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Arun Balakrishnan, Ph.D.
Professor and Head 
Anna University
Centre for Biotechnology
Chennai - 600 025   
Tamil Nadu   
Positions Held:
Position Affiliation Time Period
Professor and Head Anna University, Chennai, India Present
Area of Specialization:
Molecular Biology
Research Summary:
Estrogen receptors in Breast cancers and developed models for studies in carcinogenesis in mammary cancers in rats
Construction of specific expression systems for the production of IFN and GMCSF. Construction of cDNA library for identification of fibrion expression in Bombyx Mori
Invitro models to study bacterial - host cell interactions, specifically for klebsiella Pneumonia and Enteropathogenic E coli. Study directed to identifying new toxins and implicating a role in pathogenesis.
1. Balakrishnan, G., Janakarajan, L., Balakrishnan, A. and Lakshmi, B. S.  Molecular basis of the anti-inflammatory property exhibited by cyclo-pentano phenanthrenol isolated from Lippia nodiflora. Immunological Investigations. 2010.  39, 713-739. [PubMed]
2. Sangeetha, K. N., Sujatha, S., Muthusamy, V. S., Anand, S., Nithya, N., Velmurugan, D., Balakrishnan, A. and Lakshmi, B. S.  3beta-taraxerol of Mangifera indica, a PI3K dependent dual activator of glucose transport and glycogen synthesis in 3T3-L1 adipocytes. Biochimica et Biophysica Acta. 2010.  1800, 359-366. [PubMed]
3. Subramanian, K., Selvakkumar, C., Vinaykumar, K. S., Goswami, N., Meenakshisundaram, S., Balakrishnan, A. and Lakshmi, B. S.  Tackling multiple antibiotic resistance in enteropathogenic Escherichia coli (EPEC) clinical isolates: a diarylheptanoid from Alpinia officinarum shows promising antibacterial and immunomodulatory activity against EPEC and its lipopolysaccharide-induced inflammation. International Journal of Antimicrobial Agents. 2009.  33, 244-250. [PubMed]
4. Shankar, B., Krishnan, S., Malladi, V., Balakrishnan, A. and Williams, P. H.  Outer membrane proteins of wild-type and intimin-deficient enteropathogenic Escherichia coli induce Hep-2 cell death through intrinsic and extrinsic pathways of apoptosis. International Journal of Medical Microbiology : IJMM. 2009.  299, 121-132. [PubMed]
5. Subramanian, K., Shankar, R. B., Meenakshisundaram, S., Lakshmi, B. S., Williams, P. H. and Balakrishnan, A.  LamB-mediated adherence of enteropathogenic Escherichia coli to HEp-2 cells. Journal of Applied Microbiology. 2008.  105, 715-722. [PubMed]
6. Balakrishnan, A. and Menon, V. P.  Antioxidant properties of hesperidin in nicotine-induced lung toxicity. Fundamental & Clinical Pharmacology. 2007.  21, 535-546. [PubMed]
7. Puthenedam, M., Williams, P. H., Lakshmi, B. S. and Balakrishnan, A.  Modulation of tight junction barrier function by outer membrane proteins of enteropathogenic Escherichia coli: role of F-actin and junctional adhesion molecule-1. Cell Biology International. 2007.  31, 836-844. [PubMed]
8. Senthil, V., Ramadevi, S., Venkatakrishnan, V., Giridharan, P., Lakshmi, B. S., Vishwakarma, R. A. and Balakrishnan, A.  Withanolide induces apoptosis in HL-60 leukemia cells via mitochondria mediated cytochrome c release and caspase activation. Chemico-biological Interactions. 2007.  167, 19-30. [PubMed]
9. Gayathri, B., Manjula, N., Vinaykumar, K. S., Lakshmi, B. S. and Balakrishnan, A.  Pure compound from Boswellia serrata extract exhibits anti-inflammatory property in human PBMCs and mouse macrophages through inhibition of TNFalpha, IL-1beta, NO and MAP kinases. International Immunopharmacology. 2007.  7, 473-482. [PubMed]
10. Anandharajan, R., Jaiganesh, S., Shankernarayanan, N. P., Viswakarma, R. A. and Balakrishnan, A.  In vitro glucose uptake activity of Aegles marmelos and Syzygium cumini by activation of Glut-4, PI3 kinase and PPARgamma in L6 myotubes. Phytomedicine. 2006.  13, 434-441. [PubMed]
11. Manjula, N., Gayathri, B., Vinaykumar, K. S., Shankernarayanan, N. P., Vishwakarma, R. A. and Balakrishnan, A.  Inhibition of MAP kinases by crude extract and pure compound isolated from Commiphora mukul leads to down regulation of TNF-alpha, IL-1beta and IL-2. International Immunopharmacology. 2006.  6, 122-132. [PubMed]
12. Malladi, V., Puthenedam, M., Williams, P. H. and Balakrishnan, A.  Enteropathogenic Escherichia coli outer membrane proteins induce iNOS by activation of NF-kappaB and MAP kinases. Inflammation. 2004.  28, 345-353. [PubMed]
13. Anandharajan, R., Pathmanathan, K., Shankernarayanan, N. P., Vishwakarma, R. A. and Balakrishnan, A.  Upregulation of Glut-4 and PPAR gamma by an isoflavone from Pterocarpus marsupium on L6 myotubes: a possible mechanism of action. Journal of Ethnopharmacology. 2005.  97, 253-260. [PubMed]
14. Malladi, V., Shankar, B., Williams, P. H. and Balakrishnan, A.  Enteropathogenic Escherichia coli outer membrane proteins induce changes in cadherin junctions of Caco-2 cells through activation of PKCalpha. Microbes and Infection / Institut Pasteur. 2004.  6, 38-50. [PubMed]
15. Narayanan, K., Krishnamoorthy, B., Ezhilarasan, R., Miyamoto, S. and Balakrishnan, A.  Targeting apoptotic signalling pathway and pro-inflammatory cytokine expression as therapeutic intervention in TPE induced lung damage. Cell Biology International. 2003.  27, 375-382. [PubMed]
16. Giridharan, P., Somasundaram, S. T., Perumal, K., Vishwakarma, R. A., Karthikeyan, N. P., Velmurugan, R. and Balakrishnan, A.  Novel substituted methylenedioxy lignan suppresses proliferation of cancer cells by inhibiting telomerase and activation of c-myc and caspases leading to apoptosis. British Journal of Cancer. 2002.  87, 98-105. [PubMed]
17. Narayanan, K., Seufzer, B. J., Brockman-Schneider, R. A., Gern, J. E., Balakrishnan, A. and Miyamoto, S.  CD14-dependent activation of NF-kappaB by filarial parasitic sheath proteins. Cell Biology International. 2002.  26, 43-54. [PubMed]
18. Kumar, S. S., Malladi, V., Sankaran, K., Haigh, R., Williams, P. and Balakrishnan, A.  Extrusion of actin-positive strands from Hep-2 and Int 407 cells caused by outer membrane preparations of enteropathogenic Escherichia coil and specific attachment of wild type bacteria to the strands. Canadian Journal of Microbiology. 2001.  47, 727-734. [PubMed]
19. Kumar, S. S., Sankaran, K., Haigh, R., Williams, P. H. and Balakrishnan, A.  Cytopathic effects of outer-membrane preparations of enteropathogenic Escherichia coli and co-expression of maltoporin with secretory virulence factor, EspB. Journal of Medical Microbiology. 2001.  50, 602-612. [PubMed]
20. Krishnamoorthy, B., Narayanan, K., Miyamoto, S. and Balakrishnan, A.  Epithelial cells release proinflammatory cytokines and undergo c-Myc-induced apoptosis on exposure to filarial parasitic sheath protein-Bcl2 mediates rescue by activating c-H-Ras. In Vitro Cellular & Developmental Biology. Animal. 2000.  36, 532-538. [PubMed]
21. Narayanan, K., Balakrishnan, A. and Miyamoto, S.  NF-kappaB is essential for induction of pro-inflammatory cytokine genes by filarial parasitic sheath proteins. Molecular Immunology. 2000.  37, 115-123. [PubMed]
22. Krishnamoorthy, B., Renner, W. and Balakrishnan, A.  Apoptosis induced by filarial parasitic sheath protein in HEp 2 cell lines blocked by ectopic expression of bcl 2. Cell Biology International. 1998.  22, 483-492. [PubMed]
23. Chitra, S., Narayanan, R. B., Balakrishnan, A. and Jayaraman, K.  A rapid and specific method for the identification of Bacillus thuringiensis strains by indirect immunofluorescence. Journal of Invertebrate Pathology. 1998.  71, 286-287. [PubMed]
24. Maya, A., Jayaraman, K. and Balakrishnan, A.  Necrosis of lung epithelial cells by filarial parasitic protein via an early induction of c-H-ras and TNF alpha expression. Cell Biology International. 1997.  21, 273-280. [PubMed]
25. Usha, S., Maya, A. and Balakrishnan, A.  Mitogenic stimulation of primary cultures of lung epithelial cells by linoleic acid. Biochemistry and Cell Biology = Biochimie et Biologie Cellulaire. 1996.  74, 289-293. [PubMed]
26. Maya, A., Usha, S., Jayaraman, K., Baba, K., Sukumaran, M. and Balakrishnan, A.  Interaction of filarial proteins on growth regulation of normal lung epithelial cells in vitro. Cell Biology International. 1995.  19, 223-231. [PubMed]
27. Rajan, M. K., Balakrishnan, A. and Jayaraman, K.  Development of an antibody against a 170-kDa fragment of fibroin isolated from cocoon fibres of Bombyx mori. Journal of Biochemical and Biophysical Methods. 1992.  25, 37-43. [PubMed]


Grant Support:
Project Title Role Funding Agency Sanction Number Sanction Date
Studies on Helicobacter pylori infection, a multicentric study Principal Investigator Department of Biotechnology, Government of India 1997-2000


Ph.D. in Biochemistry, University of Madras, Chennai, India
M.Sc. in Biochemistry, University of Madras, Chennai, India
  Last modified on : Mar 7, 2011
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