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T. R. Santhosh Kumar, Ph.D.
Scientist E1 
Rajiv Gandhi Centre for Biotechnology
Thycaud, Poojappura
Thiruvananthapuram - 695 014   
Phone: +91-471-2529500
Area of Specialization:
Molecular Biology
Research Summary:
Novel cell based assays for large scale screening of plant derived compounds for anticancer property: technology development and preliminary screening
Drug resistance in cancer
1. Rashmi, R., Santhosh, K. and Karunagaran, D.  Human colon cancer cells differ in their sensitivity to curcumin-induced apoptosis and heat shock protects them by inhibiting the release of apoptosis-inducing factor and caspases. FEBS Letters. 2003.  538, 19-24. [PubMed]
2. Rashmi, R., Kumar, S. and Karunagaran, D.  Ectopic expression of Hsp70 confers resistance and silencing its expression sensitizes human colon cancer cells to curcumin-induced apoptosis. Carcinogenesis. 2004.  25, 179-187. [PubMed]
3. Rashmi, R., Kumar, S. and Karunagaran, D.  Human colon cancer cells lacking Bax resist curcumin-induced apoptosis and Bax requirement is dispensable with ectopic expression of Smac or downregulation of Bcl-XL. Carcinogenesis. 2005.  26, 713-723. [PubMed]
4. Karunagaran, D., Rashmi, R. and Kumar, T. R.  Induction of apoptosis by curcumin and its implications for cancer therapy. Current Cancer Drug Targets. 2005.  5, 117-129. [PubMed]
5. Kumar, T. R., Umashankar P.R., Lal, A. V. Effect of oxygen supplementation under xylazine - Ketamine anaesthesia in adult rats. Trends in Biomaterials and artificial Organs. 1996
6. Umashankar, P.R., Kumar, S.T.R., Lal, A. V. Modified Xylazine -Ketamine injectable anaesthesia by atropine sulfate Diazepam premedication in Rabbits for bone implantation. Trends in Biomaterials and artificial Organs.1996
7. Kumar, S.T.R., Krishnan, L.K. Endothelial cell growth factor enmeshed with polymerized fibrin to enhance proliferation of cell on polymeric materials. Biomaterials. 2001
8. Santhosh Kumar T. R. & Lissy K.Krishnan.A stable matrix for generation of tissue engineered non-thrombogenic vascular grafts. Tissue Engineering.2002
9. Sengupta, S., Smitha S.L, Thomas, N.E., Santhosh Kumar T. R., Devi, C. and Rajasekharan, K.N. DAT1, A Novel Synthetic Microtubule Inhibitor, Exerts Cytotoxicity and Shows Efficacy Towards Multidrug Resistant Cancer Cell. Mol. Biol. Cell (Suppln).2003
10. Rashmi R., Santhosh Kumar T. R., Karunagaran D.Ectopic expression of BclXL or Ku70 protects human colon cancer cellc SW 480 aginst curcumin induced apoptosis while their downregualtion potentiates it. Carcinogenesis


Ph.D. Sree Chitra Thirunal Institute for Medical Sciences and Technology, Thiruvananthapuram, India
  Last modified on : Mar 4, 2011
India Cancer Research Database has been developed by the Institute of Bioinformatics with funding from the Department of Biotechnology, Government of India.