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Sudeshna Kar, Ph.D.
Principal Investigator 
Institute of Molecular Medicine
254 Okhla Industrial Estate, Phase III
New Delhi - 110 020   
Phone: +91-11-41028710
Fax: +91-11-41028709
Positions Held:
Position Affiliation Time Period
Principal Investigator Institute of Molecular Medicine 2007-Present
Staff Fellow National Cancer Institute, National Institutes of Health, USA 2003-2007
Visiting Fellow National Cancer Institute, National Institutes of Health, USA 1999-2003
Area of Specialization:
Molecular Biology
Research Summary:
Engineering and development of tumor-killing bacterium from benign commensals.
Conversion of non-virulent resident microbes into opportunistic pathogens in the absence of any genetic changes.
Developing neuroprotective agents for neurodegenerative disease.
Building a microbial chemical factory.
1. Kar, S., Choi, E. J., Guo, F., Dimitriadis, E. K., Kotova, S. L. and Adhya, S.  Right-handed DNA supercoiling by an octameric form of histone-like protein HU: modulation of cellular transcription. The Journal of Biological Chemistry. 2006.  281, 40144-40153. [PubMed]
2. Kar, S., Edgar, R. and Adhya, S.  Nucleoid remodeling by an altered HU protein: reorganization of the transcription program. Proceedings of the National Academy of Sciences of the United States of America. 2005.  102, 16397-16402. [PubMed]
3. Rao, S., Hu, S., McHugh, L., Lueders, K., Henry, K., Zhao, Q., Fekete, R. A., Kar, S., Adhya, S. and Hamer, D. H.  Toward a live microbial microbicide for HIV: commensal bacteria secreting an HIV fusion inhibitor peptide. Proceedings of the National Academy of Sciences of the United States of America. 2005.  102, 11993-11998. [PubMed]
4. Roy, S., Dimitriadis, E. K., Kar, S., Geanacopoulos, M., Lewis, M. S. and Adhya, S.  Gal repressor-operator-HU ternary complex: pathway of repressosome formation. Biochemistry. 2005.  44, 5373-5380. [PubMed]
5. Kar, S. and Adhya, S.  Recruitment of HU by piggyback: a special role of GalR in repressosome assembly. Genes & Development. 2001.  15, 2273-2281. [PubMed]


M.Sc. in Biophysics and Molecular Biology, Calcutta University, India
Ph.D. in Life Sciences, Indian Institute of Chemical Biology, Jadavpur, Kolkata
Honors and Awards
2005-2006, Howard Hughes Institute Award of Excellence for NIH Internship program
2003,Technology Transfer Award of National Cancer Institute
1993-1998, National research fellowship from CSIR
  Last modified on : Mar 4, 2011
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