose, C. S.  Cerebellar 5HT2A receptor function under hypoxia in neonatal rats: role of glucose, oxygen, and epinephrine resuscitation. Respiratory Physiology & Neurobiology. 2010.  172, 147-153. [PubMed]
56. Mathew, J., Soman, S., Sadanandan, J. and Paulose, C. S.  Decreased GABA receptor in the striatum and spatial recognition memory deficit in epileptic rats: effect of Bacopa monnieri and bacoside-A. Journal of Ethnopharmacology. 2010.  130, 255-261. [PubMed]
57. Abraham, P. M., Paul, J. and Paulose, C. S.  Down regulation of cerebellar serotonergic receptors in streptozotocin induced diabetic rats: Effect of pyridoxine and Aegle marmelose. Brain Research Bulletin. 2010.  82, 87-94. [PubMed]
58. Mathew, J., Peeyush, K., Khan, R. S. and Paulose, C. S.  Behavioral deficit and decreased GABA receptor functional regulation in the cerebellum of epileptic rats: effect of Bacopa monnieri and bacoside A. Epilepsy & Behavior : E&B. 2010.  17, 441-447. [PubMed]
59. Antony, S., Peeyush, K., Mathew, J., Anju, T. R. and Paulose, C. S.  Hypoglycemia induced changes in cholinergic receptor expression in the cerebellum of diabetic rats. Journal of Biomedical Science. 2010.  17, 7. [PubMed]
60. Mathew, J., Paul, J., Nandhu, M. S. and Paulose, C. S.  Increased excitability and metabolism in pilocarpine induced epileptic rats: effect of Bacopa monnieri. Fitoterapia. 2010.  81, 546-551. [PubMed]
61. Peeyush, K. T., Savitha, B., Sherin, A., Anju, T. R., Jes, P. and Paulose, C. S.  Cholinergic, dopaminergic and insulin receptors gene expression in the cerebellum of streptozotocin-induced diabetic rats: functional regulation with Vitamin D3 supplementation. Pharmacology, Biochemistry, and Behavior. 2010.  95, 216-222. [PubMed]
62. Anu, J., Peeyush, K., Nandhu, M. S. and Paulose, C. S.  Enhanced NMDAR1, NMDA2B and mGlu5 receptors gene expression in the cerebellum of insulin induced hypoglycaemic and streptozotocin induced diabetic rats. European Journal of Pharmacology. 2010.  630, 61-68. [PubMed]
63. Anju, T. R., Peeyush, K. and Paulose, C. S.  Decreased GABAA receptors functional regulation in the cerebral cortex and brainstem of hypoxic neonatal rats: effect of glucose and oxygen supplementation. Cellular and Molecular Neurobiology. 2010.  30, 599-606. [PubMed]
64. Mathew, J., Paul, J., Nandhu, M. S. and Paulose, C. S.  Bacopa monnieri and Bacoside-A for ameliorating epilepsy associated behavioral deficits. Fitoterapia. 2010.  81, 315-322. [PubMed]
65. Nandhu, M. S., Paul, J., Mathew, J., Peeyush, K. and Paulose, C. S.  GYKI-52466: a potential therapeutic agent for glutamate-mediated excitotoxic injury in Cerebral Palsy. Medical Hypotheses. 2010.  74, 619-620. [PubMed]
66. Balakrishnan, S., T, P. K. and Paulose, C. S.  Glutamate (mGluR-5) gene expression in brain regions of streptozotocin induced diabetic rats as a function of age: role in regulation of calcium release from the pancreatic islets in vitro. Journal of Biomedical Science. 2009.  16, 99. [PubMed]
67. Peeyush, K. T., Gireesh, G., Jobin, M. and Paulose, C. S.  Neuroprotective role of curcumin in the cerebellum of streptozotocin-induced diabetic rats. Life Sciences. 2009.  85, 704-710. [PubMed]
68. Joseph, B., Nandhu, M. S. and Paulose, C. S.  Dopamine D1 and D2 receptor functional down regulation in the cerebellum of hypoxic neonatal rats: neuroprotective role of glucose and oxygen, epinephrine resuscitation. Pharmacological Research : the Official Journal of the Italian Pharmacological Society. 2010.  61, 136-141. [PubMed]
69. Krishnakumar, A., Nandhu, M. S. and Paulose, C. S.  Upregulation of 5-HT2C receptors in hippocampus of pilocarpine-induced epileptic rats: antagonism by Bacopa monnieri. Epilepsy & Behavior : E&B. 2009.  16, 225-230. [PubMed]
70. Balakrishnan, S., Mathew, J. and Paulose, C. S.  Cholinergic and glutamergic receptor functional regulation in long-term, low dose somatotropin and insulin treatment to ageing rats: rejuvenation of brain function. Molecular and Cellular Endocrinology. 2010.  314, 23-30. [PubMed]
71. Nandhu, M. S., Fabia, E. T. and Paulose, C. S.  Dopamine D1 receptor gene expression studies in unilateral 6-hydroxydopamine-lesioned Parkinson's rat: effect of 5-HT, GABA, and bone marrow cell supplementation. Journal of Molecular Neuroscience : MN. 2010.  41, 1-11. [PubMed]
72. Savitha, B., Joseph, B., Peeyush, K. and Paulose, C. S.  Acetylcholine and muscarinic receptor function in cerebral cortex of diabetic young and old male Wistar rats and the role of muscarinic receptors in calcium release from pancreatic islets. Biogerontology. 2010.  11, 151-166. [PubMed]
73. Anju, T. R., Babu, A. and Paulose, C. S.  Superoxide dismutase functional regulation in neonatal hypoxia: effect of glucose, oxygen and epinephrine. Indian Journal of Biochemistry & Biophysics. 2009.  46, 166-171. [PubMed]
74. Gireesh, G., Thomas, S. K., Joseph, B. and Paulose, C. S.  Antihyperglycemic and insulin secretory activity of Costus pictus leaf extract in streptozotocin induced diabetic rats and in in vitro pancreatic islet culture. Journal of Ethnopharmacology. 2009.  123, 470-474. [PubMed]
75. Krishnakumar, A., Abraham, P. M., Paul, J. and Paulose, C. S.  Down-regulation of cerebellar 5-HT(2C) receptors in pilocarpine-induced epilepsy in rats: therapeutic role of Bacopa monnieri extract. Journal of the Neurological Sciences. 2009.  284, 124-128. [PubMed]
76. Balakrishnan, S., Mathew, J., Antony, S. and Paulose, C. S.  Muscarinic M(1), M(3) receptors function in the brainstem of streptozotocin induced diabetic rats: their role in insulin secretion from the pancreatic islets as a function of age. European Journal of Pharmacology. 2009.  608, 14-22. [PubMed]
77. Gireesh, G., Kumar, T. P., Mathew, J. and Paulose, C.  Enhanced muscarinic M1 receptor gene expression in the corpus striatum of streptozotocin-induced diabetic rats. Journal of Biomedical Science. 2009.  16, 38. [PubMed]
78. George, A. K., Anju, T. R. and Paulose, C. S.  Enhanced 5-HT(2A) receptors in brain stem and ALDH activity in brain stem and liver: 5-HT(2A) regulation on ALDH in primary hepatocytes cultures in vitro. Neurochemical Research. 2009.  34, 1535-1541. [PubMed]
79. Robinson, R., Krishnakumar, A. and Paulose, C. S.  Enhanced dopamine D1 and D2 receptor gene expression in the hippocampus of hypoglycaemic and diabetic rats. Cellular and Molecular Neurobiology. 2009.  29, 365-372. [PubMed]
80. Rappai, J. P., Raman, V., Unnikrishnan, P. A., Prathapan, S., Thomas, S. K. and Paulose, C. S.  Preliminary investigations on the synthesis and antitumor activity of 3(2H)-furanones. Bioorganic & Medicinal Chemistry Letters. 2009.  19, 764-765. [PubMed]
81. Paulose, C. S. and Balakrishnan, S.  Adrenergic, dopaminergic and serotonergic gene expression in low dose, long time insulin and somatotropin treatment to ageing rats: rejuvenation of brain function. Biogerontology. 2008.  9, 429-439. [PubMed]
82. Joseph, A., Antony, S. and Paulose, C. S.  Increased glutamate receptor gene expression in the cerebral cortex of insulin induced hypoglycemic and streptozotocin-induced diabetic rats. Neuroscience. 2008.  156, 298-304. [PubMed]
83. Kaimal, S. B., George, K. A. and Paulose, C. S.  Gamma-aminobutyric acid A receptor functional decrease in the hypothalamus during pancreatic regeneration in rats. Pancreas. 2008.  37, e20-30. [PubMed]
84. Akash, K. G., Anju, T. R., Peeyush, K. T. and Paulose, C. S.  Enhanced dopamine D2 receptor function in hypothalamus and corpus striatum: their role in liver, plasma and in vitro hepatocyte ALDH regulation in ethanol treated rats. Journal of Biomedical Science. 2008.  15, 623-631. [PubMed]
85. Akash, K. G., Balarama, K. S. and Paulose, C. S.  Enhanced 5-HT(2A) receptor status in the hypothalamus and corpus striatum of ethanol-treated rats. Cellular and Molecular Neurobiology. 2008.  28, 1017-1025. [PubMed]
86. Chathu, F., Krishnakumar, A. and Paulose, C. S.  Acetylcholine esterase activity and behavioral response in hypoxia induced neonatal rats: effect of glucose, oxygen and epinephrine supplementation. Brain and Cognition. 2008.  68, 59-66. [PubMed]
87. Gireesh, G., Reas, S. K., Jobin, M. and Paulose, C. S.  Decreased muscarinic M1 receptor gene expression in the cerebral cortex of streptozotocin-induced diabetic rats and Aegle marmelose leaf extract's therapeutic function. Journal of Ethnopharmacology. 2008.  116, 296-304. [PubMed]
88. Khan, R., Krishnakumar, A. and Paulose, C. S.  Decreased glutamate receptor binding and NMDA R1 gene expression in hippocampus of pilocarpine-induced epileptic rats: neuroprotective role of Bacopa monnieri extract. Epilepsy & Behavior : E&B. 2008.  12, 54-60. [PubMed]
89. Gireesh, G., Kaimal, S. B., Kumar, T. P. and Paulose, C. S.  Decreased muscarinic M1 receptor gene expression in the hypothalamus, brainstem, and pancreatic islets of streptozotocin-induced diabetic rats. Journal of Neuroscience Research. 2008.  86, 947-953. [PubMed]
90. Paulose, C. S., Chathu, F., Khan, S. R. and Krishnakumar, A.  Neuroprotective role of Bacopa monnieri extract in epilepsy and effect of glucose supplementation during hypoxia: glutamate receptor gene expression. Neurochemical Research. 2008.  33, 1663-1671. [PubMed]
91. Joseph, A., Robinson, R. and Paulose, C. S.  Enhanced [3H] glutamate binding in the cerebellum of insulin-induced hypoglycaemic and streptozotocin-induced diabetic rats. Cellular and Molecular Neurobiology. 2007.  27, 1085-1095. [PubMed]
92. Sulaiman, P., Joseph, B., Kaimal, S. B. and Paulose, C. S.  Decreased hepatic 5-HT1A receptors during liver regeneration and neoplasia in rats. Neurochemical Research. 2008.  33, 444-449. [PubMed]
93. Balarama, K., Gireesh, G. and Paulose, C. S.  Decreased GABAA receptor function in the brain stem during pancreatic regeneration in rats. Neurochemical Research. 2007.  32, 1813-1822. [PubMed]
94. George, A. K., Balarama, K. and Paulose, C. S.  Decreased dopamine D(2) receptor function in cerebral cortex and brain stem: their role in hepatic ALDH regulation in ethanol treated rats. Molecular and Cellular Biochemistry. 2007.  304, 181-188. [PubMed]
95. Pyroja, S., Joseph, B. and Paulose, C. S.  Increased 5-HT2C receptor binding in the brain stem and cerebral cortex during liver regeneration and hepatic neoplasia in rats. Journal of the Neurological Sciences. 2007.  254, 3-8. [PubMed]
96. Shankar, P. N., Joseph, A. and Paulose, C. S.  Decreased [3H] YM-09151-2 binding to dopamine D2 receptors in the hypothalamus, brainstem and pancreatic islets of streptozotocin-induced diabetic rats. European Journal of Pharmacology. 2007.  557, 99-105. [PubMed]
97. Ani, D. a. s., Savitha, B. and Paulose, C. S.  Decreased alpha1-adrenergic receptor binding in the cerebral cortex and brain stem during pancreatic regeneration in rats. Neurochemical Research. 2006.  31, 727-734. [PubMed]
98. Shankar, E., Santhosh, K. T. and Paulose, C. S.  Dopaminergic regulation of glucose-induced insulin secretion through dopamine D2 receptors in the pancreatic islets in vitro. IUBMB Life. 2006.  58, 157-163. [PubMed]
99. Das, V. A., Chathu, F. and Paulose, C. S.  Decreased alpha2-adrenergic receptor in the brain stem and pancreatic islets during pancreatic regeneration in weanling rats. Life Sciences. 2006.  79, 1507-1513. [PubMed]
100. Renuka, T. R., Robinson, R. and Paulose, C. S.  Increased insulin secretion by muscarinic M1 and M3 receptor function from rat pancreatic islets in vitro. Neurochemical Research. 2006.  31, 313-320. [PubMed]
101. Das, V. A., Robinson, R. and Paulose, C. S.  Enhanced beta-adrenergic receptors in the brain and pancreas during pancreatic regeneration in weanling rats. Molecular and Cellular Biochemistry. 2006.  289, 11-19. [PubMed]
102. Renuka, T. R., Savitha, B. and Paulose, C. S.  Muscarinic M1 and M3 receptor binding alterations in pancreas during pancreatic regeneration of young rats. Endocrine Research. 2005.  31, 259-270. [PubMed]
103. Mohanan, V. V., Khan, R. and Paulose, C. S.  Hypothalamic 5-HT functional regulation through 5-HT1A and 5-HT2C receptors during pancreatic regeneration. Life Sciences. 2006.  78, 1603-1609. [PubMed]
104. Mohanan, V. V., Chathu, F. and Paulose, C. S.  Decreased 5-HT2C receptor binding in the cerebral cortex and brain stem during pancreatic regeneration in rats. Molecular and Cellular Biochemistry. 2005.  272, 165-170. [PubMed]
105. Mohanan, V., Kaimal, S. B. and Paulose, C. S.  Decreased 5-HT1A receptor gene expression and 5-HT1A receptor protein in the cerebral cortex and brain stem during pancreatic regeneration in rats. Neurochemical Research. 2005.  30, 25-32. [PubMed]
106. Renuka, T. R., Ani, D. V. and Paulose, C. S.  Alterations in the muscarinic M1 and M3 receptor gene expression in the brain stem during pancreatic regeneration and insulin secretion in weanling rats. Life Sciences. 2004.  75, 2269-2280. [PubMed]
107. Biju, M. P., Pyroja, S., Rajeshkumar, N. V. and Paulose, C. S.  Brain stem GABA receptor functional regulation during rat liver cell proliferation. Neurochemical Research. 2002.  27, 905-910. [PubMed]
108. Biju, M. P., Pyroja, S., Rajeshkumar, N. V. and Paulose, C. S.  Enhanced GABA(B) receptor in neoplastic rat liver: induction of DNA synthesis by baclofen in hepatocyte cultures. Journal of Biochemistry, Molecular Biology, and Biophysics : JBMBB : the Official Journal of the Federation of Asian and Oceanian Biochemists and Molecular. 2002.  6, 209-214. [PubMed]
109. Varghese, S., Shameena, B., Lakshmy, P. S., Biju, M. P., Easwar, S., Paulose, C. S. and Oommen, O. V.  Polyunsaturated fatty acids (PUFA) regulate neurotransmitter contents in rat brain. Indian Journal of Biochemistry & Biophysics. 2001.  38, 327-330. [PubMed]
110. Shameena, B., Renuka, T. R., Varghese, S., Paulose, C. S. and Oommen, O. V.  Hypothyroidism and nutritional status alter 3,5,3'-triiodothyronine (T3) receptors in isolated liver nuclei of Anabas testudineus (Bloch). Endocrine Research. 2001.  27, 329-336. [PubMed]
111. Biju, M. P., Pyroja, S., Rajeshkumar, N. V. and Paulose, C. S.  Hepatic GABA(A) receptor functional regulation during rat liver cell proliferation. Hepatology Research : the Official Journal of the Japan Society of Hepatology. 2001.  21, 136-146. [PubMed]
112. Biju, M. P., Pyroja, S., Rajeshkumar, N. V. and Paulose, C. S.  Hypothalamic GABA receptor functional regulation and liver cell proliferation. Molecular and Cellular Biochemistry. 2001.  216, 65-70. [PubMed]
113. Jackson, J. and Paulose, C. S.  Enhancement of [m-methoxy 3H]MDL100907 binding to 5HT2A receptors in cerebral cortex and brain stem of streptozotocin induced diabetic rats. Molecular and Cellular Biochemistry. 1999.  199, 81-85. [PubMed]
114 Padayatti, P. S. and Paulose, C. S.  Alpha2 adrenergic and high affinity serotonergic receptor changes in the brain stem of streptozotocin-induced diabetic rats. Life Sciences. 1999.  65, 403-414. [PubMed]
.115. Nair, A. R., Biju, M. P. and Paulose, C. S.  Effect of pyridoxine and insulin administration on brain glutamate dehydrogenase activity and blood glucose control in streptozotocin-induced diabetic rats. Biochimica et Biophysica Acta. 1998.  1381, 351-354. [PubMed]
116. Biju, M. P. and Paulose, C. S.  Brain glutamate dehydrogenase changes in streptozotocin diabetic rats as a function of age. Biochemistry and Molecular Biology International. 1998.  44, 1-7. [PubMed]
117. Balasubramanian, S. and Paulose, C. S.  Induction of DNA synthesis in primary cultures of rat hepatocytes by serotonin: possible involvement of serotonin S2 receptor. Hepatology. 1998.  27, 62-66. [PubMed]
118. Maliekal, T. T., Sudha, B. and Paulose, C. S.  Kinetic parameters of Thymidine kinase and DNA synthesis during liver regeneration: role of thyroid hormones. Life Sciences. 1997.  60, 1867-1874. [PubMed]
119. Mola, P. W., Sudha, B. and Paulose, C. S.  Effect of insulin on DNA synthesis and kinetic parameters of thymidine kinase during liver regeneration. Biochemistry and Molecular Biology International. 1996.  40, 1067-1075. [PubMed]
120. Nair, P., Padayatti, P. S., Abraham, A., Sudha, B., Raghu, K. G. and Paulose, C. S.  Glutamate dehydrogenase induction in the brain of streptozotocin diabetic rats. Indian Journal of Biochemistry & Biophysics. 1996.  33, 428-430. [PubMed]
121. Seema, P. V., Sudha, B., Padayatti, P. S., Abraham, A., Raghu, K. G. and Paulose, C. S.  Kinetic studies of purified malate dehydrogenase in liver of streptozotocin-diabetic rats and the effect of leaf extract of Aegle marmelose (L.) Correa ex Roxb. Indian Journal of Experimental Biology. 1996.  34, 600-602. [PubMed]
122. Das, A. V., Padayatti, P. S. and Paulose, C. S.  Effect of leaf extract of Aegle marmelose (L.) Correa ex Roxb. on histological and ultrastructural changes in tissues of streptozotocin induced diabetic rats. Indian Journal of Experimental Biology. 1996.  34, 341-345. [PubMed]
123. Ponnachan, P. T., Paulose, C. S. and Panikkar, K. R.  Effect of leaf extract of Aegle marmelose in diabetic rats. Indian Journal of Experimental Biology. 1993.  31, 345-347. [PubMed]
124. Viswanathan, M., Paulose, C. S., Lal, K. J., Sharma, S. K. and Dakshinamurti, K.  Alterations in brainstem alpha 2 adrenoreceptor activity in pyridoxine-deficient rat model of hypertension. Neuroscience Letters. 1990.  111, 201-205. [PubMed]
125. Dakshinamurti, K., Paulose, C. S. and Viswanathan, M.  Vitamin B6 and hypertension. Annals of the New York Academy of Sciences. 1990.  585, 241-249. [PubMed]
126. Dakshinamurti, K., Paulose, C. S., Viswanathan, M., Siow, Y. L., Sharma, S. K. and Bolster, B.  Neurobiology of pyridoxine. Annals of the New York Academy of Sciences. 1990.  585, 128-144. [PubMed]
127. Paulose, C. S., Thliveris, J. A., Viswanathan, M. and Dakshinamurti, K.  Testicular function in biotin-deficient adult rats. Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones et Metabolisme. 1989.  21, 661-665. [PubMed]
128. Viswanathan, M., Siow, Y. L., Paulose, C. S. and Dakshinamurti, K.  Pineal indoleamine metabolism in pyridoxine-deficient rats. Brain Research. 1988.  473, 37-42. [PubMed]
129. Paulose, C. S., Dakshinamurti, K., Packer, S. and Stephens, N. L.  Sympathetic stimulation and hypertension in the pyridoxine-deficient adult rat. Hypertension. 1988.  11, 387-391. [PubMed]
130. Dakshinamurti, K., Paulose, C. S., Viswanathan, M. and Siow, Y. L.  Neuroendocrinology of pyridoxine deficiency. Neuroscience and Biobehavioral Reviews. 1988.  12, 189-193. [PubMed]
131. Dakshinamurti, K., Paulose, C. S. and Vriend, J.  Hypothyroidism of hypothalamic origin in pyridoxine-deficient rats. The Journal of Endocrinology. 1986.  109, 345-349. [PubMed]
132. Dakshinamurti, K., Paulose, C. S., Thliveris, J. A. and Vriend, J.  Thyroid function in pyridoxine-deficient young rats. The Journal of Endocrinology. 1985.  104, 339-344. [PubMed]
133. Paulose, C. S. and Dakshinamurti, K.  Effect of pyridoxine deficiency in young rats on high-affinity serotonin and dopamine receptors. Journal of Neuroscience Research. 1985.  14, 263-270. [PubMed]

134.

 Paulose, C. S. and Dakshinamurti, K.  Enhancement of high affinity gamma-aminobutyric acid receptor binding in cerebellum of pyridoxine-deficient rat. Neuroscience Letters. 1984.  48, 311-316. [PubMed]
135. Dakshinamurti, K. and Paulose, C. S.  Consequences of brain monoamine changes in the pyridoxine-deficient young rat. Progress in Clinical and Biological Research. 1984.  144A, 3-9. [PubMed]
136. Dakshinamurti, K. and Paulose, C. S.  Consequences of decreased brain serotonin in the pyridoxine-deficient young rat. Progress in Neuro-psychopharmacology & Biological Psychiatry. 1983.  7, 743-746. [PubMed]
137. Paulose, C. S. and Kanungo, M. S.  Age-related and sex-related alterations in beta-adrenergic receptors in different regions of rat brain. Archives of Gerontology and Geriatrics. 1982.  1, 167-170. [PubMed]
138. Singh, N. I., Shrivastaw, K. P., Paulose, C. S. and Subba, R. a. o.  Age-dependent properties of acid & alkaline DNases in chick brain. Indian Journal of Biochemistry & Biophysics. 1982.  19, 86-90. [PubMed]
139. Chiu, S., Paulose, C. S. and Mishra, R. K.  Neuroleptic drug-induced dopamine receptor supersensitivity: antagonism by L-prolyl-L-leucyl-glycinamide. Science. 1981.  214, 1261-1262. [PubMed]
140. Moudgil, V., Kruczak, V., Eessalu, T., Paulose, C. S., Taylor, M. and Hansen, J.  Activation of progesterone receptor by ATP. European Journal of Biochemistry / FEBS. 1981.  118, 547-555. [PubMed]
141. Chiu, S., Paulose, C. S. and Mishra, R. K.  Effect of L-prolyl-L-leucyl-glycinamide (PLG) on neuroleptic-induced catalepsy and dopamine/neuroleptic receptor bindings. Peptides. 1981.  2, 105-111. [PubMed]
142. Patnaik, S. K., Paulose, C. S., Srivastava, S. K., Misra, M., Singh, A. K. and Kumar, D.  Comparative studies on arginase of the liver of some vertebrates. Indian Journal of Experimental Biology. 1976.  14, 29-30. [PubMed]
 

 
My CV:   Download
 
Education 
::
M.Sc. in Zoology, Banaras Hindu University, Varanasi, India
::
Ph.D. Banaras Hindu University, Varanasi, India
Honors and Awards
::
Fellow of International Medical Sciences Academy, 1991
::
Fellow of Geriatric Society of India, 2003
::
Shiksha Rattan Puraskar 2007 by India International Friendship Society
::
Sir Shriram Memorial Oration Award for the year 2007 - 08 by National Academy Of Medical Sciences
::
FELLOW of the National Academy of Medical Sciences (India) , FAMS in the year 2012
Member
::
Society for Neurochemistry of India
::
Indian Academy of Neuroscience
::
Indian Association for Cancer Research
::
Indian Association of Biomedical Scientists
::
Society for Reproductive Biology and Comparative Endocrinology
Type of Neoplasms
Hepatobiliary system
  Last modified on : Dec 10, 2015
India Cancer Research Database has been developed by the Institute of Bioinformatics with funding from the Department of Biotechnology, Government of India.