INCREDB ID : 289
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Ashok Kumar Giri, D.Sc., Ph.D.
Deputy Director 
 
Indian Institute of Chemical Biology
Molecular & Human Genetics
Mullick Road
Kolkata - 700 032   
West Bengal   
 
E-mail: akgiri15@yahoo.com,akgiri@iicb.res.in
 
URL: http://www.iicb.res.in/divisionwiselistofscientists/mhg/akgiri.html
 
Positions Held:
Position Affiliation Time Period
Deputy Director Indian Institute of Chemical Biology, Kolkata, India Present
 
Area of Specialization:
Molecular Biology
Research Summary:
Animutagenic and anticarcinogenic effects of black tea and its polyphenols in multiple test systems
Assessment of cytogenetic damage and DNA damage in the lymphocytes of populations exposed to arsenic through drinking water
Identification of different genes responsible for arsenic susceptibility and carcinogenicity through SNP studies
Molecular epidemiology and Environmental health
Gene expression studies of arsenic exposed individuals
Proteomic studies to devlop biomarkers for arsenic susceptibility
 
Publications:
1. Kundu, M., Ghosh, P., Mitra, S., Das, J. K., Sau, T. J., Banerjee, S., States, J. C. and Giri, A. K.  Precancerous and non-cancer disease endpoints of chronic arsenic exposure: the level of chromosomal damage and XRCC3 T241M polymorphism. Mutation Research. 2011.  706, 7-12. [PubMed]
2. Banerjee, M., Banerjee, N., Ghosh, P., Das, J. K., Basu, S., Sarkar, A. K., States, J. C. and Giri, A. K.  Evaluation of the serum catalase and myeloperoxidase activities in chronic arsenic-exposed individuals and concomitant cytogenetic damage. Toxicology and Applied Pharmacology. 2010.  249, 47-54. [PubMed]
3. Chowdhury, R., Chatterjee, R., Giri, A. K., Mandal, C. and Chaudhuri, K.  Arsenic-induced cell proliferation is associated with enhanced ROS generation, Erk signaling and CyclinA expression. Toxicology Letters. 2010.  198, 263-271. [PubMed]
4. Bhattacharya, U., Halder, B., Mukhopadhyay, S. and Giri, A. K.  Role of oxidation-triggered activation of JNK and p38 MAPK in black tea polyphenols induced apoptotic death of A375 cells. Cancer Science. 2009.  100, 1971-1978. [PubMed]
5. Banerjee, N., Banerjee, S., Sen, R., Bandyopadhyay, A., Sarma, N., Majumder, P., Das, J. K., Chatterjee, M., Kabir, S. N. and Giri, A. K.  Chronic arsenic exposure impairs macrophage functions in the exposed individuals. Journal of Clinical Immunology. 2009.  29, 582-594. [PubMed]
6. Biswas, R., Ghosh, P., Banerjee, N., Das, J. K., Sau, T., Banerjee, A., Roy, S., Ganguly, S., Chatterjee, M., Mukherjee, A. and Giri, A. K.  Analysis of T-cell proliferation and cytokine secretion in the individuals exposed to arsenic. Human & Experimental Toxicology. 2008.  27, 381-386. [PubMed]
7. Ghosh, P., Banerjee, M., Giri, A. K. and Ray, K.  Toxicogenomics of arsenic: classical ideas and recent advances. Mutation Research. 2008.  659, 293-301. [PubMed]
8. Ghosh, P., Basu, A., Singh, K. K. and Giri, A. K.  Evaluation of cell types for assessment of cytogenetic damage in arsenic exposed population. Molecular Cancer. 2008.  7, 45. [PubMed]
9. De, C., Ghosh, P., Sarma, N., Majumdar, P., Sau, T. J., Basu, S., Roychoudhury, S., Ray, K. and Giri, A. K.  Genetic variants associated with arsenic susceptibility: study of purine nucleoside phosphorylase, arsenic (+3) methyltransferase, and glutathione S-transferase omega genes. Environmental Health Perspectives. 2008.  116, 501-505. [PubMed]
10. Banerjee, M., Sarma, N., Biswas, R., Roy, J., Mukherjee, A. and Giri, A. K.  DNA repair deficiency leads to susceptibility to develop arsenic-induced premalignant skin lesions. International Journal of Cancer. Journal International Du Cancer. 2008.  123, 283-287. [PubMed]
11. Biswas, D., Banerjee, M., Sen, G., Das, J. K., Banerjee, A., Sau, T. J., Pandit, S., Giri, A. K. and Biswas, T.  Mechanism of erythrocyte death in human population exposed to arsenic through drinking water. Toxicology and Applied Pharmacology. 2008.  230, 57-66. [PubMed]
12. Banerjee, N., Banerjee, M., Ganguly, S., Bandyopadhyay, S., Das, J. K., Bandyopadhay, A., Chatterjee, M. and Giri, A. K.  Arsenic-induced mitochondrial instability leading to programmed cell death in the exposed individuals. Toxicology. 2008.  246, 101-111. [PubMed]
13. De, C., Kundu, M., Banerjee, M., Das, J. K., Majumdar, P., Basu, S., Roychoudhury, S., Singh, K. K. and Giri, A. K.  Arsenic-induced health effects and genetic damage in keratotic individuals: involvement of p53 arginine variant and chromosomal aberrations in arsenic susceptibility. Mutation Research. 2008.  659, 118-125. [PubMed]
14. Halder, B., Bhattacharya, U., Mukhopadhyay, S. and Giri, A. K.  Molecular mechanism of black tea polyphenols induced apoptosis in human skin cancer cells: involvement of Bax translocation and mitochondria mediated death cascade. Carcinogenesis. 2008.  29, 129-138. [PubMed]
15. Chowdhury, R., Dutta, A., Chaudhuri, S. R., Sharma, N., Giri, A. K. and Chaudhuri, K.  In vitro and in vivo reduction of sodium arsenite induced toxicity by aqueous garlic extract. Food and Chemical Toxicology : An International Journal Published For the British Industrial Biological Research Association. 2008.  46, 740-751. [PubMed]
16. Ghosh, P., Banerjee, M., De, C., Das, J. K., Sarma, N., Basu, A. and Giri, A. K.  Increased chromosome aberration frequencies in the Bowen's patients compared to non-cancerous skin lesions individuals exposed to arsenic. Mutation Research. 2007.  632, 104-110. [PubMed]
17. Banerjee, M., Sarkar, J., Das, J. K., Mukherjee, A., Sarkar, A. K., Mondal, L. and Giri, A. K.  Polymorphism in the ERCC2 codon 751 is associated with arsenic-induced premalignant hyperkeratosis and significant chromosome aberrations. Carcinogenesis. 2007.  28, 672-676. [PubMed]
18. De, C., Mahata, J., Das, J. K., Mukherjee, A., Ghosh, P., Sau, T. J., Mondal, L., Basu, S., Giri, A. K. and Roychoudhury, S.  Association of specific p53 polymorphisms with keratosis in individuals exposed to arsenic through drinking water in West Bengal, India. Mutation Research. 2006.  601, 102-112. [PubMed]
19. Ghosh, P., Banerjee, M., De, C., Chowdhury, R., Das, J. K., Mukherjee, A., Sarkar, A. K., Mondal, L., Baidya, K., Sau, T. J., Banerjee, A., Basu, A., Chaudhuri, K., Ray, K. and Giri, A. K.  Comparison of health effects between individuals with and without skin lesions in the population exposed to arsenic through drinking water in West Bengal, India. Journal of Exposure Science & Environmental Epidemiology. 2007.  17, 215-223. [PubMed]
20. Ghosh, P., Basu, A., Mahata, J., Basu, S., Sengupta, M., Das, J. K., Mukherjee, A., Sarkar, A. K., Mondal, L., Ray, K. and Giri, A. K.  Cytogenetic damage and genetic variants in the individuals susceptible to arsenic-induced cancer through drinking water. International Journal of Cancer. 2006.  118, 2470-2478. [PubMed]
21. Halder, B., Pramanick, S., Mukhopadhyay, S. and Giri, A. K.  Anticlastogenic effects of black tea polyphenols theaflavins and thearubigins in human lymphocytes in vitro. Toxicology in Vitro. 2006.  20, 608-613. [PubMed]
22. Basu, A., Som, A., Ghoshal, S., Mondal, L., Chaubey, R. C., Bhilwade, H. N., Rahman, M. M. and Giri, A. K.  Assessment of DNA damage in peripheral blood lymphocytes of individuals susceptible to arsenic induced toxicity in West Bengal, India. Toxicology Letters. 2005.  159, 100-112. [PubMed]
23. Halder, B., Pramanick, S., Mukhopadhyay, S. and Giri, A. K.  Inhibition of benzo[a]pyrene induced mutagenicity and genotoxicity by black tea polyphenols theaflavins and thearubigins in multiple test systems. Food and Chemical Toxicology. 2005.  43, 591-597. [PubMed]
24. Mahata, J., Chaki, M., Ghosh, P., Das, L. K., Baidya, K., Ray, K., Natarajan, A. T. and Giri, A. K.  Chromosomal aberrations in arsenic-exposed human populations: a review with special reference to a comprehensive study in West Bengal, India. Cytogenetic and Genome Research. 2004.  104, 359-364. [PubMed]
25. Basu, A., Ghosh, P., Das, J. K., Banerjee, A., Ray, K. and Giri, A. K.  Micronuclei as biomarkers of carcinogen exposure in populations exposed to arsenic through drinking water in West Bengal, India: a comparative study in three cell types. Cancer Epidemiology, Biomarkers & Prevention. 2004.  13, 820-827. [PubMed]
26. Mahata, J., Ghosh, P., Sarkar, J. N., Ray, K., Natarajan, A. T. and Giri, A. K.  Effect of sodium arsenite on peripheral lymphocytes in vitro: individual susceptibility among a population exposed to arsenic through the drinking water. Mutagenesis. 2004.  19, 223-229. [PubMed]
27. Mahata, J., Basu, A., Ghoshal, S., Sarkar, J. N., Roy, A. K., Poddar, G., Nandy, A. K., Banerjee, A., Ray, K., Natarajan, A. T., Nilsson, R. and Giri, A. K.  Chromosomal aberrations and sister chromatid exchanges in individuals exposed to arsenic through drinking water in West Bengal, India. Mutation Research. 2003.  534, 133-143. [PubMed]
28. Gupta, S., Chaudhuri, T., Seth, P., Ganguly, D. K. and Giri, A. K.  Antimutagenic effects of black tea (World Blend) and its two active polyphenols theaflavins and thearubigins in Salmonella assays. Phytotherapy Research : PTR. 2002.  16, 655-661. [PubMed]
29. Gupta, S., Saha, B. and Giri, A. K.  Comparative antimutagenic and anticlastogenic effects of green tea and black tea: a review. Mutation Research. 2002.  512, 37-65. [PubMed]
30. Basu, A., Mahata, J., Roy, A. K., Sarkar, J. N., Poddar, G., Nandy, A. K., Sarkar, P. K., Dutta, P. K., Banerjee, A., Das, M., Ray, K., Roychaudhury, S., Natarajan, A. T., Nilsson, R. and Giri, A. K.  Enhanced frequency of micronuclei in individuals exposed to arsenic through drinking water in West Bengal, India. Mutation Research. 2002.  516, 29-40. [PubMed]
31. Gupta, S., Chaudhuri, T., Ganguly, D. K. and Giri, A. K.  Anticlastogenic effects of black tea (World blend) and its two active polyphenols theaflavins and thearubigins in vivo in Swiss albino mice. Life Sciences. 2001.  69, 2735-2744. [PubMed]
32. Mukhopadhyay, A., Ray, S. and Giri, A. K.  Anticlastogenic effects of d- and l-centchroman in Swiss albino mice. 2. Subacute study in vivo and comparison with tamoxifen. Cytobios. 2001.  106, 77-86. [PubMed]
33. Basu, A., Mahata, J., Gupta, S. and Giri, A. K.  Genetic toxicology of a paradoxical human carcinogen, arsenic: a review. Mutation Research. 2001.  488, 171-194. [PubMed]
34. Patra, U., Gupta, S., Talapatra, S. N. and Giri, A. K.  Genotoxic effects after in vivo exposure of vegetable extracts containing heavy metals from the Dhapa area of Calcutta, India. I. Effects of cauliflower, spinach and radish. Food and Chemical Toxicology. 2001.  39, 67-72. [PubMed]
35. Giri, A. K., Mukhopadhyay, A., Sun, J., Hsie, A. W. and Ray, S.  Antimutagenic effects of centchroman--a contraceptive and a candidate drug for breast cancer in multiple mutational assays. Mutagenesis. 1999.  14, 613-620. [PubMed]
36. Mukhopadhyay, A., Gupta, S., Ray, S. and Giri, A. K.  Anticlastogenic effects of centchroman and its enantiomers in Swiss albino mice. I. Acute study and their comparison with tamoxifen. Cancer Letters. 1999.  144, 137-143. [PubMed]
37. Gupta, S., Mukhopadhyay, A., Ray, S. and Giri, A. K.  Comparative antimutagenic effects of D- and L-centchroman and their comparison with tamoxifen in Salmonella assay. Mutation Research. 1999.  445, 1-8. [PubMed]
38. Giri, A. K., Das, M., Reddy, V. G. and Pal, A. K.  Mutagenic and genotoxic effects of theophylline and theobromine in Salmonella assay and in vivo sister chromatid exchanges in bone marrow cells of mice. Mutation Research. 1999.  444, 17-23. [PubMed]
39. Chatterjee, T., Muhkopadhyay, A., Khan, K. A. and Giri, A. K.  Comparative mutagenic and genotoxic effects of three antimalarial drugs, chloroquine, primaquine and amodiaquine. Mutagenesis. 1998.  13, 619-624. [PubMed]
40. Giri, A. K. and Mukhopadhyay, A.  Mutagenicity assay in Salmonella and in vivo sister chromatid exchange in bone marrow cells of mice for four pyrazolone derivatives. Mutation Research. 1998.  420, 15-25. [PubMed]
41. Philipose, B., Singh, R., Khan, K. A. and Giri, A. K.  Comparative mutagenic and genotoxic effects of three propionic acid derivatives ibuprofen, ketoprofen and naproxen. Mutation Research. 1997.  393, 123-131. [PubMed]
42. Giri A. K.  Genetic toxicology of epichlorohydrin: a review. Mutation Research. 1997.  386, 25-38. [PubMed]
 

 
 
Education 
::
D.Sc. Calcutta University, India
::
Ph.D. Calcutta University, India
  Last modified on : Mar 4, 2011
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