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Gayatri Ramakrishna, Ph.D.
Centre for DNA Fingerprinting and Diagnostics
Cancer Biology Lab
Bldg. 7, Gruhakalpa, 5-4-399 / B, Nampally
Hyderabad - 500 001   
Andhra Pradesh   
Phone: +91-40-24749414
Fax: +91-40-24749448
Positions Held:
Position Affiliation Time Period
Post Doctoral Fellowship National Cancer Institute, National Institutes of Health, MD, USA
Area of Specialization:
Molecular Biology
Cancer Biology
Research Summary:
Role of K-RAS in Lung Tumorigenesis
Human Papilloma Virus (HPV) Screening in the Cervical Scrapes from Rural Andhra Pradesh
1. Bose, S., Sakhuja, P., Bezawada, L., Agarwal, A. K., Kazim, S. N., Khan, L. A., Sarin, S. K. and Ramakrishna, G.  Hepatocellular carcinoma with persistent hepatitis B virus infection shows unusual downregulation of Ras expression and differential response to Ras mediated signaling. Journal of Gastroenterology and Hepatology. 2011.  26, 135-144. [PubMed]
2. Sowjanya, A. P., Paul, P., Vedantham, H., Ramakrishna, G., Vidyadhari, D., Vijayaraghavan, K., Laksmi, S., Sudula, M., Ronnett, B. M., Das, M., Shah, K. V. and Gravitt, P. E.  Suitability of self-collected vaginal samples for cervical cancer screening in periurban villages in Andhra Pradesh, India. Cancer Epidemiology, Biomarkers & Prevention. 2009.  18, 1373-1378. [PubMed]
3. Gokul, G., Gautami, B., Malathi, S., Sowjanya, A. P., Poli, U. R., Jain, M., Ramakrishna, G. and Khosla, S.  DNA methylation profile at the DNMT3L promoter: a potential biomarker for cervical cancer. Epigenetics : Official Journal of the DNA Methylation Society. 2007.  2, 80-85. [PubMed]
4. Gokul, G., Ramakrishna, G. and Khosla, S.  Reprogramming of HeLa cells upon DNMT3L overexpression mimics carcinogenesis. Epigenetics . 2009.  4, 322-329. [PubMed]
5. Vucenik, I., Ramakrishna, G., Tantivejkul, K., Anderson, L. M. and Ramljak, D.  Inositol hexaphosphate (IP6) blocks proliferation of human breast cancer cells through a PKCdelta-dependent increase in p27Kip1 and decrease in retinoblastoma protein (pRb) phosphorylation. Breast Cancer Research and Treatment. 2005.  91, 35-45. [PubMed]
6. Padma, S., Sowjanya, A. P., Poli, U. R., Jain, M., Rao, B. and Ramakrishna, G.  Downregulation of calcineurin activity in cervical carcinoma. Cancer Cell International. 2005.  5, 7. [PubMed]
7. Singh, A., Sowjanya, A. P. and Ramakrishna, G.  The wild-type Ras: road ahead. The FASEB Journal . 2005.  19, 161-169. [PubMed]
8. Gayatri, R. and Chatterjee, S.  Effects of chlorpromazine on growth and development of Dictyostelium discoideum. Microbios. 1991.  68, 97-107. [PubMed]
9. Gayatri, R. and Chatterjee, S.  Effects of lindane on growth of cellular slime mold Dictyostelium discoideum. Bulletin of Environmental Contamination and Toxicology. 1992.  49, 285-289. [PubMed]
10. Gayatri, R. and Chatterjee, S.  Phosphatase activities in pesticide-treated growing and developing cells of Dictyostelium discoideum. Journal of Applied Toxicology : JAT. 1993.  13, 297-300. [PubMed]
11. Gayatri, R. and Chatterjee, S.  Phagocytic activity of Dictyostelium amoebae treated with an organochlorine pesticide. Cell Biology International. 1993.  17, 349-352. [PubMed]
12. Gayatri, R. and Chatterjee, S.  Pinocytic stimulation in Dictyostelium discoideum by gamma-benzene hexachloride. Journal of Cellular Physiology. 1994.  158, 523-526. [PubMed]
13. Gayatri, R. and Chatterjee, S.  Growth and development of cellular slime mould Dictyostelium discoideum treated with DDT. Environmental Pollution. 1994.  86, 135-140. [PubMed]
14. Sithanandam, G., Ramakrishna, G., Diwan, B. A. and Anderson, L. M.  Selective mutation of K-ras by N-ethylnitrosourea shifts from codon 12 to codon 61 during fetal mouse lung maturation. Oncogene. 1998.  17, 493-502. [PubMed]
15. Rice, P. L., Porter, S. E., Koski, K. M., Ramakrishna, G., Chen, A., Schrump, D., Kazlauskas, A. and Malkinson, A. M.  Reduced receptor expression for platelet-derived growth factor and epidermal growth factor in dividing mouse lung epithelial cells. Molecular Carcinogenesis. 1999.  25, 285-294. [PubMed]
16. Ramakrishna, G., Bialkowska, A., Perella, C., Birely, L., Fornwald, L. W., Diwan, B. A., Shiao, Y. H. and Anderson, L. M.  Ki-ras and the characteristics of mouse lung tumors. Molecular Carcinogenesis. 2000.  28, 156-167. [PubMed]
17. Diwan, B. A., Ramakrishna, G., Anderson, L. M. and Ramljak, D.  Overexpression of Grb2 in inflammatory lesions and preneoplastic foci and tumors induced by N-nitrosodimethylamine in Helicobacter hepaticus-infected and -noninfected A/J mice. Toxicologic Pathology. 2000.  28, 548-554. [PubMed]
18. Shiao, Y. H., Resau, J. H., Nagashima, K., Anderson, L. M. and Ramakrishna, G.  The von Hippel-Lindau tumor suppressor targets to mitochondria. Cancer Research. 2000.  60, 2816-2819. [PubMed]
19. Ramakrishna, G., Sithanandam, G., Cheng, R. Y., Fornwald, L. W., Smith, G. T., Diwan, B. A. and Anderson, L. M.  K-ras p21 expression and activity in lung and lung tumors. Experimental Lung Research. 2000.  26, 659-671. [PubMed]
20. McKenna, I. M., Ramakrishna, G., Diwan, B. A., Kang, Y., Shiao, Y. H., Wakefield, L. M., Powell, D. A., Anderson, L. M. and Jakowlew, S. B.  Heterozygous inactivation of TGF-beta1 increases the susceptibility to chemically induced mouse lung tumorigenesis independently of mutational activation of K-ras. Toxicology Letters. 2001.  123, 151-158. [PubMed]
21. Rama, Devi, A., R., Govindiah, V., Ramakrishna, G. and Naushad, S., M., Prevalence of Methylene tetrahydrofolate reductase polymorphism in South Indian population. Current Science, 86(3) 440-443.
22. Ramakrishna, G. and Chatterjee, S.: Morphogenesis of Dictyostelium discoideum cells exposed to organochlorine pesticide.  Bulletin of Environmental Contamination and Toxicology,1994, 52:  871-877.
23. Ramakrishna, G. and Anderson, L., M., : Levels and membrane localization of the c-K-ras p21 protein in lungs of mice of different genetic strains and effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and Aroclor 1254. Carcinogenesis, 1998, 19:  463-470.
24. Ramakrishna, G., Sithanadam G, Fornwald L. Smith G T and Anderson L M. GTP loading of K-ras p21 in mouse lung type 2 cells is dependent on cell density and anchorage. (submitted)
25. Shiao, Y., H., Ramakrishna, G., Anderson, L., M., Perantoni, A., O., Rice, J., M. and Diwan, B., A., :  Down-regulation of Von Hippel-Lindau protein in nitroso compound-induced rat non-clear cell kidney tumors. (submitted)


Ph.D. in Biochemistry, Jawaharlal Nehru University, New Delhi, India
  Last modified on : Mar 4, 2011
India Cancer Research Database has been developed by the Institute of Bioinformatics with funding from the Department of Biotechnology, Government of India.