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Kiranam Chatti, Ph.D.
Research Scientist 
Institute of Life Sciences
Department of Biology
University of Hyderabad Campus, Gachibowli
Hyderabad - 500 046   
Andhra Pradesh   
Positions Held:
Position Affiliation Time Period
Research Scientist Institute of Life Sciences, Hyderabad, India Present
Post Doctoral Research Associate State University of New York at Stony Brook, New York, USA 2004-2008
Area of Specialization:
Research Summary:
Exploring the potential regulation of BRK by an inactive splice variant, via autoinhibitory domain interactions
Use of the zebrafish (Danio rerio) embryos as in vivo models to study the physiological role of BRK and in a larger context, for tyrosine kinase biology
1. Rana, N., Moond, M., Marthi, A., Bapatla, S., Sarvepalli, T., Chatti, K. and Challa, A. K.  Caffeine-induced effects on heart rate in zebrafish embryos and possible mechanisms of action: an effective system for experiments in chemical biology. Zebrafish. 2010.  7, 69-81. [PubMed]
2. Xiang, B., Chatti, K., Qiu, H., Lakshmi, B., Krasnitz, A., Hicks, J., Yu, M., Miller, W. T. and Muthuswamy, S. K.  Brk is coamplified with ErbB2 to promote proliferation in breast cancer. Proceedings of the National Academy of Sciences of the United States of America. 2008.  105, 12463-12468. [PubMed]
3. Mamoon, N. M., Smith, J. K., Chatti, K., Lee, S., Kundrapu, K. and Duhe, R. J.  Multiple cysteine residues are implicated in Janus kinase 2-mediated catalysis. Biochemistry. 2007.  46, 14810-14818. [PubMed]
4. Chatti, K., Farrar, W. L. and Duhe, R. J.  Tyrosine phosphorylation of the Janus kinase 2 activation loop is essential for a high-activity catalytic state but dispensable for a basal catalytic state. Biochemistry. 2004.  43, 4272-4283. [PubMed]


Grant Support:
Project Title Role Funding Agency Sanction Number Sanction Date
Embryonic Zebrafish as a model system to study Breast Tumour Kinase (BRK) signalling Principal Investigator Department of Biotechnology, Government of India 2010-2013
Phosphoproteomic analysis of BRK tyrosine kinase signalling Principal Investigator Department of Science & Technology, Government of India 2009-2012


Ph.D. University of Mississippi Medical Center, Jackson MS, USA, 1998-2004
M.Sc. in Biotechnology, Madurai Kamaraj University, 1995-1997
Honors and Awards
2002, International Union of Pharmacology Travel Award (XIV World Congress of Pharmacology), American Society for Pharmacology and Experimental Therapeutics
2001, Fisher Scientific Graduate Student Award, Fisher Scientific
2000, Lowell M. Greenbaum Graduate Student Award, South Eastern Pharmacology Society
  Last modified on : Mar 4, 2011
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