INCREDB ID : 240
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Partha Sarathi Dasgupta, Ph.D.
Senior Scientific Officer 
 
Chittaranjan National Cancer Institute
Signal Transduction & Biogenic Amines
37, S. P. Mukherjee Road
Kolkata - 700 026   
West Bengal   
 
E-mail: parthasarathi.dasgupta@cnci.org.in
Phone: +91-33-24765101, Extn.324
Fax: +91-33-4757606
 
URL: http://www.cnci.org.in/research/research_main.html#
 
Positions Held:
Position Affiliation Time Period
Senior Scientific Officer Chittaranjan National Cancer Institute, Kolkata, India Present
 
Area of Specialization:
Pharmacology
Oncology
Research Summary:
Preclinical trials of therapeutic efficacy of Dopamine as antiangiogenic drug on different human tumors-breast, colon, stomach, lung, prostate, grown in nude mice
The etiopathological role of Dopamine in the development of T cell leukemia
Therapeutic targeting of cancer stem cells
Wound tissue repair utilizing mesenchymal stem cells
 
Publications:
1. Ganguly, S., Basu, B., Shome, S., Jadhav, T., Roy, S., Majumdar, J., Dasgupta, P. S. and Basu, S.  Dopamine, by acting through its D2 receptor, inhibits insulin-like growth factor-I (IGF-I)-induced gastric cancer cell proliferation via up-regulation of Kruppel-like factor 4 through down-regulation of IGF-IR and AKT phosphorylation. The American Journal of Pathology. 2010.  177, 2701-2707. [PubMed]
2. Basu, B., Sarkar, C., Chakroborty, D., Ganguly, S., Shome, S., Dasgupta, P. S. and Basu, S.  D1 and D2 dopamine receptor-mediated inhibition of activated normal T cell proliferation is lost in jurkat T leukemic cells. The Journal of Biological Chemistry. 2010.  285, 27026-27032. [PubMed]
3. Chakroborty, D., Chowdhury, U. R., Sarkar, C., Baral, R., Dasgupta, P. S. and Basu, S.  Dopamine regulates endothelial progenitor cell mobilization from mouse bone marrow in tumor vascularization. The Journal of Clinical Investigation. 2008.  118, 1380-1389. [PubMed]
4. Sarkar, C., Das, S., Chakroborty, D., Chowdhury, U. R., Basu, B., Dasgupta, P. S. and Basu, S.  Cutting Edge: Stimulation of dopamine D4 receptors induce T cell quiescence by up-regulating Kruppel-like factor-2 expression through inhibition of ERK1/ERK2 phosphorylation. Journal of Immunology. 2006.  177, 7525-7529. [PubMed]
5. Sarkar, C., Chakroborty, D., Mitra, R. B., Banerjee, S., Dasgupta, P. S. and Basu, S.  Dopamine in vivo inhibits VEGF-induced phosphorylation of VEGFR-2, MAPK, and focal adhesion kinase in endothelial cells. American Journal of Physiology. Heart and Circulatory Physiology. 2004.  287, H1554-60. [PubMed]
6. Chakroborty, D., Sarkar, C., Mitra, R. B., Banerjee, S., Dasgupta, P. S. and Basu, S.  Depleted dopamine in gastric cancer tissues: dopamine treatment retards growth of gastric cancer by inhibiting angiogenesis. Clinical Cancer Research. 2004.  10, 4349-4356. [PubMed]
7. Ghosh, M. C., Mondal, A. C., Basu, S., Banerjee, S., Majumder, J., Bhattacharya, D. and Dasgupta, P. S.  Dopamine inhibits cytokine release and expression of tyrosine kinases, Lck and Fyn in activated T cells. International Immunopharmacology. 2003.  3, 1019-1026. [PubMed]
8. Saha, B., Mondal, A. C., Basu, S. and Dasgupta, P. S.  Circulating dopamine level, in lung carcinoma patients, inhibits proliferation and cytotoxicity of CD4+ and CD8+ T cells by D1 dopamine receptors: an in vitro analysis. International Immunopharmacology. 2001.  1, 1363-1374. [PubMed]
9. Saha, B., Mondal, A. C., Majumder, J., Basu, S. and Dasgupta, P. S.  Physiological concentrations of dopamine inhibit the proliferation and cytotoxicity of human CD4+ and CD8+ T cells in vitro: a receptor-mediated mechanism. Neuroimmunomodulation. 2001.  9, 23-33. [PubMed]
10. Basu, S. and Dasgupta, P. S.  Role of dopamine in malignant tumor growth. Endocrine. 2000.  12, 237-241. [PubMed]
11. Basu, S. and Dasgupta, P. S.  Dopamine, a neurotransmitter, influences the immune system. Journal of Neuroimmunology. 2000.  102, 113-124. [PubMed]
12. Basu, S. and Dasgupta, P. S.  Decreased dopamine receptor expression and its second-messenger cAMP in malignant human colon tissue. Digestive Diseases and Sciences. 1999.  44, 916-921. [PubMed]
13. Basu, S. and Dasgupta, P. S.  Alteration of dopamine D2 receptors in human malignant stomach tissue. Digestive Diseases and Sciences. 1997.  42, 1260-1264. [PubMed]
14. Basu, S., Dasgupta, P. S. and Chowdhury, J. R.  Enhanced tumor growth in brain dopamine-depleted mice following 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) treatment. Journal of Neuroimmunology. 1995.  60, 1-8. [PubMed]
15. Basu, S., Dasgupta, P. S., Lahiri, T. and Chowdhury, J. R.  Uptake and biodistribution of dopamine in bone marrow, spleen and lymph nodes of normal and tumor bearing mice. Life Sciences. 1993.  53, 415-424. [PubMed]
16. Dasgupta, P. S. and Lahiri, T.  Alteration of brain catecholamines during growth of benzo(a)pyrene induced murine fibrosarcoma. Neoplasma. 1992.  39, 163-165. [PubMed]
 

 
Grant Support:
Project Title Role Funding Agency Sanction Number Sanction Date
In vitro effect of Dopamine on tumor stem cells of glioblastoma Council of Scientific and Industrial Research, Government of India
Evaluation of Dopamine as anti angiogenic drug on animal and xenotransplanted human lung carcinoma growth in mice Department of Biotechnology, Government of India
Evaluation of therapeutic effect of dopamine on human stomach tumor growth in Nude mice: analysis of the effect of dopamine on Insulin Like Growth Factors , potential mediator of malignant tumor growth Department of Science & Technology, Government of India
Role of peripheral Dopamine in Wound Angiogenesis. : An approach to develop new therapeutic modality for wound tissue repair Defence Research and Development Organisation, New Delhi, India

 
 
 
Education 
::
M.Sc.
::
Ph.D.
  Last modified on : Mar 4, 2011
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