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Kakoli Bose, Ph.D.
Principal Investigator 
Advanced Centre for Treatment Research and Education in Cancer, Tata Memorial Centre
Navi Mumbai - 410 210   
Phone: +91-22-2740 5109
Fax:  +91-22-2740 5085
Positions Held:
Position Affiliation Time Period
Post Doctoral Fellowship Tufts University School of Medicine, Boston, USA
Area of Specialization:
1. Chaganti, L. K., Kuppili, R. R. and Bose, K.  Intricate structural coordination and domain plasticity regulate activity of serine protease HtrA2. FASEB Journal : Official Publication of the Federation of American Societies For Experimental Biology. 2013.  27, 3054-3066. [PubMed]
2. Bejugam, P. R., Kuppili, R. R., Singh, N., Gadewal, N., Chaganti, L. K., Sastry, G. M. and Bose, K.  Allosteric regulation of serine protease HtrA2 through novel non-canonical substrate binding pocket. PloS One. 2013.  8, e55416. [PubMed]
3. Singh, N., Kuppili, R. R. and Bose, K.  The structural basis of mode of activation and functional diversity: a case study with HtrA family of serine proteases. Archives of Biochemistry and Biophysics. 2011.  516, 85-96. [PubMed]
4. Bose, K., Meinke, G., Bohm, A. and Baleja, J. D.  Design and characterization of an enhanced repressor of human papillomavirus E2 protein. FASEB Journal : Official Publication of the Federation of American Societies For Experimental Biology. 2011.  25, 2354-2361. [PubMed]
5. Wei, J., Liu, Y., Bose, K., Henry, G. D. and Baleja, J. D.  Disorder and structure in the Rab11 binding domain of Rab11 family interacting protein 2. Biochemistry. 2009.  48, 549-557. [PubMed]
6. Bose, K., Yoder, N. C., Kumar, K. and Baleja, J. D.  The role of conserved histidines in the structure and stability of human papillomavirus type 16 E2 DNA-binding domain. Biochemistry. 2007.  46, 1402-1411. [PubMed]
7. Bose, K. and Clark, A. C.  pH effects on the stability and dimerization of procaspase-3. Protein Science. 2005.  14, 24-36. [PubMed]
8. Bose, K. Pop, C., Feeney, B. and Clark, A. C.  An uncleavable procaspase-3 mutant has a lower catalytic efficiency but an active site similar to that of mature caspase-3. Biochemistry. 2003.  42, 12298-12310. [PubMed]
9. Bose, K. and Clark, A. C.  Dimeric procaspase-3 unfolds via a four-state equilibrium process. Biochemistry. 2001.  40, 14236-14242. [PubMed]
10. Pop, C., Chen, Y. R., Smith, B., Bose, K., Bobay, B., Tripathy, A., Franzen, S. and Clark, A. C.  Removal of the pro-domain does not affect the conformation of the procaspase-3 dimer. Biochemistry. 2001.  40, 14224-14235. [PubMed]


Grant Support:
Project Title Role Funding Agency Sanction Number Sanction Date
Structural and functional characterization of proapoptotic proteins: Human papillomavirus E2 and serine protease HtrA2
Understanding protein-protein interactions involved in papillomavirus E2 induced apoptosis
Proapoptotic serine protease HtrA2/Omi: structural determinants of its mechanism of action


Ph.D. in Biochemistry, North Carolina State University, Department of Biochemistry, Raleigh, USA
M.Sc. in Chemistry
Honors and Awards
Designed a papillomaviral inhibitor that is currently being developed by the Tufts University for Technology Transfer for turning it into a patent application and being evaluated by a company to license the technology
2005, Received Natalie Zucker Research Grant Award
2005, Received honorable mention in Tufts Dean’s letter
2002, Received award for best poster presentation in the Research Triangle Park Annual Conference on Biochemistry, NC
Obtained full Scholarship from NC State University for Doctoral study
Member, American Chemical Society
Member, American Association for the Advancement of Science
Member, The Protein Society
  Last modified on : Dec 14, 2015
India Cancer Research Database has been developed by the Institute of Bioinformatics with funding from the Department of Biotechnology, Government of India.